Photo of Martha B. Pitman,  MD

Martha B. Pitman, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-3185
Fax: (617) 724-6564


mpitman@partners.org

Martha B. Pitman, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Director of Cytopathology, Pathologist, Pathology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My clinical practice focuses on the early diagnosis of cancer using the cytological method of diagnosis. My clinical research has centered on pre-operative diagnosis of pancreatic cancer, especially early cancer arising in pancreatic cysts. I have demonstrated the value of cyst fluid analysis using a multimodal approach which incorporates cytological analysis of the cells in the cyst fluid, biochemical and molecular testing with clinical and imaging characteristics of the pancreatic cyst, for accurate diagnosis. This research was the first to correlate cytological and histological features of IPMN, to demonstrate the superior accuracy of cytology over imaging in the early detection of malignant cysts, and to demonstrate the value of integrating all ancillary testing of cyst fluid into a comprehensive pathological diagnosis. I have defined the cytological features of high-grade cellular atypia in pancreatic mucinous cysts and led a multidisciplinary team that developed an international standardized terminology system for cytological diagnosis of pancreaticobiliary cytology. I have over 25 years experience as a diagnostic cytopathologist and am a recognized international expert in the field, especially with regard to the interpretation of pancreatic cytology.

Publications

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  • Kulemann B, Rösch S, Seifert S, Timme S, Bronsert P, Seifert G, Martini V, Kuvendjiska J, Glatz T, Hussung S, Fritsch R, Becker H, Pitman MB, Hoeppner J. Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations. Sci Rep 2017; 7:4510. PubMed
  • Chen AL, Misdraji J, Brugge WR, Ferrone CR, Pitman MB. Acinar cell cystadenoma: A challenging cytology diagnosis, facilitated by moray(®) micro-forceps biopsy. Diagn Cytopathol 2017. PubMed
  • Rosenbaum MW, Jones M, Dudley JC, Le LP, Iafrate AJ, Pitman MB. Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts. Cancer 2016; 125:41-47. PubMed
  • Scourtas A, Dudley JC, Brugge WR, Kadayifci A, Mino-Kenudson M, Pitman MB. Preoperative characteristics and cytological features of 136 histologically confirmed pancreatic mucinous cystic neoplasms. Cancer 2016. PubMed
  • Ly A, Ono JC, Hughes KS, Pitman MB, Balassanian R. Fine-Needle Aspiration Biopsy of Palpable Breast Masses: Patterns of Clinical Use and Patient Experience. J Natl Compr Canc Netw 2016; 14:527-36. PubMed
  • Dudley JC, Zheng Z, McDonald T, Le LP, Dias-Santagata D, Borger D, Batten J, Vernovsky K, Sweeney B, Arpin RN, Brugge WR, Forcione DG, Pitman MB, Iafrate AJ. Next-Generation Sequencing and Fluorescence in Situ Hybridization Have Comparable Performance Characteristics in the Analysis of Pancreaticobiliary Brushings for Malignancy. J Mol Diagn 2015. PubMed
  • Jones M, Zheng Z, Wang J, Dudley J, Albanese E, Kadayifci A, Dias-Santagata D, Le L, Brugge WR, Castillo CF, Mino-Kenudson M, Iafrate AJ, Pitman MB. Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts. Gastrointest Endosc 2015. PubMed
  • Pitman MB, Centeno BA, Ali SZ, Genevay M, Stelow E, Mino-Kenudson M, Fernandez-del Castillo C, Max Schmidt C, Brugge W, Layfield L, . Standardized terminology and nomenclature for pancreatobiliary cytology: the Papanicolaou Society of Cytopathology guidelines. Diagn Cytopathol 2014; 42:338-50. PubMed
  • Pitman MB, Centeno BA, Ali SZ, Genevay M, Stelow E, Mino-Kenudson M, Castillo CF, Schmidt CM, Brugge WR, Layfield LJ. Standardized terminology and nomenclature for pancreatobiliary cytology: The Papanicolaou Society of Cytopathology Guidelines. Cytojournal 2014; 11:3. PubMed