Photo of Karin B. Michels,  MPH, PhD, ScD

Karin B. Michels, MPH, PhD, ScD

Brigham And Women's Hospital

Brigham And Women's Hospital

Karin B. Michels, MPH, PhD, ScD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Associate Professor, Epidemiology, Harvard T.H. Chan School Of Public Health
  • Associate Professor, Obstetrics and Gynecology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Publications

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  • Brinton LA, Key TJ, Kolonel LN, Michels KB, Sesso HD, Ursin G, Van Den Eeden SK, Wood SN, Falk RT, Parisi D, Guillemette C, Caron P, Turcotte V, Habel LA, Isaacs CJ, Riboli E, Weiderpass E, Cook MB. Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk. J Clin Oncol 2015; 33:2041-50. PubMed
  • Charlton BM, Wu K, Zhang X, Giovannucci EL, Fuchs CS, Missmer SA, Rosner B, Hankinson SE, Willett WC, Michels KB. Oral Contraceptive Use and Colorectal Cancer in the Nurses' Health Study I and II. Cancer Epidemiol Biomarkers Prev 2015. PubMed
  • Cook MB, Guénel P, Gapstur SM, van den Brandt PA, Michels KB, Casagrande JT, Cooke R, Van Den Eeden SK, Ewertz M, Falk RT, Gaudet MM, Gkiokas G, Habel LA, Hsing AW, Johnson K, Kolonel LN, La Vecchia C, Lynge E, Lubin JH, McCormack VA, Negri E, Olsson H, Parisi D, Petridou ET, Riboli E, Sesso HD, Swerdlow A, Thomas DB, Willett WC, Brinton LA. Tobacco and alcohol in relation to male breast cancer: an analysis of the male breast cancer pooling project consortium. Cancer Epidemiol Biomarkers Prev 2015; 24:520-31. PubMed
  • Devore EE, Kim S, Ramin CA, Wegrzyn LR, Massa J, Holmes MD, Michels KB, Tamimi RM, Forman JP, Schernhammer ES. Antihypertensive medication use and incident breast cancer in women. Breast Cancer Res Treat 2015; 150:219-29. PubMed
  • Dougan MM, Hankinson SE, Vivo I, Tworoger SS, Glynn RJ, Michels KB. Prospective study of body size throughout the life-course and the incidence of endometrial cancer among premenopausal and postmenopausal women. Int J Cancer 2015. PubMed
  • Barrow TM, Barault L, Ellsworth RE, Harris HR, Binder AM, Valente AL, Shriver CD, Michels KB. Aberrant methylation of imprinted genes is associated with negative hormone receptor status in invasive breast cancer. Int J Cancer 2015. PubMed
  • Barrow TM, Michels KB. Epigenetic epidemiology of cancer. Biochem Biophys Res Commun 2014. PubMed
  • Brinton LA, Cook MB, McCormack V, Johnson KC, Olsson H, Casagrande JT, Cooke R, Falk RT, Gapstur SM, Gaudet MM, Gaziano JM, Gkiokas G, Guénel P, Henderson BE, Hollenbeck A, Hsing AW, Kolonel LN, Isaacs C, Lubin JH, Michels KB, Negri E, Parisi D, Petridou ET, Pike MC, Riboli E, Sesso HD, Snyder K, Swerdlow AJ, , Trichopoulos D, Ursin G, van den Brandt PA, Van Den Eeden SK, Weiderpass E, Willett WC, Ewertz M, Thomas DB. Anthropometric and hormonal risk factors for male breast cancer: male breast cancer pooling project results. Journal of the National Cancer Institute 2014; 106:djt465. PubMed
  • Charlton BM, Rich-Edwards JW, Colditz GA, Missmer SA, Rosner BA, Hankinson SE, Speizer FE, Michels KB. Oral contraceptive use and mortality after 36 years of follow-up in the Nurses' Health Study: prospective cohort study. BMJ 2014; 349:g6356. PubMed
  • Michels KB. Contralateral mastectomy for women with hereditary breast cancer. BMJ 2014; 348:g1379. PubMed
  • Charlton BM, Carwile JL, Michels KB, Feldman S. A Cervical Abnormality Risk Prediction Model: Can We Use Clinical Information to Predict Which Patients With ASCUS/LSIL Pap Tests Will Develop CIN 2/3 or AIS? J Low Genit Tract Dis 2013. PubMed
  • Barault L, Ellsworth RE, Harris HR, Valente AL, Shriver CD, Michels KB. Leukocyte DNA as surrogate for the evaluation of imprinted Loci methylation in mammary tissue DNA. PLoS ONE 2013; 8:e55896. PubMed
  • Michels KB, Terry KL, Eliassen AH, Hankinson SE, Willett WC. Adult weight change and incidence of premenopausal breast cancer. Int J Cancer 2011. PubMed
