Photo of Laurence A. Turka,  MD

Laurence A. Turka, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-7740
Fax: (617) 726-6925


lturka@partners.org

Laurence A. Turka, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Harold and Ellen Danser Professor of Surgery, Surgery, Harvard Medical School
  • Professor, Medicine, Harvard Medical School
  • Co-Director, Transplantation Biology Research Center, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Publications

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  • McDonald-Hyman C, Turka LA, Blazar BR. Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Sci Transl Med 2015; 7:280rv2. PubMed
  • DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity 2015; 42:227-38. PubMed
  • Priyadharshini B, Turka LA. T-cell energy metabolism as a controller of cell fate in transplantation. Curr Opin Organ Transplant 2015; 20:21-8. PubMed
  • Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol 2015; 16:188-96. PubMed
  • Newton RH, Lu Y, Papa A, Whitcher GH, Kang YJ, Yan C, Pandolfi PP, Turka LA. Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity. Blood 2015; 125:852-5. PubMed
  • Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP. Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function. Cell 2014; 157:595-610. PubMed
  • Huynh A, Zhang R, Turka LA. Signals and pathways controlling regulatory T cells. Immunol Rev 2014; 258:117-31. PubMed
  • Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N. Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol 2013; 191:4447-55. PubMed
  • Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity 2013; 38:1211-22. PubMed
  • Huynh A, Turka LA. Control of T cell tolerance by phosphatase and tensin homolog. Ann N Y Acad Sci 2013; 1280:27-9. PubMed
  • Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH. MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A 2013; 110:2270-5. PubMed
  • Zhang R, Huynh A, Whitcher G, Chang J, Maltzman JS, Turka LA. An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest 2013; 123:580-93. PubMed
  • Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, Scott P, Turka LA, Cherry S, Reiner SL, Cua D, Belkaid Y, Elloso MM, Hunter CA. The cytokines interleukin 27 and interferon-粒 promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 2012; 37:511-23. PubMed
  • Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest 2012; 122:2395-404. PubMed
  • Lieberman SM, Kim JS, Corbo-Rodgers E, Kambayashi T, Maltzman JS, Behrens EM, Turka LA. Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol 2012; 42:1429-35. PubMed
  • Newton RH, Turka LA. Regulation of T cell homeostasis and responses by pten. 2012; 3:151. PubMed
  • Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA. Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest 2010; 120:2497-507. PubMed
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