Photo of Kenneth K. Tanabe,  MD

Kenneth K. Tanabe, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-3868
Fax: (617) 724-3895

Kenneth K. Tanabe, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Surgery, Harvard Medical School
  • Chief, Surgical Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

DF/HCC ASSOCIATIONS

  • Member, Center Scientific Council

Research Abstract

Clinical Research Areas: Liver cancer surgery and melanoma surgery.

Laboratory Research Areas: 1) Viral oncolysis/gene therapy; 2) hepatocellular transformation.

One laboratory research focus is on viral oncolysis of solid tumors. We have examined Herpes simplex virus 1 immediately early gene regulation as a strategy to achieve preferential HSV-1 replication in transformed cells compared to normal cells. We are also involved in integration of specific therapeutic transgenes into these viral mutants. The laboratory work centers on genetic engineering of viral mutants, preclinical characterization, and clinical trials of viral oncolytic gene therapy.

A second laboratory research focus is on pathways involved in hepatocellular transformation to hepatocellular carcinoma (HCC) in the setting of cirrhosis. Recent studies on the EGF gene demonstrate a functional single nucleotide polymorphism that increases serum and liver EGF levels and significantly raises risk for HCC. Prevention of HCC by blockade of EGFR signalling can prevent HCC in preclinical models.

Publications

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  • Tapias LF, Gilpin SE, Ren X, Wei L, Fuchs BC, Tanabe KK, Lanuti M, Ott HC. Assessment of Proliferation and Cytotoxicity in a Biomimetic Three-Dimensional Model of Lung Cancer. Ann Thorac Surg 2015. PubMed
  • Luo S, Lobo AZ, Tanabe KK, Muzikansky A, Durazzo T, Sober A, Tsao H, Cosimi AB, Lawrence DP, Duncan LM. Clinical Significance of Microscopic Melanoma Metastases in the Nonhottest Sentinel Lymph Nodes. JAMA Surg 2015. PubMed
  • Lin WM, Luo S, Muzikansky A, Lobo AZ, Tanabe KK, Sober AJ, Cosimi AB, Tsao H, Duncan LM. Outcome of patients with de novo versus nevus-associated melanoma. J Am Acad Dermatol 2014; 72:54-8. PubMed
  • Fong ZV, Tanabe KK. The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: A comprehensive and evidence-based comparison and review. Cancer 2014. PubMed
  • Murai T, Yamada S, Fuchs BC, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Tanabe KK, Kodera Y. Epithelial-to-mesenchymal transition predicts prognosis in clinical gastric cancer. J Surg Oncol 2014; 109:684-9. PubMed
  • Kuruppu D, Brownell AL, Shah K, Mahmood U, Tanabe KK. Molecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability. Cancer Res 2014. PubMed
  • Yamada S, Okumura N, Wei L, Fuchs BC, Fujii T, Sugimoto H, Nomoto S, Takeda S, Tanabe KK, Kodera Y. Epithelial to Mesenchymal Transition is Associated with Shorter Disease-Free Survival in Hepatocellular Carcinoma. Ann Surg Oncol 2014. PubMed
  • Coit DG, Thompson JA, Andtbacka R, Anker CJ, Bichakjian CK, Carson WE, Daniels GA, Daud A, Dimaio D, Fleming MD, Gonzalez R, Guild V, Halpern AC, Hodi FS, Kelley MC, Khushalani NI, Kudchadkar RR, Lange JR, Martini MC, Olszanski AJ, Ross MI, Salama A, Swetter SM, Tanabe KK, Trisal V, Urist MM, McMillian NR, Ho M. Melanoma, version 4.2014. J Natl Compr Canc Netw 2014; 12:621-9. PubMed
  • Borger DR, Goyal L, Yau T, Poon RT, Ancukiewicz M, Deshpande V, Christiani DC, Liebman HM, Yang H, Kim H, Yen K, Faris JE, Iafrate AJ, Kwak EL, Clark JW, Allen JN, Blaszkowsky LS, Murphy JE, Saha SK, Hong TS, Wo JY, Ferrone CR, Tanabe KK, Bardeesy N, Straley KS, Agresta S, Schenkein DP, Ellisen LW, Ryan DP, Zhu AX. Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma. Clin Cancer Res 2014; 20:1884-90. PubMed