  • Harris HR, Willett WC, Terry KL, Michels KB. Body fat distribution and risk of premenopausal breast cancer in the Nurses' Health Study II. Journal of the National Cancer Institute 2011; 103:273-8. PubMed
  • Xue F, Willett WC, Rosner BA, Hankinson SE, Michels KB. Cigarette smoking and the incidence of breast cancer. Arch Intern Med 2011; 171:125-33. PubMed
  • Nielsen TS, Khan G, Davis J, Michels KB, Hilakivi-Clarke L. Prepubertal exposure to cow's milk reduces susceptibility to carcinogen-induced mammary tumorigenesis in rats. Int J Cancer 2010; 128:12-20. PubMed
  • Michels KB. The promises and challenges of epigenetic epidemiology. 2010; 45:297-301. PubMed
  • Stephansson O, Granath F, Ekbom A, Michels KB. Risk of breast cancer among daughters of mothers with diabetes: a population-based cohort study. Breast Cancer Res 2010; 12:R14. PubMed
  • Ogunleye AA,Xue F,Michels KB. Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res Treat 2009; 119:477-84. PubMed
  • Osterhues A, Holzgreve W, Michels KB. Shall we put the world on folate? Lancet 2009; 374:959-61. PubMed
  • Carwile JL, Luu HT, Bassett LS, Driscoll DA, Yuan C, Chang JY, Ye X, Calafat AM, Michels KB. Polycarbonate bottle use and urinary bisphenol A concentrations. Environ Health Perspect 2009; 117:1368-72. PubMed
  • Stuebe AM, Willett WC, Xue F, Michels KB. Lactation and incidence of premenopausal breast cancer: a longitudinal study. Arch Intern Med 2009; 169:1364-71. PubMed
  • Michels KB, zur Hausen H. HPV vaccine for all. Lancet 2009; 374:268-70. PubMed
  • Caughey RW,Michels KB. Birth weight and childhood leukemia: a meta-analysis and review of the current evidence. Int J Cancer 2009; 124:2658-70. PubMed
  • Michels KB, Willett WC. The Women's Health Initiative Randomized Controlled Dietary Modification Trial: a post-mortem. Breast Cancer Res Treat 2009; 114:1-6. PubMed
  • Michels KB. The promise and challenges of population strategies of prevention. Int J Epidemiol 2008; 37:914-6. PubMed
  • Colbert LH,Graubard BI,Michels KB,Willett WC,Forman MR. Physical activity during pregnancy and age at menarche of the daughter. Cancer Epidemiol Biomarkers Prev 2008; 17:2656-62. PubMed
  • Rosner B,Michels KB,Chen YH,Day NE. Measurement error correction for nutritional exposures with correlated measurement error: use of the method of triads in a longitudinal setting. Stat Med 2008; 27:3466-89. PubMed
  • Simard JF, Rosner BA, Michels KB. Exposure to Cigarette Smoke In Utero: Comparison of Reports from Mother and Daughter. Epidemiology 2008; 19:628-33. PubMed
  • Xue F,Hilakivi-Clarke LA,Maxwell GL,Hankinson SE,Michels KB. Infant feeding and the incidence of endometrial cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:1316-21. PubMed
  • Xue F, Hilakivi-Clarke L, Maxwell G, Hankinson S, Michels K. Longitudinal study on birthweight and the incidence of endometrial cancer. Br J Cancer 2008; 98:1288-91. PubMed
  • Ray JG, Mohllajee AP, van Dam RM, Michels KB. Breast size and risk of type 2 diabetes mellitus. CMAJ 2008; 178:289-95. PubMed
  • Xue F, Willett WC, Rosner BA, Forman MR, Michels KB. Parental characteristics as predictors of birthweight. Hum Reprod 2007; 23:168-77. PubMed
  • Xue F, Michels KB. Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. Lancet Oncol 2007; 8:1088-100. PubMed
  • Michos A, Xue F, Michels KB. Birth weight and the risk of testicular cancer: a meta-analysis. Int J Cancer 2007; 121:1123-31. PubMed
  • Xue F, Colditz GA, Willett WC, Rosner BA, Michels KB. Parental age at delivery and incidence of breast cancer: a prospective cohort study. Breast Cancer Res Treat 2007; 104:331-40. PubMed
  • Xue F, Michels KB. Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence. Am J Clin Nutr 2008; 86:s823-35. PubMed
  • Michels KB, Willett WC, Graubard BI, Vaidya RL, Cantwell MM, Sansbury LB, Forman MR. A longitudinal study of infant feeding and obesity throughout life course. Int J Obes Relat Metab Disord 2007; 31:1078-85. PubMed
