Photo of Mark C. Poznansky,  MD, PhD

Mark C. Poznansky, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-6375
Fax: (617) 726-4691


mpoznansky@partners.org

Mark C. Poznansky, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Medicine, Harvard Medical School
  • Attending Physician, Infectious Diseases Medicine, Brigham And Women's Hospital
  • Associate Professor, Infectious Disease Unit, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Publications

Powered by Harvard Catalyst
  • Kashiwagi S, Brauns T, Gelfand J, Poznansky MC. Laser vaccine adjuvants: History, progress, and potential. Hum Vaccin Immunother 2014. PubMed
  • Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol 2014; 7:15. PubMed
  • Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A 2012; 109:17561-6. PubMed
  • Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Evan Secor W, Ruprecht RM. Relative Transmissibility of an R5 Clade C Simian-Human Immunodeficiency Virus Across Different Mucosae in Macaques Parallels the Relative Risks of Sexual HIV-1 Transmission in Humans via Different Routes. J Infect Dis 2010; 201:1155-63. PubMed
  • Santosuosso M, Righi E, Leblanc PR, Poznansky MC. Reply to cummins et Al. J Infect Dis 2010; 201:1274-5. PubMed
  • Lee JY, Buzney CD, Poznansky MC, Sackstein R. Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukoc Biol 2009; 86:1285-94. PubMed
  • Jaafar F, Righi E, Lindstrom V, Linton C, Nohadani M, Van Noorden S, Lloyd T, Poznansky J, Stamp G, Dina R, Coleman DV, Poznansky MC. Correlation of CXCL12 expression and FoxP3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer. Am J Pathol 2009; 175:1525-35. PubMed
  • Stevceva L,Yoon V,Carville A,Pacheco B,Santosuosso M,Korioth-Schmitz B,Mansfield K,Poznansky MC. The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo. J Immunol 2008; 181:5510-21. PubMed
  • Huttenlocher A, Poznansky MC. Reverse leukocyte migration can be attractive or repulsive. Trends Cell Biol 2008; 18:298-306. PubMed
  • Papeta N, Chen T, Vianello F, Gererty L, Malik A, Mok YT, Tharp WG, Bagley J, Zhao G, Stevceva L, Yoon V, Sykes M, Sachs D, Iacomini J, Poznansky MC. Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent. Transplantation 2007; 83:174-83. PubMed
  • Stevceva L, Yoon V, Anastasiades D, Poznansky MC. Immune responses to HIV Gp120 that facilitate viral escape. Curr HIV Res 2007; 5:47-54. PubMed
  • Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu SY, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG, Poznansky MC. Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol 2005; 79:539-54. PubMed
  • Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Pal. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol 2006; 176:2902-14. PubMed
  • Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 2005; 439:599-603. PubMed
  • Vianello F, Kraft P, Mok YT, Hart WK, White N, Poznansky MC. A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus. J Immunol 2005; 175:5115-25. PubMed
  • Adams GB, Chabner KT, Foxall RB, Weibrecht KW, Rodrigues NP, Dombkowski D, Fallon R, Poznansky MC, Scadden DT. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood 2002; 101:45-51. PubMed
  • Poznansky MC, Evans RH, Foxall RB, Olszak IT, Piascik AH, Hartman KE, Brander C, Meyer TH, Pykett MJ, Chabner KT, Kalams SA, Rosenzweig M, Scadden DT. Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat Biotechnol 2000; 18:729-34. PubMed
  • Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, Scadden DT. Active movement of T cells away from a chemokine. Nat Med 2000; 6:543-8. PubMed
  • Poznansky MC, La Vecchio J, Silva-Arietta S, Porter-Brooks J, Brody K, Olszak IT, Adams GB, Ramstedt U, Marasco WA, Scadden DT. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and monocytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat. Hum Gene Ther 1999; 10:2505-14. PubMed
  • Adams GB, McMullen M, Turner S, Olszak IT, Scadden DT, McClure MO, Poznansky MC. Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors. J Acquir Immune Defic Syndr 1999; 21:1-8. PubMed
  • Adams GB, Pym AS, Poznansky MC, McClure MO, Weber JN. The in vivo effects of combination antiretroviral drug therapy on peripheral blood CD34+ cell colony-forming units from HIV type 1-infected patients. AIDS Res Hum Retroviruses 1999; 15:551-9. PubMed
  • Poznansky MC, Foxall R, Mhashilkar A, Coker R, Jones S, Ramstedt U, Marasco W. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat. Hum Gene Ther 1998; 9:487-96. PubMed
  • el Oakley RM, Brand NJ, Burton PB, McMullen MC, Adams GB, Poznansky MC, Barton PJ, Yacoub MH. Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts. J Thorac Cardiovasc Surg 1998; 115:1-8. PubMed
  • Landau R, Coker R, Vermeulen E, Touquet R, Fothergill J, Poznansky MC. Patients unaware of their HIV status present to inner city accident and emergency department with respiratory complications. J Accid Emerg Med 1997; 14:304-6. PubMed
  • Poznansky MC, Adams GB. The development of a gene therapy for HIV infection. Int J STD AIDS 1997; 8:145-7; quiz 148-9. PubMed
  • Poznansky MC, Walters J, Cruikshank A, Pollock R, Dendrowskyj P, Lewis K, Parry JV, Fothergill J, Weber J. The rising prevalence of HIV-1 infection in patients attending an inner city accident and emergency department. J Accid Emerg Med 1996; 13:424-5. PubMed
  • Coker RJ, Poznansky MC. Physicians' experience and survival in patients with AIDS. N Engl J Med 1996; 335:349; author reply 350-1. PubMed
  • Poznansky MC, Torkington J, Turner G, Bankes MJ, Parry JV, Connell JA, Touquet R, Weber J. Prevalence of HIV infection in patients attending an inner city accident and emergency department. BMJ 1994; 308:636. PubMed
  • Langhoff E, Terwilliger EF, Bos HJ, Kalland KH, Poznansky MC, Bacon OM, Haseltine WA. Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc Natl Acad Sci U S A 1991; 88:7998-8002. PubMed
  • Poznansky MC, Walker B, Haseltine WA, Sodroski J, Langhoff E. A rapid method for quantitating the frequency of peripheral blood cells containing HIV-1 DNA. J Acquir Immune Defic Syndr 1991; 4:368-73. PubMed
  • Poznansky MC, Gordon AC, Grant IW, Wyllie AH. A cellular abnormality in glucocorticoid resistant asthma. Clin Exp Immunol 1985; 61:135-42. PubMed
  • Poznansky MC, Gordon AC, Douglas JG, Krajewski AS, Wyllie AH, Grant IW. Resistance to methylprednisolone in cultures of blood mononuclear cells from glucocorticoid-resistant asthmatic patients. Clin Sci (Lond) 1984; 67:639-45. PubMed
Hide