  • Fuchs BC, Hoshida Y, Fujii T, Wei L, Yamada S, Lauwers GY, McGinn CM, Deperalta DK, Chen X, Kuroda T, Lanuti M, Schmitt AD, Gupta S, Crenshaw A, Onofrio R, Taylor B, Winckler W, Bardeesy N, Caravan P, Golub TR, Tanabe KK. Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology 2014; 59:1577-90. PubMed
  • Deperalta DK, Hoang MP, Tanabe KK. Approaches to regional nodes in patients with melanoma. J Clin Oncol 2014; 32:881-5. PubMed
  • Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, Misdraji J, Kim AY, Lauer GM. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology 2014; 146:550-61. PubMed
  • Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO. Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 2014; 14:518. PubMed
  • King LY, Johnson KB, Zheng H, Wei L, Gudewicz T, Hoshida Y, Corey KE, Ajayi T, Ufere N, Baumert TF, Chan AT, Tanabe KK, Fuchs BC, Chung RT. Host genetics predict clinical deterioration in HCV-related cirrhosis. PLoS ONE 2014; 9:e114747. PubMed
  • Tanabe KK, Hoshida Y. Prognostic gene signatures for hepatocellular carcinoma: what are we measuring? Ann Surg Oncol 2013; 20:3707-8. PubMed
  • Yamada S, Fuchs BC, Fujii T, Shimoyama Y, Sugimoto H, Nomoto S, Takeda S, Tanabe KK, Kodera Y, Nakao A. Epithelial-to-mesenchymal transition predicts prognosis of pancreatic cancer. Surgery 2013; 154:946-54. PubMed
  • Coit DG, Andtbacka R, Anker CJ, Bichakjian CK, Carson WE, Daud A, Dimaio D, Fleming MD, Guild V, Halpern AC, Hodi FS, Kelley MC, Khushalani NI, Kudchadkar RR, Lange JR, Lind A, Martini MC, Olszanski AJ, Pruitt SK, Ross MI, Swetter SM, Tanabe KK, Thompson JA, Trisal V, Urist MM, McMillian N, Ho M. Melanoma, Version 2.2013: Featured Updates to the NCCN Guidelines. J Natl Compr Canc Netw 2013; 11:395-407. PubMed
  • Tanabe KK, Chiocca EA. "Infectious" optimism for treatment of hepatocellular carcinoma. Mol Ther 2013; 21:722-4. PubMed
  • Hayano K, Desai GS, Kambadakone AR, Fuentes JM, Tanabe KK, Sahani DV. Quantitative characterization of hepatocellular carcinoma and metastatic liver tumor by CT perfusion. Cancer Imaging 2013; 13:512-9. PubMed
  • Suenaga M, Yamada S, Fujii T, Fuchs BC, Okumura N, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Takeda S, Hayashi K, Tanabe KK, Goto H, Kodera Y. A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients. Onco Targets Ther 2013; 6:1805-12. PubMed
  • Lobo AZ, Tanabe KK, Luo S, Muzikansky A, Sober AJ, Tsao H, Cosimi AB, Duncan LM. The distribution of microscopic melanoma metastases in sentinel lymph nodes: implications for pathology protocols. Am J Surg Pathol 2012; 36:1841-8. PubMed
  • Hung T, Piris A, Lobo A, Mihm MC, Sober AJ, Tsao H, Tanabe KK, Duncan LM. Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors. Hum Pathol 2012. PubMed
  • Hoshida Y, Fuchs BC, Tanabe KK. Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges. Curr Cancer Drug Targets 2012. PubMed
  • Abu Dayyeh BK, Yang M, Fuchs BC, Karl DL, Yamada S, Sninsky JJ, O'Brien TR, Dienstag JL, Tanabe KK, Chung RT, . A Functional Polymorphism in the Epidermal Growth Factor Gene is Associated with Risk for Hepatocellular Carcinoma. Gastroenterology 2011. PubMed
  • Tsao H, Tanabe KK, Lawrence DP, Piris A. Case records of the Massachusetts General Hospital. Case 30-2010. A 15-year-old boy with a recurrent skin lesion. N Engl J Med 2010; 363:1352-60. PubMed