  • Brody JG, Rudel RA, Michels KB, Moysich KB, Bernstein L, Attfield KR, Gray S. Environmental pollutants, diet, physical activity, body size, and breast cancer: where do we stand in research to identify opportunities for prevention? Cancer 2007; 109:2627-2634. PubMed
  • Michels KB, Mohllajee AP, Roset-Bahmanyar E, Beehler GP, Moysich KB. Diet and breast cancer: a review of the prospective observational studies. Cancer 2007; 109:2712-2749. PubMed
  • Michels KB, Xue F, Colditz GA, Willett WC. Induced and spontaneous abortion and incidence of breast cancer among young women: a prospective cohort study. Arch Intern Med 2007; 167:814-20. PubMed
  • Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 2007; 27:363-88. PubMed
  • Terry KL, Willett WC, Rich-Edwards JW, Michels KB. A prospective study of infertility due to ovulatory disorders, ovulation induction, and incidence of breast cancer. Arch Intern Med 2006; 166:2484-9. PubMed
  • Michels KB, Xue F, Terry KL, Willett WC. Longitudinal study of birthweight and the incidence of breast cancer in adulthood. Carcinogenesis 2006; 27:2464-8. PubMed
  • Michels KB, Terry KL, Willett WC. Longitudinal study on the role of body size in premenopausal breast cancer. Arch Intern Med 2006; 166:2395-402. PubMed
  • Baer HJ, Rich-Edwards JW, Colditz GA, Hunter DJ, Willett WC, Michels KB. Adult height, age at attained height, and incidence of breast cancer in premenopausal women. Int J Cancer 2006; 119:2231-5. PubMed
  • Michels KB, Xue F. Role of birthweight in the etiology of breast cancer. Int J Cancer 2006; 119:2007-25. PubMed
  • Michels KB. The women's health initiative--curse or blessing? Int J Epidemiol 2006; 35:814-6. PubMed
  • Pinheiro SP, Schernhammer ES, Tworoger SS, Michels KB. A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women. Cancer Res 2006; 66:5521-5. PubMed
  • Kusano AS, Trichopoulos D, Terry KL, Chen WY, Willett WC, Michels KB. A prospective study of breast size and premenopausal breast cancer incidence. Int J Cancer 2006; 118:2031-4. PubMed
  • Michels KB, Giovannucci E, Chan AT, Singhania R, Fuchs CS, Willett WC. Fruit and vegetable consumption and colorectal adenomas in the Nurses' Health Study. Cancer Res 2006; 66:3942-53. PubMed
  • Michels KB, Rosner BA, Chumlea WC, Colditz GA, Willett WC. Preschool diet and adult risk of breast cancer. Int J Cancer 2005; 118:749-54. PubMed
  • Stuebe AM, Rich-Edwards JW, Willett WC, Manson JE, Michels KB. Duration of lactation and incidence of type 2 diabetes. JAMA 2005; 294:2601-10. PubMed
  • Michels KB. Diet and cancer: current knowledge, methodologic pitfalls and future directions. Int J Cancer 2005; 116:665-6. PubMed
  • Barbieri RL, Anastos L, Michels KB. Economic factors and the percentage of residency positions filled by United States medical graduates. Obstet Gynecol 2005; 106:581-4. PubMed
  • Holm IA, Manson JE, Michels KB, Alexander EK, Willett WC, Utiger RD. Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism. Arch Intern Med 2005; 165:1606-11. PubMed
  • Terry KL, Willett WC, Rich-Edwards JW, Hunter DJ, Michels KB. Menstrual cycle characteristics and incidence of premenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14:1509-13. PubMed
  • Michels KB, Welch AA, Luben R, Bingham SA, Day NE. Measurement of fruit and vegetable consumption with diet questionnaires and implications for analyses and interpretation. Am J Epidemiol 2005; 161:987-94. PubMed
  • Michels KB, Fuchs CS, Giovannucci E, Colditz GA, Hunter DJ, Stampfer MJ, Willett WC. Fiber intake and incidence of colorectal cancer among 76,947 women and 47,279 men. Cancer Epidemiol Biomarkers Prev 2005; 14:842-9. PubMed
  • Michels KB. The role of nutrition in cancer development and prevention. Int J Cancer 2004; 114:163-5. PubMed
  • Michels KB, Willett WC, Fuchs CS, Giovannucci E. Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer. J Natl Cancer Inst 2005; 97:282-92. PubMed
