Photo of Kristin White,  PhD

Kristin White, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-4440
Fax: (617) 726-4453


kristin.white@CBRC2.MGH.harvard.edu

Kristin White, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Dermatology, Harvard Medical School
  • Associate Biologist, Cutaneous Biology Research Center, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The long term goal of our research is to understand the regulation and execution of apoptosis, using the powerful genetic and molecular techniques available in Drosophila. Initially, we identified several genes which act as regulators of apoptosis during normal Drosophila development. The genes: reaper (rpr), grim, and head involution defective (hid) are clustered in a small region of the genome. Recent evidence suggests that these three genes act together to initiate apoptosis. Our current research is focused on dissecting how these genes activate the apoptotic program, and how their activity is regulated during development.

Publications

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  • Arya R, White K. Cell death in development: Signaling pathways and core mechanisms. Semin Cell Dev Biol 2015. PubMed
  • Sarkissian T, Timmons A, Arya R, Abdelwahid E, White K. Detecting apoptosis in Drosophila tissues and cells. Methods 2014. PubMed
  • Perez B, Paquette N, Pa├»dassi H, Zhai B, White K, Skvirsky R, Lacy-Hulbert A, Stuart LM. Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production. J Biol Chem 2012. PubMed
  • Tan Y, Yamada-Mabuchi M, Arya R, St Pierre S, Tang W, Tosa M, Brachmann C, White K. Coordinated expression of cell death genes regulates neuroblast apoptosis. Development 2011; 138:2197-206. PubMed
  • Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K. Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim Biophys Acta 2010. PubMed
  • Krieser RJ,White K. Inside an enigma: do mitochondria contribute to cell death in Drosophila? Apoptosis 2009; 14:961-8. PubMed
  • Moon NS,Di Stefano L,Morris EJ,Patel R,White K,Dyson NJ. E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 2008; 4:e1000153. PubMed
  • Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J 2007; 26:3144-56. PubMed
  • Krieser RJ, Moore FE, Dresnek D, Pellock BJ, Patel R, Huang A, Brachmann C, White K. The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis. Development 2007; 134:2407-14. PubMed
  • Abdelwahid E, Yokokura T, Krieser RJ, Balasundaram S, Fowle WH, White K. Mitochondrial disruption in Drosophila apoptosis. Dev Cell 2007; 12:793-806. PubMed
  • Tseng AS, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, White K, Hariharan IK. Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol 2007; 17:728-33. PubMed
  • Pellock BJ, Buff E, White K, Hariharan IK. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol 2007; 304:102-15. PubMed
  • Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris EJ, Taylor-Harding B, White K, Dyson NJ. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell 2005; 9:463-75. PubMed
  • Kornbluth S, White K. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci 2005; 118:1779-87. PubMed
  • Krieser RJ, White K. Engulfment mechanism of apoptotic cells. Curr Opin Cell Biol 2002; 14:734-8. PubMed
  • Wing JP, Schreader BA, Yokokura T, Wang Y, Andrews PS, Huseinovic N, Dong CK, Ogdahl JL, Schwartz LM, White K, Nambu JR. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat Cell Biol 2002; 4:451-6. PubMed
  • Peterson C, Carney GE, Taylor BJ, White K. reaper is required for neuroblast apoptosis during Drosophila development. Development 2002; 129:1467-76. PubMed
  • White K. Signaling survival: how axons rescue their glia. Dev Cell 2002; 2:128-30. PubMed
  • Wu JN, Nguyen N, Aghazarian M, Tan Y, Sevrioukov EA, Mabuchi M, Tang W, Monserrate JP, White K, Brachmann CB. grim promotes programmed cell death of Drosophila microchaete glial cells. Mech Dev 2010; 127:407-17. PubMed
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