Photo of Mariano Viapiano,  PhD

Mariano Viapiano, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-5650
Fax: (617) 713-3050


mviapiano@partners.org

Mariano Viapiano, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Neurosurgery, Harvard Medical School
  • Principal Investigator, Neurosurgery, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My work seeks to understand the role of the tumor microenvironment in the formation and progression of brain tumors, with emphasis on the tumor extracellular matrix (ECM). We specifically investigate how tumor cells introduce changes in the brain ECM and how these changes trigger mechanisms that facilitate brain tumor dispersion and resistance to conventional therapies. Understanding these mechanisms has allowed us to develop targeted biological agents that may disrupt tumor growth and invasion, which are currently under pre-clinical investigation. Since my first independent appointment in 2006, my laboratory has trained and continues to train undergraduates, graduate and medical students, and postdoctoral researchers in the field of brain cancer biology, thanks to support from NIH, NSF, the American Brain Tumor Association, the National Brain Tumor Society, and the International Brain Research Organization, among others. I have directed multiple neuroscience courses and developed graduate-level courses specifically focused on tumor microenvironment. I continue to be actively engaged in teaching and mentoring activities together with my research in brain tumor biology.

Publications

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  • Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE. Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries. ACS Comb Sci 2016. PubMed
  • Xue R, Nelson MT, Teixeira SA, Viapiano MS, Lannutti JJ. Cancer cell aggregate hypoxia visualized in vitro via biocompatible fiber sensors. Biomaterials 2015; 76:208-17. PubMed
  • Ropper AE, Zeng X, Haragopal H, Anderson JE, Aljuboori Z, Han I, Abd-El-Barr M, Lee HJ, Sidman RL, Snyder EY, Viapiano MS, Kim SU, Chi JH, Teng YD. Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. Neurosurgery 2015. PubMed
  • Long PM, Tighe SW, Driscoll HE, Fortner KA, Viapiano MS, Jaworski DM. Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest. J Cell Physiol 2015. PubMed
  • Xue R, Ge C, Richardson K, Palmer A, Viapiano M, Lannutti JJ. Microscale Sensing of Oxygen via Encapsulated Porphyrin Nanofibers: Effect of Indicator and Polymer "Core" Permeability. 2015. PubMed
  • Dwyer CA, Bi WL, Viapiano MS, Matthews RT. Brevican knockdown reduces late-stage glioma tumor aggressiveness. J. Neurooncol. 2014; 120:63-72. PubMed
  • Nandhu MS, Hu B, Cole SE, Erdreich-Epstein A, Rodriguez-Gil DJ, Viapiano MS. Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas. Cancer Res 2014; 74:5435-48. PubMed
  • Roth AD, Elmer J, Harris DR, Huntley J, Palmer AF, Nelson T, Johnson JK, Xue R, Lannutti JJ, Viapiano MS. Hemoglobin regulates the migration of glioma cells along poly(ε-caprolactone)-aligned nanofibers. Biotechnol. Prog. 2014; 30:1214-20. PubMed
  • Rao SS, Lannutti JJ, Viapiano MS, Sarkar A, Winter JO. Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cells. Tissue Eng Part B Rev 2014. PubMed
  • Tsen AR, Long PM, Driscoll HE, Davies MT, Teasdale BA, Penar PL, Pendlebury WW, Spees JL, Lawler SE, Viapiano MS, Jaworski DM. Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. Int J Cancer 2014; 134:1300-10. PubMed
  • Long PM, Moffett JR, Namboodiri AM, Viapiano MS, Lawler SE, Jaworski DM. N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells. J Biol Chem 2013; 288:26188-200. PubMed
  • Xue R, Behera P, Viapiano MS, Lannutti JJ. Rapid response oxygen-sensing nanofibers. Mater Sci Eng C Mater Biol Appl 2013; 33:3450-7. PubMed
  • Rao SS, Nelson MT, Xue R, DeJesus JK, Viapiano MS, Lannutti JJ, Sarkar A, Winter JO. Mimicking white matter tract topography using core-shell electrospun nanofibers to examine migration of malignant brain tumors. Biomaterials 2013; 34:5181-90. PubMed
  • Long PM, Tighe SW, Driscoll HE, Moffett JR, Namboodiri AM, Viapiano MS, Lawler SE, Jaworski DM. Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells. PLoS ONE 2013; 8:e80714. PubMed
  • Kwiatkowska A, Nandhu MS, Behera P, Chiocca EA, Viapiano MS. Strategies in gene therapy for glioblastoma. Cancers (Basel) 2013; 5:1271-305. PubMed
  • Hu B, Nandhu MS, Sim H, Agudelo-Garcia PA, Saldivar JC, Dolan CE, Mora ME, Nuovo GJ, Cole SE, Viapiano MS. Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer Res 2012; 72:3873-85. PubMed
  • Andrews EM, Richards RJ, Yin FQ, Viapiano MS, Jakeman LB. Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury. Exp Neurol 2012; 235:174-87. PubMed
  • Agudelo-Garcia PA, De Jesus JK, Williams SP, Nowicki MO, Chiocca EA, Liyanarachchi S, Li PK, Lannutti JJ, Johnson JK, Lawler SE, Viapiano MS. Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia 2011; 13:831-40. PubMed
  • Hu B, Thirtamara-Rajamani KK, Sim H, Viapiano MS. Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. Mol Cancer Res 2009; 7:1756-70. PubMed
  • Sim H, Hu B, Viapiano MS. Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas. J Biol Chem 2009; 284:26547-56. PubMed
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