Photo of Leonid Mirny,  PhD

Leonid Mirny, PhD

Massachusetts Institute of Technology

Massachusetts Institute of Technology
Phone: (617) 452-4862


leonid@mit.edu

Leonid Mirny, PhD

Massachusetts Institute of Technology

EDUCATIONAL TITLES

  • Associate Professor, Heath, Sciences and Technology, Massachusetts Institute of Technology
  • Associate Professor, with tenure, of Health Sciences and Technology, and Physics, MIT, Harvard-MIT Division of Health, Sciences and Technology, Massachusetts Institute of Technology

DF/HCC PROGRAM AFFILIATION

Publications

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  • Khrameeva EE, Fudenberg G, Gelfand MS, Mirny LA. History of chromosome rearrangements reflects the spatial organization of yeast chromosomes. J Bioinform Comput Biol 2016; 14:1641002. PubMed
  • Boettiger AN, Bintu B, Moffitt JR, Wang S, Beliveau BJ, Fudenberg G, Imakaev M, Mirny LA, Wu CT, Zhuang X. Super-resolution imaging reveals distinct chromatin folding for different epigenetic states. Nature 2016; 529:418-22. PubMed
  • Kind J, Pagie L, de Vries SS, Nahidiazar L, Dey SS, Bienko M, Zhan Y, Lajoie B, de Graaf CA, Amendola M, Fudenberg G, Imakaev M, Mirny LA, Jalink K, Dekker J, van Oudenaarden A, van Steensel B. Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells. Cell 2015; 163:134-47. PubMed
  • Imakaev MV, Tchourine KM, Nechaev SK, Mirny LA. Effects of topological constraints on globular polymers. Soft Matter 2014; 11:665-71. PubMed
  • Mizuguchi T, Fudenberg G, Mehta S, Belton JM, Taneja N, Folco HD, FitzGerald P, Dekker J, Mirny L, Barrowman J, Grewal SI. Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe. Nature 2014. PubMed
  • McFarland CD, Mirny LA, Korolev KS. Tug-of-war between driver and passenger mutations in cancer and other adaptive processes. Proc Natl Acad Sci U S A 2014; 111:15138-43. PubMed
  • Doyle B, Fudenberg G, Imakaev M, Mirny LA. Chromatin loops as allosteric modulators of enhancer-promoter interactions. PLoS Comput. Biol. 2014; 10:e1003867. PubMed
  • Yaglom JA, McFarland C, Mirny L, Sherman MY. Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer. 2014; 5:8367-78. PubMed
  • Naumova N, Imakaev M, Fudenberg G, Zhan Y, Lajoie BR, Mirny LA, Dekker J. Organization of the mitotic chromosome. Science 2013; 342:948-53. PubMed
  • Le TB, Imakaev MV, Mirny LA, Laub MT. High-resolution mapping of the spatial organization of a bacterial chromosome. Science 2013; 342:731-4. PubMed
  • Dekker J, Marti-Renom MA, Mirny LA. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data. Nat Rev Genet 2013. PubMed
  • McFarland CD, Korolev KS, Kryukov GV, Sunyaev SR, Mirny LA. Impact of deleterious passenger mutations on cancer progression. Proc Natl Acad Sci U S A 2013; 110:2910-5. PubMed
  • Imakaev M, Fudenberg G, McCord RP, Naumova N, Goloborodko A, Lajoie BR, Dekker J, Mirny LA. Iterative correction of Hi-C data reveals hallmarks of chromosome organization. Nat Methods 2012; 9:999-1003. PubMed
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