  • Geevarghese SK, Geller DA, de Haan H, Hörer M, Knoll A, Mescheder A, Nemunaitis J, Reid T, Sze DY, Tanabe KK. Phase I/II Study of an Oncolytic Herpes Simplex Virus, NV1020, in Patients with Heavily Pretreated Refractory Colorectal Cancer Metastatic to the Liver. Hum Gene Ther 2010; 21:1119-28. PubMed
  • Pandalai PK, Dominguez FJ, Michaelson J, Tanabe KK. Clinical Value of Radiographic Staging in Patients Diagnosed With AJCC Stage III Melanoma. Ann Surg Oncol 2010. PubMed
  • Tanabe KK, Jara S, Michaelson J. Creating and Providing Predictions of Melanoma Outcome. Ann Surg Oncol 2010; 17:1981-2. PubMed
  • Michaelson JS, Chen LL, Silverstein MJ, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J. How cancer at the primary site and in the lymph nodes contributes to the risk of cancer death. Cancer 2009; 115:5095-107. PubMed
  • Chen LL, Nolan ME, Silverstein MJ, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J, Michaelson JS. The impact of primary tumor size, lymph node status, and other prognostic factors on the risk of cancer death. Cancer 2009; 115:5071-83. PubMed
  • Domart MC, Esposti DD, Sebagh M, Olaya N, Harper F, Pierron G, Franc B, Tanabe KK, Debuire B, Azoulay D, Brenner C, Lemoine A. Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy. J Hepatol 2009; 51:881-9. PubMed
  • Cleary JM, Tanabe KT, Lauwers GY, Zhu AX. Hepatic toxicities associated with the use of preoperative systemic therapy in patients with metastatic colorectal adenocarcinoma to the liver. Oncologist 2009; 14:1095-105. PubMed
  • Michaelson JS, Chen LL, Silverstein MJ, Cheongsiatmoy JA, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J. Why cancer at the primary site and in the lymph nodes contributes to the risk of cancer death. Cancer 2009; 115:5084-94. PubMed
  • Cheung WY, Zhai R, Kulke MH, Heist RS, Asomaning K, Ma C, Wang Z, Su L, Lanuti M, Tanabe KK, Christiani DC, Liu G. Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk. Carcinogenesis 2009; 30:1363-7. PubMed
  • Konstantinidis IT,Deshpande V,Genevay M,Berger D,Fernandez-del Castillo C,Tanabe KK,Zheng H,Lauwers GY,Ferrone CR. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg 2009; 144:441-7; discussion 447. PubMed
  • Coit DG,Andtbacka R,Bichakjian CK,Dilawari RA,Dimaio D,Guild V,Halpern AC,Hodi FS,Kashani-Sabet M,Lange JR,Lind A,Martin L,Martini MC,Pruitt SK,Ross MI,Sener SF,Swetter SM,Tanabe KK,Thompson JA,Trisal V,Urist MM,Weber J,Wong MK. Melanoma. J Natl Compr Canc Netw 2009; 7:250-75. PubMed
  • Tanabe KK. The past 60 years in liver surgery. Cancer 2008; 113:1888-96. PubMed
  • Lanuti M,Liu G,Goodwin JM,Zhai R,Fuchs BC,Asomaning K,Su L,Nishioka NS,Tanabe KK,Christiani DC. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res 2008; 14:3216-22. PubMed
  • Fuchs BC, Fujii T, Dorfman JD, Goodwin JM, Zhu AX, Lanuti M, Tanabe KK. Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 2008; 68:2391-9. PubMed
  • Tanabe KK, Lemoine A, Finkelstein DM, Kawasaki H, Fujii T, Chung RT, Lauwers GY, Kulu Y, Muzikansky A, Kuruppu D, Lanuti M, Goodwin JM, Azoulay D, Fuchs BC. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA 2008; 299:53-60. PubMed
  • Pawlik TM, Gleisner AL, Bauer TW, Adams RB, Reddy SK, Clary BM, Martin RC, Scoggins CR, Tanabe KK, Michaelson JS, Kooby DA, Staley CA, Schulick RD, Vauthey JN, Abdalla EK, Curley SA, Choti MA, Elias D. Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis. Ann Surg Oncol 2007; 14:2807-16. PubMed
