Photo of Laurie E. Cohen,  MD

Laurie E. Cohen, MD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-7476
Fax: (617) 730-0194


laurie.cohen@childrens.harvard.edu

Laurie E. Cohen, MD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Pediatrics, Harvard Medical School
  • Consultant in Pediatric Endocrinology, Pediatric Hematology/Oncology, Dana-Farber Cancer Institute
  • Program Director in Neuroendocrinology, Endocrinology, Boston Children's Hospital

Research Abstract

Clinical research interest in endocrine late effects in childhood cancer survivors, in particular those with brain tumors or high risk neuroblastoma.

Publications

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  • Cohen LE. Idiopathic short stature: a clinical review. JAMA 2014; 311:1787-96. PubMed
  • Lee JJ, Mitchell PD, Hood HC, Grand RJ, Cohen LE. Potential Role of IGF-1 z Score to Predict Permanent Linear Growth Impairment in Children With IBD. J Pediatr Gastroenterol Nutr 2014; 58:472-6. PubMed
  • Cohen LE, Gordon JH, Popovsky EY, Gunawardene S, Duffey-Lind E, Lehmann LE, Diller LR. Late effects in children treated with intensive multimodal therapy for high-risk neuroblastoma: high incidence of endocrine and growth problems. Bone Marrow Transplant 2014; 49:502-8. PubMed
  • Nahata L, Rosoklija I, Yu RN, Cohen LE. Klinefelter syndrome: are we missing opportunities for early detection? Clin Pediatr (Phila) 2013; 52:936-41. PubMed
  • Robison NJ, Prabhu SP, Sun P, Chi SN, Kieran MW, Manley PE, Cohen LE, Goumnerova L, Smith ER, Scott RM, London WB, Ullrich NJ. Predictors of neoplastic disease in children with isolated pituitary stalk thickening. Pediatr Blood Cancer 2013. PubMed
  • Wassner AJ, Cohen LE, Hechter E, Dauber A. Isolated Central Hypothyroidism in Young Siblings as a Manifestation of PROP1 Deficiency: Clinical Impact of Whole Exome Sequencing. Horm Res Paediatr 2013. PubMed
  • Nahata L, Cohen LE, Lehmann LE, Yu RN. Semen analysis in adolescent cancer patients prior to bone marrow transplantation: when is it too late for fertility preservation? Pediatr Blood Cancer 2012; 60:129-32. PubMed
  • Kenney LB, Cohen LE, Shnorhavorian M, Metzger ML, Lockart B, Hijiya N, Duffey-Lind E, Constine L, Green D, Meacham L. Male reproductive health after childhood, adolescent, and young adult cancers: a report from the Children's Oncology Group. J Clin Oncol 2012; 30:3408-16. PubMed
  • Cohen LE. GLI2 mutations as a cause of hypopituitarism. Pediatr Endocrinol Rev 2013; 9:706-9. PubMed
  • Manley PE, McKendrick K, McGillicudy M, Chi SN, Kieran MW, Cohen LE, Kothare S, Michael Scott R, Goumnerova LC, Sun P, London W, Marcus KJ, Pomeroy SL, Ullrich NJ. Sleep dysfunction in long term survivors of craniopharyngioma. J. Neurooncol. 2012; 108:543-9. PubMed
  • Cohen LE, Gordon JH, Popovsky EY, Sainath NN, Feldman HA, Kieran MW, Gordon CM. Bone density in post-pubertal adolescent survivors of childhood brain tumors. Pediatr Blood Cancer 2012; 58:959-63. PubMed
  • Nahata L, Cohen LE, Yu RN. Barriers to fertility preservation in male adolescents with cancer: it's time for a multidisciplinary approach that includes urologists. Urology 2012; 79:1206-9. PubMed
  • Cohen LE. Genetic disorders of the pituitary. Curr Opin Endocrinol Diabetes Obes 2011; 19:33-9. PubMed
  • Hood HC, Cohen LE, Lee JJ. Late adolescent linear growth pattern in pediatric-onset inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2011; 53:246-9. PubMed
  • Winkfield KM, Tsai HK, Yao X, Larson E, Neuberg D, Pomeroy SL, Ullrich NJ, Cohen LE, Kieran MW, Scott RM, Goumnerova LC, Marcus KJ. Long-term clinical outcomes following treatment of childhood craniopharyngioma. Pediatr Blood Cancer 2010. PubMed
  • Topor LS, Feldman HA, Bauchner H, Cohen LE. Variation in Methods of Predicting Adult Height for Children With Idiopathic Short Stature. Pediatrics 2010. PubMed
  • Masoud MI, Masoud I, Kent RL, Gowharji N, Hassan AH, Cohen LE. Relationship between blood-spot insulin-like growth factor 1 levels and hand-wrist assessment of skeletal maturity. Am J Orthod Dentofacial Orthop 2009; 136:59-64. PubMed
  • Fofanova-Gambetti OV, Hwa V, Kirsch S, Pihoker C, Chiu HK, Högler W, Cohen LE, Jacobsen C, Derr MA, Rosenfeld RG. Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. Horm Res 2009; 71:100-10. PubMed
