Photo of Megan Rice,  ScD

Megan Rice, ScD

Brigham And Women's Hospital

Brigham And Women's Hospital


mrice1@mgh.harvard.edu

Megan Rice, ScD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Assistant Investigator, Medicine, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focus is to better understand breast and ovarian cancer risk by incorporating molecular markers in epidemiologic studies of lifestyle factors. I have published several papers on both breast and ovarian cancer risk, including analyses of intermediate markers of risk, such as mammographic density and breast lobule type.

Publications

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  • Zhang X, Rice M, Tworoger SS, Rosner BA, Eliassen AH, Tamimi RM, Joshi AD, Lindstrom S, Qian J, Colditz GA, Willett WC, Kraft P, Hankinson SE. Addition of a polygenic risk score, mammographic density, and endogenous hormones to existing breast cancer risk prediction models: A nested case-control study. PLoS Med. 2018; 15:e1002644. PubMed
  • Merritt MA, Rice MS, Barnard ME, Hankinson SE, Matulonis UA, Poole EM, Tworoger SS. Pre-diagnosis and post-diagnosis use of common analgesics and ovarian cancer prognosis (NHS/NHSII): a cohort study. Lancet Oncol. 2018; 19:1107-1116. PubMed
  • Rice MS, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Norman AD, Visscher DW, Chen YY, Brandt KR, Couch FJ, Shepherd JA, Fan B, Wu FF, Ma L, Collins LC, Cummings SR, Kerlikowske K, Vachon CM. Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics. Breast Cancer Res Treat 2018. PubMed
  • Harris HR, Rice MS, Shafrir AL, Poole EM, Gupta M, Hecht JL, Terry KL, Tworoger SS. Lifestyle and Reproductive Factors and Ovarian Cancer Risk by p53 and MAPK Expression. Cancer Epidemiol Biomarkers Prev 2018; 27:96-102. PubMed
  • Rice MS, Rist PM, Winter AC, Kurth T, Tworoger SS. Migraine and invasive epithelial ovarian cancer risk in the Nurses' Health Study II and the Women's Health Study. Int. J. Cancer 2017. PubMed
  • Hirko KA, Lajous M, Ortiz-Panozo E, Lopez-Ridaura R, Christine PJ, Lȇ-Scherban F, Rice MS, Barrientos-Gutierrez T. Socioeconomic position and markers of adiposity among female teachers in Mexico. J Epidemiol Community Health 2017. PubMed
  • Rice MS, Tworoger SS, Hankinson SE, Tamimi RM, Eliassen AH, Willett WC, Colditz G, Rosner B. Breast cancer risk prediction: an update to the Rosner-Colditz breast cancer incidence model. Breast Cancer Res Treat 2017. PubMed
  • Rice MS, Rosner BA, Tamimi RM. Percent mammographic density prediction: development of a model in the nurses' health studies. Cancer Causes Control 2017; 28:677-684. PubMed
  • Burton A, Maskarinec G, Perez-Gomez B, Vachon C, Miao H, Lajous M, López-Ridaura R, Rice M, Pereira A, Garmendia ML, Tamimi RM, Bertrand K, Kwong A, Ursin G, Lee E, Qureshi SA, Ma H, Vinnicombe S, Moss S, Allen S, Ndumia R, Vinayak S, Teo SH, Mariapun S, Fadzli F, Peplonska B, Bukowska A, Nagata C, Stone J, Hopper J, Giles G, Ozmen V, Aribal ME, Schüz J, Van Gils CH, Wanders JOP, Sirous R, Sirous M, Hipwell J, Kim J, Lee JW, Dickens C, Hartman M, Chia KS, Scott C, Chiarelli AM, Linton L, Pollan M, Flugelman AA, Salem D, Kamal R, Boyd N, Dos-Santos-Silva I, McCormack V. Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide. PLoS Med. 2017; 14:e1002335. PubMed
  • Begg CB, Rice MS, Zabor EC, Tworoger SS. Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries. Br J Cancer 2017; 116:1088-1091. PubMed
