Martin C. Mihm, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-1350
Fax: (617) 726-1866


mmihm@partners.org

Martin C. Mihm, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Professor of Pathology, Harvard Medical School, Dermatology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory is oriented toward understanding the prognosis of malignant melanoma, specifically in relationship to tumor infiltrating lymphocytes and other histologic markers. The lab also attempts to better understand the basis of the prognostic markers effort. For example, the antigenic component of melanoma cells with a striking host response and good prognosis compared to the ones with no response will be studied. Another aspect of our research is to understand the relationship of the benign cells to placenta cells and any causative relationship between the two have on our studies of the phenotypic similarities of the cells.

Publications

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  • Goldberg J, Fisher DE, Demetri GD, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut CP, George S, Morgan JA, Wagner AJ, Freeman GJ, Ritz J, Lezcano C, Mihm MC, Canning C, Hodi FS, Dranoff G. Biologic Activity of Autologous, Granulocyte-Macrophage Colony Stimulating Factor Secreting Alveolar Soft Parts Sarcoma and Clear Cell Sarcoma Vaccines. Clin Cancer Res 2015. PubMed
  • Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. J Invest Dermatol 2015. PubMed
  • Piris A, Mihm MC, Hoang MP. BAP1 and BRAFV600E expression in benign and malignant melanocytic proliferations. Hum Pathol 2015; 46:239-45. PubMed
  • Larson AR, Dresser KA, Zhan Q, Lezcano C, Woda BA, Yosufi B, Thompson JF, Scolyer RA, Mihm MC, Shi YG, Murphy GF, Lian CG. Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors. Mod Pathol 2014. PubMed
  • Hodi FS, Lawrence D, Lezcano C, Wu X, Zhou J, Sasada T, Zeng W, Giobbie-Hurder A, Atkins MB, Ibrahim N, Friedlander P, Flaherty KT, Murphy GF, Rodig S, Velazquez EF, Mihm MC, Russell S, DiPiro PJ, Yap JT, Ramaiya N, Van den Abbeele AD, Gargano M, McDermott D. Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol Res 2014. PubMed
  • Balch CM, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC, Morton DL, Atkins MB, Flaherty KT, Sondak VK. Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients. Ann Surg Oncol 2014; 21:1075-81. PubMed
  • Gerami P, Busam K, Cochran A, Cook MG, Duncan LM, Elder DE, Fullen DR, Guitart J, Leboit PE, Mihm MC, Prieto VG, Rabkin MS, Scolyer RA, Xu X, Yun SJ, Obregon R, Yazdan P, Cooper C, Weitner BB, Rademaker A, Barnhill RL. Histomorphologic Assessment and Interobserver Diagnostic Reproducibility of Atypical Spitzoid Melanocytic Neoplasms With Long-term Follow-up. Am J Surg Pathol 2014. PubMed
  • Jalian HR, Avram MM, Garibyan L, Mihm MC, Anderson RR. Paradoxical adipose hyperplasia after cryolipolysis. JAMA Dermatol 2014; 150:317-9. PubMed
  • Lezcano C, Lee CW, Larson AR, Menzies AM, Kefford RF, Thompson JF, Mihm MC, Ogino S, Long GV, Scolyer RA, Murphy GF. Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors. Mod Pathol 2014. PubMed
  • Li WQ, Han J, Widlund HR, Correll M, Wang YE, Quackenbush J, Mihm MC, Canales AL, Wu S, Golub T, Hoshida Y, Hunter DJ, Murphy G, Kupper TS, Qureshi AA. CXCR4 pathway associated with family history of melanoma. Cancer Causes Control 2014; 25:125-32. PubMed
