Photo of Jyothi Jagannathan,  MD

Jyothi Jagannathan, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 582-7447


jjagannathan@partners.org

Jyothi Jagannathan, MD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Instructor, Radiology, Harvard Medical School
  • Clinical Director of MRI , Imaging, Dana-Farber Cancer Institute

Research Abstract

My activities since being appointed to the faculty at Dana-Farber Cancer Institute (DFCI) and Brigham and Women’s Hospital (BWH), have been dedicated to clinical service (70%), research (20%), teaching and administration (10%). As an academic radiologist at a leading cancer center, I have established myself as an excellent diagnostic radiologist among our referring physicians, and participated in several research projects that have resulted in peer-reviewed manuscripts. I have strived to be an imaging- clinician-scientist, working to bridge the gap between oncologists and the radiologists by way of innovative research meaningful to clinical practice.

I completed my radiology residency in May 2002, at one of oldest and leading medical colleges in India. I completed a two year fellowship training in oncoradiology at Dana-Farber Cancer Institute (DFCI) in November 2007. I have had a strong commitment to academic and research pursuits. During my training, I conducted research on uterine artery embolization for treatment of fibroids in Indian women, submitted as my post graduate thesis in May 2002. I also served as the Chief Resident in 2001-2002, and was instrumental in developing the departmental teaching file. In my fellowship year, I specialized in cancer imaging, and thereafter, I chose to specialize in oncologic imaging and joined the staff at BWH/DFCI radiology to further pursue my goal of becoming an excellent imaging clinician-scientist.

My clinical expertise and achievements are developed in two major areas, Magnetic Resonance Imaging and tumor response criteria. I have completed several research projects focused on cancer imaging and monitoring the response of cancer to therapy. I have been actively involved in the MRI division at DFCI since its inception in 2005, and have been instrumental in developing the musculoskeletal tumor imaging service and whole body MR imaging at DFCI. In my current role as MRI director, I facilitate and oversee all clinical and MRI research activities at DFCI.

My interest in whole body MRI began with a collaborative radiology and oncology project in my second year attending the DFCI faculty. This is a prospective study of whole body MRI as a screening tool for patients with Li-Fraumeni syndrome, and is under accrual phase. Following the successful implementation of the whole body MRI protocol in this cohort, we are collaborating with various disease groups to expand the role of whole body MR imaging in diagnosis, risk stratification and therapeutic decision making

In addition to clinical and research work, I am also committed to teaching in academic medicine. As the Clinical Director of MRI, I have been actively involved in teaching activities that promote the fellows knowledge of MRI with relevance to clinical practice, oncologic and imaging expertise. Day to day, I serve as a junior faculty mentor for our radiology fellows and rotating residents, providing guidance in career decisions, research projects and in other scholarly activities.

 

