Photo of Michael J. Barry,  MD

Michael J. Barry, MD

Massachusetts General Hospital

Massachusetts General Hospital

Michael J. Barry, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Chief, General Medicine Unit, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Barry's work focuses on outcomes research, which seeks to define the results of common strategies of care in terms that are most relevant to patients, particularly in terms of symptom burden and functional status. The content area of this research has been largely, but not exclusively, at the interface of primary care and urology. Using prostatic disease as a paradigm for other largely preference-driven medical problems requiring shared care between generalists and specialists, Dr. Barry has studied the diagnosis, prognosis, and treatment outcomes of this common set of disorders among older men. Methods employed have included decision analysis, analysis of the operating characteristics of diagnostic tests, development and validation of disease-specific health status measurements, predictive modeling, and technology assessment. A particular theme has been to develop methods to allow patients greater participation in their medical decisions, and to measure the impact of that involvement. The results of this work have had a direct impact on the treatment of prostatic diseases in the United States and worldwide.

Publications

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  • Barry MJ, Nelson JB. Patients Present with More Advanced Prostate Cancer since the USPSTF Screening Recommendations. J Urol 2015. PubMed
  • Barry MJ, Hayes JH. Evaluating an Elevated Screening PSA Test. JAMA 2015; 314:2073-4. PubMed
  • Barry MJ, Wexler RM, Brackett CD, Sepucha KR, Simmons LH, Gerstein BS, Stringfellow VL, Fowler FJ. Responses to a Decision Aid on Prostate Cancer Screening in Primary Care Practices. Am J Prev Med 2015. PubMed
  • El-Jawahri A, Mitchell SL, Paasche-Orlow MK, Temel JS, Jackson VA, Rutledge RR, Parikh M, Davis AD, Gillick MR, Barry MJ, Lopez L, Walker-Corkery ES, Chang Y, Finn K, Coley C, Volandes AE. A Randomized Controlled Trial of a CPR and Intubation Video Decision Support Tool for Hospitalized Patients. J Gen Intern Med 2015. PubMed
  • Hoffman RM, Koyama T, Albertsen PC, Barry MJ, Daskivich TJ, Goodman M, Hamilton AS, Stanford JL, Stroup AM, Potosky AL, Penson DF. Self-Reported Health Status Predicts Other-Cause Mortality in Men with Localized Prostate Cancer: Results from the Prostate Cancer Outcomes Study. J Gen Intern Med 2015. PubMed
  • Barry MJ. A Shared Decision-making Intervention: Success or Failure? Anesthesiology 2015. PubMed
  • Barry MJ. Incidentaloma fatigue. JAMA Intern Med 2014. PubMed
  • Hoffman RM, Penson DF, Zietman AL, Barry MJ. Comparative effectiveness research in localized prostate cancer treatment. J Comp Eff Res 2013; 2:583-93. PubMed
  • Hayes JH, Barry MJ, McMahon PM. Observation versus initial treatment for prostate cancer. Ann Intern Med 2013; 159:574. PubMed
  • Carter HB, Albertsen PC, Barry MJ, Etzioni R, Freedland SJ, Greene KL, Holmberg L, Kantoff P, Konety BR, Murad MH, Penson DF, Zietman AL. Early detection of prostate cancer: AUA Guideline. J Urol 2013. PubMed
  • Hayes JH, Ollendorf DA, Pearson SD, Barry MJ, Kantoff PW, Lee PA, McMahon PM. Observation versus initial treatment for men with localized, low-risk prostate cancer: a cost-effectiveness analysis. Ann Intern Med 2013; 158:853-60. PubMed
  • Qaseem A, Barry MJ, Denberg TD, Owens DK, Shekelle P, . Screening for prostate cancer: a guidance statement from the Clinical Guidelines Committee of the American College of Physicians. Ann Intern Med 2013. PubMed
