Photo of Martin E. Dorf,  PhD

Martin E. Dorf, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-1978
Fax: (617) 432-2789


dorf@hms.harvard.edu

Martin E. Dorf, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Professor, Microbiology and Immunobiology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our lab works in the broad fields of cell signaling, ubiquitination and gene regulation with special emphasis on applying these systems to investigate cell growth and innate immunity. Research in my lab uses a combination of cellular and molecular methodologies for analysis of host responses. Our lab has made extensive use of genetic and proteomic-based tools to identify novel cellular interaction partners for the NF-kB and IRF signaling systems. In many cases we identified critical roles for E3 ubiquitin ligases in these pathways.

Publications

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  • Li S, Wang L, Fu B, Berman MA, Diallo A, Dorf ME. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Proc Natl Acad Sci U S A 2014. PubMed
  • Fu B, Li S, Wang L, Berman MA, Dorf ME. The ubiquitin conjugating enzyme UBE2L3 regulates TNF留-induced linear ubiquitination. Cell Res 2014; 24:510. PubMed
  • Fu B, Li S, Wang L, Berman MA, Dorf ME. The ubiquitin conjugating enzyme UBE2L3 regulates TNFα-induced linear ubiquitination. Cell Res 2014; 24:376-9. PubMed
  • Wang L, Li S, Dorf ME. NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. PLoS ONE 2012; 7:e43756. PubMed
  • Li S, Wang L, Berman M, Kong YY, Dorf ME. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 2011; 35:426-40. PubMed
  • Abromson-Leeman S, Bronson RT, Dorf ME. Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol 2009; 215:10-24. PubMed
  • Li S,Wang L,Dorf ME. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell 2009; 33:30-42. PubMed
  • Di Y, Li S, Wang L, Zhang Y, Dorf ME. Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling. Cell Signal 2008; 20:705-13. PubMed
  • Sidorov A, Dorf M, Zorin V, Bokhanov A, Izotov I, Razin S, Skalyga V, Rossbach J, Spadtke P, Balabaev A. Multiaperture ion beam extraction from gas-dynamic electron cyclotron resonance source of multicharged ions. Rev Sci Instrum 2008; 79:02A317. PubMed
  • Abromson-Leeman S, Ladell DS, Bronson RT, Dorf ME. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 2007; 192:3-12. PubMed
  • Li S, Wang L, Berman MA, Zhang Y, Dorf ME. RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol Cell 2006; 24:497-509. PubMed