Photo of Liliana C. Goumnerova,  MD

Liliana C. Goumnerova, MD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-6364
Fax: (617) 730-0906


liliana.goumnerova@childrens.harvard.edu

Liliana C. Goumnerova, MD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Neurosurgery, Harvard Medical School
  • Director, Clinical Pediatric Neurosurgical Oncology, Boston Children's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My interest is in both the areas of basic science and clinical research in pediatric brain tumors. I am interested in the role of neurotrophin receptors and their role in medulloblastoma. Specifically, we are studying the role of trkC and its role in modifying biologic behaviour of medulloblastoma. We are also studying the role of other developmentally regulated genes in cerebellar development and their potential role in medulloblastoma (shh, gli, ptc). I am also interested in the role of stereotactic radiosurgery in brain tumors. We are looking at the effect of radiosurgery in both adjuvant and upfront therapy for brain tumors.

Publications

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  • Dodgshun AJ, SantaCruz N, Hwang J, Ramkissoon SH, Malkin H, Bergthold G, Manley P, Chi S, MacGregor D, Goumnerova L, Sullivan M, Ligon K, Beroukhim R, Herrington B, Kieran MW, Hansford JR, Bandopadhayay P. Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation. J. Neurooncol. 2016. PubMed
  • Bergthold G, Bandopadhayay P, Hoshida Y, Ramkissoon S, Ramkissoon L, Rich B, Maire CL, Paolella BR, Schumacher SE, Tabak B, Ferrer-Luna R, Ozek M, Sav A, Santagata S, Wen PY, Goumnerova LC, Ligon AH, Stiles C, Segal R, Golub T, Grill J, Ligon KL, Chan JA, Kieran MW, Beroukhim R. Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. 2015. PubMed
  • Bandopadhayay P, Silvera VM, Ciarlini PD, Malkin H, Bi WL, Bergthold G, Faisal AM, Ullrich NJ, Marcus K, Scott RM, Beroukhim R, Manley PE, Chi SN, Ligon KL, Goumnerova LC, Kieran MW. Myxopapillary ependymomas in children: imaging, treatment and outcomes. J. Neurooncol. 2015. PubMed
  • Ullrich NJ, Pomeroy SL, Kapur K, Manley PE, Goumnerova LC, Loddenkemper T. Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia 2015; 56:1599-604. PubMed
  • Dabscheck G, Prabhu SP, Manley PE, Goumnerova L, Ullrich NJ. Risk of seizures in children with tectal gliomas. Epilepsia 2015; 56:e139-42. PubMed
  • Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA. A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. 2015. PubMed
  • Kim AH, Thompson EA, Governale LS, Santa C, Cahll K, Kieran MW, Chi SN, Ullrich NJ, Scott RM, Goumnerova LC. Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging. J Neurosurg Pediatrics 2014; 14:356-64. PubMed
  • Bandopadhayay P, Bergthold G, London WB, Goumnerova LC, Morales La Madrid A, Marcus KJ, Guo D, Ullrich NJ, Robison NJ, Chi SN, Beroukhim R, Kieran MW, Manley PE. Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: an analysis of the Surveillance Epidemiology and End Results (SEER) database. Pediatr Blood Cancer 2014. PubMed
  • Robison NJ, Prabhu SP, Sun P, Chi SN, Kieran MW, Manley PE, Cohen LE, Goumnerova L, Smith ER, Scott RM, London WB, Ullrich NJ. Predictors of neoplastic disease in children with isolated pituitary stalk thickening. Pediatr Blood Cancer 2013. PubMed
  • Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A 2013; 110:8188-93. PubMed
  • Bandopadhayay P, Dagi L, Robison N, Goumnerova L, Ullrich NJ. Morning glory disc anomaly in association with ipsilateral optic nerve glioma. Arch Ophthalmol 2012; 130:1082-3. PubMed
  • Manley PE, McKendrick K, McGillicudy M, Chi SN, Kieran MW, Cohen LE, Kothare S, Michael Scott R, Goumnerova LC, Sun P, London W, Marcus KJ, Pomeroy SL, Ullrich NJ. Sleep dysfunction in long term survivors of craniopharyngioma. J. Neurooncol. 2012; 108:543-9. PubMed
