Photo of Joseph D Mancias,  MD, PhD

Joseph D Mancias, MD, PhD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute

Joseph D Mancias, MD, PhD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Attending Radiation Oncologist, Radiation Oncology, Dana-Farber Cancer Institute
  • Attending Radiation Oncologist, Radiation Oncology , Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Joseph Mancias is a radiation oncologist at the Dana-Farber/Brigham and Women's Cancer Center and Assistant Professor of Radiation Oncology at Harvard Medical School. He specializes in the care of gastrointestinal cancer patients including pancreatic cancer patients and runs an independent laboratory at the Dana-Farber Cancer Institute focused on the biology of pancreatic cancer.

He received his medical and graduate degrees as part of the Tri-Institutional Weill Cornell/Rockefeller/Sloan-Kettering M.D.-Ph.D. Program earning a Ph.D. degree from the Weill Cornell Graduate School of Medical Sciences in 2007 and his M.D. from Weill Cornell Medical College in 2008. His internship in Internal Medicine at Brigham and Women’s Hospital was followed by a residency in Radiation Oncology in the combined Harvard Radiation Oncology Program completed in 2013. His postdoctoral research in the laboratories of Dr. Wade Harper in the Department of Cell Biology at Harvard Medical School and Dr. Alec Kimmelman in the Department of Radiation Oncology at Dana-Farber Cancer Institute focused on the role of autophagy in pancreatic cancer biology. From 2013-2016, he maintained a focused clinical practice in the Department of Radiation Oncology at Beth Israel Deaconess Medical Center as an Instructor in Radiation Oncology treating patients seen in the BIDMC Pancreatic Cancer Center. Dr. Mancias joined the Department of Radiation Oncology at Dana-Farber Cancer Institute and Brigham and Women’s Hospital in 2016.

Dr. Mancias' research focuses on critical aspects of the biology of pancreatic cancer in order to develop novel therapeutic approaches. The lab takes a comprehensive approach combining biochemical, quantitative mass spectrometry-based proteomic, gene editing, cell biological, and mouse modeling techniques to advance our understanding of the role of selective autophagy and iron metabolism in pancreatic cancer. His research has been published in Nature, Cell, Molecular Cell, eLife, and JAMA Surgery.

Publications

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  • Biancur DE, Paulo JA, Małachowska B, Del Rey MQ, Sousa CM, Wang X, Sohn ASW, Chu GC, Gygi SP, Harper JW, Fendler W, Mancias JD, Kimmelman AC. Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism. Nat Commun 2017; 8:15965. PubMed
  • Paulo JA, Mancias JD, Gygi SP. Proteome-Wide Protein Expression Profiling Across Five Pancreatic Cell Lines. Pancreas 2017. PubMed
  • Perez K, Clancy TE, Mancias JD, Rosenthal MH, Wolpin BM. When, What, and Why of Perioperative Treatment of Potentially Curable Pancreatic Adenocarcinoma. J Clin Oncol 2016. PubMed
  • Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA. Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron 2016; 92:813-828. PubMed
  • Mancias JD, Kimmelman AC. Mechanisms of Selective Autophagy in Normal Physiology and Cancer. J Mol Biol 2016; 428:1659-80. PubMed
  • Storino A, Castillo-Angeles M, Watkins AA, Vargas C, Mancias JD, Bullock A, Demirjian A, Moser AJ, Kent TS. Assessing the Accuracy and Readability of Online Health Information for Patients With Pancreatic Cancer. JAMA Surg 2016. PubMed
  • Dagoglu N, Callery M, Moser J, Tseng J, Kent T, Bullock A, Miksad R, Mancias JD, Mahadevan A. Stereotactic Body Radiotherapy (SBRT) Reirradiation for Recurrent Pancreas Cancer. J Cancer 2016; 7:283-8. PubMed
  • Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife 2015. PubMed
  • Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 2014. PubMed
  • Bryant KL, Mancias JD, Kimmelman AC, Der CJ. KRAS: feeding pancreatic cancer proliferation. Trends Biochem Sci 2014; 39:91-100. PubMed
  • Mancias JD, Kimmelman AC. Targeting autophagy addiction in cancer. 2012; 2:1302-6. PubMed
  • Mancias JD, Goldberg J. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. EMBO J 2008; 27:2918-28. PubMed
  • Bi X, Mancias JD, Goldberg J. Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. Dev Cell 2007; 13:635-45. PubMed
  • Fath S, Mancias JD, Bi X, Goldberg J. Structure and organization of coat proteins in the COPII cage. Cell 2007; 129:1325-36. PubMed
  • Mancias JD, Goldberg J. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. Mol Cell 2007; 26:403-14. PubMed
  • Mancias JD, Goldberg J. Exiting the endoplasmic reticulum. Traffic 2005; 6:278-85. PubMed
  • West MW, Wang W, Patterson J, Mancias JD, Beasley JR, Hecht MH. De novo amyloid proteins from designed combinatorial libraries. Proc Natl Acad Sci U S A 1999; 96:11211-6. PubMed
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