Photo of Kevin S. Hughes,  MD

Kevin S. Hughes, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-0048


kshughes@partners.org

Kevin S. Hughes, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Surgery, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

Research relates to the identification of women at high risk of breast and ovarian cancer, and the appropriate management of these individuals. This work is done in collaboration with the Avon Comprehensive Breast Evaluation Center at the Massachusetts General Hospital.

Publications

Powered by Harvard Catalyst
  • Hughes KS, Schnaper LA. Can older women with early breast cancer avoid radiation? Lancet Oncol. 2015; 16:235-7. PubMed
  • Tang R, Coopey SB, Specht MC, Lei L, Gadd MA, Hughes KS, Brachtel EF, Smith BL. Lumpectomy specimen margins are not reliableĀ in predicting residual disease in breast conserving surgery. Am J Surg 2015. PubMed
  • Miller CL, West JA, Bettini AC, Koerner FC, Gudewicz TM, Freer PE, Coopey SB, Gadd MA, Hughes KS, Smith BL, Rafferty E, Specht MC. Surgical excision of radial scars diagnosed by core biopsy may help predict future risk of breast cancer. Breast Cancer Res Treat 2014. PubMed
  • Wood ME, Kadlubek P, Pham TH, Wollins DS, Lu KH, Weitzel JN, Neuss MN, Hughes KS. Quality of cancer family history and referral for genetic counseling and testing among oncology practices: a pilot test of quality measures as part of the American Society of Clinical Oncology Quality Oncology Practice Initiative. J Clin Oncol 2014; 32:824-9. PubMed
  • Lu KH, Wood ME, Daniels M, Burke C, Ford J, Kauff ND, Kohlmann W, Lindor NM, Mulvey TM, Robinson L, Rubinstein WS, Stoffel EM, Snyder C, Syngal S, Merrill JK, Wollins DS, Hughes KS, . American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers. J Clin Oncol 2014; 32:833-40. PubMed
  • Fitzgibbons PL, Dillon DA, Alsabeh R, Berman MA, Hayes DF, Hicks DG, Hughes KS, Nofech-Mozes S. Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Breast. Arch Pathol Lab Med 2013. PubMed
  • Hughes KS, Schnaper LA, Bellon JR, Cirrincione CT, Berry DA, McCormick B, Muss HB, Smith BL, Hudis CA, Winer EP, Wood WC. Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol 2013; 31:2382-7. PubMed
  • Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, Polubriaginof F, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi AJ, Roche CA, Hughes KS. The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions. Breast Cancer Res Treat 2012. PubMed
  • Ozanne E, Drohan B, Bosinoff P, Semine A, Jellinek M, Cronin C, Millham F, Dowd D, Rourke T, Block C, Hughes KS. Which risk model to use? Clinical implications of the ACS MRI screening guidelines. Cancer Epidemiol Biomarkers Prev 2012. PubMed
  • Buckley JM, Coopey SB, Sharko J, Polubriaginof F, Drohan B, Belli AK, Kim EM, Garber JE, Smith BL, Gadd MA, Specht MC, Roche CA, Gudewicz TM, Hughes KS. The feasibility of using natural language processing to extract clinical information from breast pathology reports. J Pathol Inform 2012; 3:23. PubMed
  • Samphao S, Wheeler AJ, Rafferty E, Michaelson JS, Specht MC, Gadd MA, Hughes KS, Smith BL. Diagnosis of breast cancer in women age 40 and younger: delays in diagnosis result from underuse of genetic testing and breast imaging. Am J Surg 2009; 198:538-43. PubMed
  • Javid SH, Kirstein LJ, Rafferty E, Lipsitz S, Moore R, Rusby JE, Murphy CD, Hughes KS, Specht MC, Taghian AG, Smith BL. Outcome of multiple-wire localization for larger breast cancers: do multiple wires translate into additional imaging, biopsies, and recurrences? Am J Surg 2009; 198:368-72. PubMed
