Photo of Mehra Golshan,  MD

Mehra Golshan, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 632-2174
Fax: (617) 582-7740


mgolshan@partners.org

Mehra Golshan, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Surgery, Harvard Medical School
  • Dr. Abdul Mohsen and Sultana Al-Tuwaijri Distinguished Chair, Surgical Oncology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Golshan serves at the Medical Director of International Oncology Programs at the Dana Farber/Brigham and Women’s Cancer Center and is the incumbent Dr. Abdul Mohsen and Sultana Al-Tuwaijri Distinguished Chair in Surgical Oncology at the Brigham and Women’s Hospital. Dr. Golshan is also the Director of Breast Surgical Services at the Dana Farber/Brigham and Women's Cancer Center and an Associate Professor of Surgery at Harvard Medical School. Dr. Golshan helps coordinate international oncology relations at DFBWCC with institutions around the world. Dr. Golshan leads one of the world’s largest breast surgery programs of 11 full-time breast surgeons operating on nearly 2800 women a year. He organizes the clinical and research efforts of the breast surgeons at the Brigham and Women’s Hospital and Dana Farber Cancer Institute.

Dr. Golshan's research interest is focused primarily on neoadjuvant therapies for breast cancer and the use of novel imaging and operative technologies targeting breast carcinoma. The focus of the preoperative therapy trials is to target treatment for women with cancer and develop genotypic profiles that will in the future lead to individualized tailored therapies for women with breast cancer. The role of intraoperative and preoperative imaging is also an area of research. In the United States, nearly 40% of women who undergo lumpectomy will need a second operation to achieve clear margins. We are currently trying to determine if more accurate tumor assessment with breast MRI prior to surgery will lead to a decrease in the number of operative procedures required to achieve clear margins. We are also working on the use of intraoperative imaging assessment with breast MRI in the Advanced Multimodality Image Guided Operative Suite (AMIGO) to determine if we can find residual tumor while the patient is under anesthesia and improve operative outcomes.

 

