Photo of Lisa Diller,  MD

Lisa Diller, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-5642
Fax: (617) 582-9049

Lisa Diller, MD

Dana-Farber Cancer Institute


  • Professor, Pediatrics, Harvard Medical School
  • Assistant in Medicine, Hematology-Oncology, Boston Children's Hospital
  • Director, Childhood Cancer Survivor Program, Dana-Farber Cancer Institute



  • Member, Center Scientific Council

Research Abstract

My research focuses on secondary cancer prevention and detection in childhood cancer survivors. Ongoing studies include assessment of genetic risk factors for primary and secondary cancers, evaluation of breast cancer screening after chest irradiation during childhood and studies of the role of genetic counseling and genetic testing in promoting quality-of-life of survivors. In addition, we are interested in the long-term effects of cancer treatment on adolescent and young adult survivors, specifically assessing medical and psychological outcomes such as hearing, fertility and cardiac function after chemotherapy exposure and cognitive function after brain irradiation.


Powered by Harvard Catalyst
  • Krishnadas DK, Shusterman S, Bai F, Diller L, Sullivan JE, Cheerva AC, George RE, Lucas KG. A phase I trial combining decitabine/dendritic cell vaccine targeting MAGE-A1, MAGE-A3 and NY-ESO-1 for children with relapsed or therapy-refractory neuroblastoma and sarcoma. Cancer Immunol Immunother 2015. PubMed
  • Masters GA, Krilov L, Bailey HH, Brose MS, Burstein H, Diller LR, Dizon DS, Fine HA, Kalemkerian GP, Moasser M, Neuss MN, O'Day SJ, Odenike O, Ryan CJ, Schilsky RL, Schwartz GK, Venook AP, Wong SL, Patel JD. Clinical cancer advances 2015: annual report on progress against cancer from the american society of clinical oncology. J Clin Oncol 2015; 33:786-809. PubMed
  • Park ER, Kirchhoff AC, Perez GK, Leisenring W, Weissman JS, Donelan K, Mertens AC, Reschovsky JD, Armstrong GT, Robison LL, Franklin M, Hyland KA, Diller LR, Recklitis CJ, Kuhlthau KA. Childhood cancer survivor study participants' perceptions and understanding of the affordable care act. J Clin Oncol 2015; 33:764-72. PubMed
  • Alderfer MA, Zelley K, Lindell RB, Novokmet A, Mai PL, Garber JE, Nathan D, Scollon S, Chun NM, Patenaude AF, Ford JM, Plon SE, Schiffman JD, Diller LR, Savage SA, Malkin D, Ford CA, Nichols KE. Parent decision-making around the genetic testing of children for germline TP53 mutations. Cancer 2014. PubMed
  • Tieu MT, Cigsar C, Ahmed S, Ng A, Diller L, Millar BA, Crystal P, Hodgson DC. Breast cancer detection among young survivors of pediatric Hodgkin lymphoma with screening magnetic resonance imaging. Cancer 2014. PubMed
  • Yeh JM, Nohria A, Diller L. Routine echocardiography screening for asymptomatic left ventricular dysfunction in childhood cancer survivors: a model-based estimation of the clinical and economic effects. Ann Intern Med 2014; 160:661-71. PubMed
  • Perkins JL, Chen Y, Harris A, Diller L, Stovall M, Armstrong GT, Yasui Y, Robison LL, Sklar CA, . Infections Among Long-Term Survivors of Childhood and Adolescent Cancer: A Report From the Childhood Cancer Survivor Study. Cancer 2014. PubMed
  • Moskowitz CS, Chou JF, Wolden SL, Bernstein JL, Malhotra J, Friedman DN, Mubdi NZ, Leisenring WM, Stovall M, Hammond S, Smith SA, Henderson TO, Boice JD, Hudson MM, Diller LR, Bhatia S, Kenney LB, Neglia JP, Begg CB, Robison LL, Oeffinger KC. Breast Cancer After Chest Radiation Therapy for Childhood Cancer. J Clin Oncol 2014. PubMed
