Photo of Milton C. Weinstein,  PhD

Milton C. Weinstein, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-0805
Fax: (617) 432-0190

Milton C. Weinstein, PhD

Harvard T.H. Chan School Of Public Health


  • Henry J. Kaiser Professor, Health Policy and Management, Harvard T.H. Chan School Of Public Health


Research Abstract

My research concerns allocation of health resources and the use of analytical tools to guide resource allocation decisions. My current work relating to cancer includes the following:

I do methodologic research on cost-effectiveness, decision modeling and preference assessment for economic evaluation of medical and public health interventions.

My research on HIV and HCV policy modeling involves costs and outcomes of associated cancers.

I am collaborating on a study of costs and outcomes for thyroid cancer, with Dr. Carrie Lubitz, M.D. (MGH/HMS).

I participate as a faculty advisor in the Program on Cancer Outcomes Research Training, in which capacity I supervise PhD students and post-doctoral fellows.


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  • Jönsson L, Sandin R, Ekman M, Ramsberg J, Charbonneau C, Huang X, Jönsson B, Weinstein MC, Drummond M. Analyzing overall survival in randomized controlled trials with crossover and implications for economic evaluation. Value Health 2014; 17:707-13. PubMed
  • Fust K, Li X, Maschio M, Barron R, Weinstein MC, Parthan A, Walli-Attaei M, Chandler DB, Lyman GH. Cost-effectiveness of prophylaxis treatment strategies for febrile neutropenia in patients with recurrent ovarian cancer. Gynecol Oncol 2014. PubMed
  • Lubitz CC, Kong CY, McMahon PM, Daniels GH, Chen Y, Economopoulos KP, Gazelle GS, Weinstein MC. Annual financial impact of well-differentiated thyroid cancer care in the United States. Cancer 2014; 120:1345-52. PubMed
  • Hill G, Barron R, Fust K, Skornicki ME, Taylor DC, Weinstein MC, Lyman GH. Primary vs secondary prophylaxis with pegfilgrastim for the reduction of febrile neutropenia risk in patients receiving chemotherapy for non-Hodgkin's lymphoma: cost-effectiveness analyses. J Med Econ 2013; 17:32-42. PubMed
  • Lawrence D, Maschio M, Leahy KJ, Yunger S, Easaw JC, Weinstein MC. Economic analysis of bevacizumab, cetuximab, and panitumumab with fluoropyrimidine-based chemotherapy in the first-line treatment of KRAS wild-type metastatic colorectal cancer (mCRC). J Med Econ 2013; 16:1387-98. PubMed
  • McMahon PM, Kong CY, Johnson BE, Weinstein MC, Weeks JC, Tramontano AC, Cipriano LE, Bouzan C, Gazelle GS. Chapter 9: The MGH-HMS lung cancer policy model: tobacco control versus screening. Risk Anal 2012; 32 Suppl 1:S117-24. PubMed
  • Taylor DC, Pawar V, Kruzikas D, Gilmore KE, Pandya A, Iskandar R, Weinstein MC. Methods of model calibration: observations from a mathematical model of cervical cancer. 2010; 28:995-1000. PubMed
  • Groot Koerkamp B, Stijnen T, Weinstein MC, Hunink MG. The Combined Analysis of Uncertainty and Patient Heterogeneity in Medical Decision Models. Med Decis Making 2010. PubMed
  • Neumann PJ, Weinstein MC. Legislating against use of cost-effectiveness information. N Engl J Med 2010; 363:1495-7. PubMed
  • Weinstein MC, Skinner JA. Comparative effectiveness and health care spending--implications for reform. N Engl J Med 2010; 362:460-5. PubMed
  • Ladapo JA, Jaffer FA, Hoffmann U, Thomson CC, Bamberg F, Dec W, Cutler DM, Weinstein MC, Gazelle GS. Clinical outcomes and cost-effectiveness of coronary computed tomography angiography in the evaluation of patients with chest pain. J Am Coll Cardiol 2010; 54:2409-22. PubMed
  • Bentley TG,Weinstein MC,Willett WC,Kuntz KM. A cost-effectiveness analysis of folic acid fortification policy in the United States. Public Health Nutr 2008; 12:455-67. PubMed