  • Livestro DP, Kaine EM, Michaelson JS, Mihm MC, Haluska FG, Muzikansky A, Sober AJ, Tanabe KK. Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis. Cancer 2007; 110:614-24. PubMed
  • Ohashi R, Takahashi F, Cui R, Yoshioka M, Gu T, Sasaki S, Tominaga S, Nishio K, Tanabe KK, Takahashi K. Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell. Cancer Lett 2007; 252:225-34. PubMed
  • Yoon SS, Tanabe KK. Should Surgical Resection Be Combined with Imatinib Therapy for Locally Advanced or Metastatic Gastrointestinal Stromal Tumors? Ann Surg Oncol 2007; 14:1784-6. PubMed
  • Tanabe KK. New techniques of liver surgery. Semin Oncol 2006; 33:S39-41. PubMed
  • Tanabe K, Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Hirade K, Katagiri Y, Dohi S, Kozawa O. Modulation by the steroid/thyroid hormone superfamily of TGF-beta-stimulated VEGF release from vascular smooth muscle cells. J Cell Biochem 2006; 99:187-95. PubMed
  • Wada Y, Yoshida K, Suzuki T, Mizuiri H, Konishi K, Ukon K, Tanabe K, Sakata Y, Fukushima M. Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines. Int J Cancer 2006; 119:783-91. PubMed
  • Blanchard K, Colbert JA, Kopans DB, Moore R, Halpern EF, Hughes KS, Smith BL, Tanabe KK, Michaelson JS. Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use. Radiology 2006; 240:335-42. PubMed
  • Kim R, Arihiro K, Emi M, Tanabe K, Osaki A. Potential role of HER-2; in primary breast tumor with bone metastasis. Oncol Rep 2006; 15:1477-84. PubMed
  • Watanabe S, Ogawa S, Hara Y, Tanabe K, Toma H, Abe R. Expression level of costimulatory receptor ICOS is critical for determining the polarization of helper T cell function. Transpl Immunol 2006; 15:255-63. PubMed
  • Yoon SS, Kim SH, Gonen M, Heffernan NM, Detwiller KY, Jarnagin WR, D'Angelica M, Blumgart LH, Tanabe KK, Dematteo RP. Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases. Ann Surg Oncol 2006; 13:353-62. PubMed
  • Cui R, Takahashi K, Takahashi F, Tanabe KK, Fukuchi Y. Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity. Cancer Lett 2005; 232:262-71. PubMed
  • Kim R, Emi M, Tanabe K, Murakami S, Uchida Y, Arihiro K. Regulation and interplay of apoptotic and non-apoptotic cell death. J Pathol 2005; 208:319-26. PubMed
  • Kim R, Emi M, Tanabe K, Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2005; 11:5-13. PubMed
  • Michaelson JS, Cheongsiatmoy JA, Dewey F, Silverstein MJ, Sgroi D, Smith B, Tanabe KK. Spread of human cancer cells occurs with probabilities indicative of a nongenetic mechanism. Br J Cancer 2005; 93:1244-9. PubMed
  • Zhang Z, Harada H, Tanabe K, Hatta H, Hiraoka M, Nishimoto S. Aminopeptidase N/CD13 targeting fluorescent probes: synthesis and application to tumor cell imaging. Peptides 2005; 26:2182-7. PubMed
  • Kim R, Emi M, Matsuura K, Tanabe K. [Therapeutic potential of antisense (AS) Bcl-2 as a chemosensitizer for patients with gastric and breast carcinoma] Gan To Kagaku Ryoho 2005; 32:1540-5. PubMed
  • Tanabe KK, Blaszkowsky LS, Chung RT, Blake MA, Lauwers GY. Case records of the Massachusetts General Hospital. Case 23-2005. A 57-year-old man with a mass in the liver. N Engl J Med 2005; 353:401-10. PubMed
  • Pierie JP, Muzikansky A, Tanabe KK, Ott MJ. The Outcome of Surgical Resection Versus Assignment to the Liver Transplant Waiting List for Hepatocellular Carcinoma. Ann Surg Oncol 2005; 12:552-60. PubMed
  • Yoon SS, Tanabe KK, Warshaw AL. Adult primary retroperitoneal teratoma. Surgery 2005; 137:663-4. PubMed
  • Kuruppu D, Tanabe KK. Viral oncolysis by herpes simplex virus and other viruses. Cancer Biol Ther 2005; 4:524-31. PubMed
