Photo of Martin E. Dorf,  PhD

Martin E. Dorf, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-1978
Fax: (617) 432-2789


dorf@hms.harvard.edu

Martin E. Dorf, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Professor, Microbiology and Immunobiology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our lab works in the broad fields of cell signaling, ubiquitination and gene regulation with special emphasis on applying these systems to investigate cell growth and innate immunity. Research in my lab uses a combination of cellular and molecular methodologies for analysis of host responses. Our lab has made extensive use of genetic and proteomic-based tools to identify novel cellular interaction partners for the NF-kB and IRF signaling systems. In many cases we identified critical roles for E3 ubiquitin ligases in these pathways.

Publications

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  • Li S, Wang L, Fu B, Berman MA, Diallo A, Dorf ME. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Proc Natl Acad Sci U S A 2014. PubMed
  • Fu B, Li S, Wang L, Berman MA, Dorf ME. The ubiquitin conjugating enzyme UBE2L3 regulates TNF留-induced linear ubiquitination. Cell Res 2014; 24:510. PubMed
  • Fu B, Li S, Wang L, Berman MA, Dorf ME. The ubiquitin conjugating enzyme UBE2L3 regulates TNF留-induced linear ubiquitination. Cell Res 2014; 24:376-9. PubMed
  • Wang L, Li S, Dorf ME. NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses. PLoS ONE 2012; 7:e43756. PubMed
  • Li S, Wang L, Berman M, Kong YY, Dorf ME. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 2011; 35:426-40. PubMed
  • Abromson-Leeman S, Bronson RT, Dorf ME. Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol 2009; 215:10-24. PubMed
  • Li S,Wang L,Dorf ME. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell 2009; 33:30-42. PubMed
  • Di Y, Li S, Wang L, Zhang Y, Dorf ME. Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling. Cell Signal 2008; 20:705-13. PubMed
  • Sidorov A, Dorf M, Zorin V, Bokhanov A, Izotov I, Razin S, Skalyga V, Rossbach J, Spadtke P, Balabaev A. Multiaperture ion beam extraction from gas-dynamic electron cyclotron resonance source of multicharged ions. Rev Sci Instrum 2008; 79:02A317. PubMed
  • Abromson-Leeman S, Ladell DS, Bronson RT, Dorf ME. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 2007; 192:3-12. PubMed
  • Li S, Wang L, Berman MA, Zhang Y, Dorf ME. RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol Cell 2006; 24:497-509. PubMed
  • Lee I, Wang L, Wells AD, Dorf ME, Ozkaynak E, Hancock WW. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 2005; 201:1037-44. PubMed
  • Zhai Q, Luo Y, Zhang Y, Berman MA, Dorf ME. Low nuclear levels of nuclear factor-kappa B are essential for KC self-induction in astrocytes: requirements for shuttling and phosphorylation. Glia 2004; 48:327-36. PubMed
  • Luo Y, Berman MA, Abromson-Leeman SR, Dorf ME. Tumor necrosis factor is required for RANTES-induced astrocyte monocyte chemoattractant protein-1 production. Glia 2003; 43:119-27. PubMed
  • Zhang Y, Luo Y, Zhai Q, Ma L, Dorf ME. Negative role of cAMP-dependent protein kinase A in RANTES-mediated transcription of proinflammatory mediators through Raf. FASEB J 2003; 17:734-6. PubMed
  • Tanabe S, Nakadai T, Furuoka H, Oomachi T, Kobayashi Y, Omata Y, Koyama T, Hondo E, Uzuka Y, Sarashina T, Ducusin RJ, Shida T, Dorf ME. Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma. Vet Rec 2003; 151:729-33. PubMed
  • Luo Y, Berman MA, Zhai Q, Fischer FR, Abromson-Leeman SR, Zhang Y, Kuziel WA, Gerard C, Dorf ME. RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes. Glia 2002; 39:19-30. PubMed
  • Zhang Y, Zhai Q, Luo Y, Dorf ME. RANTES-mediated chemokine transcription in astrocytes involves activation and translocation of p90 ribosomal S6 protein kinase (RSK). J Biol Chem 2002; 277:19042-8. PubMed
  • Fischer FR, Luo Y, Luo M, Santambrogio L, Dorf ME. RANTES-induced chemokine cascade in dendritic cells. J Immunol 2001; 167:1637-43. PubMed
  • Abromson-Leeman S, Maverakis E, Bronson R, Dorf ME. CD40-mediated activation of T cells accelerates, but is not required for, encephalitogenic potential of myelin basic protein-recognizing T cells in a model of progressive experimental autoimmune encephalomyelitis. Eur J Immunol 2001; 31:527-38. PubMed
  • Stein JV, Rot A, Luo Y, Narasimhaswamy M, Nakano H, Gunn MD, Matsuzawa A, Quackenbush EJ, Dorf ME, von Andrian UH. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules J Exp Med 2000; 191:61-76. PubMed
  • Luo Y, Lloyd C, Gutierrez-Ramos JC, Dorf ME. Chemokine amplification in mesangial cells. J Immunol 1999; 163:3985-92. PubMed
  • Santambrogio L, Pakaski M, Wong ML, Cipriani B, Brosnan CF, Lees MB, Dorf ME. Antigen presenting capacity of brain microvasculature in altered peptide ligand modulation of experimental allergic encephalomyelitis. J Neuroimmunol 1999; 93:81-91. PubMed
  • Luo Y, Kim R, Gabuzda D, Mi S, Collins-Racie LA, Lu Z, Jacobs KA, Dorf ME. The CXC-chemokine, H174: expression in the central nervous system. J Neurovirol 1999; 4:575-85. PubMed
  • Yoshizawa I, Bronson R, Ben-Nun A, Richert JR, Dorf ME, Abromson-Leeman S. Differential recognition of MBP epitopes in BALB/c mice determines the site of inflammatory disease induction. J Neuroimmunol 1998; 89:73-82. PubMed
  • Yoshizawa I, Bronson R, Dorf ME, Abromson-Leeman S. T-cell responses to myelin basic protein in normal and MBP-deficient mice. J Neuroimmunol 1998; 84:131-8. PubMed
  • Heesen M, Berman MA, Charest A, Housman D, Gerard C, Dorf ME. Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Immunogenetics 1998; 47:364-70. PubMed
  • Tanabe S, Heesen M, Berman MA, Fischer MB, Yoshizawa I, Luo Y, Dorf ME. Murine astrocytes express a functional chemokine receptor. J Neurosci 1997; 17:6522-8. PubMed
  • Tanabe S, Heesen M, Yoshizawa I, Berman MA, Luo Y, Bleul CC, Springer TA, Okuda K, Gerard N, Dorf ME. Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. J Immunol 1997; 159:905-11. PubMed
  • Heesen M, Berman MA, H. Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms. J Immunol 1997; 158:3561-4. PubMed
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