  • Hettmer S, Archer NM, Somers GR, Novokmet A, Wagers AJ, Diller L, Rodriguez-Galindo C, Teot LA, Malkin D. Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers. Cancer 2014; 120:1068-75. PubMed
  • Kenney LB, Duffey-Lind E, Ebb D, Sklar CA, Grier H, Diller L. Impaired Testicular Function After an Ifosfamide-containing Regimen for Pediatric Osteosarcoma: A Case Series and Review of the Literature. J. Pediatr. Hematol. Oncol. 2014; 36:237-40. PubMed
  • Chen MH, Blackington LH, Zhou J, Chu TF, Gauvreau K, Marcus KJ, Fisher DC, Diller LR, Ng AK. Blood pressure is associated with occult cardiovascular disease in prospectively studied Hodgkin lymphoma survivors after chest radiation. Leuk Lymphoma 2014. PubMed
  • Huang TT, Chen Y, Dietz AC, Yasui Y, Donaldson SS, Stokes DC, Stovall M, Leisenring WM, Sklar CA, Diller LR, Mertens AC, Armstrong GT, Green DM, Robison LL, Ness KK. Pulmonary outcomes in survivors of childhood central nervous system malignancies: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer 2013; 61:319-25. PubMed
  • Green DM, Nolan VG, Goodman PJ, Whitton JA, Srivastava D, Leisenring WM, Neglia JP, Sklar CA, Kaste SC, Hudson MM, Diller LR, Stovall M, Donaldson SS, Robison LL. The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer 2013; 61:53-67. PubMed
  • Kreissman SG, Seeger RC, Matthay KK, London WB, Sposto R, Grupp SA, Haas-Kogan DA, Laquaglia MP, Yu AL, Diller L, Buxton A, Park JR, Cohn SL, Maris JM, Reynolds CP, Villablanca JG. Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial. Lancet Oncol 2013; 14:999-1008. PubMed
  • Barton SE, Najita JS, Ginsburg ES, Leisenring WM, Stovall M, Weathers RE, Sklar CA, Robison LL, Diller L. Infertility, infertility treatment, and achievement of pregnancy in female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort. Lancet Oncol 2013; 14:873-81. PubMed
  • Ng AK, Garber JE, Diller LR, Birdwell RL, Feng Y, Neuberg DS, Silver B, Fisher DC, Marcus KJ, Mauch PM. Prospective Study of the Efficacy of Breast Magnetic Resonance Imaging and Mammographic Screening in Survivors of Hodgkin Lymphoma. J Clin Oncol 2013. PubMed
  • Emmons KM, Puleo E, Sprunck-Harrild K, Ford J, Ostroff JS, Hodgson D, Greenberg M, Diller L, de Moor J, Tyc V. Partnership for health-2, a web-based versus print smoking cessation intervention for childhood and young adult cancer survivors: randomized comparative effectiveness study. J Med Internet Res 2013; 15:e218. PubMed
  • Granger M, Grupp SA, Kletzel M, Kretschmar C, Naranjo A, London WB, Diller L. Feasibility of a tandem autologous peripheral blood stem cell transplant regimen for high risk neuroblastoma in a cooperative group setting: a Pediatric Oncology Group study: a report from the Children's Oncology Group. Pediatr Blood Cancer 2012; 59:902-7. PubMed
  • Nuchtern JG, London WB, Barnewolt CE, Naranjo A, McGrady PW, Geiger JD, Diller L, Schmidt ML, Maris JM, Cohn SL, Shamberger RC. A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: a Children's Oncology Group study. Ann Surg 2012; 256:573-80. PubMed
  • Yeh JM, Diller L. Pediatric Hodgkin lymphoma: trade-offs between short- and long-term mortality risks. Blood 2012; 120:2195-202. PubMed