  • Baer HJ, Colditz GA, Rosner B, Michels KB, Rich-Edwards JW, Hunter DJ, Willett WC. Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res 2005; 7:R314-25. PubMed
  • Day NE, Wong MY, Bingham S, Khaw KT, Luben R, Michels KB, Welch A, Wareham NJ. Correlated measurement error--implications for nutritional epidemiology. Int J Epidemiol 2004; 33:1373-81. PubMed
  • Michels KB, Willett WC. Breast cancer--early life matters. N Engl J Med 2004; 351:1679-81. PubMed
  • Rich-Edwards JW, Stampfer MJ, Manson JE, Rosner B, Hu FB, Michels KB, Willett WC. Breastfeeding during infancy and the risk of cardiovascular disease in adulthood. Epidemiology 2004; 15:550-6. PubMed
  • Michels KB, Bingham SA, Luben R, Welch AA, Day NE. The effect of correlated measurement error in multivariate models of diet. Am J Epidemiol 2004; 160:59-67. PubMed
  • Michels KB, Xue F, Brandt L, Ekbom A. Hyperparathyroidism and subsequent incidence of breast cancer. Int J Cancer 2004; 110:449-51. PubMed
  • Michels KB, Ekbom A. Caloric restriction and incidence of breast cancer. JAMA 2004; 291:1226-30. PubMed
  • Sills ES, Fryman JT, Perloe M, Michels KB, Tucker MJ. Chromatin fluorescence characteristics and standard semen analysis parameters: correlations observed in andrology testing among 136 males referred for infertility evaluation. J Obstet Gynaecol 2003; 24:74-7. PubMed
  • Michels KB. Nutritional epidemiology--past, present, future. Int J Epidemiol 2003; 32:486-8. PubMed
  • Michels KB, Solomon CG, Hu FB, Rosner BA, Hankinson SE, Colditz GA, Manson JE,. Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study. Diabetes Care 2003; 26:1752-8. PubMed
  • Michels KB, Manson JE. Postmenopausal hormone therapy: a reversal of fortune. Circulation 2003; 107:1830-3. PubMed
  • Michels KB, Rothman KJ. Update on unethical use of placebos in randomised trials. Bioethics 2003; 17:188-204. PubMed
  • Michels KB. Early life predictors of chronic disease. J Womens Health (Larchmt) 2003; 12:157-61. PubMed
  • Michels KB. Hormone replacement therapy in epidemiologic studies and randomized clinical trials - are we checkmate? Epidemiology 2002; 14:3-5. PubMed
  • Michels KB, Wolk A. A prospective study of variety of healthy foods and mortality in women. Int J Epidemiol 2002; 31:847-54. PubMed
  • Michels KB, Braunwald E. Estimating treatment effects from observational data: dissonant and resonant notes from the SYMPHONY trials. JAMA 2002; 287:3130-2. PubMed
  • Michels KB, Day NE. The role of correlated errors in the multivariate analysis of dietary data. IARC Sci Publ 2002; 156:21-2. PubMed
  • Michels KB, Giovannucci E, Joshipura KJ, Rosner BA, Stampfer MJ, Fuchs CS, Colditz GA, Speizer FE, Willett WC. Fruit and vegetable consumption and colorectal cancer incidence. IARC Sci Publ 2002; 156:139-40. PubMed
  • Michels KB, Holmberg L, Bergkvist L, Wolk A. Coffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women. Ann Epidemiol 2001; 12:21-6. PubMed
  • Michels KB. The contribution of the environment (especially diet) to breast cancer risk. Breast Cancer Res 2002; 4:58-61. PubMed
  • Michels KB. A renaissance for measurement error. Int J Epidemiol 2001; 30:421-2. PubMed
  • Terry P, Giovannucci E, Michels KB, Bergkvist L, Hansen H, Holmberg L, Wolk A. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst 2001; 93:525-33. PubMed
  • Michels KB, Holmberg L, Bergkvist L, Ljung H, Bruce A, Wolk A. Dietary antioxidant vitamins, retinol, and breast cancer incidence in a cohort of Swedish women. Int J Cancer 2001; 91:563-7. PubMed
  • Michels KB, Trichopoulos D, Rosner BA, Hunter DJ, Colditz GA, Hankinson SE, Speizer FE, Willett WC. Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies. Am J Epidemiol 2001; 153:275-83. PubMed
  • Michels KB. Fourth International Conference on Dietary Assessment Methods. Int J Epidemiol 2001; 29:1103. PubMed