Publications

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  • Sagara Y, Freedman RA, Vaz-Luis I, Mallory MA, Wong SM, Aydogan F, DeSantis S, Barry WT, Golshan M. Patient Prognostic Score and Associations With Survival Improvement Offered by Radiotherapy After Breast-Conserving Surgery for Ductal Carcinoma In Situ: A Population-Based Longitudinal Cohort Study. J Clin Oncol 2016; 34:1190-6. PubMed
  • Wong SM, Freedman RA, Sagara Y, Aydogan F, Barry WT, Golshan M. Growing Use of Contralateral Prophylactic Mastectomy Despite no Improvement in Long-term Survival for Invasive Breast Cancer. Ann Surg 2016. PubMed
  • Golshan M, Losk K, Mallory MA, Camuso K, Cutone L, Caterson S, Bunnell CA. Implementation of a Breast/Reconstruction Surgery Coordinator to Reduce Preoperative Delays for Patients Undergoing Mastectomy With Immediate Reconstruction. J Oncol Pract 2016; 12:e338-43. PubMed
  • Sagara Y, Barry WT, Mallory MA, Vaz-Luis I, Aydogan F, Brock JE, Winer EP, Golshan M, Metzger-Filho O. Surgical Options and Locoregional Recurrence in Patients Diagnosed with Invasive Lobular Carcinoma of the Breast. Ann Surg Oncol 2015. PubMed
  • Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, Winer EP, Krop IE, Jain RK. Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. Proc Natl Acad Sci U S A 2015; 112:14325-30. PubMed
  • Nakhlis F, Gilmore L, Gelman R, Bedrosian I, Ludwig K, Hwang ES, Willey S, Hudis C, Iglehart JD, Lawler E, Ryabin NY, Golshan M, Schnitt SJ, King TA. Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020). Ann Surg Oncol 2015. PubMed
  • Rosenberg SM, Sepucha K, Ruddy KJ, Tamimi RM, Gelber S, Meyer ME, Schapira L, Come SE, Borges VF, Golshan M, Winer EP, Partridge AH. Local Therapy Decision-Making and Contralateral Prophylactic Mastectomy in Young Women with Early-Stage Breast Cancer. Ann Surg Oncol 2015. PubMed
  • Mallory MA, Losk K, Camuso K, Caterson S, Nimbkar S, Golshan M. Does "Two is Better Than One" Apply to Surgeons? Comparing Single-Surgeon Versus Co-surgeon Bilateral Mastectomies. Ann Surg Oncol 2015. PubMed
  • Liao GS, Chou YC, Golshan M, Hsu HM, Hong ZJ, Yu JC, Zhu JH. Prognostic value of the lymph node ratio in breast cancer subtypes. Am J Surg 2015. PubMed
  • Wong SM, Freedman RA, Stamell E, Sagara Y, Brock JE, Desantis SD, Golshan M. Modern Trends in the Surgical Management of Paget's Disease. Ann Surg Oncol 2015; 22:3308-16. PubMed
  • Mallory MA, Losk K, Lin NU, Sagara Y, Birdwell RL, Cutone L, Camuso K, Bunnell C, Aydogan F, Golshan M. The Influence of Radiology Image Consultation in the Surgical Management of Breast Cancer Patients. Ann Surg Oncol 2015; 22:3383-8. PubMed
  • Bellon JR, Golshan M, Solin LJ. Controversies in Radiation Oncology for Early-Stage Breast Cancer. Ann Surg Oncol 2015; 22:3213-8. PubMed
  • Wong SM, Freedman RA, Sagara Y, Stamell EF, Desantis SD, Barry WT, Golshan M. The effect of Paget disease on axillary lymph node metastases and survival in invasive ductal carcinoma. Cancer 2015. PubMed
  • Golshan M, Cirrincione CT, Sikov WM, Berry DA, Jasinski S, Weisberg TF, Somlo G, Hudis C, Winer E, Ollila DW, . Impact of neoadjuvant chemotherapy in stage II-III triple negative breast cancer on eligibility for breast-conserving surgery and breast conservation rates: surgical results from CALGB 40603 (Alliance). Ann Surg 2015; 262:434-9; discussion 438-9. PubMed
  • Golshan M, Losk K, Mallory MA, Camuso K, Troyan S, Lin NU, Kadish S, Bunnell CA. Variation in Additional Breast Imaging Orders and Impact on Surgical Wait Times at a Comprehensive Cancer Center. Ann Surg Oncol 2015. PubMed
  • Sagara Y, Mallory MA, Wong S, Aydogan F, DeSantis S, Barry WT, Golshan M. Survival Benefit of Breast Surgery for Low-Grade Ductal Carcinoma In Situ: A Population-Based Cohort Study. JAMA Surg 2015. PubMed
  • Aydogan F, Mallory MA, Tukenmez M, Sagara Y, Ozturk E, Ince Y, Celik V, Akca T, Golshan M. A low cost training phantom model for radio-guided localization techniques in occult breast lesions. J Surg Oncol 2015; 112:449-51. PubMed
  • Nakhlis F, Ahmadiyeh N, Lester S, Raza S, Lotfi P, Golshan M. Papilloma on core biopsy: excision vs. observation. Ann Surg Oncol 2015; 22:1479-82. PubMed
  • Mallory MA, Golshan M, Chikarmane SA, Raza S, Lester S, Caterson SA. Bilateral synchronous benign phyllodes tumors. Am Surg 2015; 81:E192-4. PubMed
  • McGuire KP, Hwang ES, Cantor A, Golshan M, Meric-Bernstam F, Horton JK, Nanda R, Amos KD, Forero A, Hudis CA, Meszoely I, De Los Santos JF. Surgical patterns of care in patients with invasive breast cancer treated with neoadjuvant systemic therapy and breast magnetic resonance imaging: results of a secondary analysis of TBCRC 017. Ann Surg Oncol 2014. PubMed
