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M. Amin Arnaout

Massachusetts General Hospital

Massachusetts General Hospital

M. Amin Arnaout

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Physician/Division Chief, Medicine/Nephrology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

A major effort in our laboratory is to understand the structural basis of integrin activation and signaling using biochemical, structural approaches in addition to animal models. A potential outcome is the discovery of antagonists to treat common diseases such as heart disease, stroke and cancer linked to integrin dysfunction.

Publications

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  • Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA. Structural basis for pure antagonism of integrin 留V硫3 by a high-affinity form of fibronectin. Nat Struct Mol Biol 2014; 21:383-8. PubMed
  • Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA. Atomic basis for the species-specific inhibition of 留V integrins by mAb 17E6 is revealed by the crystal structure of 留V硫3 ectodomain-17E6 Fab complex. J Biol Chem 2014. PubMed
  • Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA. Stress hematopoiesis is regulated by the Kr端ppel-like transcription factor ZBP-89. Stem Cells 2014; 32:791-801. PubMed
  • Frohlich EM, Alonso JL, Borenstein JT, Zhang X, Arnaout MA, Charest JL. Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers. Lab Chip 2013. PubMed
  • Adair BD, Xiong JP, Alonso JL, Hyman BT, Arnaout MA. EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS ONE 2013; 8:e57951. PubMed
  • Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol 2011; 187:6393-401. PubMed
  • Xiong JP, Mahalingham B, Alonso JL, Borrelli LA, Rui X, Anand S, Hyman BT, Rysiok T, Müller-Pompalla D, Goodman SL, Arnaout MA. Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J Cell Biol 2009; 186:589-600. PubMed
  • Arnaout MA, Goodman SL, Xiong JP. Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol 2007; 19:495-507. PubMed
  • Li X, Xiong JW, Shelley CS, Park H, Arnaout MA. The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development 2006; 133:3641-50. PubMed
  • Adair BD, Xiong JP, Maddock C, Goodman SL, Arnaout MA, Yeager M. Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. J Cell Biol 2005; 168:1109-18. PubMed
  • Alonso JL, Essafi M, Xiong JP, Stehle T, Arnaout MA. Does the integrin alphaA domain act as a ligand for its betaA domain? Curr Biol 2002; 12:R340-2. PubMed
  • Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science 2002; 296:151-5. PubMed
  • Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, and Arnaout MA.. Crystal structure of the extracellular segment of integrin alphaVbeta3. Science 2001; 294:339-345.
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