Photo of Michaela Higgins,  MB BCh

Michaela Higgins, MB BCh

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-4920
Fax: (617) 643-0589


mjhiggins@partners.org

Michaela Higgins, MB BCh

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Assistant Physician, Hematology/Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Higgins is a clinical researcher with a focus on the use of novel therapies for the treatment of early and advanced breast cancer. She has a clinic in Yawkey, Massachusetts General Hospital and is also involved with teaching of DF/HCC Medical Oncology Fellows. Dr. Higgins is a member of the American Society of Clinical Oncology Cancer Prevention and Epidemiology Scientific Committee.

Publications

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  • Sarangi S, Mosulpuria K, Higgins MJ, Bardia A. The Evolving Role of Circulating Tumor Cells in the Personalized Management of Breast Cancer: from Enumeration to Molecular Characterization. Curr Breast Cancer Rep 2014; 6:146-153. PubMed
  • Fathi AT, Sadrzadeh H, Comander AH, Higgins MJ, Bardia A, Perry A, Burke M, Silver R, Matulis CR, Straley KS, Yen KE, Agresta S, Kim H, Schenkein DP, Borger DR. Isocitrate Dehydrogenase 1 (IDH1) Mutation in Breast Adenocarcinoma Is Associated With Elevated Levels of Serum and Urine 2-Hydroxyglutarate. Oncologist 2014. PubMed
  • Beaver JA, Jelovac D, Balukrishna S, Cochran R, Croessmann S, Zabransky D, Wong HY, Valda Toro P, Cidado J, Blair BG, Chu D, Burns TF, Higgins MJ, Stearns V, Jacobs LK, Habibi M, Lange JR, Hurley PJ, Lauring J, Vandenberg D, Kessler J, Jeter SC, Samuels M, Maar D, Cope L, Cimino-Mathews A, Argani P, Wolff AC, Park BH. Detection of Cancer DNA in Plasma of Early Stage Breast Cancer Patients. Clin Cancer Res 2014. PubMed
  • Reynolds KL, Higgins MJ. Endocrine therapy for breast cancer: a tough pill to swallow. Menopause 2013; 20:714-6. PubMed
  • Higgins MJ, Liedke PE, Goss PE. Extended adjuvant endocrine therapy in hormone dependent breast cancer: The paradigm of the NCIC-CTG MA.17/BIG 1-97 trial. Crit Rev Oncol Hematol 2012. PubMed
  • Higgins MJ, Stearns V. Pharmacogenetics of endocrine therapy for breast cancer. Annu Rev Med 2011; 62:281-93. PubMed
  • Higgins MJ, Beaver JA, Wong HY, Gustin JP, Lauring JD, Garay JP, Konishi H, Mohseni M, Wang GM, Cidado J, Jelovac D, Cosgrove DP, Tamaki A, Abukhdeir AM, Park BH. PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells. Cancer Biol Ther 2011; 11:358-67. PubMed
  • Higgins MJ, Baselga J. Breast cancer in 2010: Novel targets and therapies for a personalized approach. Nat Rev Clin Oncol 2011; 8:65-6. PubMed
  • Higgins MJ, Wolff AC. The androgen receptor in breast cancer: learning from the past. Breast Cancer Res Treat 2010; 124:619-21. PubMed
  • Higgins MJ, Stearns V. CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep 2010; 12:7-15. PubMed
  • Higgins MJ, Ettinger DS. Chemotherapy for lung cancer: the state of the art in 2009. Expert Rev Anticancer Ther 2009; 9:1365-78. PubMed
  • Higgins MJ, Stearns V. Understanding resistance to tamoxifen in hormone receptor-positive breast cancer. Clin Chem 2009; 55:1453-5. PubMed
  • Higgins MJ, Park BH. Expanding role of bisphosphonates in the management of early breast cancer. Expert Rev Anticancer Ther 2009; 9:1051-4. PubMed
  • Higgins MJ, Forastiere A, Marur S. New directions in the systemic treatment of metastatic thyroid cancer. Oncology (Huntingt) 2009; 23:768-75. PubMed
  • Gustin JP, Karakas B, Weiss MB, Abukhdeir AM, Lauring J, Garay JP, Cosgrove D, Tamaki A, Konishi H, Konishi Y, Mohseni M, Wang G, Rosen DM, Denmeade SR, Higgins MJ, Vitolo MI, Bachman KE, Park BH. Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proc Natl Acad Sci U S A 2009; 106:2835-40. PubMed
  • Higgins MJ, Rae JM, Flockhart DA, Hayes DF, Stearns V. Pharmacogenetics of tamoxifen: who should undergo CYP2D6 genetic testing? J Natl Compr Canc Netw 2009; 7:203-13. PubMed
  • Higgins MJ, Davidson NE. What is the current status of ovarian suppression/ablation in women with premenopausal early-stage breast cancer? Curr Oncol Rep 2008; 11:45-50. PubMed
  • Higgins MJ, Wolf AC. Adjuvant endocrine therapy for premenopausal hormone receptor-positive breast cancer; much done, more to do. Oncology (Huntingt) 2009; 23:40, 42, 44. PubMed
  • Higgins MJ, Wolff AC. Therapeutic options in the management of metastatic breast cancer. Oncology (Huntingt) 2008; 22:614-23; discussion 623, 627-9. PubMed
  • Lee KS, Higgins MJ, Patel BM, Larson JS, Rady MY. Paraneoplastic coma and acquired central alveolar hypoventilation as a manifestation of brainstem encephalitis in a patient with ANNA-1 antibody and small-cell lung cancer. Neurocrit Care 2006; 4:137-9. PubMed
  • Higgins MJ, Fonseca R. Genetics of multiple myeloma. Best Pract Res Clin Haematol 2005; 18:525-36. PubMed
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