  • Winkfield KM, Tsai HK, Yao X, Larson E, Neuberg D, Pomeroy SL, Ullrich NJ, Cohen LE, Kieran MW, Scott RM, Goumnerova LC, Marcus KJ. Long-term clinical outcomes following treatment of childhood craniopharyngioma. Pediatr Blood Cancer 2010. PubMed
  • Wong JM, Chi SN, Marcus KJ, Levine BS, Ullrich NJ, MacDonald S, Lechpammer M, Goumnerova LC. Germinoma with malignant transformation to nongerminomatous germ cell tumor. J Neurosurg Pediatrics 2010; 6:295-8. PubMed
  • Huttner AJ, Kieran MW, Yao X, Cruz L, Ladner J, Quayle K, Goumnerova LC, Irons MB, Ullrich NJ. Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1. Pediatr Blood Cancer 2010; 54:890-6. PubMed
  • Klimo P, Codd PJ, Grier H, Goumnerova LC. Primary pediatric intraspinal sarcomas. Report of 3 cases. J Neurosurg Pediatrics 2009; 4:222-9. PubMed
  • Turner CD,Chordas CA,Liptak CC,Rey-Casserly C,Delaney BL,Ullrich NJ,Goumnerova LC,Scott RM,Begley HC,Fletcher WJ,Yao X,Chi S,Kieran MW. Medical, psychological, cognitive and educational late-effects in pediatric low-grade glioma survivors treated with surgery only. Pediatr Blood Cancer 2009; 53:417-23. PubMed
  • Manley P,Li X,Turner C,Chi S,Zimmerman MA,Chordas C,Gordon A,Baker A,Ullrich NJ,Goumnerova L,Marcus K,Hoffman K,Kieran MW. A prospective, blinded analysis of A-PROTEIN (recoverin or CAR protein) levels in pediatric patients with central nervous system tumors. Pediatr Blood Cancer 2009; 53:343-7. PubMed
  • Qian X,Goumnerova LC,De Girolami U,Cibas ES. Cerebrospinal fluid cytology in patients with ependymoma: a bi-institutional retrospective study. Cancer 2008; 114:307-14. PubMed
  • Gilheeney SW, Saad A, Chi S, Turner C, Ullrich NJ, Goumnerova L, Scott RM, Marcus K, Lehman L, De Girolami U, Kieran MW. Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. J Neurooncol 2008; 89:89-95. PubMed
  • Goumnerova L, Drzymalski D, Kieran M, Pomeroy S, Scott RM, Tarbell N. Long-term neurological and neurosurgical outcomes after surgery only in children with low-grade brain tumors. J Neurosurg Pediatrics 2008; 1:A354-5. PubMed
  • Binning M, Klimo P Jr, Gluf W, Goumnerova L. Spinal tumors in children. Neurosurg Clin N Am 2007; 18:631-58. PubMed
  • Ullrich NJ, Raja AI, Irons MB, Kieran MW, Goumnerova L. Brainstem lesions in neurofibromatosis type 1. Neurosurgery 2007; 61:762-6; discussion 766-7. PubMed
  • Ullrich NJ, Robertson R, Kinnamon DD, Scott RM, Kieran MW, Turner CD, Chi SN, Goumnerova L, Proctor M, Tarbell NJ, Marcus KJ, Pomeroy SL. Moyamoya following cranial irradiation for primary brain tumors in children. Neurology 2007; 68:932-8. PubMed
  • Turner CD, Chi S, Marcus KJ, MacDonald T, Packer RJ, Poussaint TY, Vajapeyam S, Ullrich N, Goumnerova LC, Scott RM, Briody C, Chordas C, Zimmerman MA, Kieran MW. Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. J Neurooncol 2006; 82:95-101. PubMed
  • Klimo P, Goumnerova LC. Endoscopic third ventriculocisternostomy for brainstem tumors. J Neurosurg 2007; 105:271-4. PubMed
  • Ullrich NJ, Marcus K, Pomeroy SL, Turner CD, Zimmerman M, Lehmann LE, Scott RM, Goumnerova L, Gillan E, Kieran MW, Chi SN. Transverse Myelitis After Therapy For Primitive Neuroectodermal Tumors. Pediatr Neurol 2006; 35:122-125. PubMed
  • Waber DP, Pomeroy SL, Chiverton AM, Kieran MW, Scott RM, Goumnerova LC, Rivkin MJ. Everyday cognitive function after craniopharyngioma in childhood. Pediatr Neurol 2005; 34:13-9. PubMed
  • Heath JA, Turner CD, Poussaint TY, Scott RM, Goumnerova L, Kieran MW. Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience. Pediatr Hematol Oncol 2003; 20:497-504. PubMed
  • Carpentieri SC, Waber DP, Pomeroy SL, Scott RM, Goumnerova LC, Kieran MW, Billett AL, Tarbell NJ. Neuropsychological functioning after surgery in children treated for brain tumor. Neurosurgery 2003; 52:1348-56; discussion 1356-. PubMed
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