Photo of Lois A. Lampson,   Ph.D.

Lois A. Lampson, Ph.D.

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 278-0363
Fax: (617) 547-9580


llampson@rics.bwh.harvard.edu

Lois A. Lampson, Ph.D.

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Neurosurgery, Harvard Medical School
  • Immunologist, Neurosurgery, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

General area: Immunobiology of the nervous system and its tumors.

Specific areas:

(1) Site-specific immune regulation. How classical neuro-regulatory molecules (substance P, glutamate) modulate immune activity within the brain. Focus on ctokine-mediated control of T cell traffic and MHC expression, and its modulation by local neurochemicals.

(2) Exploiting T cells to deliver therapy to microscopic brain tumor. Micro-tumor is defined as any tumor that is too small to be imaged or accessed by current methods. It includes infiltrative, invasive, disseminated or residual primary brain tumors (astrocytoma, glioma, etc.), CNS lymphoma, and micro-metastases of tumors from other sites, especially brain-metastasizing breast cancer.

Methods: Rat model. Stereotactic intracerebral injection of cytokines and lacZ-expressing tumors. Histochemistry for b-gal to reveal tumor; antibody staining for T cells, MHC; computer-assisted image analysis of tumor, T cells, T cell-tumor interactions.

Publications

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  • Lampson LA. Brain tumor immunotherapy: seeing the brain in the body. Drug Discov Today 2013; 18:399-406. PubMed
  • Lampson LA. Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier. MAbs 2011; 3:153-60. PubMed
  • Lampson LA. Targeted therapy for neuro-oncology: reviewing the menu. Drug Discov Today 2008; 14:185-91. PubMed
  • Lampson LA. Brain tumor immunotherapy: an immunologist's perspective. J Neurooncol 2003; 64:3-11. PubMed
  • Lampson LA. New animal models to probe brain tumor biology, therapy, and immunotherapy: advantages and remaining concerns. J Neurooncol 2001; 53:275-87. PubMed
  • McCluskey LP, Lampson LA. Local immune regulation in the central nervous system by substance P vs. glutamate. J Neuroimmunol 2001; 116:136-46. PubMed
  • McCluskey LP, Lampson LA. Local neurochemicals and site-specific immune regulation in the CNS. J Neuropathol Exp Neurol 2000; 59:177-87. PubMed
  • Phillips LM, Simon PJ, Lampson LA. Site-specific immune regulation in the brain: differential modulation of major histocompatibility complex (MHC) proteins in brainstem vs. hippocampus. J Comp Neurol 1999; 405:322-33. PubMed
  • Lampson LA. Beyond inflammation: site-directed immunotherapy. Immunol Today 1998; 19:17-22. PubMed
  • Lampson LA. Interpreting MHC class I expression and class I/class II reciprocity in the CNS: reconciling divergent findings. Microsc Res Tech 1995; 32:267-85. PubMed
  • Grabowska A, Lampson LA. MHC expression in nonlymphoid tissues of the developing embryo: strongest class I or class II expression in separate populations of potential antigen-presenting cells in the skin, lung, gut, and inter-organ connective tissue. Dev Comp Immunol 1995; 19:425-50. PubMed
  • Lampson LA, Chen A, Vortmeyer AO, Sloan AE, Ghogawala Z, Kim L. Enhanced T cell migration to sites of microscopic CNS disease: complementary treatments evaluated by 2- and 3-D image analysis. Brain Pathol 1994; 4:125-34. PubMed
  • Lehky TJ, Cowan EP, Lampson LA, Jacobson S. Induction of HLA class I and class II expression in human T-lymphotropic virus type I-infected neuroblastoma cells. J Virol 1994; 68:1854-63. PubMed
  • Drew PD, Lonergan M, Goldstein ME, Lampson LA, Ozato K, McFarlin DE. Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlates with expression of the genes. J Immunol 1993; 150:3300-10. PubMed
  • Lampson LA, Lampson MA, Dunne AD. Exploiting the lacZ reporter gene for quantitative analysis of disseminated tumor growth within the brain: use of the lacZ gene product as a tumor antigen, for evaluation of antigenic modulation, and to facilitate image analysis of tumor growth in situ. Cancer Res 1993; 53:176-82. PubMed
  • Lampson LA, Wen P, Roman VA, Morris JH, Sarid JA. Disseminating tumor cells and their interactions with leukocytes visualized in the brain. Cancer Res 1992; 52:1018-25. PubMed
  • Wen PY, Lampson MA, Lampson LA. Effects of gamma-interferon on major histocompatibility complex antigen expression and lymphocytic infiltration in the 9L gliosarcoma brain tumor model: implications for strategies of immunotherapy. J Neuroimmunol 1992; 36:57-68. PubMed
  • Lampson LA, Kushner PD, Sobel RA. Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis. Ann Neurol 1990; 28:365-72. PubMed
  • Wen P, Loeffler JS, Morris JH, Lampson LA. The effects of irradiation on major histocompatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model. J Neuroimmunol 1990; 27:239-44. PubMed
  • Turner WJ, Chatten J, Lampson LA. Human neuroblastoma cell growth in xenogeneic hosts: comparison of T cell-deficient and NK-deficient hosts, and subcutaneous or intravenous injection routes. J Neurooncol 1990; 8:121-32. PubMed
  • Main EK, Monos DS, Lampson LA. IFN-treated neuroblastoma cell lines remain resistant to T cell-mediated allo-killing, and susceptible to non-MHC-restricted cytotoxicity. J Immunol 1988; 141:2943-50. PubMed
  • Lampson LA, Hickey WF. Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement. J Immunol 1986; 136:4054-62. PubMed
  • Whelan JP, Chatten J, Lampson LA. HLA class I and beta 2-microglobulin expression in frozen and formaldehyde-fixed paraffin sections of neuroblastoma tumors. Cancer Res 1985; 45:5976-83. PubMed
  • Main EK, Lampson LA, Hart MK, Kornbluth J, Wilson DB. Human neuroblastoma cell lines are susceptible to lysis by natural killer cells but not by cytotoxic T lymphocytes. J Immunol 1985; 135:242-6. PubMed
  • Lampson LA, Fisher CA. Weak HLA and beta 2-microglobulin expression of neuronal cell lines can be modulated by interferon. Proc Natl Acad Sci U S A 1984; 81:6476-80. PubMed
  • Lampson LA, Fisher CA, Whelan JP. Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines. J Immunol 1983; 130:2471-8. PubMed
  • Lampson LA, Levy R. Two populations of Ia-like molecules on a human B cell line. J Immunol 1980; 125:293-9. PubMed
  • Lampson LA, Levy R. A role for clonal antigens in cancer diagnosis and therapy. J Natl Cancer Inst 1979; 62:217-20. PubMed
  • Lampson LA, Levy R, Grumet FC, Ness D, Pious D. Production in vitro of murine antibody to a human histocompatibility alloantigen. Nature 1978; 271:461-2. PubMed
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