  • Schatton T, Scolyer RA, Thompson JF, Mihm MC. Tumor-infiltrating lymphocytes and their significance in melanoma prognosis. Methods Mol Biol 2013; 1102:287-324. PubMed
  • Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Coit DG, Atkins MB, Ding S, Cochran AJ, Eggermont AM, Flaherty KT, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, McMasters KM, Mihm MC, Morton DL, Ross MI, Sondak VK. Age as a prognostic factor in patients with localized melanoma and regional metastases. Ann Surg Oncol 2013; 20:3961-8. PubMed
  • Abraham RM, Karakousis G, Acs G, Ziober AF, Cerroni L, Mihm MC, Elder DE, Xu X. Lymphatic Invasion Predicts Aggressive Behavior in Melanocytic Tumors of Uncertain Malignant Potential (MELTUMP). Am J Surg Pathol 2013; 37:669-75. PubMed
  • Aboutalebi A, Jessup CJ, North PE, Mihm MC. Histopathology of vascular anomalies. Facial Plast Surg 2012; 28:545-53. PubMed
  • Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 2012; 491:449-53. PubMed
  • Abreu-Velez AM, Howard MS, Pereyo NY, Delman KA, Mihm MC, Rizzo M. CD45/CD8 Myeloid Histioid Antigen and Plasma Cell Antibody Immune Response in a Case of Malignant Melanoma. N Am J Med Sci 2012; 4:507-9. PubMed
  • Leong SP, Mihm MC, Murphy GF, Hoon DS, Kashani-Sabet M, Agarwala SS, Zager JS, Hauschild A, Sondak VK, Guild V, Kirkwood JM. Progression of cutaneous melanoma: implications for treatment. Clin Exp Metastasis 2012; 29:775-96. PubMed
  • Hawryluk EB, Sober AJ, Piris A, Nazarian RM, Hoang MP, Tsao H, Mihm MC, Duncan LM. Histologically challenging melanocytic tumors referred to a tertiary care pigmented lesion clinic. J Am Acad Dermatol 2012; 67:727-35. PubMed
  • Leong SP, Mihm MC, Murphy GF, Hoon DS, Kashani-Sabet M, Agarwala SS, Zager JS, Hauschild A, Sondak VK, Guild V, Kirkwood JM. Erratum to: Progression of cutaneous melanoma: implications for treatment. Clin Exp Metastasis 2012; 29:797-9. PubMed
  • Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 2012; 150:1135-46. PubMed
  • Hung T, Piris A, Lobo A, Mihm MC, Sober AJ, Tsao H, Tanabe KK, Duncan LM. Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors. Hum Pathol 2012. PubMed
  • Le LP, Dias-Santagata D, Pawlak AC, Cosper AK, Nguyen AT, Selim MA, Deng A, Horick NK, Iafrate AJ, Mihm MC, Hoang MP. Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. PLoS ONE 2012; 7:e47290. PubMed
  • Piris A, Mihm MC, Duncan LM. AJCC melanoma staging update: impact on dermatopathology practice and patient management. J Cutan Pathol 2011; 38:394-400. PubMed
  • Phadke PA, Rakheja D, Le LP, Selim MA, Kapur P, Davis A, Mihm MC, Hoang MP. Proliferative Nodules Arising Within Congenital Melanocytic Nevi: A Histologic, Immunohistochemical, and Molecular Analyses of 43 Cases. Am J Surg Pathol 2011. PubMed
  • Farasat S, Yu SS, Neel VA, Nehal KS, Lardaro T, Mihm MC, Byrd DR, Balch CM, Califano JA, Chuang AY, Sharfman WH, Shah JP, Nghiem P, Otley CC, Tufaro AP, Johnson TM, Sober AJ, Liégeois NJ. A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: Creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol 2011. PubMed
  • Schoenfeld J, Jinushi M, Nakazaki Y, Wiener D, Park J, Soiffer R, Neuberg D, Mihm M, Hodi FS, Dranoff G. Active immunotherapy induces antibody responses that target tumor angiogenesis. Cancer Res 2010; 70:10150-60. PubMed
  • Broekaert SM, Roy R, Okamoto I, Van Den Oord J, Bauer J, Garbe C, Barnhill RL, Busam KJ, Cochran AJ, Cook MG, Elder DE, McCarthy SW, Mihm MC, Schadendorf D, Scolyer RA, Spatz A, Bastian BC. Genetic and morphologic features for melanoma classification. Pigment Cell Melanoma Res 2010; 23:763-70. PubMed
