Photo of Joseph V. Bonventre,  MD, PhD

Joseph V. Bonventre, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-5960
Fax: (617) 582-6010

Joseph V. Bonventre, MD, PhD

Brigham And Women's Hospital


  • Samuel A. Levine Professor of Medicine, Medicine, Harvard Medical School
  • Chief, Renal Division, Medicine, Brigham And Women's Hospital
  • Director, Health Sciences and Technology, Massachusetts General Hospital
  • Professor, Harvard-MIT Health Sciences and Technology, Brigham And Women's Hospital


Research Abstract

One focus of the lab is on Kidney injury molecule-1 which is markedly upregulated in renal cell carcinoma and other conditions where the kidney proximal epithelial cell is dedifferentiated. We are studying the functional role of this protein and its role as a urinary biomarker for renal cell carcinoma and renal epithelial cell injury. Another focus is on phospholipase A2 (PLA2) and the role of this family of enzymes on carcinogenesis, acute tissue injury, apoptosis, signal transduction and transcriptional regulation. We have created a cPLA2 null mouse and are studying the effects of absence of this gene on bowel cancer development in mice carrying the Min mutation as well as angiogenesis and tumor growth in the cPLA2 -/- mouse . Studies are carried to understand how phospholipases A2 contribute to apoptosis, to evaluate the importance of kinases such as the stress-activated MAP protein kinases, and the proteins interacting with cPLA2 to potentiate cell death, and to identify and characterize transcription factors that play important roles in the cell cycle. We have isolated a nuclear protein that interacts with the cytosolic 85 kDa cPLA2 and potentiates apoptosis. Gene therapy approaches with adenovirus are being used.

We have isolated a cDNA encoding TRIP-Br1, a novel transcriptional regulator which interacts with the PHD-bromodomain of the co-repressors of KRAB-mediated repression, KRIP-1(TIF1?) and TIF1?, as well as the co-activator/adaptor p300/CBP. TRIP-Br proteins make a direct functional contact with DP-1, resulting in the stimulation of E2F-1/DP-1 transcriptional activity. In this novel context, KRIP-1 cooperates with TRIP-Br proteins to co-activate E2F-1/DP-1. Co-expression of the retinoblastoma gene product (RB) abolishes baseline E2F-1/DP-1 transcriptional activity as well as TRIP-Br/KRIP-1 co-activation, both of which are restored in the presence of the E1A oncoprotein. These features suggest that TRIP-Br proteins function at E2F-responsive promoters to integrate regulatory signals provided by PHD zinc finger- and/or bromodomain-containing transcription factors such as KRIP-1 and p300/CBP.


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  • Deml KF, Schildhaus HU, Compérat E, von Teichman A, Storz M, Schraml P, Bonventre JV, Fend F, Fleige B, Nerlich A, Gabbert HE, GaBler N, Grobholz R, Hailemariam S, Hinze R, Knüchel R, Lhermitte B, Nesi G, Rüdiger T, Sauter G, Moch H. Clear Cell Papillary Renal Cell Carcinoma and Renal Angiomyoadenomatous Tumor: Two Variants of a Morphologic, Immunohistochemical, and Genetic Distinct Entity of Renal Cell Carcinoma. Am J Surg Pathol 2015; 39:889-901. PubMed
  • Lam AQ, Bonventre JV. Regenerating the nephron with human pluripotent stem cells. Curr Opin Organ Transplant 2015. PubMed
  • Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T. Polycystin-1 and G留12 regulate the cleavage of E-cadherin in kidney epithelial cells. Physiol Genomics 2015; 47:24-32. PubMed
  • Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol 2015. PubMed
  • Lam AQ, Freedman BS, Bonventre JV. Directed Differentiation of Pluripotent Stem Cells to Kidney Cells. Semin Nephrol 2014; 34:445-461. PubMed
  • Zhang PL, Mashni JW, Sabbisetti VS, Schworer CM, Wilson GD, Wolforth SC, Kernen KM, Seifman BD, Amin MB, Geddes TJ, Lin F, Bonventre JV, Hafron JM. Urine kidney injury molecule-1: a potential non-invasive biomarker for patients with renal cell carcinoma. Int Urol Nephrol 2014; 46:379-88. PubMed
  • Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem 2014; 289:1491-504. PubMed
  • Bonventre JV. Maladaptive proximal tubule repair: cell cycle arrest. Nephron Clin Pract 2014; 127:61-4. PubMed
  • Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV. Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm That Forms Tubules Expressing Kidney Proximal Tubular Markers. J Am Soc Nephrol 2013. PubMed
  • Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV. Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations. J Am Soc Nephrol 2013; 24:1571-86. PubMed
  • Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest 2013; 123:4023-35. PubMed
  • Waikar SS, Betensky RA, Emerson SC, Bonventre JV. Imperfect gold standards for biomarker evaluation. Clin Trials 2013; 10:696-700. PubMed
  • Susantitaphong P, Perianayagam MC, Tighiouart H, Liangos O, Bonventre JV, Jaber BL. Tumor necrosis factor alpha promoter polymorphism and severity of acute kidney injury. Nephron Clin Pract 2013; 123:67-73. PubMed
  • Sangoi AR, McKenney JK, Brooks JD, Bonventre JV, Higgins JP. Evaluation of putative renal cell carcinoma markers PAX-2, PAX-8, and hKIM-1 in germ cell tumors: a tissue microarray study of 100 cases. Appl Immunohistochem Mol Morphol 2012; 20:451-3. PubMed
  • Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A 2012; 109:12105-10. PubMed
  • Sengupta P, Basu S, Soni S, Pandey A, Roy B, Oh MS, Chin KT, Paraskar AS, Sarangi S, Connor Y, Sabbisetti VS, Kopparam J, Kulkarni A, Muto K, Amarasiriwardena C, Jayawardene I, Lupoli N, Dinulescu DM, Bonventre JV, Mashelkar RA, Sengupta S. Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity. Proc Natl Acad Sci U S A 2012; 109:11294-9. PubMed
  • Mizuguchi KA, Mitani A, Waikar SS, Ireland P, Panizales C, Deluke G, Sugarbaker DJ, Bonventre JV, Frendl G. Use of postoperative creatinine to predict sustained kidney injury in patients undergoing mesothelioma surgery. Clin J Am Soc Nephrol 2012; 7:1071-8. PubMed
  • Li B, Castano AP, Hudson TE, Nowlin BT, Lin SL, Bonventre JV, Swanson KD, Duffield JS. The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair. FASEB J 2010; 24:4767-81. PubMed
  • Kim J, Kim DS, Park M, Cho HJ, Zervos AS, Bonventre JV, Park KM. Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol 2010; 298:F1332-40. PubMed
  • Nishihara K, Masuda S, Nakagawa S, Yonezawa A, Ichimura T, Bonventre JV, Inui KI. Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats. Am J Physiol Renal Physiol 2010; 298:F923-34. PubMed
  • Ferguson MA, Vaidya VS, Waikar SS, Collings FB, Sunderland KE, Gioules CJ, Bonventre JV. Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. Kidney Int 2010; 77:708-14. PubMed
  • Schröppel B, Krüger B, Walsh L, Yeung M, Harris S, Garrison K, Himmelfarb J, Lerner SM, Bromberg JS, Zhang PL, Bonventre JV, Wang Z, Farris AB, Colvin RB, Murphy BT, Vella JP. Tubular expression of KIM-1 does not predict delayed function after transplantation. J Am Soc Nephrol 2010; 21:536-42. PubMed
  • Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2009; 176:85-97. PubMed
  • Waikar SS, Betensky RA, Bonventre JV. Creatinine as the gold standard for kidney injury biomarker studies? Nephrol. Dial. Transplant. 2009; 24:3263-5. PubMed
  • Bonventre JV. Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transplant 2009; 24:3265-8. PubMed
  • Lamour NF, Subramanian P, Wijesinghe DS, Stahelin RV, Bonventre JV, Chalfant CE. Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis. J Biol Chem 2009; 284:26897-907. PubMed
  • Gunaratnam L,Bonventre JV. HIF in Kidney Disease and Development. J Am Soc Nephrol 2009; 20:1877-87. PubMed
  • Liangos O, Tighiouart H, Perianayagam MC, Kolyada A, Han WK, Wald R, Bonventre JV, Jaber BL. Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers 2009; 14:423-31. PubMed
  • Prozialeck WC,Edwards JR,Lamar PC,Liu J,Vaidya VS,Bonventre JV. Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury. Toxicol Appl Pharmacol 2009; 238:306-14. PubMed
  • Prozialeck WC,Edwards JR,Vaidya VS,Bonventre JV. Preclinical Evaluation of Novel Urinary Biomarkers of Cadmium Nephrotoxicity. Toxicol Appl Pharmacol 2009; 238:301-5. PubMed
  • Takakura A,Contrino L,Zhou X,Bonventre JV,Sun Y,Humphreys BD,Zhou J. Renal Injury is a Third Hit Promoting Rapid Development of Adult Polycystic Kidney Disease. Hum Mol Genet 2009; 18:2523-31. PubMed
  • Vaidya VS,Ford GM,Waikar SS,Wang Y,Clement MB,Ramirez V,Glaab WE,Troth SP,Sistare FD,Prozialeck WC,Edwards JR,Bobadilla NA,Mefferd SC,Bonventre JV. A rapid urine test for early detection of kidney injury. Kidney Int 2009; 76:108-14. PubMed
  • Sieber M,Hoffmann D,Adler M,Vaidya VS,Clement M,Bonventre JV,Zidek N,Rached E,Amberg A,Callanan JJ,Dekant W,Mally A. Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity. Toxicol Sci 2009; 109:336-49. PubMed
  • Kramer AB,van Timmeren MM,Schuurs TA,Vaidya VS,Bonventre JV,van Goor H,Navis G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time. Am J Physiol Renal Physiol 2009; 296:F1136-45. PubMed
  • Bonventre JV. Microvesicles from mesenchymal stromal cells protect against acute kidney injury. J Am Soc Nephrol 2009; 20:927-8. PubMed
  • Waikar SS,Bonventre JV. Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 2009; 20:672-9. PubMed
  • Cheong JK,Gunaratnam L,Zang ZJ,Yang CM,Sun X,Nasr SL,Sim KG,Peh BK,Rashid SB,Bonventre JV,Salto-Tellez M,Hsu SI. TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. J Transl Med 2009; 7:8. PubMed
  • Zang ZJ,Gunaratnam L,Cheong JK,Lai LY,Hsiao LL,O'Leary E,Sun X,Salto-Tellez M,Bonventre JV,Hsu SI. Identification of PP2A as a novel interactor and regulator of TRIP-Br1. Cell Signal 2008; 21:34-42. PubMed
  • Zhang J, Goering PL, Espandiari P, Shaw M, Bonventre JV, Vaidya VS, Brown RP, Keenan J, Kilty CG, Sadrieh N, Hanig JP. Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine. Toxicol Pathol 2009; 37:629-43. PubMed
  • Vaidya VS,Waikar SS,Ferguson MA,Collings FB,Sunderland K,Gioules C,Bradwin G,Matsouaka R,Betensky RA,Curhan GC,Bonventre JV. Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans. Clin Transl Sci 2009; 1:200-208. PubMed
  • Taylor AL,Bonventre JV,Uliasz TF,Hewett JA,Hewett SJ. Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death. J Neurochem 2008; 106:1828-40. PubMed
