Leo L. Cheng, MPP, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-6593
Fax: (617) 726-5684


cheng@nmr.mgh.harvard.edu

Leo L. Cheng, MPP, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research aim at measuring NMR spectra of intact tissue specimens and correlating tissue cellular metabolic changes with its pathology. The current research projects include NIH funded studies of human brain tumors and prostate cancer.

Publications

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  • Spur EM, Decelle EA, Cheng LL. Metabolomic imaging of prostate cancer with magnetic resonance spectroscopy and mass spectrometry. Eur J Nucl Med Mol Imaging 2013. PubMed
  • Decelle EA, Cheng LL. High-resolution magic angle spinning (1) H MRS in prostate cancer. NMR Biomed 2013. PubMed
  • DeFeo EM, Cheng LL. Characterizing human cancer metabolomics with ex vivo 1H HRMAS MRS. Technol. Cancer Res. Treat. 2010; 9:381-91. PubMed
  • Maxeiner A, Adkins CB, Zhang Y, Taupitz M, Halpern EF, McDougal WS, Wu CL, Cheng LL. Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles. Prostate 2010; 70:710-7. PubMed
  • Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL. Assessing prostate cancer growth with mRNA of spermine metabolic enzymes. Cancer Biol Ther 2010; 9:736-42. PubMed
  • Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med 2010; 2:16ra8. PubMed
  • Jordan KW,Nordenstam J,Lauwers GY,Rothenberger DA,Alavi K,Garwood M,Cheng LL. Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum 2009; 52:520-5. PubMed
  • Jordan KW, Cheng LL. NMR-based metabolomics approach to target biomarkers for human prostate cancer. Expert Rev Proteomics 2007; 4:389-400. PubMed
  • Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg 2002; 96:1023-31. PubMed
  • Cheng LL, Chang IW, Smith BL, Gonzalez RG. Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy. J Magn Reson 1998; 135:194-202. PubMed
  • Cheng LL, Chang IW, Louis DN, Gonzalez RG. Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens. Cancer Res 1998; 58:1825-32. PubMed
  • Cheng LL, Ma MJ, Becerra L, Ptak T, Tracey I, Lackner A, Gonz. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 1997; 94:6408-13. PubMed
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