Photo of Lee Gehrke,  PhD

Lee Gehrke, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 253-7608
Fax: (509) 357-7835


lee_gehrke@hms.harvard.edu

Lee Gehrke, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Professor, Health Sciences and Technology, Harvard Medical School
  • Professor, Microbiology and Immunobiology, Harvard Medical School
  • Professor, Inst. for Med. Engineering & Sci., Massachusetts Institute of Technology

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory is interested in finding ways to prevent hepatitis C virus (HCV) infections from developing into liver cancer (hepatocellular carcinoma). HCV infections affect large numbers of people, and many infections progress to liver cancer. Our research is directed at activating the innate immune system, which is also linked to pathways that destroy cells, called apoptotic mechanisms. We use small RNA molecules to activate innate immune responses, and experiments are directed at determining if apoptotic responses are also activated. By using small RNAs to activate innate immunity and apoptosis, it may be possible to deliver a double attack to HCV-infected cells that could destroy infected cells before they can progress to cancerous cells.

Publications

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  • Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol 2014. PubMed
  • Uzri, D. and Gehrke, L.. Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities J Virol 2009; 83:4174-4184.