  • Sikov WM, Berry DA, Perou CM, Singh B, Cirrincione CT, Tolaney SM, Kuzma CS, Pluard TJ, Somlo G, Port ER, Golshan M, Bellon JR, Collyar D, Hahn OM, Carey LA, Hudis CA, Winer EP. Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (A J Clin Oncol 2014. PubMed
  • Son BH, Dominici LS, Aydogan F, Shulman LN, Ahn SH, Cho JY, Coopey SB, Kim SB, Min HE, Valero M, Wang J, Caragacianu D, Gong GY, Hevelone ND, Baek S, Golshan M. Young women with breast cancer in the United States and South Korea: comparison of demographics, pathology and management. Asian Pac. J. Cancer Prev. 2015; 16:2531-5. PubMed
  • Giess CS, Golshan M, Flaherty K, Birdwell RL. Clinical experience with aspiration of breast abscesses based on size and etiology at an academic medical center. J Clin Ultrasound 2014; 42:513-21. PubMed
  • Golshan M, Losk K, Kadish S, Lin NU, Hirshfield-Bartek J, Cutone L, Sagara Y, Aydogan F, Camuso K, Weingart SN, Bunnell C. Understanding process-of-care delays in surgical treatment of breast cancer at a comprehensive cancer center. Breast Cancer Res Treat 2014; 148:125-33. PubMed
  • Calligaris D, Caragacianu D, Liu X, Norton I, Thompson CJ, Richardson AL, Golshan M, Easterling ML, Santagata S, Dillon DA, Jolesz FA, Agar NY. Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis. Proc Natl Acad Sci U S A 2014. PubMed
  • Golshan M, Sagara Y, Wexelman B, Aydogan F, Desantis S, Elise Min H, Vosburgh K, Jagadeesan J, Caragacianu D, Gombos E, Jolesz FA. Pilot study to evaluate feasibility of image-guided breast-conserving therapy in the advanced multimodal image-guided operating (AMIGO) suite. Ann Surg Oncol 2014; 21:3356-7. PubMed
  • Tolaney SM, Jeong J, Guo H, Brock J, Morganstern D, Come SE, Golshan M, Bellon J, Winer EP, Krop IE. A phase II study of preoperative capecitabine in women with operable hormone receptor positive breast cancer. Cancer Med 2014; 3:293-9. PubMed
  • Bunnell CA, Losk K, Kadish S, Lin N, Hirshfield-Bartek J, Cutone L, Camuso K, Golshan M, Weingart S. Measuring opportunities to improve timeliness of breast cancer care at Dana-Farber/Brigham and Women's Cancer Center. J Natl Compr Canc Netw 2014; 12 Suppl 1:S5-9. PubMed
  • Camp MS, Valero MG, Opara N, Benabou K, Cutone L, Caragacianu D, Dominici L, Golshan M. Intraoperative digital specimen mammography: a significant improvement in operative efficiency. Am J Surg 2013; 206:526-9. PubMed
  • Kansal KJ, Dominici LS, Tolaney SM, Isakoff SJ, Smith BL, Jiang W, Brock JE, Winer EP, Krop IE, Golshan M. Neoadjuvant bevacizumab: surgical complications of mastectomy with and without reconstruction. Breast Cancer Res Treat 2013; 141:255-9. PubMed
  • Russo AL, Arvold ND, Niemierko A, Wong N, Wong JS, Bellon JR, Punglia RS, Golshan M, Troyan SL, Brock JE, Harris JR. Margin status and the risk of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy. Breast Cancer Res Treat 2013; 140:353-61. PubMed
  • Childs SK, Chen YH, Duggan MM, Golshan M, Pochebit S, Punglia RS, Wong JS, Bellon JR. Impact of margin status on local recurrence after mastectomy for ductal carcinoma in situ. Int J Radiat Oncol Biol Phys 2013. PubMed
  • Margalit DN, Sreedhara M, Chen YH, Catalano PJ, Nguyen PL, Golshan M, Overmoyer BA, Harris JR, Brock JE. Microinvasive breast cancer: ER, PR, and HER-2/neu status and clinical outcomes after breast-conserving therapy or mastectomy. Ann Surg Oncol 2013. PubMed
  • Toi M, Benson JR, Winer EP, Forbes JF, von Minckwitz G, Golshan M, Robertson JF, Sasano H, Cole BF, Chow LW, Pegram MD, Han W, Huang CS, Ikeda T, Kanao S, Lee ES, Noguchi S, Ohno S, Partridge AH, Rouzier R, Tozaki M, Sugie T, Yamauchi A, Inamoto T. Preoperative systemic therapy in locoregional management of early breast cancer: highlights from the Kyoto Breast Cancer Consensus Conference. Breast Cancer Res Treat 2012. PubMed
  • Dominici L, Liao GS, Brock J, Iglehart JD, Lotfi P, Meyer J, Pandalai P, Golshan M. Large needle core biopsy of atypical ductal hyperplasia: results of surgical excision. Breast J 2012. PubMed
  • Hu YY, Weeks CM, In H, Dodgion CM, Golshan M, Chun YS, Hassett MJ, Corso KA, Gu X, Lipsitz SR, Greenberg CC. Impact of neoadjuvant chemotherapy on breast reconstruction. Cancer 2011. PubMed
  • Bafford A, Gadd M, Gu X, Lipsitz S, Golshan M. Diminishing morbidity with the increased use of sentinel node biopsy in breast carcinoma. Am J Surg 2010; 200:374-7. PubMed
  • Javid S, Segara D, Lotfi P, Raza S, Golshan M. Can Breast MRI Predict Axillary Lymph Node Metastasis in Women Undergoing Neoadjuvant Chemotherapy. Ann Surg Oncol 2010; 17:1841-6. PubMed
