Photo of M. Amin Arnaout,

M. Amin Arnaout

Massachusetts General Hospital

Massachusetts General Hospital

M. Amin Arnaout

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Physician/Division Chief, Medicine/Nephrology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

A major effort in our laboratory is to understand the structural basis of integrin activation and signaling using biochemical, structural approaches in addition to animal models. A potential outcome is the discovery of antagonists to treat common diseases such as heart disease, stroke and cancer linked to integrin dysfunction.

Publications

Powered by Harvard Catalyst
  • Rui X, Mehrbod M, Van Agthoven JF, Anand S, Xiong JP, Mofrad MR, Arnaout MA. The 留-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in 硫3 integrins. J Biol Chem 2014; 289:23256-63. PubMed
  • Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA. Atomic basis for the species-specific inhibition of 留V integrins by mAb 17E6 is revealed by the crystal structure of 留V硫3 ectodomain-17E6 Fab complex. J Biol Chem 2014. PubMed
  • Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA. Structural basis for pure antagonism of integrin 留V硫3 by a high-affinity form of fibronectin. Nat Struct Mol Biol 2014; 21:383-8. PubMed
  • Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA. Stress hematopoiesis is regulated by the Kr端ppel-like transcription factor ZBP-89. Stem Cells 2014; 32:791-801. PubMed
  • Palmyre A, Lee J, Ryklin G, Camarata T, Selig MK, Duchemin AL, Nowak P, Arnaout MA, Drummond IA, Vasilyev A. Collective epithelial migration drives kidney repair after acute injury. PLoS ONE 2014; 9:e101304. PubMed
  • Frohlich EM, Alonso JL, Borenstein JT, Zhang X, Arnaout MA, Charest JL. Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers. Lab Chip 2013. PubMed
  • Adair BD, Xiong JP, Alonso JL, Hyman BT, Arnaout MA. EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS ONE 2013; 8:e57951. PubMed
  • Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol 2011; 187:6393-401. PubMed
  • Xiong JP, Mahalingham B, Alonso JL, Borrelli LA, Rui X, Anand S, Hyman BT, Rysiok T, Müller-Pompalla D, Goodman SL, Arnaout MA. Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J Cell Biol 2009; 186:589-600. PubMed
  • Arnaout MA, Goodman SL, Xiong JP. Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol 2007; 19:495-507. PubMed
  • Li X, Xiong JW, Shelley CS, Park H, Arnaout MA. The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development 2006; 133:3641-50. PubMed
  • Adair BD, Xiong JP, Maddock C, Goodman SL, Arnaout MA, Yeager M. Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. J Cell Biol 2005; 168:1109-18. PubMed
  • Alonso JL, Essafi M, Xiong JP, Stehle T, Arnaout MA. Does the integrin alphaA domain act as a ligand for its betaA domain? Curr Biol 2002; 12:R340-2. PubMed
  • Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science 2002; 296:151-5. PubMed
  • Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, and Arnaout MA.. Crystal structure of the extracellular segment of integrin alphaVbeta3. Science 2001; 294:339-345.
Hide