  • Ozanne EM,Loberg A,Hughes S,Lawrence C,Drohan B,Semine A,Jellinek M,Cronin C,Milham F,Dowd D,Block C,Lockhart D,Sharko J,Grinstein G,Hughes KS. Identification and management of women at high risk for hereditary breast/ovarian cancer syndrome. Breast J 2009; 15:155-62. PubMed
  • Schwartz GF,Hughes KS,Lynch HT,Fabian CJ,Fentiman IS,Robson ME,Domchek SM,Hartmann LC,Holland R,Winchester DJ,Anderson BO,Arun BK,Bartelink H,Bernard P,Bonanni B,Cady B,Clough KB,Feig SA,Heywang-Kobrunner SH,Howell A,Isaacs C,Kopans DB,Mansel RE,Masood S,Palazzo JP,Pressman PI,Solin LJ,Untch M. Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. Breast J 2009; 15:4-16. PubMed
  • Alm El-Din MA, Hughes KS, Raad RA, Goldberg SI, Aisenberg AC, Niemierko A, Taghian AG. Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis. Radiat Oncol 2009; 4:19. PubMed
  • Alm El-Din MA,Hughes KS,Finkelstein DM,Betts KA,Yock TI,Tarbell NJ,Aisenberg AC,Taghian AG. Breast cancer after treatment of Hodgkin's lymphoma: risk factors that really matter. Int J Radiat Oncol Biol Phys 2008; 73:69-74. PubMed
  • Murphy CD,Lee JM,Drohan B,Euhus DM,Kopans DB,Gadd MA,Rafferty EA,Specht MC,Smith BL,Hughes KS. The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing. Cancer 2008; 113:3116-20. PubMed
  • Schwartz GF,Hughes KS,Lynch HT,Fabian CJ,Fentiman IS,Robson ME,Domchek SM,Hartmann LC,Holland R,Winchester DJ. Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. Cancer 2008; 113:2627-37. PubMed
  • Murphy CD,Jones JL,Javid SH,Michaelson JS,Nolan ME,Lipsitz SR,Specht MC,Lesnikoski BA,Hughes KS,Gadd MA,Smith BL. Do sentinel node micrometastases predict recurrence risk in ductal carcinoma in situ and ductal carcinoma in situ with microinvasion? Am J Surg 2008; 196:566-8. PubMed
  • Kirstein LJ,Rafferty E,Specht MC,Moore RH,Taghian AG,Hughes KS,Gadd MA,Smith BL. Outcomes of multiple wire localization for larger breast cancers: when can mastectomy be avoided? J Am Coll Surg 2008; 207:342-6. PubMed
  • Chakravorty SJ, Hughes KR, Craig AG. Host response to cytoadherence in Plasmodium falciparum. Biochem Soc Trans 2008; 36:221-8. PubMed
  • Hughes KS. Why do we believe that breast cancer in the elderly is the same as breast cancer in young women? Drugs Aging 2008; 25:47-8. PubMed
  • Dominguez FJ, Golshan M, Black DM, Hughes KS, Gadd MA, Christian R, Lesnikoski BA, Specht M, Michaelson J, Smith BL. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ. Ann Surg Oncol 2007; 15:268-73. PubMed
  • Black D, Specht M, Lee JM, Dominguez F, Gadd M, Hughes K, Rafferty E, Smith B. Detecting occult malignancy in prophylactic mastectomy: preoperative MRI versus sentinel lymph node biopsy. Ann Surg Oncol 2007; 14:2477-84. PubMed
  • Dominguez FJ, Lawrence C, Halpern EF, Drohan B, Grinstein G, Black DM, Smith BL, Gadd MA, Specht M, Kopans DB, Moore RH, Hughes SS, Roche CA, Hughes KS. Accuracy of Self-Reported Personal History of Cancer in an Outpatient Breast Center. J Genet Couns 2007; 16:341-5. PubMed
  • del Carmen MG, Halpern EF, Kopans DB, Moy B, Moore RH, Goss PE, Hughes KS. Mammographic breast density and race. AJR Am J Roentgenol 2007; 188:1147-50. PubMed
  • Dominguez FJ, Black DM, Kawaguchi AL, O'Malley CA, Hughes KS. Elastic stay hooks and self-retaining retractor technique for mastectomy skin flaps. Surgery 2007; 141:272-4. PubMed
  • Kozak KR, Smith BL, Adams J, Kornmehl E, Katz A, Gadd M, Specht M, Hughes K, Gioioso V, Lu HM, Braaten K, Recht A, Powell SN, DeLaney TF, Taghian AG. Accelerated partial-breast irradiation using proton beams: initial clinical experience. Int J Radiat Oncol Biol Phys 2006; 66:691-8. PubMed