  • Le Huu AR, Jokinen CH, Ruben BP, Mihm MC, Weiss SW, North PE, Dadras SS. Expression of prox1, lymphatic endothelial nuclear transcription factor, in kaposiform hemangioendothelioma and tufted angioma. Am J Surg Pathol 2010; 34:1563-73. PubMed
  • Kolman O, Hoang MP, Piris A, Mihm MC, Duncan LM. Histologic processing and reporting of cutaneous pigmented lesions: recommendations based on a survey of 94 dermatopathologists. J Am Acad Dermatol 2010; 63:661-7. PubMed
  • Magro CM, Crowson AN, Mihm MC, Kline M. De novo intraepidermal epithelioid melanocytic dysplasia: an emerging entity. J Cutan Pathol 2010; 37:866-9. PubMed
  • Piris A, Scopsi L, Clemente C, Cetti Serbelloni F, Mihm MC, Hoang MP. Epidermal Growth Factor Receptor Gene Status by Fluorescence In Situ Hybridization in Malignant, Atypical, and Benign Hidradenomas. Am J Dermatopathol 2010. PubMed
  • Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Ding S, Byrd DR, Cascinelli N, Cochran AJ, Coit DG, Eggermont AM, Johnson T, Kirkwood JM, Leong SP, McMasters KM, Mihm MC, Morton DL, Ross MI, Sondak VK. Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases. J Clin Oncol 2010; 28:2452-9. PubMed
  • Rao UN, Lee SJ, Luo W, Mihm MC, Kirkwood JM. Presence of tumor-infiltrating lymphocytes and a dominant nodule within primary melanoma are prognostic factors for relapse-free survival of patients with thick (t4) primary melanoma: pathologic analysis of the e1690 and e1694 intergroup trials. Am J Clin Pathol 2010; 133:646-53. PubMed
  • Mihm MC, Nelson JS. Hypothesis: the metastatic niche theory can elucidate infantile hemangioma development. J Cutan Pathol 2010; 37 Suppl 1:83-7. PubMed
  • Barnhill RL, Cerroni L, Cook M, Elder DE, Kerl H, LeBoit PE, McCarthy SW, Mihm MC, Mooi WJ, Piepkorn MW, Prieto VG, Scolyer RA. State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop. Adv Anat Pathol 2010; 17:73-90. PubMed
  • Magro CM, Crowson AN, Mihm MC, Gupta K, Walker MJ, Solomon G. The dermal-based borderline melanocytic tumor: a categorical approach. J Am Acad Dermatol 2010; 62:469-79. PubMed
  • Jia W, Sun V, Tran N, Choi B, Liu SW, Mihm MC, Phung TL, Nelson JS. Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment. Lasers Surg Med 2010; 42:105-12. PubMed
  • Benoit MM, North PE, McKenna MJ, Mihm MC, Johnson MM, Cunningham MJ. Facial nerve hemangiomas: vascular tumors or malformations? 2010; 142:108-14. PubMed
  • Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC, Morton DL, Ross MI, Sober AJ, Sondak VK. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009; 27:6199-206. PubMed
  • Mandal RV, Murali R, Lundquist KF, Ragsdale BD, Heenan P, McCarthy SW, Mihm MC, Scolyer RA, Zembowicz A. Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up. Am J Surg Pathol 2009; 33:1778-82. PubMed
  • Michaelson JS, Chen LL, Silverstein MJ, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J. How cancer at the primary site and in the lymph nodes contributes to the risk of cancer death. Cancer 2009; 115:5095-107. PubMed
  • Chen LL, Nolan ME, Silverstein MJ, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J, Michaelson JS. The impact of primary tumor size, lymph node status, and other prognostic factors on the risk of cancer death. Cancer 2009; 115:5071-83. PubMed