  • Ichimura T, Asseldonk EJ, Humphreys BD, Gunaratnam L, Duffield JS, Bonventre JV. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest 2008; 118:1657-1668. PubMed
  • Cubells L, de Muga SV, Tebar F, Bonventre JV, Balsinde J, Pol A, Grewal T, Enrich C. Annexin A6-induced inhibition of cytoplasmic phospholipase A2 is linked to caveolin-1 export from the Golgi. J Biol Chem 2008; 283:10174-83. PubMed
  • Zeidel M, Bonventre J, Forrest J, Sukhatme V. A national course for renal fellows: the origins of renal physiology. J Am Soc Nephrol 2008; 19:649-50. PubMed
  • Lock EA, Bonventre JV. Biomarkers in translation; past, present and future. Toxicology 2008; 245:163-6. PubMed
  • Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2:284-91. PubMed
  • Zhang PL, Rothblum LI, Han WK, Blasick TM, Potdar S, Bonventre JV. Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int 2007; 73:608-14. PubMed
  • Bonventre JV. Urine neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury in critically ill children. Nat Clin Pract Nephrol 2007; 4:78-9. PubMed
  • Zhang J, Brown RP, Shaw M, Vaidya VS, Zhou Y, Espandiari P, Sadrieh N, Stratmeyer M, Keenan J, Kilty CG, Bonventre JV, Goering PL. Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidney of Gentamicin-, Mercury-, or Chromium-Treated Rats: Relationship to Renal Distributions of iNOS and Nitrotyrosine. Toxicol Pathol 2008; 36:397-409. PubMed
  • Zhou Y, Vaidya VS, Brown RP, Zhang J, Rosenzweig BA, Thompson KL, Miller TJ, Bonventre JV, Goering PL. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci 2007; 101:159-70. PubMed
  • Waikar SS,Bonventre JV. Biomarkers for the diagnosis of acute kidney injury. Nephron Clin Pract 2008; 109:c192-7. PubMed
  • van Timmeren MM, Vaidya VS, van Ree RM, Oterdoom LH, de Vries AP, Gans RO, van Goor H, Stegeman CA, Bonventre JV, Bakker SJ. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation 2008; 84:1625-30. PubMed
  • Waikar SS, Bonventre JV. Biomarkers for the diagnosis of acute kidney injury. Curr Opin Nephrol Hypertens 2007; 16:557-64. PubMed
  • Espandiari P, Zhang J, Rosenzweig BA, Vaidya VS, Sun J, Schnackenberg L, Herman EH, Knapton A, Bonventre JV, Beger RD, Thompson KL, Hanig J. The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity. Toxicol Sci 2007; 99:637-48. PubMed
  • Munoz NM, Meliton AY, Arm JP, Bonventre JV, Cho W, Leff AR. Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice. J Immunol 2007; 179:4800-7. PubMed
  • Zhang Z, Humphreys BD, Bonventre JV. Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region. J Am Soc Nephrol 2007; 18:2704-14. PubMed
  • Kikawada E, Bonventre JV, Arm JP. Group V secretory PLA2 regulates TLR2-dependent eicosanoid generation in mouse mast cells through amplification of ERK and cPLA2{alpha} activation. Blood 2007; 110:561-7. PubMed
  • Humphreys BD, Bonventre JV. The contribution of adult stem cells to renal repair. Nephrol Ther 2007; 3:3-10. PubMed
  • Liangos O, Perianayagam MC, Vaidya VS, Han WK, Wald R, Tighiouart H, MacKinnon RW, Li L, Balakrishnan VS, Pereira BJ, Bonventre JV, Jaber BL. Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol 2007; 18:904-12. PubMed
  • Lin F, Zhang PL, Yang XJ, Shi J, Blasick T, Han WK, Wang HL, Shen SS, Teh BT, Bonventre JV. Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma. Am J Surg Pathol 2007; 31:371-81. PubMed
  • Perianayagam MC, Liangos O, Kolyada AY, Wald R, MacKinnon RW, Li L, Rao M, Balakrishnan VS, Bonventre JV, Pereira BJ, Jaber BL. NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure. J Am Soc Nephrol 2006; 18:255-63. PubMed