  • Yang M, Prescott J, Poole EM, Rice MS, Kubzansky LD, Idahl A, Lundin E, De Vivo I, Tworoger SS. Prediagnosis Leukocyte Telomere Length and Risk of Ovarian Cancer. Cancer Epidemiol Biomarkers Prev 2017; 26:339-345. PubMed
  • Burton A, Byrnes G, Stone J, Tamimi RM, Heine J, Vachon C, Ozmen V, Pereira A, Garmendia ML, Scott C, Hipwell JH, Dickens C, Schüz J, Aribal ME, Bertrand K, Kwong A, Giles GG, Hopper J, Pérez Gómez B, Pollán M, Teo SH, Mariapun S, Taib NA, Lajous M, Lopez-Riduara R, Rice M, Romieu I, Flugelman AA, Ursin G, Qureshi S, Ma H, Lee E, Sirous R, Sirous M, Lee JW, Kim J, Salem D, Kamal R, Hartman M, Miao H, Chia KS, Nagata C, Vinayak S, Ndumia R, van Gils CH, Wanders JO, Peplonska B, Bukowska A, Allen S, Vinnicombe S, Moss S, Chiarelli AM, Linton L, Maskarinec G, Yaffe MJ, Boyd NF, Dos-Santos-Silva I, McCormack VA. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems. Breast Cancer Res 2016; 18:130. PubMed
  • Townsend MK, Lajous M, Medina-Campos RH, Catzin-Kuhlmann A, López-Ridaura R, Rice MS. Risk factors for urinary incontinence among postmenopausal Mexican women. 2016. PubMed
  • Shafrir AL, Rice MS, Gupta M, Terry KL, Rosner BA, Tamimi RM, Hecht JL, Tworoger SS. The association between reproductive and hormonal factors and ovarian cancer by estrogen-α and progesterone receptor status. Gynecol Oncol 2016. PubMed
  • Huang T, Tworoger SS, Hecht JL, Rice MS, Sood AK, Kubzansky LD, Poole EM. Association of ovarian tumor β2-adrenergic receptor status with ovarian cancer risk factors and survival. Cancer Epidemiol Biomarkers Prev 2016. PubMed
  • Rice MS, Eliassen AH, Hankinson SE, Lenart EB, Willett WC, Tamimi RM. Breast Cancer Research in the Nurses' Health Studies: Exposures Across the Life Course. Am J Public Health 2016; 106:1592-8. PubMed
  • Reeves KW, Okereke OI, Qian J, Tworoger SS, Rice MS, Hankinson SE. Antidepressant use and circulating prolactin levels. Cancer Causes Control 2016; 27:853-61. PubMed
  • McCormack VA, Burton A, Dos-Santos-Silva I, Hipwell JH, Dickens C, Salem D, Kamal R, Hartman M, Lee CP, Chia KS, Ozmen V, Aribal ME, Flugelman AA, Lajous M, Lopez-Riduara R, Rice M, Romieu I, Ursin G, Qureshi S, Ma H, Lee E, van Gils CH, Wanders JO, Vinayak S, Ndumia R, Allen S, Vinnicombe S, Moss S, Won Lee J, Kim J, Pereira A, Garmendia ML, Sirous R, Sirous M, Peplonska B, Bukowska A, Tamimi RM, Bertrand K, Nagata C, Kwong A, Vachon C, Scott C, Perez-Gomez B, Pollan M, Maskarinec G, Giles G, Hopper J, Stone J, Rajaram N, Teo SH, Mariapun S, Yaffe MJ, Schüz J, Chiarelli AM, Linton L, Boyd NF. International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries. 2016; 40:141-151. PubMed
  • Rice MS, Bertrand KA, Lajous M, Tamimi RM, Torres G, López-Ridaura R, Romieu I. Reproductive and lifestyle risk factors and mammographic density in Mexican women. Ann Epidemiol 2015; 25:868-73. PubMed
  • Moseson H, Rice MS, López-Ridaura R, Bertrand KA, Torres G, Blanco M, Tamayo-Orozco JA, Lajous M, Romieu I. Bone mineral density and mammographic density in Mexican women. Cancer Causes Control 2015. PubMed
  • Lajous M, Ortiz-Panozo E, Monge A, Santoyo-Vistrain R, García-Anaya A, Yunes-Díaz E, Rice MS, Blanco M, Hernández-Ávila M, Willett WC, Romieu I, López-Ridaura R. Cohort Profile: The Mexican Teachers' Cohort (MTC). Int J Epidemiol 2015. PubMed
  • Kotsopoulos J, Shafrir AL, Rice M, Hankinson SE, Eliassen AH, Tworoger SS, Narod SA. The relationship between bilateral oophorectomy and plasma hormone levels in postmenopausal women. Horm Cancer 2015; 6:54-63. PubMed