  • Kasuya H, Kuruppu DK, Donahue JM, Choi EW, Kawasaki H, Tanabe KK. Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignancies. Cancer Res 2005; 65:3823-7. PubMed
  • Emi M, Kim R, Tanabe K, Uchida Y, Toge T. Targeted therapy against Bcl-2-related proteins in breast cancer cells. Breast Cancer Res 2005; 7:R940-52. PubMed
  • Kim R, Emi M, Tanabe K, Uchida Y, Toge T. The role of Fas ligand and transforming growth factor beta in tumor progression: molecular mechanisms of immune privilege via Fas-mediated apoptosis and potential targets for cancer therapy. Cancer 2004; 100:2281-91. PubMed
  • Kim R, Osaki A, Tanabe K, Toge T. Neoadjuvant chemotherapy for local advanced breast cancer with stage IIIB. Oncol Rep 2004; 11:1265-72. PubMed
  • Elias N, Tanabe KK, Sober AJ, Gadd MA, Mihm MC, Goodspeed B, Cosimi AB. Is completion lymphadenectomy after a positive sentinel lymph node biopsy for cutaneous melanoma always necessary? Arch Surg 2004; 139:400-4; discussion 404-5. PubMed
  • Kasuya H, Pawlik TM, Mullen JT, Donahue JM, Nakamura H, Chandrasekhar S, Kawasaki H, Choi E, Tanabe KK. Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigen. Cancer Res 2004; 64:2561-7. PubMed
  • Kim R, Tanabe K, Emi M, Uchida Y, Toge T. Potential roles of antisense therapy in the molecular targeting of genes involved in cancer (review). Int J Oncol 2003; 24:5-17. PubMed
  • Michaelson JS, Silverstein M, Sgroi D, Cheongsiatmoy JA, Taghian A, Powell S, Hughes K, Comegno A, Tanabe KK, Smith B. The effect of tumor size and lymph node status on breast carcinoma lethality. Cancer 2003; 98:2133-43. PubMed
  • Kim R, Tanabe K, Emi M, Uchida Y, Toge T. Death receptor-dependent and -independent pathways in anticancer drug-induced apoptosis of breast cancer cells. Oncol Rep 2003; 10:1925-30. PubMed
  • Kim R, Emi M, Tanabe K, Uchida Y, Toge T. Chemosensitivity testing for gastrointestinal cancer: survival benefit potential and limitations. Anticancer Drugs 2003; 14:715-23. PubMed
  • Soiffer R, Hodi FS, Haluska F, Jung K, Gillessen S, Singer S, Tanabe K, Duda R, Mentzer S, Jaklitsch M, Bueno R, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Mihm M, Dranoff G. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol 2003; 21:3343-50. PubMed
  • Mullen JT, Tanabe KK. Viral oncolysis for malignant liver tumors. Ann Surg Oncol 2003; 10:596-605. PubMed
  • Yuki H, Kondo T, Zhao QL, Fujiwara Y, Tanabe K, Ogawa R, Nakashima A, Fushiki H, Fujimura M, Saito S. A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines. Free Radic Res 2003; 37:631-43. PubMed
  • Kim R, Tanabe K, Uchida Y, Emi M, Toge T. Effect of Bcl-2 antisense oligonucleotide on drug-sensitivity in association with apoptosis in undifferentiated thyroid carcinoma. Int J Mol Med 2003; 11:799-804. PubMed
  • Evans HL, Krag DN, Teates CD, Patterson JW, Meijer S, Harlow SP, Tanabe KK, Loggie BW, Whitworth PW, Kusminsky RE, Carp NZ, Gadd MA, Slingluff CL. Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision. Ann Surg Oncol 2003; 10:416-25. PubMed
  • Gazelle GS, Hunink MG, Kuntz KM, McMahon PM, Halpern EF, Beinfeld M, Lester JS, Tanabe KK, Weinstein MC. Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysis. Ann Surg 2003; 237:544-55. PubMed
  • Tanabe K, Kim R, Inoue H, Emi M, Uchida Y, Toge T. Antisense Bcl-2 and HER-2 oligonucleotide treatment of breast cancer cells enhances their sensitivity to anticancer drugs. Int J Oncol 2003; 22:875-81. PubMed