  • Park ER, Kirchhoff AC, Zallen JP, Weissman JS, Pajolek H, Mertens AC, Armstrong GT, Robison LL, Donelan K, Recklitis CJ, Diller LR, Kuhlthau KA. Childhood Cancer Survivor Study participants' perceptions and knowledge of health insurance coverage: implications for the Affordable Care Act. J Cancer Surviv 2012; 6:251-9. PubMed
  • Henderson TO, Rajaraman P, Stovall M, Constine LS, Olive A, Smith SA, Mertens A, Meadows A, Neglia JP, Hammond S, Whitton J, Inskip PD, Robison LL, Diller L. Risk factors associated with secondary sarcomas in childhood cancer survivors: a report from the childhood cancer survivor study. Int J Radiat Oncol Biol Phys 2012; 84:224-30. PubMed
  • Henderson TO, Oeffinger KC, Whitton J, Leisenring W, Neglia J, Meadows A, Crotty C, Rubin DT, Diller L, Inskip P, Smith SA, Stovall M, Constine LS, Hammond S, Armstrong GT, Robison LL, Nathan PC. Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study. Ann Intern Med 2012; 156:757-66, W-260. PubMed
  • Goldsby R, Chen Y, Raber S, Li L, Diefenbach K, Shnorhavorian M, Kadan-Lottick N, Kastrinos F, Yasui Y, Stovall M, Oeffinger K, Sklar C, Armstrong GT, Robison LL, Diller L. Survivors of Childhood Cancer Have Increased Risk of Gastrointestinal Complications Later in Life. Gastroenterology 2011. PubMed
  • Chen MH, Colan SD, Diller L. Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res 2011; 108:619-28. PubMed
  • Kenney LB, Bradeen H, Kadan-Lottick NS, Diller L, Homans A, Schwartz CL. The current status of follow-up services for childhood cancer survivors, are we meeting goals and expectations: A report from the consortium for New England childhood cancer survivors. Pediatr Blood Cancer 2011. PubMed
  • Kris MG, Benowitz SI, Adams S, Diller L, Ganz P, Kahlenberg MS, Le QT, Markman M, Masters GA, Newman L, Obel JC, Seidman AD, Smith SM, Vogelzang N, Petrelli NJ. Clinical cancer advances 2010: annual report on progress against cancer from the American Society of Clinical Oncology. J Clin Oncol 2010; 28:5327-47. PubMed
  • McCullough L, Ng A, Najita J, Janov A, Henderson T, Mauch P, Diller L. Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy. Cancer 2010; 116:4866-71. PubMed
  • Smith SM, Ford JS, Rakowski W, Moskowitz CS, Diller L, Hudson MM, Mertens AC, Stanton AL, Henderson TO, Leisenring WM, Robison LL, Oeffinger KC. Inconsistent mammography perceptions and practices among women at risk of breast cancer following a pediatric malignancy: a report from the Childhood Cancer Survivor Study. Cancer Causes Control 2010; 21:1585-95. PubMed
  • George RE, Lahti JM, Adamson PC, Zhu K, Finkelstein D, Ingle AM, Reid JM, Krailo M, Neuberg D, Blaney SM, Diller L. Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer 2010; 55:629-38. PubMed
  • London WB, Frantz CN, Campbell LA, Seeger RC, Brumback BA, Cohn SL, Matthay KK, Castleberry RP, Diller L. Phase II randomized comparison of topotecan plus cyclophosphamide versus topotecan alone in children with recurrent or refractory neuroblastoma: a Children's Oncology Group study. J Clin Oncol 2010; 28:3808-15. PubMed
  • Frazier AL, Shamberger RC, Henderson TO, Diller L. Decision analysis to compare treatment strategies for Stage I/favorable histology Wilms tumor. Pediatr Blood Cancer 2010; 54:879-84. PubMed
  • George RE, Diller L, Bernstein ML. Pharmacotherapy of neuroblastoma. Expert Opin Pharmacother 2010; 11:1467-78. PubMed