  • Michaelson JS, Chen LL, Silverstein MJ, Cheongsiatmoy JA, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J. Why cancer at the primary site and in the lymph nodes contributes to the risk of cancer death. Cancer 2009; 115:5084-94. PubMed
  • Chakera AH, Hesse B, Burak Z, Ballinger JR, Britten A, Caracò C, Cochran AJ, Cook MG, Drzewiecki KT, Essner R, Even-Sapir E, Eggermont AM, Stopar TG, Ingvar C, Mihm MC, McCarthy SW, Mozzillo N, Nieweg OE, Scolyer RA, Starz H, Thompson JF, Trifirò G, Viale G, Vidal-Sicart S, Uren R, Waddington W, Chiti A, Spatz A, Testori A, . EANM-EORTC general recommendations for sentinel node diagnostics in melanoma. Eur J Nucl Med Mol Imaging 2009; 36:1713-42. PubMed
  • Ho VT, Vanneman M, Kim H, Sasada T, Kang YJ, Pasek M, Cutler C, Koreth J, Alyea E, Sarantopoulos S, Antin JH, Ritz J, Canning C, Kutok J, Mihm MC, Dranoff G, Soiffer R. Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation. Proc Natl Acad Sci U S A 2009; 106:15825-30. PubMed
  • Wanner M, Avram M, Gagnon D, Mihm MC, Zurakowski D, Watanabe K, Tannous Z, Anderson RR, Manstein D. Effects of non-invasive, 1,210 nm laser exposure on adipose tissue: results of a human pilot study. Lasers Surg Med 2009; 41:401-7. PubMed
  • Piris A,Mihm MC Jr. Progress in melanoma histopathology and diagnosis. Hematol Oncol Clin North Am 2009; 23:467-80, viii. PubMed
  • Magro CM,Yaniv S,Mihm MC. The superficial atypical Spitz tumor and malignant melanoma of superficial spreading type arising in association with the superficial atypical Spitz tumor: A distinct form of dysplastic Spitzoid nevomelanocytic proliferation. J Am Acad Dermatol 2009; 60:814-23. PubMed
  • King R,Hayzen BA,Page RN,Googe PB,Zeagler D,Mihm MC Jr. Recurrent nevus phenomenon: a clinicopathologic study of 357 cases and histologic comparison with melanoma with regression. Mod Pathol 2009; 22:611-7. PubMed
  • Ito K,Mihm MC. Pigmented epithelioid melanocytoma: report of first Japanese cases previously diagnosed as cellular blue nevus. J Cutan Pathol 2009; 36:439-43. PubMed
  • Oble DA,Loewe R,Yu P,Mihm MC Jr. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma. Cancer Immun 2009; 9:3. PubMed
  • Dadras SS,Skrzypek A,Nguyen L,Shin JW,Schulz MM,Arbiser J,Mihm MC,Detmar M. Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J Invest Dermatol 2008; 128:2798-806. PubMed
  • Jinushi M,Nakazaki Y,Carrasco DR,Draganov D,Souders N,Johnson M,Mihm MC,Dranoff G. Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. Cancer Res 2008; 68:8889-98. PubMed
  • Zbytek B, Carlson JA, Granese J, Ross J, Mihm MC, Slominski A. Current concepts of metastasis in melanoma. 2009; 3:569-585. PubMed
  • Oble DA,Mino-Kenudson M,Goldsmith J,Hodi FS,Seliem RM,Dranoff G,Mihm M,Hasserjian R,Lauwers GY. Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis. Am J Surg Pathol 2008; 32:1130-7. PubMed
  • Crowson AN, Magro CM, Mihm MC Jr. Interface dermatitis. Arch Pathol Lab Med 2008; 132:652-66. PubMed
  • Abbasi NR, Yancovitz M, Gutkowicz-Krusin D, Panageas KS, Mihm MC, Googe P, King R, Prieto V, Osman I, Friedman RJ, Rigel DS, Kopf AW, Polsky D. Utility of lesion diameter in the clinical diagnosis of cutaneous melanoma. Arch Dermatol 2008; 144:469-74. PubMed
  • Friedman RJ, Gutkowicz-Krusin D, Farber MJ, Warycha M, Schneider-Kels L, Papastathis N, Mihm MC Jr, Googe P, King R, Prieto VG, Kopf AW, Polsky D, Rabinovitz H, Oliviero M, Cognetta A, Rigel DS, Marghoob A, Rivers J, Johr R, Grant-Kels JM, Tsao H. The diagnostic performance of expert dermoscopists vs a computer-vision system on small-diameter melanomas. Arch Dermatol 2008; 144:476-82. PubMed
  • Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, Macrae S, Nelson M, Canning C, Lowy I, Korman A, Lautz D, Russell S, Jaklitsch MT, Ramaiya N, Chen TC, Neuberg D, Allison JP, Mihm MC, Dranoff G. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A 2008; 105:3005-10. PubMed
  • Gleason BC, Hirsch MS, Nucci MR, Schmidt BA, Zembowicz A, Mihm MC, McKee PH, Brenn T. Atypical genital nevi. A clinicopathologic analysis of 56 cases. Am J Surg Pathol 2007; 32:51-7. PubMed
  • Walters RF, Groben PA, Busam K, Millikan RC, Rabinovitz H, Cognetta A, Mihm MC Jr, Prieto VG, Googe PB, King R, Moore DT, Woosley J, Thomas NE. Consumption of the epidermis: a criterion in the differential diagnosis of melanoma and dysplastic nevi that is associated with increasing breslow depth and ulceration. Am J Dermatopathol 2007; 29:527-33. PubMed
  • Crowson AN, Magro C, Miller A, Mihm MC Jr. The molecular basis of melanomagenesis and the metastatic phenotype. Semin Oncol 2007; 34:476-90. PubMed
  • Sugiyama A, Sugiura M, Piris A, Tomita Y, Mihm MC. Apocrine cystadenoma and apocrine hidrocystoma: examination of 21 cases with emphasis on nomenclature according to proliferative features. J Cutan Pathol 2007; 34:912-7. PubMed
  • Zembowicz A, Knoepp SM, Bei T, Stergiopoulos S, Eng C, Mihm MC, Stratakis CA. Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions. Am J Surg Pathol 2007; 31:1764-75. PubMed
  • Crowson AN, Magro C, Mihm MC Jr. Unusual histologic and clinical variants of melanoma: implications for therapy. Curr Oncol Rep 2007; 9:403-10. PubMed
  • Livestro DP, Kaine EM, Michaelson JS, Mihm MC, Haluska FG, Muzikansky A, Sober AJ, Tanabe KK. Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis. Cancer 2007; 110:614-24. PubMed
  • Denlinger CE, Slingluff CL Jr, Mihm MC Jr, Patterson JW. Extensive neurocristic hamartoma with skeletal muscle involvement. J Cutan Pathol 2007; 34:634-9. PubMed
  • Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G. Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells. Blood 2007; 110:954-61. PubMed
  • Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF. J Clin Invest 2007; 117:1902-13. PubMed
  • Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, Wu B, Pasqualucci L, Neuberg D, Aguiar RC, Dal Cin P, Ladd C, Pinkus GS, Salles G, Harris NL, Dalla-Favera R, Habermann TM, Aster JC, Golub TR, Shipp MA. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2004; 105:1851-61. PubMed
  • Zembowicz A, Carney JA, Mihm MC. Re: Zembowicz A, Carney JA, Mihm MC. Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus. Am J Surg Pathol. 2004;28:31-40. Am J Surg Pathol 2004; 28:1115-6. PubMed
  • Mulliken JB, Anupindi S, Ezekowitz RA, Mihm MC. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-2004. A newborn girl with a large cutaneous lesion, thrombocytopenia, and anemia. N Engl J Med 2004; 350:1764-75. PubMed
  • Elias N, Tanabe KK, Sober AJ, Gadd MA, Mihm MC, Goodspeed B, Cosimi AB. Is completion lymphadenectomy after a positive sentinel lymph node biopsy for cutaneous melanoma always necessary? Arch Surg 2004; 139:400-4; discussion 404-5. PubMed
  • Scarr. What is new in melanoma research: genetics and epidemiology of melanoma in 2003? Review of a workshop held in Milan in May 2003. Melanoma Res 2004; 14:77-84. PubMed