  • Hoffman RM, Koyama T, Fan KH, Albertsen PC, Barry MJ, Goodman M, Hamilton AS, Potosky AL, Stanford JL, Stroup AM, Penson DF. Mortality after radical prostatectomy or external beam radiotherapy for localized prostate cancer. Journal of the National Cancer Institute 2013. PubMed
  • Barry MJ, Cantor A, Roehrborn CG, . Relationships among participant international prostate symptom score, benign prostatic hyperplasia impact index changes and global ratings of change in a trial of phytotherapy in men with lower urinary tract symptoms. J Urol 2013. PubMed
  • Volandes AE, Paasche-Orlow MK, Mitchell SL, El-Jawahri A, Davis AD, Barry MJ, Hartshorn KL, Jackson VA, Gillick MR, Walker-Corkery ES, Chang Y, L√≥pez L, Kemeny M, Bulone L, Mann E, Misra S, Peachey M, Abbo ED, Eichler AF, Epstein AS, Noy A, Levin TT, Temel JS. Randomized controlled trial of a video decision support tool for cardiopulmonary resuscitation decision making in advanced cancer. J Clin Oncol 2013; 31:380-6. PubMed
  • Barry MJ, Andriole GL, Culkin DJ, Fox SH, Jones KM, Carlyle MH, Wilt TJ. Ascertaining cause of death among men in the prostate cancer intervention versus observation trial. Clin Trials 2013; 10:907-14. PubMed
  • Atlas SJ, Ashburner JM, Chang Y, Lester WT, Barry MJ, Grant RW. Population-based breast cancer screening in a primary care network. Am J Manag Care 2013; 18:821-9. PubMed
  • Hoffman RM, Barry MJ, Roberts RG, Sox HC. Reconciling primary care and specialist perspectives on prostate cancer screening. Ann Fam Med 2012; 10:568-71. PubMed
  • Wilt TJ, Brawer MK, Jones KM, Barry MJ, Aronson WJ, Fox S, Gingrich JR, Wei JT, Gilhooly P, Grob BM, Nsouli I, Iyer P, Cartagena R, Snider G, Roehrborn C, Sharifi R, Blank W, Pandya P, Andriole GL, Culkin D, Wheeler T, . Radical prostatectomy versus observation for localized prostate cancer. N Engl J Med 2012; 367:203-13. PubMed
  • Hoffman RM, Roberts RG, Barry MJ. Battling prostate cancer with 5-alpha-reductase inhibitors: a pyrrhic victory? J Gen Intern Med 2011. PubMed
  • McVary KT, Roehrborn CG, Avins AL, Barry MJ, Bruskewitz RC, Donnell RF, Foster HE, Gonzalez CM, Kaplan SA, Penson DF, Ulchaker JC, Wei JT. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol 2011. PubMed
  • Hayes JH, Ollendorf DA, Pearson SD, Barry MJ, Kantoff PW, Stewart ST, Bhatnagar V, Sweeney CJ, Stahl JE, McMahon PM. Active surveillance compared with initial treatment for men with low-risk prostate cancer: a decision analysis. JAMA 2010; 304:2373-80. PubMed
  • Atlas SJ, Grant RW, Lester WT, Ashburner JM, Chang Y, Barry MJ, Chueh HC. A Cluster-Randomized Trial of a Primary Care Informatics-Based System for Breast Cancer Screening. J Gen Intern Med 2010. PubMed
  • Lee CN, Dominik R, Levin CA, Barry MJ, Cosenza C, O'Connor AM, Mulley AG, Sepucha KR. Development of instruments to measure the quality of breast cancer treatment decisions. Health Expect 2010; 13:258-72. PubMed
  • Barry MJ. The prostate cancer treatment bazaar: comment on "physician visits prior to treatment for clinically localized prostate cancer". Arch Intern Med 2010; 170:450-2. PubMed
  • Barry MJ, Schroeder AA. Cavernous sinus syndrome secondary to pituitary adenoma: A case report. Ear Nose Throat J 2010; 89:E1-3. PubMed
  • El-Jawahri A, Podgurski LM, Eichler AF, Plotkin SR, Temel JS, Mitchell SL, Chang Y, Barry MJ, Volandes AE. Use of video to facilitate end-of-life discussions with patients with cancer: a randomized controlled trial. J Clin Oncol 2010; 28:305-10. PubMed
  • Sepucha KR, Barry MJ. Making patient-centered cancer care a reality. Cancer 2009; 115:5610-1. PubMed
  • Hu JC, Gu X, Lipsitz SR, Barry MJ, D'Amico AV, Weinberg AC, Keating NL. Comparative effectiveness of minimally invasive vs open radical prostatectomy. JAMA 2009; 302:1557-64. PubMed