Publications

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  • Baheti AD, Tirumani SH, Rosenthal MH, Howard SA, Shinagare AB, Ramaiya NH, Jagannathan JP. Myxoid soft-tissue neoplasms: comprehensive update of the taxonomy and MRI features. AJR Am J Roentgenol 2015; 204:374-85. PubMed
  • Cooley CL, Jagannathan JP, Kurra V, Tirumani SH, Saboo SS, Ramaiya NH, Shinagare AB. Imaging Features and Metastatic Pattern of Non-IVC Retroperitoneal Leiomyosarcomas: Are They Different From IVC Leiomyosarcomas? J Comput Assist Tomogr 2014. PubMed
  • Gordon RW, Tirumani SH, Kurra V, Shinagare AB, Jagannathan JP, Hornick JL, Ramaiya NH. MRI, MDCT features, and clinical outcome of extremity leiomyosarcomas: experience in 47 patients. Skeletal Radiol 2014; 43:615-22. PubMed
  • Tirumani SH, Shinagare AB, Jagannathan JP, Krajewski KM, Munshi NC, Ramaiya NH. MRI features of extramedullary myeloma. AJR Am J Roentgenol 2014; 202:803-10. PubMed
  • Shinagare AB, Jagannathan JP, Kurra V, Urban T, Manola J, Choy E, Demetri GD, George S, Ramaiya NH. Comparison of performance of various tumour response criteria in assessment of regorafenib activity in advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib. Eur J Cancer 2014; 50:981-6. PubMed
  • Tirumani SH, Shinagare AB, Hargreaves J, Jagannathan JP, Hornick JL, Wagner AJ, Ramaiya NH. Imaging features of primary and metastatic malignant perivascular epithelioid cell tumors. AJR Am J Roentgenol 2014; 202:252-8. PubMed
  • Tirumani SH, Baez JC, Jagannathan JP, Shinagare AB, Ramaiya NH. Tumor-bowel fistula: what radiologists should know. Abdom Imaging 2013. PubMed
  • Kim KW, Ramaiya NH, Krajewski KM, Jagannathan JP, Tirumani SH, Srivastava A, Ibrahim N. Ipilimumab associated hepatitis: imaging and clinicopathologic findings. Invest New Drugs 2013. PubMed
  • Cabral FC, Krajewski KM, Kim KW, Ramaiya NH, Jagannathan JP. Peritoneal lymphomatosis: CT and PET/CT findings and how to differentiate between carcinomatosis and sarcomatosis. Cancer Imaging 2013; 13:162-70. PubMed
  • Tirumani SH, Jagannathan JP, O'Regan K, Kim KW, Shinagare AB, Krajewski KM, Ramaiya NH. Molecular targeted therapies in non-GIST soft tissue sarcomas: what the radiologist needs to know. Cancer Imaging 2013; 13:197-211. PubMed
  • Saboo SS, Krajewski KM, Zukotynski K, Howard S, Jagannathan JP, Hornick JL, Ramaiya N. Imaging features of primary and secondary adult rhabdomyosarcoma. AJR Am J Roentgenol 2012; 199:W694-703. PubMed
  • Shinagare AB, Krajewski KM, Hornick JL, Zukotynski K, Kurra V, Jagannathan JP, Ramaiya NH. MRI for evaluation of myeloid sarcoma in adults: a single-institution 10-year experience. AJR Am J Roentgenol 2012; 199:1193-8. PubMed
  • Shinagare AB, Howard SA, Krajewski KM, Zukotynski KA, Jagannathan JP, Ramaiya NH. Pneumatosis intestinalis and bowel perforation associated with molecular targeted therapy: an emerging problem and the role of radiologists in its management. AJR Am J Roentgenol 2012; 199:1259-65. PubMed
  • Sneag DB, Krajewski KM, Howard S, Jagannathan JP, Star KV, Ramaiya N. Sclerotic osseous metastases from renal cell carcinoma. Skeletal Radiol 2012; 41:1169-75. PubMed
  • Bakri A, Shinagare AB, Krajewski KM, Howard SA, Jagannathan JP, Hornick JL, Ramaiya NH. Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response. AJR Am J Roentgenol 2012; 199:W208-15. PubMed
  • Vinjamoori AH, Jagannathan JP, Shinagare AB, Taplin ME, Oh WK, Van den Abbeele AD, Ramaiya NH. Atypical metastases from prostate cancer: 10-year experience at a single institution. AJR Am J Roentgenol 2012; 199:367-72. PubMed
  • Howard SA, Krajewski KM, Thornton E, Jagannathan JP, O'Regan K, Cleary J, Ramaiya N. Decade of molecular targeted therapy: abdominal manifestations of drug toxicities--what radiologists should know. AJR Am J Roentgenol 2012; 199:58-64. PubMed
  • Dabydeen DA, Jagannathan JP, Ramaiya N, Krajewski K, Schutz FA, Cho DC, Pedrosa I, Choueiri TK. Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: incidence, radiographic findings and correlation with clinical outcome. Eur J Cancer 2012; 48:1519-24. PubMed