  • Izawa K, Tanabe K, Omiya K, Yamada S, Yokoyama Y, Ishiguro T, Yagi M, Hirano Y, Kasahara Y, Osada N, Miyake F, Murayama M. Impaired chronotropic response to exercise in acute myocardial infarction patients with type 2 diabetes mellitus. Jpn Heart J 2003; 44:187-99. PubMed
  • Yoshida K, Tanabe K, Ueno H, Ohta K, Hihara J, Toge T, Nishiyama M. Future prospects of personalized chemotherapy in gastric cancer patients: results of a prospective randomized pilot study. Gastric Cancer 2003; 6 Suppl 1:82-9. PubMed
  • Kim R, Tanabe K, Emi M, Uchida Y, Inoue H, Toge T. Inducing cancer cell death by targeting transcription factors. Anticancer Drugs 2003; 14:3-11. PubMed
  • Kim R, Tanabe K, Uchida Y, Emi M, Inoue H, Toge T. Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemother Pharmacol 2002; 50:343-52. PubMed
  • Cusack JC, Tanabe KK. Introduction to cancer gene therapy. Surg Oncol Clin N Am 2002; 11:497-519, v. PubMed
  • Donahue JM, Mullen JT, Tanabe KK. Viral oncolysis. Surg Oncol Clin N Am 2002; 11:661-80. PubMed
  • Arai Y, Kondo T, Tanabe K, Zhao QL, Li FJ, Ogawa R, Li M, Kasuya M. Enhancement of hyperthermia-induced apoptosis by local anesthetics on human histiocytic lymphoma U937 cells. J Biol Chem 2002; 277:18986-93. PubMed
  • Curley SA, Cusack JC, Tanabe KK, Stoelzing O, Ellis LM. Advances in the treatment of liver tumors. Curr Probl Surg 2002; 39:449-571. PubMed
  • Kim R, Tanabe K, Inoue H, Toge T. Mechanism(s) of antitumor action in protracted infusion of low dose 5-fluorouracil and cisplatin in gastric carcinoma. Int J Oncol 2002; 20:549-55. PubMed
  • Mullen JT, Tanabe KK. Viral oncolysis. Oncologist 2002; 7:106-19. PubMed
  • Nakamura H, Mullen JT, Chandrasekhar S, Pawlik TM, Yoon SS, Tanabe KK. Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil. Cancer Res 2001; 61:5447-52. PubMed
  • Kim R, Inoue H, Tanabe K, Toge T. Effect of inhibitors of cysteine and serine proteases in anticancer drug-induced apoptosis in gastric cancer cells. Int J Oncol 2001; 18:1227-32. PubMed
  • Kim R, Osaki A, Tanabe K, Kojima J, Toge T. A phase II trial of mitomycin C, 5'-deoxy-5-fluorouridine, etoposide and medroxyprogesterone acetate (McVD-MPA) as a salvage chemotherapy to anthracycline-resistant tumor in relapsed breast cancer and its mechanism(s) of antitumor action. Oncol Rep 2001; 8:597-603. PubMed
  • Kameda K, Kondo T, Tanabe K, Zhao QL, Seto H. The role of intracellular Ca(2+) in apoptosis induced by hyperthermia and its enhancement by verapamil in U937 cells. Int J Radiat Oncol Biol Phys 2001; 49:1369-79. PubMed
  • Amano T, Tanabe K, Eto T, Narumiya S, Mizuno K. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem J 2001; 354:149-59. PubMed
  • Kohara Y, Tanabe K, Matsuoka K, Kanda N, Matsuda H, Karasuyama H, Yonekawa H. A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9. Immunogenetics 2001; 53:15-21. PubMed
  • Harlow SP, Krag DN, Ashikaga T, Weaver DL, Meijer SJ, Loggie BW, Tanabe KK, Whitworth P, Kuhn J, Kusminsky R, Carp NZ, Gadd M, Rawlings M, Slingluff CL. Gamma probe guided biopsy of the sentinel node in malignant melanoma: a multicentre study. Melanoma Res 2001; 11:45-55. PubMed
  • Pawlik TM, Tanabe KK. Radiofrequency ablation for primary and metastatic liver tumors. Cancer Treat Res 2002; 109:247-67. PubMed
  • Koike J, Yamaguchi Y, Horita S, Tanabe K, Fuchinoue S, Toma H, Nihei H. Clinical and pathological assessment of acute vascular rejection in the transplant kidney. Clin Transplant 2002; 15 Suppl 5:41-4. PubMed
  • Ichikura H, Tanabe K, Tokumoto T, Shimuzu T, Ishikawa N, Harano M, Inui M, Manu M, Ito S, Shimmura H, Okuda H, Yagisawa T, Fuchinoue S, Toma H. Conversion of renal transplant immunosuppression from tacrolimus (FK 506) to cyclosporine: a single center experience. Transplant Proc 2000; 32:1733-5. PubMed