  • Mihm MC, Sober AJ. Melanoma before and after Thomas B. Fitzpatrick. J Invest Dermatol 2004; 122:xxxii-xxxiii. PubMed
  • Tsao H, Mihm MC, Sheehan C. PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma. J Am Acad Dermatol 2003; 49:865-72. PubMed
  • Crowson AN, Nuovo GJ, Mihm MC, Magro C. Cutaneous manifestations of Crohn's disease, its spectrum, and its pathogenesis: intracellular consensus bacterial 16S rRNA is associated with the gastrointestinal but not the cutaneous manifestations of Crohn's disease. Hum Pathol 2003; 34:1185-92. PubMed
  • Carlson JA, Slominski A, Mihm MC. What are the clinicopathologic features of matricoma? Am J Dermatopathol 2003; 25:446-7. PubMed
  • Middelkamp-Hup MA, S. Photodynamic therapy for cutaneous proliferative vascular tumors in a mouse model. J Invest Dermatol 2003; 121:634-9. PubMed
  • Soiffer R, Hodi FS, Haluska F, Jung K, Gillessen S, Singer S, Tanabe K, Duda R, Mentzer S, Jaklitsch M, Bueno R, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Mihm M, Dranoff G. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol 2003; 21:3343-50. PubMed
  • Redondo P, S. Immunologic escape and angiogenesis in human malignant melanoma. J Am Acad Dermatol 2003; 49:255-63. PubMed
  • Dadras SS, Paul T, Bertoncini J, Brown LF, Muzikansky A, Jackson DG, Ellwanger U, Garbe C, Mihm MC, Detmar M. Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 2003; 162:1951-60. PubMed
  • Mihm MJ, Yu F, Reiser PJ, Bauer JA. Effects of peroxynitrite on isolated cardiac trabeculae: selective impact on myofibrillar energetic controllers. Biochimie 2003; 85:587-96. PubMed
  • Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G. Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med 2003; 197:1213-9. PubMed
  • Carlson JA, Slominski A, Linette GP, Mihm MC, Ross JS. Biomarkers in melanoma: staging, prognosis and detection of early metastases. Expert Rev Mol Diagn 2003; 3:303-30. PubMed
  • Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, Davis T, Henry-Spires R, MacRae S, Willman A, Padera R, Jaklitsch MT, Shankar S, Chen TC, Korman A, Allison JP, Dranoff G. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci U S A 2003; 100:4712-7. PubMed
  • Schmollinger JC, Vonderheide RH, Hoar KM, Maecker B, Schultze JL, Hodi FS, Soiffer RJ, Jung K, Kuroda MJ, Letvin NL, Greenfield EA, Mihm M, Kutok JL, Dranoff G. Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction. Proc Natl Acad Sci U S A 2003; 100:3398-403. PubMed
  • Abe S, Yamamoto Y, Uno S, Andou M, Akasaka T, Mihm MC. Malignant melanoma arising in a sebaceous nevus of the scalp. Br J Plast Surg 2003; 56:171-3. PubMed
  • Carlson JA, Slominski A, Linette GP, Mihm MC, Ross JS. Biomarkers in melanoma: predisposition, screening and diagnosis. Expert Rev Mol Diagn 2003; 3:163-84. PubMed
  • Salgia R, Lynch T, Skarin A, Lucca J, Lynch C, Jung K, Hodi FS, Jaklitsch M, Mentzer S, Swanson S, Lukanich J, Bueno R, Wain J, Mathisen D, Wright C, Fidias P, Donahue D, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Sugarbaker D, Mihm M, Dranoff G. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol 2003; 21:624-30. PubMed
  • Crowson AN, Mihm MC, Magro C. Pyoderma gangrenosum: a review. J Cutan Pathol 2003; 30:97-107. PubMed
  • Liu V, Mihm MC. Pathology of malignant melanoma. Surg Clin North Am 2003; 83:31-60, v. PubMed
  • Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Gershenwald JE, Houghton A, Kirkwood JM, McMasters KM, Mihm MF, Morton DL, Reintgen DS, Ross MI, Sober A, Thompson JA, Thompson JF. New TNM melanoma staging system: linking biology and natural history to clinical outcomes. Semin Surg Oncol 2003; 21:43-52. PubMed
  • Gogas H, Paterakis G, Frangia K, Bafaloukos D, Pectasides D, Kalofonos HP, Loukopoulos D, Stavropoulou-Giokas C, Ioannovich J, Mihm MC. Lymphocyte subpopulations and interleukin levels in high-risk melanoma patients treated with high-dose interferon A-2B. Am J Clin Oncol 2002; 25:591-6. PubMed
  • Izikson L, Sober AJ, Mihm MC, Zembowicz A. Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases. Arch Dermatol 2002; 138:1562-6. PubMed
  • Richardson SK, Tannous ZS, Mihm MC. Congenital and infantile melanoma: review of the literature and report of an uncommon variant, pigment-synthesizing melanoma. J Am Acad Dermatol 2002; 47:77-90. PubMed
  • Hodi FS, Schmollinger JC, Soiffer RJ, Salgia R, Lynch T, Ritz J, Alyea EP, Yang J, Neuberg D, Mihm M, Dranoff G. ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction. Proc Natl Acad Sci U S A 2002; 99:6919-24. PubMed
  • Tannous ZS, Mihm MC, Flotte TJ, Gonz. In vivo examination of lentigo maligna and malignant melanoma in situ, lentigo maligna type by near-infrared reflectance confocal microscopy: comparison of in vivo confocal images with histologic sections. J Am Acad Dermatol 2002; 46:260-3. PubMed
  • Carlson JA, Mu XC, Slominski A, Weismann K, Crowson AN, Malfetano J, Prieto VG, Mihm MC. Melanocytic proliferations associated with lichen sclerosus. Arch Dermatol 2002; 138:77-87. PubMed
  • Fishman C, Mihm MC, Sober AJ. Diagnosis and management of nevi and cutaneous melanoma in infants and children. Clin Dermatol 2002; 20:44-50. PubMed
  • Crowson AN, Magro CM, Sanchez-Carpintero I, Mihm MC. The precursors of malignant melanoma. Recent Results Cancer Res 2002; 160:75-84. PubMed
  • Balch CM, Mihm MC. Reply to the article "The AJCC staging proposal for cutaneous melanoma: comments by the EORTC Melanoma Group", by D. J. Ruiter et al. (Ann Oncol 2001; 12: 9-11). American Joint Committee on Cancer. Ann Oncol 2002; 13:175-6. PubMed
  • Gillessen S, Mach N, Small C, Mihm M, Dranoff G. Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity. Blood 2001; 97:922-8. PubMed
  • Elbaum M, Kopf AW, Rabinovitz HS, Langley RG, Kamino H, Mihm MC, Sober AJ, Peck GL, Bogdan A, Gutkowicz-Krusin D, Greenebaum M, Keem S, Oliviero M, Wang S. Automatic differentiation of melanoma from melanocytic nevi with multispectral digital dermoscopy: a feasibility study. J Am Acad Dermatol 2001; 44:207-18. PubMed
  • King R, Googe PB, Weilbaecher KN, Mihm MC, Fisher DE. Microphthalmia transcription factor expression in cutaneous benign, malignant melanocytic, and nonmelanocytic tumors. Am J Surg Pathol 2001; 25:51-7. PubMed
  • King R, Googe PB, Mihm MC. Thin melanomas. Clin Lab Med 2001; 20:713-29. PubMed
  • Bonta MD, Tannous ZS, Demierre MF, Gonzalez E, Harris NL, Duncan LM. Rapidly progressing mycosis fungoides presenting as follicular mucinosis. J Am Acad Dermatol 2000; 43:635-40. PubMed
  • Greenberg DB, Jonasch E, Gadd MA, Ryan BF, Everett JR, Sober AJ, Mihm MA, Tanabe KK, Ott M, Haluska FG. Adjuvant therapy of melanoma with interferon-alpha-2b is associated with mania and bipolar syndromes. Cancer 2000; 89:356-62. PubMed
  • Mach N, Gillessen S, Wilson SB, Sheehan C, Mihm M, Dranoff G. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res 2000; 60:3239-46. PubMed