  • Hoffman RM, Couper MP, Zikmund-Fisher BJ, Levin CA, McNaughton-Collins M, Helitzer DL, VanHoewyk J, Barry MJ. Prostate cancer screening decisions: results from the National Survey of Medical Decisions (DECISIONS study). Arch Intern Med 2009; 169:1611-8. PubMed
  • Lu-Yao GL, Albertsen PC, Moore DF, Shih W, Lin Y, DiPaola RS, Barry MJ, Zietman A, O'Leary M, Walker-Corkery E, Yao SL. Outcomes of localized prostate cancer following conservative management. JAMA 2009; 302:1202-9. PubMed
  • Dahl DM, Barry MJ, McGovern FJ, Chang Y, Walker-Corkery E, McDougal WS. A prospective study of symptom distress and return to baseline function after open versus laparoscopic radical prostatectomy. J Urol 2009; 182:956-65. PubMed
  • Kilbridge KL,Fraser G,Krahn M,Nelson EM,Conaway M,Bashore R,Wolf A,Barry MJ,Gong DA,Nease RF Jr,Connors AF. Lack of comprehension of common prostate cancer terms in an underserved population. J Clin Oncol 2009; 27:2015-21. PubMed
  • Barry MJ. Screening for prostate cancer--the controversy that refuses to die. N Engl J Med 2009; 360:1351-4. PubMed
  • Barry MJ,Mulley AJ Jr. Why are a high overdiagnosis probability and a long lead time for prostate cancer screening so important? Journal of the National Cancer Institute 2009; 101:362-3. PubMed
  • Lester WT,Ashburner JM,Grant RW,Chueh HC,Barry MJ,Atlas SJ. Mammography FastTrack: an intervention to facilitate reminders for breast cancer screening across a heterogeneous multi-clinic primary care network. J Am Med Inform Assoc 2008; 16:187-95. PubMed
  • Wilt TJ,Brawer MK,Barry MJ,Jones KM,Kwon Y,Gingrich JR,Aronson WJ,Nsouli I,Iyer P,Cartagena R,Snider G,Roehrborn C,Fox S. The Prostate cancer Intervention Versus Observation Trial:VA/NCI/AHRQ Cooperative Studies Program #407 (PIVOT): design and baseline results of a randomized controlled trial comparing radical prostatectomy to watchful waiting for men with clinically locali Contemp Clin Trials 2008; 30:81-7. PubMed
  • Barry MJ. Screening for prostate cancer among men 75 years of age or older. N Engl J Med 2008; 359:2515-6. PubMed
  • Sepucha KR,Levin CA,Uzogara EE,Barry MJ,O'Connor AM,Mulley AG. Developing instruments to measure the quality of decisions: early results for a set of symptom-driven decisions. Patient Educ Couns 2008; 73:504-10. PubMed
  • Lu-Yao G,Albertsen PC,Stanford JL,Stukel TA,Walker-Corkery E,Barry MJ. Screening, treatment, and prostate cancer mortality in the Seattle area and Connecticut: fifteen-year follow-up. J Gen Intern Med 2008; 23:1809-14. PubMed
  • Barry MJ. Editorial Comment on: Poor Overall Survival in Septa- and Octogenarian Patients after Radical Prostatectomy and Radiotherapy for Prostate Cancer: A Population-Based Study of 6183 Men. Eur Urol 2008; 54:116-7. PubMed
  • Barry MJ,Wescott PH,Reifler EJ,Chang Y,Moulton BW. Reactions of potential jurors to a hypothetical malpractice suit: alleging failure to perform a prostate-specific antigen test. J Law Med Ethics 2008; 36:396-402, 214. PubMed
  • Barry MJ,Kaufman DS,Wu CL. Case records of the Massachusetts General Hospital. Case 15-2008. A 55-year-old man with an elevated prostate-specific antigen level and early-stage prostate cancer. N Engl J Med 2008; 358:2161-8. PubMed
  • Barry MJ. Commentary: how serious is getting a diagnosis of prostate cancer? Oncologist 2008; 13:306-8. PubMed
  • Barry MJ, Link CL, McNaughton-Collins MF, McKinlay JB. Overlap of different urological symptom complexes in a racially and ethnically diverse, community-based population of men and women. BJU Int 2007; 101:45-51. PubMed
  • Hu JC, Link CL, McNaughton-Collins M, Barry MJ, McKinlay JB. The association of abuse and symptoms suggestive of chronic prostatitis/chronic pelvic pain syndrome: results from the Boston Area Community Health survey. J Gen Intern Med 2007; 22:1532-7. PubMed