  • Zabicki K, Colbert JA, Dominguez FJ, Gadd MA, Hughes KS, Jones JL, Specht MC, Michaelson JS, Smith BL. Breast Cancer Diagnosis in Women PubMed
  • Blanchard K, Colbert JA, Kopans DB, Moore R, Halpern EF, Hughes KS, Smith BL, Tanabe KK, Michaelson JS. Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use. Radiology 2006; 240:335-42. PubMed
  • Schwartz GF, Veronesi U, Clough KB, Dixon JM, Fentiman IS, Heywang-K. Proceedings of the consensus conference on breast conservation, Milan, Italy, April 28-May 1, 2005. Int J Radiat Oncol Biol Phys 2006; 65:1281-8. PubMed
  • Schwartz GF, Veronesi U, Clough KB, Dixon JM, Fentiman IS, Heywang-K. Consensus conference on breast conservation. J Am Coll Surg 2006; 203:198-207. PubMed
  • Schwartz GF, Veronesi U, Clough KB, Dixon JM, Fentiman IS, Heywang-K. Proceedings of the consensus conference on breast conservation, April 28 to May 1, 2005, Milan, Italy. Cancer 2006; 107:242-50. PubMed
  • Schwartz GF, Veronesi U, Clough KB, Dixon JM, Fentiman IS, Heywang-K. Consensus conference on breast conservation, Milan, Italy, April 28-May 1, 2005. Breast J 2006; 12:398-407. PubMed
  • Taghian AG, Kozak KR, Doppke KP, Katz A, Smith BL, Gadd M, Specht M, Hughes K, Braaten K, Kachnic LA, Recht A, Powell SN. Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys 2006; 64:1092-9. PubMed
  • Dominguez FJ, Jones JL, Zabicki K, Smith BL, Gadd MA, Specht M, Kopans DB, Moore RH, Michaelson JS, Hughes KS. Prevalence of hereditary breast/ovarian carcinoma risk in patients with a personal history of breast or ovarian carcinoma in a mammography population. Cancer 2005; 104:1849-53. PubMed
  • Howard-McNatt M, Hughes KS, Schnaper LA, Jones JL, Gadd M, Smith BL. Breast cancer treatment in older women. Surg Oncol Clin N Am 2004; 14:85-102. PubMed
  • Shabo A, Hughes KS. Family History Information Exchange Services Using HL7 Clinical Genomics Standard Specifications. Int'l Journalon Semantic Web & Information Systems 2006; 1:42-65.
  • Colbert JA, Kaine EM, Bigby J, Smith DN, Moore RH, Rafferty E, Georgian-Smith D, Anne D'Alessandro H, Yeh E, Kopans DB, Halpern EF, Hughes K, Smith BL, Tanabe KK, Michaelson JS. The age at which women begin mammographic screening. Cancer 2004; 101:1850-9. PubMed
  • Hughes KS, Schnaper LA, Berry D, Cirrincione C, McCormick B, Shank B, Wheeler J, Champion LA, Smith TJ, Smith BL, Shapiro C, Muss HB, Winer E, Hudis C, Wood W, Sugarbaker D, Henderson IC, Norton L, , ,. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 2004; 351:971-7. PubMed
  • del Carmen MG, Hughes KS, Halpern E, Rafferty E, Kopans D, Parisky YR, Sardi A, Esserman L, Rust S, Michaelson J. Racial differences in mammographic breast density. Cancer 2003; 98:590-6. PubMed
  • Hughes KS, Roche C, Campbell CT, Siegel N, Salisbury L, Chekos A, Katz MS, Edell E. Prevalence of family history of breast and ovarian cancer in a single primary care practice using a self-administered questionnaire. Breast J 2003; 9:19-25. PubMed
  • Drohan B, Ozanne EM, Hughes KS. Electronic health records and the management of women at high risk of hereditary breast and ovarian cancer. Breast J 2009; 15 Suppl 1:S46-55. PubMed
  • Schwartz GF, Bartelink H, Burstein HJ, Cady B, Cataliotti L, Fentiman IS, Holland R, Hughes KS, Masood S, McCormick B, Palazzo JA, Pressman PI, Reis-Filho J, Pusztai L, Rutgers EJ, Seidman AD, Solin LJ, Sparano JA. Adjuvant therapy in stage I carcinoma of the breast: the influence of multigene analyses and molecular phenotyping. Breast J 2012; 18:303-11. PubMed
Hide