  • Yeh JM, Nekhlyudov L, Goldie SJ, Mertens AC, Diller L. A model-based estimate of cumulative excess mortality in survivors of childhood cancer. Ann Intern Med 2010; 152:409-17, W131-8. PubMed
  • Henderson TO, Amsterdam A, Bhatia S, Hudson MM, Meadows AT, Neglia JP, Diller LR, Constine LS, Smith RA, Mahoney MC, Morris EA, Montgomery LL, Landier W, Smith SM, Robison LL, Oeffinger KC. Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer. Ann Intern Med 2010; 152:444-55; W144-54. PubMed
  • Laufer MR, Upton J, Schuster SR, Grier H, Emans SJ, Diller L. Ovarian Tissue Autologous Transplantation to the Upper Extremity for Girls Receiving Abdominal/Pelvic Radiation: 20-year Follow-up of Reproductive Endocrine Function. J Pediatr Adolesc Gynecol 2010; 23:107-10. PubMed
  • Henderson TO, Hlubocky FJ, Wroblewski KE, Diller L, Daugherty CK. Physician preferences and knowledge gaps regarding the care of childhood cancer survivors: a mailed survey of pediatric oncologists. J Clin Oncol 2010; 28:878-83. PubMed
  • Recklitis CJ, Diller LR, Li X, Najita J, Robison LL, Zeltzer L. Suicide ideation in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol 2010; 28:655-61. PubMed
  • Kenney LB, Nancarrow CM, Najita J, Vrooman LM, Rothwell M, Recklitis C, Li FP, Diller L. Health status of the oldest adult survivors of cancer during childhood. Cancer 2010; 116:497-505. PubMed
  • Park ER, Bober SL, Campbell EG, Recklitis CJ, Kutner JS, Diller L. General internist communication about sexual function with cancer survivors. J Gen Intern Med 2009; 24 Suppl 2:S407-11. PubMed
  • Bober SL, Recklitis CJ, Campbell EG, Park ER, Kutner JS, Najita JS, Diller L. Caring for cancer survivors: a survey of primary care physicians. Cancer 2009; 115:4409-18. PubMed
  • Inskip PD, Robison LL, Stovall M, Smith SA, Hammond S, Mertens AC, Whitton JA, Diller L, Kenney L, Donaldson SS, Meadows AT, Neglia JP. Radiation dose and breast cancer risk in the childhood cancer survivor study. J Clin Oncol 2009; 27:3901-7. PubMed
  • Laverdière C, Liu Q, Yasui Y, Nathan PC, Gurney JG, Stovall M, Diller LR, Cheung NK, Wolden S, Robison LL, Sklar CA. Long-term outcomes in survivors of neuroblastoma: a report from the Childhood Cancer Survivor Study. Journal of the National Cancer Institute 2009; 101:1131-40. PubMed
  • Diller L,Chow EJ,Gurney JG,Hudson MM,Kadin-Lottick NS,Kawashima TI,Leisenring WM,Meacham LR,Mertens AC,Mulrooney DA,Oeffinger KC,Packer RJ,Robison LL,Sklar CA. Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings. J Clin Oncol 2009; 27:2339-55. PubMed
  • Shapiro CL,McCabe MS,Syrjala KL,Friedman D,Jacobs LA,Ganz PA,Diller L,Campell M,Orcena K,Marcus AC. The LIVESTRONG Survivorship Center of Excellence Network. J Cancer Surviv 2009; 3:4-11. PubMed
  • Winer E,Gralow J,Diller L,Karlan B,Loehrer P,Pierce L,Demetri G,Ganz P,Kramer B,Kris M,Markman M,Mayer R,Pfister D,Raghavan D,Ramsey S,Reaman G,Sandler H,Sawaya R,Schuchter L,Sweetenham J,Vahdat L,Schilsky RL. Clinical cancer advances 2008: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology. J Clin Oncol 2008; 27:812-26. PubMed
  • Oeffinger KC,Ford JS,Moskowitz CS,Diller LR,Hudson MM,Chou JF,Smith SM,Mertens AC,Henderson TO,Friedman DL,Leisenring WM,Robison LL. Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer. JAMA 2009; 301:404-14. PubMed
