Photo of Kristin White,  PhD

Kristin White, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-4440
Fax: (617) 726-4453


kristin.white@CBRC2.MGH.harvard.edu

Kristin White, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Dermatology, Harvard Medical School
  • Associate Biologist, Cutaneous Biology Research Center, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The long term goal of our research is to understand the regulation and execution of apoptosis, using the powerful genetic and molecular techniques available in Drosophila. Initially, we identified several genes which act as regulators of apoptosis during normal Drosophila development. The genes: reaper (rpr), grim, and head involution defective (hid) are clustered in a small region of the genome. Recent evidence suggests that these three genes act together to initiate apoptosis. Our current research is focused on dissecting how these genes activate the apoptotic program, and how their activity is regulated during development.

Publications

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  • Arya R, White K. Cell death in development: Signaling pathways and core mechanisms. Semin Cell Dev Biol 2015. PubMed
  • Sarkissian T, Timmons A, Arya R, Abdelwahid E, White K. Detecting apoptosis in Drosophila tissues and cells. Methods 2014. PubMed
  • Perez B, Paquette N, Pa├»dassi H, Zhai B, White K, Skvirsky R, Lacy-Hulbert A, Stuart LM. Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production. J Biol Chem 2012. PubMed
  • Tan Y, Yamada-Mabuchi M, Arya R, St Pierre S, Tang W, Tosa M, Brachmann C, White K. Coordinated expression of cell death genes regulates neuroblast apoptosis. Development 2011; 138:2197-206. PubMed
  • Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K. Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim Biophys Acta 2010. PubMed
  • Krieser RJ,White K. Inside an enigma: do mitochondria contribute to cell death in Drosophila? Apoptosis 2009; 14:961-8. PubMed
  • Moon NS,Di Stefano L,Morris EJ,Patel R,White K,Dyson NJ. E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 2008; 4:e1000153. PubMed
  • Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J 2007; 26:3144-56. PubMed
  • Krieser RJ, Moore FE, Dresnek D, Pellock BJ, Patel R, Huang A, Brachmann C, White K. The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis. Development 2007; 134:2407-14. PubMed
  • Abdelwahid E, Yokokura T, Krieser RJ, Balasundaram S, Fowle WH, White K. Mitochondrial disruption in Drosophila apoptosis. Dev Cell 2007; 12:793-806. PubMed
  • Tseng AS, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, White K, Hariharan IK. Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol 2007; 17:728-33. PubMed
  • Pellock BJ, Buff E, White K, Hariharan IK. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol 2007; 304:102-15. PubMed
  • Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris EJ, Taylor-Harding B, White K, Dyson NJ. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell 2005; 9:463-75. PubMed
  • Kornbluth S, White K. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci 2005; 118:1779-87. PubMed
  • Yokokura T, Dresnek D, Huseinovic N, Lisi S, Abdelwahid E, Bangs P, White K. Dissection of DIAP1 functional domains via a mutant replacement strategy. J Biol Chem 2004; 279:52603-12. PubMed
  • Krieser RJ, White K. Engulfment mechanism of apoptotic cells. Curr Opin Cell Biol 2002; 14:734-8. PubMed
  • Wing JP, Schreader BA, Yokokura T, Wang Y, Andrews PS, Huseinovic N, Dong CK, Ogdahl JL, Schwartz LM, White K, Nambu JR. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat Cell Biol 2002; 4:451-6. PubMed
  • Peterson C, Carney GE, Taylor BJ, White K. reaper is required for neuroblast apoptosis during Drosophila development. Development 2002; 129:1467-76. PubMed
  • White K. Signaling survival: how axons rescue their glia. Dev Cell 2002; 2:128-30. PubMed
  • White K, Lisi S, Kurada P, Franc N, Bangs P. Methods for studying apoptosis and phagocytosis of apoptotic cells in Drosophila tissues and cell lines. Methods Cell Biol 2001; 66:321-38. PubMed
  • Bangs P, Franc N, White K. Molecular mechanisms of cell death and phagocytosis in Drosophila. Cell Death Differ 2001; 7:1027-34. PubMed
  • Bangs P, White K. Regulation and execution of apoptosis during Drosophila development. Dev Dyn 2000; 218:68-79. PubMed
  • Franc NC, White K. Innate recognition systems in insect immunity and development: new approaches in Drosophila. Microbes Infect 2000; 2:243-50. PubMed
  • White K. Cell death: drosophila Apaf-1 - no longer in the (d)Ark. Curr Biol 2000; 10:R167-9. PubMed
  • Lisi S, Mazzon I, White K. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics 2000; 154:669-78. PubMed
  • Wu JN, Nguyen N, Aghazarian M, Tan Y, Sevrioukov EA, Mabuchi M, Tang W, Monserrate JP, White K, Brachmann CB. grim promotes programmed cell death of Drosophila microchaete glial cells. Mech Dev 2010; 127:407-17. PubMed
  • White K. The third horseman takes wing. Nat Cell Biol 1999; 1:E123-4. PubMed
  • Kurada P, White K. Epidermal growth factor receptor: its role in Drosophila eye differentiation and cell survival. Apoptosis 2003; 4:239-43. PubMed
  • Franc NC, Heitzler P, Ezekowitz RA, White K. Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila. Science 1999; 284:1991-4. PubMed
  • Franc NC, White K, Ezekowitz RA. Phagocytosis and development: back to the future. Curr Opin Immunol 1999; 11:47-52. PubMed
  • Kurada P, White K. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 1998; 95:319-29. PubMed
  • Sibayan SA, Latina MA, Sherwood ME, Flotte TJ, White K. Apoptosis and morphologic changes in drug-treated trabecular meshwork cells in vitro. Exp Eye Res 1998; 66:521-9. PubMed
  • White K, Tahaoglu E, Steller H. Cell killing by the Drosophila gene reaper. Science 1996; 271:805-7. PubMed
  • White K, Steller H. The control of apoptosis in Drosophila. Trends Cell Biol 2004; 5:74-8. PubMed
  • White K, Grether ME, Abrams JM, Young L, Farrell K, Steller H. Genetic control of programmed cell death in Drosophila. Science 1994; 264:677-83. PubMed
  • Abrams JM, White K, Fessler LI, Steller H. Programmed cell death during Drosophila embryogenesis. Development 1993; 117:29-43. PubMed
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