  • Tannous ZS, Lerner LH, Duncan LM, Mihm MC, Flotte TJ. Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type. Hum Pathol 2000; 31:705-8. PubMed
  • North PE, Mizeracki A, Mihm MC, Mrak RE. GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma. Clin Neuropathol 2003; 19:131-7. PubMed
  • Jonasch E, Kumar UN, Linette GP, Hodi FS, Soiffer RJ, Ryan BF, Sober AJ, Mihm MC, Tsao H, Langley RG, Cosimi BA, Gadd MA, Tanabe KK, Souba W, Haynes HA, Barnhill R, Osteen R, Haluska FG. Adjuvant high-dose interferon alfa-2b in patients with high-risk melanoma. Cancer J 2000; 6:139-45. PubMed
  • Balch CM, Soong S, Ross MI, Urist MM, Karakousis CP, Temple WJ, Mihm MC, Barnhill RL, Jewell WR, Wanebo HJ, Harrison R. Long-term results of a multi-institutional randomized trial comparing prognostic factors and surgical results for intermediate thickness melanomas (1.0 to 4.0 mm). Intergroup Melanoma Surgical Trial. Ann Surg Oncol 2000; 7:87-97. PubMed
  • Slominski A, Wortsman J, Carlson A, Mihm M, Nickoloff B, McClatchey K. Molecular pathology of soft tissue and bone tumors. A review. Arch Pathol Lab Med 1999; 123:1246-59. PubMed
  • Mihm MJ, Coyle CM, Jing L, Bauer JA. Vascular peroxynitrite formation during organic nitrate tolerance. J Pharmacol Exp Ther 1999; 291:194-8. PubMed
  • King R, Weilbaecher KN, McGill G, Cooley E, Mihm M, Fisher DE. Microphthalmia transcription factor. A sensitive and specific melanocyte marker for MelanomaDiagnosis. Am J Pathol 1999; 155:731-8. PubMed
  • Yu LL, Flotte TJ, Tanabe KK, Gadd MA, Cosimi AB, Sober AJ, Mihm MC, Duncan LM. Detection of microscopic melanoma metastases in sentinel lymph nodes. Cancer 1999; 86:617-27. PubMed
  • Carlson JA, Healy K, Slominski A, Mihm MC. Melanocytic matricoma: a report of two cases of a new entity. Am J Dermatopathol 1999; 21:344-9. PubMed
  • Crowson AN, Magro CM, Mihm MC. Malignant melanoma with prominent pigment synthesis: "animal type" melanoma--a clinical and histological study of six cases with a consideration of other melanocytic neoplasms with prominent pigment synthesis. Hum Pathol 1999; 30:543-50. PubMed
  • Flotte TJ, Mihm MC. Lentigo maligna and malignant melanoma in situ, lentigo maligna type. Hum Pathol 1999; 30:533-6. PubMed
  • Wharton JM, Carlson JA, Mihm MC. Desmoplastic malignant melanoma: diagnosis of early clinical lesions. Hum Pathol 1999; 30:537-42. PubMed
  • Barnhill RL, Argenyi ZB, From L, Glass LF, Maize JC, Mihm MC, Rabkin MS, Ronan SG, White WL, Piepkorn M. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol 1999; 30:513-20. PubMed
  • Saeki H, Etoh T, Toda K, Mihm MC. Pseudolymphoma syndrome due to carbamazepine. J Dermatol 1999; 26:329-31. PubMed
  • Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Dranoff G. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A 1998; 95:13141-6. PubMed
  • Mach N, Lantz CS, Galli SJ, Reznikoff G, Mihm M, Small C, Granstein R, Beissert S, Sadelain M, Mulligan RC, Dranoff G. Involvement of interleukin-3 in delayed-type hypersensitivity. Blood 1998; 91:778-83. PubMed
  • Wick MM, Sober AJ, Fitzpatrick TB, Mihm MC, Kopf AW, Clark WH, Blois MS. Clinical characteristics of early cutaneous melanoma. Cancer 1980; 45:2684-6. PubMed
  • Sober AJ, Fitzpatrick TB, Mihm MC, Wise TG, Pearson BJ, Clark WH, Kopf AW. Early recognition of cutaneous melanoma. JAMA 1979; 242:2795-9. PubMed
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