  • De Borst MH, van Timmeren MM, Vaidya VS, Van Dalen MB, Kramer AB, Schuurs TA, Bonventre JV, Navis G, van Goor H. Induction of Kidney injury molecule-1 (Kim-1) in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol 2007; 292:F313-20. PubMed
  • Humphreys BD, Duffield JD, Bonventre JV. Renal stem cells in recovery from acute kidney injury. Minerva Urol Nefrol 2006; 58:13-21. PubMed
  • Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, Bonventre JV. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest 2005; 115:1743-1755. PubMed
  • Hentschel DM, Park KM, Cilenti L, Zervos AS, Drummond I, Bonventre JV. Acute renal failure in zebrafish: a novel system to study a complex disease. Am J Physiol Renal Physiol 2004; 288:F923-9. PubMed
  • Ilsley JN, Nakanishi M, Flynn C, Belinsky GS, De Guise S, Adib JN, Dobrowsky RT, Bonventre JV, Rosenberg DW. Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis. Cancer Res 2005; 65:2636-43. PubMed
  • Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV. Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol 2005; 16:1126-34. PubMed
  • Park KM, Cho HJ, Bonventre JV. Orchiectomy reduces susceptibility to renal ischemic injury: a role for heat shock proteins. Biochem Biophys Res Commun 2005; 328:312-7. PubMed
  • Cilenti L, Kyriazis GA, Soundarapandian MM, Stratico V, Yerkes A, Park KM, Sheridan AM, Alnemri ES, Bonventre JV, Zervos AS. Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells. Am J Physiol Renal Physiol 2004; 288:F371-9. PubMed
  • Park KM, Kim JI, Ahn Y, Bonventre AJ, Bonventre JV. Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem 2004; 279:52282-92. PubMed
  • Han WK, Bonventre JV. Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care 2004; 10:476-82. PubMed
  • Sim KG, Zang Z, Yang CM, Bonventre JV, Hsu SI. TRIP-Br links E2F to novel functions in the regulation of cyclin e expression during cell cycle progression and in the maintenance of genomic stability. Cell Cycle 2004; 3:1296-304. PubMed
  • Meyer AM, Dwyer-Nield LD, Hurteau GJ, Keith RL, O'Leary E, You M, Bonventre JV, Nemenoff RA, Malkinson AM. Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis 2004; 25:1517-24. PubMed
  • Huang Z, Philippin B, O'Leary E, Bonventre JV, Kriz W, Witzgall R. Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus. J Biol Chem 1999; 274:7640-8. PubMed
  • Witzgall R, Oberm. Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia. Am J Physiol 1998; 275:F928-37. PubMed
  • Bonventre JV, Force T. Mitogen-activated protein kinases and transcriptional responses in renal injury and repair. Curr Opin Nephrol Hypertens 1998; 7:425-33. PubMed
  • Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, Sanicola M. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 1998; 273:4135-42. PubMed
  • Force T, Bonventre JV. Growth factors and mitogen-activated protein kinases. Hypertension 1998; 31:152-61. PubMed
  • Bonventre JV, Huang Z, Taheri MR, O'Leary E, Li E, Moskowitz MA, Sapirstein A. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature 1997; 390:622-5. PubMed
  • Brown D, Lee R, Bonventre JV. Redistribution of villin to proximal tubule basolateral membranes after ischemia and reperfusion. Am J Physiol 1998; 273:F1003-12. PubMed
  • Kim SS, Chen YM, O'Leary E, Witzgall R, Vidal M, Bonventre JV. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc Natl Acad Sci U S A 1996; 93:15299-304. PubMed