  • Emmons KM,Puleo E,Mertens A,Gritz ER,Diller L,Li FP. Long-term smoking cessation outcomes among childhood cancer survivors in the Partnership for Health Study. J Clin Oncol 2008; 27:52-60. PubMed
  • Dubois SG,London WB,Zhang Y,Matthay KK,Monclair T,Ambros PF,Cohn SL,Pearson A,Diller L. Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer 2008; 51:589-92. PubMed
  • George RE,Sanda T,Hanna M,Frohling S,Luther W 2nd,Zhang J,Ahn Y,Zhou W,London WB,McGrady P,Xue L,Zozulya S,Gregor VE,Webb TR,Gray NS,Gilliland DG,Diller L,Greulich H,Morris SW,Meyerson M,Look AT. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008; 455:975-8. PubMed
  • Ng AK, Li S, Recklitis C, Diller LR, Neuberg D, Silver B, Mauch PM. Health Practice in Long-Term Survivors of Hodgkin Lymphoma. Int J Radiat Oncol Biol Phys 2008; 71:468-76. PubMed
  • Masciari S, Van den Abbeele AD, Diller LR, Rastarhuyeva I, Yap J, Schneider K, Digianni L, Li FP, Fraumeni JF Jr, Syngal S, Garber JE. F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome. JAMA 2008; 299:1315-9. PubMed
  • Radulescu VC, Gerrard M, Moertel C, Grundy PE, Mathias L, Feusner J, Diller L, Dome JS. Treatment of recurrent clear cell sarcoma of the kidney with brain metastasis. Pediatr Blood Cancer 2007; 50:246-9. PubMed
  • Kuohung W, Ram K, Cheng DM, Marcus KJ, Diller LR, Laufer MR. Laparoscopic oophoropexy prior to radiation for pediatric brain tumor and subsequent ovarian function. Hum Reprod 2007; 23:117-21. PubMed
  • Recklitis CJ, Licht I, Ford J, Oeffinger K, Diller L. Screening adult survivors of childhood cancer with the distress thermometer: a comparison with the SCL-90-R. Psychooncology 2007; 16:1046-9. PubMed
  • O'leary TE, Diller L, Recklitis CJ. The effects of response bias on self-reported quality of life among childhood cancer survivors. Qual Life Res 2007; 16:1211-20. PubMed
  • Henderson TO, Whitton J, Stovall M, Mertens AC, Mitby P, Friedman D, Strong LC, Hammond S, Neglia JP, Meadows AT, Robison L, Diller L. Secondary sarcomas in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. Journal of the National Cancer Institute 2007; 99:300-8. PubMed
  • George RE, Attiyeh EF, Li S, Moreau LA, Neuberg D, Li C, Fox EA, Meyerson M, Diller L, Fortina P, Look AT, Maris JM. Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays. PLoS ONE 2007; 2:e255. PubMed
  • Duffey-Lind EC, O'Holleran E, Healey M, Vettese M, Diller L, Park ER. Transitioning to survivorship: a pilot study. J Pediatr Oncol Nurs 2006; 23:335-43. PubMed
  • Moreau LA, McGrady P, London WB, Shimada H, Cohn SL, Maris JM, Diller L, Look AT, George RE. Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study. Clin Cancer Res 2006; 12:5693-7. PubMed
  • Guinan EC, Kalish LA, Berry WS, McDaniel S, Lehmann LE, Diller LR. A novel pattern of transaminase elevation associated with autologous transplant for neuroblastoma. Pediatr Transplant 2006; 10:669-76. PubMed
  • Recklitis CJ, Lockwood RA, Rothwell MA, Diller LR. Suicidal ideation and attempts in adult survivors of childhood cancer. J Clin Oncol 2006; 24:3852-7. PubMed
  • George RE, Li S, Medeiros-Nancarrow C, Neuberg D, Marcus K, Shamberger RC, Pulsipher M, Grupp SA, Diller L. High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update. J Clin Oncol 2006; 24:2891-6. PubMed
  • George RE, London WB, Cohn SL, Maris JM, Kretschmar C, Diller L, Brodeur GM, Castleberry RP, Look AT. Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol 2005; 23:6466-73. PubMed