  • Eto H, Yoon SS, Bode BP, Kamidono S, Makino K, Saya H, Nakamura H, Tanabe KK. Mapping and regulation of the tumor-associated epitope recognized by monoclonal antibody RS-11. J Biol Chem 2000; 275:27075-83. PubMed
  • Del Governatore M, Hamblin MR, Shea CR, Rizvi I, Molpus KG, Tanabe KK, Hasan T. Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorin(e6) immunoconjugate. Cancer Res 2000; 60:4200-5. PubMed
  • Amo Y, Tanei R, Tanabe K, Katsuoka K. Dermatitis herpetiformis in a Japanese patient with anaplastic large cell lymphoma. J Dermatol 2000; 27:533-6. PubMed
  • Greenberg DB, Jonasch E, Gadd MA, Ryan BF, Everett JR, Sober AJ, Mihm MA, Tanabe KK, Ott M, Haluska FG. Adjuvant therapy of melanoma with interferon-alpha-2b is associated with mania and bipolar syndromes. Cancer 2000; 89:356-62. PubMed
  • Morino Y, Hara K, Ushikoshi H, Tanabe K, Kuroda Y, Noguchi T, Ayabe S, Hara H, Yanbe Y, Kozuma K, Ikari Y, Saeki F, Tamura T. [Gamma-interferon-induced cardiomyopathy during treatment of renal cell carcinoma: a case report] J Cardiol 2000; 36:49-57. PubMed
  • Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK. Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer 2000; 88:2452-63. PubMed
  • Pawlik TM, Nakamura H, Yoon SS, Mullen JT, Chandrasekhar S, Chiocca EA, Tanabe KK. Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus. Cancer Res 2000; 60:2790-5. PubMed
  • Asano T, Shiraga H, Akioka Y, Hattori M, Ishikawa N, Tanabe K, Toma H, Ito K. [Clinical study of 18 pediatric cadaveric renal transplantations: organ sharing in pediatric renal transplantation after enforcement of the organ transplant law in Japan] Nippon Jinzo Gakkai Shi 2000; 42:327-32. PubMed
  • Wrone DA, Tanabe KK, Cosimi AB, Gadd MA, Souba WW, Sober AJ. Lymphedema after sentinel lymph node biopsy for cutaneous melanoma: a report of 5 cases. Arch Dermatol 2000; 136:511-4. PubMed
  • Choi SH, Takahashi K, Eto H, Yoon SS, Tanabe KK. CD44s expression in human colon carcinomas influences growth of liver metastases. Int J Cancer 2000; 85:523-6. PubMed
  • Hong TS, DeLaney TF, Mamon HJ, Willett CG, Yeap BY, Niemierko A, Wolfgang JA, Lu HM, Adams J, Weyman EA, Arellano RS, Blaszkowsky LS, Allen JN, Tanabe KK, Ryan DP, Zhu AX. A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors. 2014; 4:316-22. PubMed
  • Hiraoka Y, Ogawa M, Sakai Y, Takeuchi Y, Komatsu N, Shiozawa M, Tanabe K, Aiso S. PLP-I: a novel prolactin-like gene in rodents. Biochim Biophys Acta 1999; 1447:291-7. PubMed
  • Tanabe KK. Ephemeral seeds: microembolization of tumor cells during surgery. Ann Surg Oncol 1999; 6:631-2. PubMed
  • Yu LL, Flotte TJ, Tanabe KK, Gadd MA, Cosimi AB, Sober AJ, Mihm MC, Duncan LM. Detection of microscopic melanoma metastases in sentinel lymph nodes. Cancer 1999; 86:617-27. PubMed
  • Shebani KO, Souba WW, Finkelstein DM, Stark PC, Elgadi KM, Tanabe KK, Ott MJ. Prognosis and survival in patients with gastrointestinal tract carcinoid tumors. Ann Surg 1999; 229:815-21; discussion 822-3. PubMed
  • Mangi AA, Smith BL, Gadd MA, Tanabe KK, Ott MJ, Souba WW. Surgical management of phyllodes tumors. Arch Surg 1999; 134:487-92; discussion 492-3. PubMed
  • Gadd MA, Cosimi AB, Yu J, Duncan LM, Yu L, Flotte TJ, Souba WW, Ott MJ, Wong LS, Sober AJ, Mihm MC, Haluska FG, Tanabe KK. Outcome of patients with melanoma and histologically negative sentinel lymph nodes. Arch Surg 1999; 134:381-7. PubMed
