Photo of Linda S. Huang,  PhD

Linda S. Huang, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (617) 287-6674
Fax: (617) 287-6650


linda.huang@umb.edu

Linda S. Huang, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Associate Professor, College of Science and Math, University Of Massachusetts - Boston
  • Associate Member, Cancer Biology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory uses the budding yeast Saccharomyces cerevisiae to understand basic aspects of cell biology. We are interested in understanding how cell shape and architecture are regulated. The research in my lab focuses on the process of sporulation, which is the yeast cell’s version of gametogenesis and involves meiosis followed by spore morphogenesis. Research projects in the lab include studies on how the PH-domain containing protein Spo71 regulates membrane shape and size and how the MAP kinase Smk1 and the PAK-family GCKIII kinase Sps1 regulate spore morphogenesis.

Publications

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  • Parodi EM, Baker CS, Tetzlaff C, Villahermosa S, Huang LS. SPO71 Mediates Prospore Membrane Size and Maturation in Saccharomyces cerevisiae. Eukaryot Cell 2012; 11:1191-200. PubMed
  • Davison EM, Saffer AM, Huang LS, Demodena J, Sternberg PW, Horvitz HR. The LIN-15A and LIN-56 Transcriptional Regulators Interact to Negatively Regulate EGF/Ras Signaling in Caenorhabditis elegans Vulval Cell-Fate Determination. Genetics 2011; 187:803-15. PubMed
  • Auld KL, Hitchcock AL, Doherty HK, Frietze S, Huang LS, Silver PA. The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae. Genetics 2006; 174:215-27. PubMed
  • Huang LS, Doherty HK, Herskowitz I. The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 2005; 102:12431-6. PubMed
  • Blondel M, Alepuz PM, Huang LS, Shaham S, Ammerer G, Peter M. Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev 1999; 13:2284-300. PubMed
  • Kaffman A, Rank NM, O'Neill EM, Huang LS, O'Shea EK. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature 1998; 396:482-6. PubMed
  • Butty AC, Pryciak PM, Huang LS, Herskowitz I, Peter M. The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating. Science 1998; 282:1511-6. PubMed
  • Sternberg PW, Lesa G, Lee J, Katz WS, Yoon C, Clandinin TR, Huang LS, Chamberlin HM, Jongeward G. LET-23-mediated signal transduction during Caenorhabditis elegans development. Mol Reprod Dev 1995; 42:523-8. PubMed
  • Huang LS, Sternberg PW. Genetic dissection of developmental pathways. Methods Cell Biol 1995; 48:97-122. PubMed
  • Huang LS, Tzou P, Sternberg PW. The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol Biol Cell 1994; 5:395-411. PubMed
  • Sternberg PW, Yoon CH, Lee J, Jongeward GD, Kayne PS, Katz WS, Lesa G, Liu J, Golden A, Huang LS. Molecular genetics of proto-oncogenes and candidate tumor suppressors in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol 1994; 59:155-63. PubMed
  • Sternberg PW, Hill RJ, Jongeward G, Huang LS, Carta L. Intercellular signaling during Caenorhabditis elegans vulval induction. Cold Spring Harb Symp Quant Biol 1992; 57:353-62. PubMed
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