  • Shah SH, Jagannathan JP, Krajewski K, O'Regan KN, George S, Ramaiya NH. Uterine sarcomas: then and now. AJR Am J Roentgenol 2012; 199:213-23. PubMed
  • Saboo SS, Krajewski KM, Jagannathan JP, Ramaiya N. IVC tumor thrombus: an advanced case of rare extraosseous Ewing sarcoma of the adrenal gland. Urology 2012; 79:e77-8. PubMed
  • Nishino M, Jagannathan JP, Krajewski KM, O'Regan K, Hatabu H, Shapiro G, Ramaiya NH. Personalized Tumor Response Assessment in the Era of Molecular Medicine: Cancer-Specific and Therapy-Specific Response Criteria to Complement Pitfalls of RECIST. AJR Am J Roentgenol 2012; 198:737-45. PubMed
  • Jagannathan JP, Ramaiya NH, Shinagare AB, Hornick JL, George S. Intracranial Metastasis From Pediatric GI Stromal Tumor. J Clin Oncol 2012. PubMed
  • Saboo SS, Krajewski KM, Shinagare AB, Jagannathan JP, Hornick JL, Ramaiya N. Imaging features of primary extranodal histiocytic sarcoma: report of two cases and a review of the literature. Cancer Imaging 2012; 12:253-8. PubMed
  • Baez JC, Jagannathan JP, Krajewski K, O'Regan K, Zukotynski K, Kulke M, Ramaiya NH. Pheochromocytoma and paraganglioma: imaging characteristics. Cancer Imaging 2012; 12:153-62. PubMed
  • Shinagare AB, Ramaiya NH, Jagannathan JP, Hornick JL, Swanson RS. Primary follicular dendritic cell sarcoma of liver treated with cyclophosphamide, doxorubicin, vincristine, and prednisone regimen and surgery. J Clin Oncol 2011; 29:e849-51. PubMed
  • Shinagare AB, Ramaiya NH, Jagannathan JP, Krajewski KM, Giardino AA, Butrynski JE, Raut CP. A to Z of desmoid tumors. AJR Am J Roentgenol 2011; 197:W1008-14. PubMed
  • Giardino AA, Ramaiya NH, Shinagare AB, Jagannathan JP, Stachler MD, Raut CP. Case report: Calcifying fibrous tumor presenting as an asymptomatic pelvic mass. Indian J Radiol Imaging 2012; 21:306-8. PubMed
  • Saboo SS, Jagannathan JP, Krajewski KM, O'Regan K, Hornick JL, Fisher DC, Ramaiya N. Symptomatic Extranodal Rosai-Dorfman Disease Treated With Steroids, Radiation, and Surgery. J Clin Oncol 2011. PubMed
  • Hall MN, Jagannathan JP, Ramaiya NH, Shinagare AB, Van den Abbeele AD. Imaging of extraosseous myeloma: CT, PET/CT, and MRI features. AJR Am J Roentgenol 2010; 195:1057-65. PubMed
  • Oei TN, Jagannathan JP, Ramaiya N, Ros PR. Peritoneal sarcomatosis versus peritoneal carcinomatosis: imaging findings at MDCT. AJR Am J Roentgenol 2010; 195:W229-35. PubMed
  • Jagannathan JP, Ramaiya N, Gill RR, Alyea EP, Ros P. Imaging of complications of hematopoietic stem cell transplantation. Radiol Clin North Am 2008; 46:397-417, x. PubMed
  • Kalva SP, Jagannathan JP, Hahn PF, Wicky ST. Venous thromboembolism: indirect CT venography during CT pulmonary angiography--should the pelvis be imaged? Radiology 2008; 246:605-11. PubMed
  • Kim KW, Shinagare AB, Krajewski KM, Pyo J, Tirumani SH, Jagannathan JP, Ramaiya NH. Fluid retention associated with imatinib treatment in patients with gastrointestinal stromal tumor: quantitative radiologic assessment and implications for management. Korean J Radiol 2015; 16:304-13. PubMed
  • Tirumani SH, Fairchild A, Krajewski KM, Nishino M, Howard SA, Baheti AD, Rosenthal MH, Jagannathan JP, Shinagare AB, Ramaiya NH. Anti-VEGF Molecular Targeted Therapies in Common Solid Malignancies: Comprehensive Update for Radiologists. Radiographics 2015; 35:455-74. PubMed
  • Tirumani SH, Krajewski KM, Shinagare AB, Jagannathan JP, Ramaiya NH. Gallbladder complications associated with molecular targeted therapies: clinical and imaging features. Clin Imaging 2013; 38:50-5. PubMed
  • Tirumani SH, Jagannathan JP, Shinagare AB, Kim Kw, Krajewski KM, Ramaiya NH. Acute pancreatitis associated with molecular targeted therapies: a retrospective review of the clinico-radiological features, management and outcome. Pancreatology 2013; 13:461-7. PubMed
  • O'Regan KN, Shinagare AB, Saboo SS, Ramaiya NH, Jagannathan JP, Tirumani SH. Gastrointestinal stromal tumors (GIST): lesser known facts. Clin Imaging 2013; 37:821-9. PubMed
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