  • Ott MJ, Tanabe KK, Gadd MA, Stark P, Smith BL, Finkelstein DM, Souba WW. Multimodality management of Merkel cell carcinoma. Arch Surg 1999; 134:388-92; discussion 392-3. PubMed
  • Takahashi K, Eto H, Tanabe KK. Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells. Int J Cancer 1999; 80:387-95. PubMed
  • Yoon SS, Tanabe KK. Surgical treatment and other regional treatments for colorectal cancer liver metastases. Oncologist 1999; 4:197-208. PubMed
  • Takahashi K, Takahashi F, Tanabe KK, Takahashi H, Fukuchi Y. The carboxyl-terminal fragment of osteopontin suppresses arginine-glycine-asparatic acid-dependent cell adhesion. Biochem Mol Biol Int 1999; 46:1081-92. PubMed
  • Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Dranoff G. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A 1998; 95:13141-6. PubMed
  • Yoon SS, Carroll NM, Chiocca EA, Tanabe KK. Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector. Ann Surg 1998; 228:366-74. PubMed
  • Cusack JC, Tanabe KK. Cancer gene therapy. Surg Oncol Clin N Am 1998; 7:421-69. PubMed
  • Sasaki JI, Tanabe KK, Takahashi K, Okamoto I, Fujimoto H, Matsumoto M, Suga M, Ando M, Saya H. Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas. Int J Oncol 1998; 12:525-33. PubMed
  • Carroll NM, Chase M, Chiocca EA, Tanabe KK. The effect of ganciclovir on herpes simplex virus-mediated oncolysis. J Surg Res 1997; 69:413-7. PubMed
  • Dasgupta A, Takahashi K, Cutler M, Tanabe KK. O-linked glycosylation modifies CD44 adhesion to hyaluronate in colon carcinoma cells. Biochem Biophys Res Commun 1996; 227:110-7. PubMed
  • Carroll NM, Chiocca EA, Takahashi K, Tanabe KK. Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus. Ann Surg 1996; 224:323-9; discussion 329-30. PubMed
  • Fischer CP, Bode BP, Takahashi K, Tanabe KK, Souba WW. Glucocorticoid-dependent induction of interleukin-6 receptor expression in human hepatocytes facilitates interleukin-6 stimulation of amino acid transport. Ann Surg 1996; 223:610-8; discussion 618-9. PubMed
  • Takahashi K, Stamenkovic I, Cutler M, Dasgupta A, Tanabe KK. Keratan sulfate modification of CD44 modulates adhesion to hyaluronate. J Biol Chem 1996; 271:9490-6. PubMed
  • Takahashi K, Stamenkovic I, Cutler M, Saya H, Tanabe KK. CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas. Oncogene 1995; 11:2223-32. PubMed
  • Tanabe KK, Stamenkovic I, Cutler M, Takahashi K. Restoration of CD44H expression in colon carcinomas reduces tumorigenicity. Ann Surg 1995; 222:493-501; discussion 501-3. PubMed
  • Nagasaka S, Tanabe KK, Bruner JM, Saya H, Sawaya RE, Morrison RS. Alternative RNA splicing of the hyaluronic acid receptor CD44 in the normal human brain and in brain tumors. J Neurosurg 1995; 82:858-63. PubMed
  • Tanabe KK, Pollock RE, Ellis LM, Murphy A, Sherman N, Romsdahl MM. Influence of surgical margins on outcome in patients with preoperatively irradiated extremity soft tissue sarcomas. Cancer 1994; 73:1652-9. PubMed
  • Juarez J, Clayman G, Nakajima M, Tanabe KK, Saya H, Nicolson GL, Boyd D. Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity. Int J Cancer 1993; 55:10-8. PubMed
  • Tanabe KK, Ellis LM, Saya H. Expression of CD44R1 adhesion molecule in colon carcinomas and metastases. Lancet 1993; 341:725-6. PubMed
  • Tanabe KK, Nishi T, Saya H. Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. Mol Carcinog 1993; 7:212-20. PubMed
  • Tanabe KK, Jones WG, Barie PS. Clostridial sepsis and malignant disease. Surg Gynecol Obstet 1989; 169:423-8. PubMed
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