  • Chun YS, Verma K, Rosen H, Lipsitz SR, Breuing K, Guo L, Golshan M, Grigorian N, Eriksson E. Use of tumescent mastectomy technique as a risk factor for native breast skin flap necrosis following immediate breast reconstruction. Am J Surg 2010. PubMed
  • Garber JE, Golshan M. Contralateral breast cancer in BRCA1/BRCA2 mutation carriers: the story of the other side. J Clin Oncol 2009; 27:5862-4. PubMed
  • Ahmadiyeh N,Stoleru MA,Raza S,Lester SC,Golshan M. Management of Intraductal Papillomas of the Breast: An Analysis of 129 Cases and Their Outcome. Ann Surg Oncol 2009; 16:2264-9. PubMed
  • Bafford AC,Burstein HJ,Barkley CR,Smith BL,Lipsitz S,Iglehart JD,Winer EP,Golshan M. Breast surgery in stage IV breast cancer: impact of staging and patient selection on overall survival. Breast Cancer Res Treat 2008; 115:7-12. PubMed
  • Javid SH,Smith BL,Mayer E,Bellon J,Murphy CD,Lipsitz S,Golshan M. Tubular carcinoma of the breast: results of a large contemporary series. Am J Surg 2008; 197:674-7. PubMed
  • Ligibel JA,Partridge A,Giobbie-Hurder A,Golshan M,Emmons K,Winer EP. Physical activity behaviors in women with newly diagnosed ductal carcinoma-in-situ. Ann Surg Oncol 2008; 16:106-12. PubMed
  • Chen RC,Lin NU,Golshan M,Harris JR,Bellon JR. Internal mammary nodes in breast cancer: diagnosis and implications for patient management -- a systematic review. J Clin Oncol 2008; 26:4981-9. PubMed
  • Barkley CR,Ligibel JA,Wong JS,Lipsitz S,Smith BL,Golshan M. Mucinous breast carcinoma: a large contemporary series. Am J Surg 2008; 196:549-51. PubMed
  • Partridge A,Winer JP,Golshan M,Bellon JR,Blood E,Dees EC,Sampson E,Emmons KM,Winer E. Perceptions and management approaches of physicians who care for women with ductal carcinoma in situ. Clin Breast Cancer 2008; 8:275-80. PubMed
  • Katz A, Smith BL, Golshan M, Niemierko A, Kobayashi W, Raad RA, Kelada A, Rizk L, Wong JS, Bellon JR, Gadd M, Specht M, Taghian AG. Nomogram for the prediction of having four or more involved nodes for sentinel lymph node-positive breast cancer. J Clin Oncol 2008; 26:2093-8. PubMed
  • Partridge A, Adloff K, Blood E, Dees EC, Kaelin C, Golshan M, Ligibel J, de Moor JS, Weeks J, Emmons K, Winer E. Risk perceptions and psychosocial outcomes of women with ductal carcinoma in situ: longitudinal results from a cohort study. Journal of the National Cancer Institute 2008; 100:243-51. PubMed
  • Greenberg CC, Bafford AC, Golshan M. Is axillary dissection needed in node-positive breast cancer? Expert Rev Anticancer Ther 2008; 8:195-8. PubMed
  • Dominguez FJ, Golshan M, Black DM, Hughes KS, Gadd MA, Christian R, Lesnikoski BA, Specht M, Michaelson J, Smith BL. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ. Ann Surg Oncol 2007; 15:268-73. PubMed
  • Carlson JW, Birdwell RL, Gombos EC, Golshan M, Smith DN, Lester SC. MRI-directed, wire-localized breast excisions: incidence of malignancy and recommendations for pathologic evaluation. Hum Pathol 2007; 38:1754-9. PubMed
  • Javid SH, Carlson JW, Garber JE, Birdwell RL, Lester S, Lipsitz S, Golshan M. Breast MRI wire-guided excisional biopsy: specimen size as compared to mammogram wire-guided excisional biopsy and implications for use. Ann Surg Oncol 2007; 14:3352-8. PubMed
  • Golshan M, Rusby J, Dominguez F, Smith BL. Breast conservation for male breast carcinoma. Breast 2007; 16:653-6. PubMed
  • Segara D, Krop IE, Garber JE, Winer E, Harris L, Bellon JR, Birdwell R, Lester S, Lipsitz S, Iglehart JD, Golshan M. Does MRI predict pathologic tumor response in women with breast cancer undergoing preoperative chemotherapy? J Surg Oncol 2007; 96:474-80. PubMed
  • Rusby JE, Smith BL, Dominguez FJ, Golshan M. Sentinel lymph node biopsy in men with breast cancer: a report of 31 consecutive procedures and review of the literature. Clin Breast Cancer 2007; 7:406-10. PubMed
  • Golshan M, Nakhlis F. Can methylene blue only be used in sentinel lymph node biopsy for breast cancer? Breast J 2006; 12:428-30. PubMed
  • Golshan M, Smith B. Prevention and management of arm lymphedema in the patient with breast cancer. J Support Oncol 2006; 4:381-6. PubMed
  • Golshan M, Miron A, Nixon AJ, Garber JE, Cash EP, Iglehart JD, Harris JR, Wong JS. The prevalence of germline BRCA1 and BRCA2 mutations in young women with breast cancer undergoing breast-conservation therapy. Am J Surg 2006; 192:58-62. PubMed
  • Golshan M, Lesnikoski BA, Lester S. Sentinel lymph node biopsy for occult breast cancer detected during breast reduction surgery. Am Surg 2006; 72:397-400. PubMed
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