  • Welch HG, Fisher ES, Gottlieb DJ, Barry MJ. Detection of prostate cancer via biopsy in the Medicare-SEER population during the PSA era. Journal of the National Cancer Institute 2007; 99:1395-400. PubMed
  • Hofherr SE, Mok H, Gushiken FC, Lopez JA, Barry MA. Polyethylene glycol modification of adenovirus reduces platelet activation, endothelial cell activation, and thrombocytopenia. Hum Gene Ther 2007; 18:837-48. PubMed
  • Barnato AE, Llewellyn-Thomas HA, Peters EM, Siminoff L, Collins ED, Barry MJ. Communication and decision making in cancer care: setting research priorities for decision support/patients' decision aids. Med Decis Making 2007; 27:626-34. PubMed
  • O'Connor AM, Bennett C, Stacey D, Barry MJ, Col NF, Eden KB, Entwistle V, Fiset V, Holmes-Rovner M, Khangura S, Llewellyn-Thomas H, Rovner DR. Do patient decision aids meet effectiveness criteria of the international patient decision aid standards collaboration? A systematic review and meta-analysis. Med Decis Making 2007; 27:554-74. PubMed
  • Hayes JH, Barry MJ, Kantoff PW, Stahl JE. Prostate-specific antigen screening for prostate cancer: a decision-analytical perspective. BJU Int 2007; 100:486-8. PubMed
  • Kawachi MH, Bahnson RR, Barry M, Carroll PR, Carter HB, Catalona WJ, Epstein JI, Etzioni RB, Hemstreet GP 3rd, Howe RJ, Kopin JD, Lange PH, Lilja H, Mohler J, Moul J, Nadler RB, Patterson S, Pollack A, Presti JC, Stroup AM, Urban DA, Wake R, Wei JT. Prostate cancer early detection. Clinical practice guidelines in oncology. J Natl Compr Canc Netw 2007; 5:714-36. PubMed
  • Lu-Yao GL, Barry MJ, Albertsen PC, Yao SL. Outcomes of treatment vs observation of localized prostate cancer in elderly men. JAMA 2007; 297:1651; author reply 1652-3. PubMed
  • Barry MJ. Review: evidence from 2 low quality screening studies does not show a reduction in death from prostate cancer. Evid Based Med 2007; 12:40. PubMed
  • D'Amico AV, Barry MJ. Prostate cancer prevention and finasteride. J Urol 2006; 176:2010-2; discussion 2012-3. PubMed
  • Barry MJ, Delorenzo MA, Walker-Corkery ES, Lucas FL, Wennberg DC. The rising prevalence of androgen deprivation among older American men since the advent of prostate-specific antigen testing: a population-based cohort study. BJU Int 2006; 98:973-8. PubMed
  • Rodearmel SJ, Wyatt HR, Barry MJ, Dong F, Pan D, Israel RG, Cho SS, McBurney MI, Hill JO. A family-based approach to preventing excessive weight gain. Obesity (Silver Spring) 2006; 14:1392-401. PubMed
  • Fowler FJ, Barry MJ, Walker-Corkery B, Caubet JF, Bates DW, Lee JM, Hauser A, McNaughton-Collins M. The impact of a suspicious prostate biopsy on patients' psychological, socio-behavioral, and medical care outcomes. J Gen Intern Med 2006; 21:715-21. PubMed
  • Hoffman RM, Barry MJ, Stanford JL, Hamilton AS, Hunt WC, Collins MM. Health outcomes in older men with localized prostate cancer: results from the Prostate Cancer Outcomes Study. Am J Med 2006; 119:418-25. PubMed
  • Chan EC, Barry MJ, Vernon SW, Ahn C. Brief report: physicians and their personal prostate cancer-screening practices with prostate-specific antigen. A national survey. J Gen Intern Med 2006; 21:257-9. PubMed
  • Chan EC, Barry MJ, Vernon SW, Ahn C. BRIEF REPORT: Physicians and Their Personal Prostate Cancer-screening Practices with Prostate-specific Antigen. J Gen Intern Med 2006. PubMed
  • Barry MJ. The PSA Conundrum. Arch Intern Med 2006; 166:7-8. PubMed
  • Volandes AE, Barry MJ, Chang Y, Paasche-Orlow MK. Improving decision making at the end of life with video images. Med Decis Making 2010; 30:29-34. PubMed
  • Hoffman RM, Lewis CL, Pignone MP, Couper MP, Barry MJ, Elmore JG, Levin CA, Van Hoewyk J, Zikmund-Fisher BJ. Decision-making processes for breast, colorectal, and prostate cancer screening: the DECISIONS survey. Med Decis Making 2010; 30:53S-64S. PubMed
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