Leo L. Cheng, MPP, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-6593
Fax: (617) 726-5684


cheng@nmr.mgh.harvard.edu

Leo L. Cheng, MPP, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research aim at measuring NMR spectra of intact tissue specimens and correlating tissue cellular metabolic changes with its pathology. The current research projects include NIH funded studies of human brain tumors and prostate cancer.

Publications

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  • Decelle EA, Cheng LL. High-resolution magic angle spinning 1H MRS in prostate cancer. NMR Biomed 2013. PubMed
  • Spur EM, Decelle EA, Cheng LL. Metabolomic imaging of prostate cancer with magnetic resonance spectroscopy and mass spectrometry. Eur J Nucl Med Mol Imaging 2013. PubMed
  • DeFeo EM, Cheng LL. Characterizing human cancer metabolomics with ex vivo 1H HRMAS MRS. Technol. Cancer Res. Treat. 2010; 9:381-91. PubMed
  • Maxeiner A, Adkins CB, Zhang Y, Taupitz M, Halpern EF, McDougal WS, Wu CL, Cheng LL. Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles. Prostate 2010; 70:710-7. PubMed
  • Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL. Assessing prostate cancer growth with mRNA of spermine metabolic enzymes. Cancer Biol Ther 2010; 9:736-42. PubMed
  • Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med 2010; 2:16ra8. PubMed
  • Jordan KW,Nordenstam J,Lauwers GY,Rothenberger DA,Alavi K,Garwood M,Cheng LL. Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum 2009; 52:520-5. PubMed
  • Jordan KW, Cheng LL. NMR-based metabolomics approach to target biomarkers for human prostate cancer. Expert Rev Proteomics 2007; 4:389-400. PubMed