  • Poole EM, Rice MS, Crum CP, Tworoger SS. Salpingectomy as a potential ovarian cancer risk-reducing procedure. Journal of the National Cancer Institute 2015. PubMed
  • Winter AC, Rice MS, Fortner RT, Eliassen AH, Kurth T, Tamimi RM. Migraine and breast cancer risk: a prospective cohort study and meta-analysis. Journal of the National Cancer Institute 2014; 107:381. PubMed
  • Rice MS, Tworoger SS, Bertrand KA, Hankinson SE, Rosner BA, Feeney YB, Clevenger CV, Tamimi RM. Immunoassay and Nb2 lymphoma bioassay prolactin levels and mammographic density in premenopausal and postmenopausal women the Nurses' Health Studies. Breast Cancer Res Treat 2015; 149:245-53. PubMed
  • Tworoger SS, Rice MS, Rosner BA, Feeney YB, Clevenger CV, Hankinson SE. Bioactive prolactin levels and risk of breast cancer: a nested case-control study. Cancer Epidemiol Biomarkers Prev 2015. PubMed
  • Cassidy A, Huang T, Rice MS, Rimm EB, Tworoger SS. Intake of dietary flavonoids and risk of epithelial ovarian cancer. Am J Clin Nutr 2014; 100:1344-51. PubMed
  • Rice MS, Hankinson SE, Tworoger SS. Tubal ligation, hysterectomy, unilateral oophorectomy, and risk of ovarian cancer in the Nurses' Health Studies. Fertil Steril 2014. PubMed
  • Rice MS, Murphy MA, Vitonis AF, Cramer DW, Titus LJ, Tworoger SS, Terry KL. Tubal ligation, hysterectomy and epithelial ovarian cancer in the New England Case-Control Study. Int J Cancer 2013. PubMed
  • Rice MS, Biessy C, Lajous M, Bertrand KA, Tamimi RM, Torres-Mejía G, López-Ridaura R, Romieu I. Metabolic syndrome and mammographic density in Mexican women. Cancer Prev Res (Phila Pa) 2013; 6:701-10. PubMed
  • Xie J, Tworoger SS, Franke AA, Terry KL, Rice MS, Rosner BA, Willett WC, Hankinson SE, Eliassen AH. Plasma enterolactone and breast cancer risk in the Nurses' Health Study II. Breast Cancer Res Treat 2013; 139:801-9. PubMed
  • Rice MS, Bertrand KA, Lajous M, Tamimi RM, Torres-Mejía G, Biessy C, López-Ridaura R, Romieu I. Body size throughout the life course and mammographic density in Mexican women. Breast Cancer Res Treat 2013; 138:601-10. PubMed
  • Rice MS, Tworoger SS, Rosner BA, Pollak MN, Hankinson SE, Tamimi RM. Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, growth hormone, and mammographic density in the Nurses' Health Studies. Breast Cancer Res Treat 2012. PubMed
  • Mostofsky E, Rice MS, Levitan EB, Mittleman MA. Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis. Circ Heart Fail 2012; 5:401-5. PubMed
  • Gu F, Kraft P, Rice M, Michels KB. Leptin and leptin receptor genes in relation to premenopausal breast cancer incidence and grade in Caucasian women. Breast Cancer Res Treat 2011. PubMed
  • Rice MS, Tamimi RM, Connolly JL, Collins LC, Shen D, Pollak MN, Rosner B, Hankinson SE, Tworoger SS. Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II. Breast Cancer Res 2012; 14:R44. PubMed
  • Rice MS, Murphy MA, Tworoger SS. Tubal ligation, hysterectomy and ovarian cancer: A meta-analysis. 2012; 5:13. PubMed
  • Rice MS, Custer BS, Hindes DA, Hirschler NV, Nguyen KA, Busch MP, Murphy EL. Genetic research in the blood bank: acceptability to Northern California donors. Transfusion 2010; 50:1951-8. PubMed
  • Rice MS, Bertrand KA, VanderWeele TJ, Rosner BA, Liao X, Adami HO, Tamimi RM. Mammographic density and breast cancer risk: a mediation analysis. Breast Cancer Res 2016; 18:94. PubMed
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