  • Michels KB, Edward Giovannucci , Joshipura KJ, Rosner BA, Stampfer MJ, Fuchs CS, Colditz GA, Speizer FE, Willett WC. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst 2000; 92:1740-52. PubMed
  • Melbye M, Wohlfahrt J, Lei U, N. alpha-fetoprotein levels in maternal serum during pregnancy and maternal breast cancer incidence. J Natl Cancer Inst 2000; 92:1001-5. PubMed
  • Michels KB. The placebo problem remains. Arch Gen Psychiatry 2000; 57:321-2. PubMed
  • Tomeo CA, Rich-Edwards JW, Michels KB, Berkey CS, Hunter DJ, Frazier AL, Willett WC, Buka SL. Reproducibility and validity of maternal recall of pregnancy-related events. Epidemiology 1999; 10:774-7. PubMed
  • Greenland S, Michels KB, Robins JM, Poole C, Willett WC. Presenting statistical uncertainty in trends and dose-response relations. Am J Epidemiol 1999; 149:1077-86. PubMed
  • Michels KB. Problems assessing nonserious adverse drug reactions: antidepressant drug therapy and sexual dysfunction. Pharmacotherapy 1999; 19:424-9. PubMed
  • Hu FB, Manson JE, Liu S, Hunter D, Colditz GA, Michels KB, Speizer FE, Giovannucci E. Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women. J Natl Cancer Inst 1999; 91:542-7. PubMed
  • Michels KB, Rosner BA, Walker AM, Stampfer MJ, Manson JE, Colditz GA, Hennekens CH, Willett WC. Calcium channel blockers, cancer incidence, and cancer mortality in a cohort of U.S. women: the nurses' health study. Cancer 1998; 83:2003-7. PubMed
  • Michels KB, Rosner BA, Manson JE, Stampfer MJ, Walker AM, Willett WC, Hennekens CH. Prospective study of calcium channel blocker use, cardiovascular disease, and total mortality among hypertensive women: the Nurses' Health Study. Circulation 1998; 97:1540-8. PubMed
  • Michels KB, Greenland S, Rosner BA. Does body mass index adequately capture the relation of body composition and body size to health outcomes? Am J Epidemiol 1998; 147:167-72. PubMed
  • Michels KB, Trichopoulos D, Robins JM, Rosner BA, Manson JE, Hunter DJ, Colditz GA, Hankinson SE, Speizer FE, Willett WC. Birthweight as a risk factor for breast cancer. Lancet 1996; 348:1542-6. PubMed
  • Michels KB, Rosner BA. Data trawling: to fish or not to fish. Lancet 1996; 348:1152-3. PubMed
  • Michels KB, Willett WC. Does induced or spontaneous abortion affect the risk of breast cancer? Epidemiology 1996; 7:521-8. PubMed
  • Michels KB, Willett WC, Rosner BA, Manson JE, Hunter DJ, Colditz GA, Hankinson SE, Speizer FE. Prospective assessment of breastfeeding and breast cancer incidence among 89,887 women. Lancet 1996; 347:431-6. PubMed
  • Troy LM, Michels KB, Hunter DJ, Spiegelman D, Manson JE, Colditz GA, Stampfer MJ, Willett WC. Self-reported birthweight and history of having been breastfed among younger women: an assessment of validity. Int J Epidemiol 1996; 25:122-7. PubMed
  • Michels KB, Willett WC. The women's health initiative: will it resolve the issues? Recent Results Cancer Res 1996; 140:295-305. PubMed
  • Michels KB. The origins of Hodgkin's disease. Eur J Cancer Prev 1995; 4:379-88. PubMed
  • Lipworth L, Katsouyanni K, Ekbom A, Michels KB, Trichopoulos D. Abortion and the risk of breast cancer: a case-control study in Greece. Int J Cancer 1995; 61:181-4. PubMed
  • Michels KB, Yusuf S. Does PTCA in acute myocardial infarction affect mortality and reinfarction rates? A quantitative overview (meta-analysis) of the randomized clinical trials. Circulation 1995; 91:476-85. PubMed
  • Michels KB, Hsieh CC, Trichopoulos D, Willett WC. Abortion and breast cancer risk in seven countries. Cancer Causes Control 1995; 6:75-82. PubMed
  • Rothman KJ, Michels KB. The continuing unethical use of placebo controls. N Engl J Med 1994; 331:394-8. PubMed
  • Michels KB, Willett WC. Vitamins and cancer: a practical means of prevention? Important Adv Oncol 1994. PubMed
  • Michels KB. Quo vadis meta-analysis? A potentially dangerous tool if used without adequate rules. Important Adv Oncol 1992. PubMed
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