  • Jacobsen CM, Cohen LE. Short stature in a phenotypic male caused by mixed gonadal dysgenesis. Nat Clin Pract Endocrinol Metab 2008; 4:524-8. PubMed
  • Masoud M, Masoud I, Kent RL, Gowharji N, Cohen LE. Assessing skeletal maturity by using blood spot insulin-like growth factor I (IGF-I) testing. Am J Orthod Dentofacial Orthop 2008; 134:209-16. PubMed
  • Cohen LE. Cancer treatment and the ovary: the effects of chemotherapy and radiation. Ann N Y Acad Sci 2008; 1135:123-5. PubMed
  • Dorsey MJ, Cohen LE, Phipatanakul W, Denufrio D, Schneider LC. Assessment of adrenal suppression in children with asthma treated with inhaled corticosteroids: use of dehydroepiandrosterone sulfate as a screening test. Ann. Allergy Asthma Immunol. 2006; 97:182-6. PubMed
  • Cohen LE. Endocrine late effects of cancer treatment. Endocrinol Metab Clin North Am 2005; 34:769-89, xi. PubMed
  • Fleischman A, Brue C, Poussaint TY, Kieran M, Pomeroy SL, Goumnerova L, Scott RM, Cohen LE. Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance. Pediatrics 2005; 115:e742-8. PubMed
  • Cohen RN, Cohen LE, Botero D, Yu C, Sagar A, Jurkiewicz M, Radovick S. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab 2003; 88:4832-9. PubMed
  • Dalton VK, Rue M, Silverman LB, Gelber RD, Asselin BL, Barr RD, Clavell LA, Hurwitz CA, Moghrabi A, Samson Y, Schorin M, Tarbell NJ, Sallan SE, Cohen LE. Height and weight in children treated for acute lymphoblastic leukemia: relationship to CNS treatment. J Clin Oncol 2003; 21:2953-60. PubMed
  • Hashimoto Y, Cisternino M, Cohen LE. A novel nonsense mutation in the Pit-1 gene: evidence for a gene dosage effect. J Clin Endocrinol Metab 2003; 88:1241-7. PubMed
  • Cohen LE. Endocrine late effects of cancer treatment. Curr Opin Pediatr 2003; 15:3-9. PubMed
  • Cohen LE, Radovick S. Other transcription factors and hypopituitarism. Rev Endocr Metab Disord 2002; 3:301-11. PubMed
  • Cohen LE, Radovick S. Molecular basis of combined pituitary hormone deficiencies. Endocr Rev 2002; 23:431-42. PubMed
  • Carpentieri SC, Waber DP, Scott RM, Goumnerova LC, Kieran MW, Cohen LE, Kim F, Billett AL, Tarbell NJ, Pomeroy SL. Memory deficits among children with craniopharyngiomas. Neurosurgery 2002; 49:1053-7; discussion 1057-8. PubMed
  • Hashimoto K, Zanger K, Hollenberg AN, Cohen LE, Radovick S, Wondisford FE. cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes. J Biol Chem 2000; 275:33365-72. PubMed
  • Cohen LE. Genetic regulation of the embryology of the pituitary gland and somatotrophs. Endocrine 2000; 12:99-106. PubMed
  • Cohen LE, Radovick S, Wondisford FE. Transcription Factors and Hypopituitarism. Trends Endocrinol Metab 2001; 10:326-332. PubMed
  • Cohen LE, Hashimoto Y, Zanger K, Wondisford F, Radovick S. CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression. J Clin Invest 1999; 104:1123-30. PubMed
  • Cohen LE, Zanger K, Brue T, Wondisford FE, Radovick S. Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency. Mol Endocrinol 1999; 13:476-84. PubMed
  • Zanger K, Cohen LE, Hashimoto K, Radovick S, Wondisford FE. A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein. Mol Endocrinol 1999; 13:268-75. PubMed
  • Hamilton J, Chitayat D, Blaser S, Cohen LE, Phillips JA, Daneman D. Familial growth hormone deficiency associated with MRI abnormalities. Am J Med Genet 1998; 80:128-32. PubMed
  • Radovick S, Cohen LE, Wondisford FE. The molecular basis of hypopituitarism. Horm Res 1998; 49 Suppl 1:30-6. PubMed
  • Medlock MD, Madsen JR, Barnes PD, Anthony DS, Cohen LE, Scott RM. Optic chiasm astrocytomas of childhood. 1. Long-term follow-up. Pediatr Neurosurg 1998; 27:121-8. PubMed
  • Poussaint TY, Barnes PD, Nichols K, Anthony DC, Cohen L, Tarbell NJ, Goumnerova L. Diencephalic syndrome: clinical features and imaging findings. AJNR Am J Neuroradiol 1997; 18:1499-505. PubMed
  • Cohen LE, Wondisford FE, Radovick S. Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin. Endocrinol Metab Clin North Am 1996; 25:523-40. PubMed
  • Cohen LE, Wondisford FE, Salvatoni A, Maghnie M, Brucker-Davis F, Weintraub BD, Radovick S. A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates. J Clin Endocrinol Metab 1995; 80:679-84. PubMed
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