  • O'Sullivan AK, Pandya A, Papadopoulos G, Thompson D, Langston A, Perfect J, Weinstein MC. Cost-Effectiveness of Posaconazole versus Fluconazole or Itraconazole in the Prevention of Invasive Fungal Infections among Neutropenic Patients in the United States. Value Health 2009. PubMed
  • Ruger JP, Emmons KM, Kearney MH, Weinstein MC. Measuring the costs of outreach motivational interviewing for smoking cessation and relapse prevention among low-income pregnant women. BMC Pregnancy Childbirth 2009; 9:46. PubMed
  • O'Sullivan AK,Thompson D,Chu P,Lee DW,Stewart EA,Weinstein MC. Cost-effectiveness of magnetic resonance guided focused ultrasound for the treatment of uterine fibroids. Int J Technol Assess Health Care 2009; 25:14-25. PubMed
  • McMahon PM, Kong CY, Weinstein MC, Tramontano AC, Cipriano LE, Johnson BE, Weeks JC, Gazelle GS. Adopting helical CT screening for lung cancer : potential health consequences during a 15-year period. Cancer 2008; 113:3440-9. PubMed
  • Ciaranello AL,Seage GR 3rd,Freedberg KA,Weinstein MC,Lockman S,Walensky RP. Antiretroviral drugs for preventing mother-to-child transmission of HIV in sub-Saharan Africa: balancing efficacy and infant toxicity. AIDS 2008; 22:2359-69. PubMed
  • Walensky RP,Freedberg KA,Weinstein MC. Monitoring of antiretroviral therapy in low-resource settings. Lancet 2008; 372:288; author reply 289. PubMed
  • McMahon PM, Kong CY, Johnson BE, Weinstein MC, Weeks JC, Kuntz KM, Shepard JA, Swensen SJ, Gazelle GS. Estimating Long-term Effectiveness of Lung Cancer Screening in the Mayo CT Screening Study. Radiology 2008; 248:278-87. PubMed
  • Weinstein MC. How much are Americans willing to pay for a quality-adjusted life year? Med Care 2008; 46:343-5. PubMed
  • Ruger JP, Weinstein MC, Hammond SK, Kearney MH, Emmons KM. Cost-effectiveness of motivational interviewing for smoking cessation and relapse prevention among low-income pregnant women: a randomized controlled trial. Value Health 2007; 11:191-8. PubMed
  • Stokes ME, Thompson D, Montoya EL, Weinstein MC, Winer EP, Earle CC. Ten-year survival and cost following breast cancer recurrence: estimates from SEER-medicare data. Value Health 2008; 11:213-20. PubMed
  • Lee JM, Kopans DB, McMahon PM, Halpern EF, Ryan PD, Weinstein MC, Gazelle GS. Breast cancer screening in BRCA1 mutation carriers: effectiveness of MR imaging--Markov Monte Carlo decision analysis. Radiology 2008; 246:763-71. PubMed
  • Cohen JT, Neumann PJ, Weinstein MC. Does preventive care save money? Health economics and the presidential candidates. N Engl J Med 2008; 358:661-3. PubMed
  • Chan DC, Heidenreich PA, Weinstein MC, Fonarow GC. Heart failure disease management programs: a cost-effectiveness analysis. Am Heart J 2008; 155:332-8. PubMed
  • Walensky RP, Freedberg KA, Weinstein MC, Paltiel AD. Cost-effectiveness of HIV testing and treatment in the United States. Clin Infect Dis 2008; 45 Suppl 4:S248-54. PubMed
  • Schackman BR, Scott CA, Sax PE, Losina E, Wilkin TJ, McKinnon JE, Swindells S, Weinstein MC, Freedberg KA. Potential risks and benefits of HIV treatment simplification: a simulation model of a proposed clinical trial. Clin Infect Dis 2007; 45:1062-70. PubMed
  • Yazdanpanah Y, Vray M, Meynard J, Losina E, Weinstein MC, Morand-Joubert L, Goldie SJ, Hsu HE, Walensky RP, Dalban C, Sax PE, Girard PM, Freedberg KA. The long-term benefits of genotypic resistance testing in patients with extensive prior antiretroviral therapy: a model-based approach. HIV Med 2007; 8:439-50. PubMed
  • Thompson D, Taylor DC, Montoya EL, Winer EP, Jones SE, Weinstein MC. Cost-effectiveness of switching to exemestane after 2 to 3 years of therapy with tamoxifen in postmenopausal women with early-stage breast cancer. Value Health 2007; 10:367-76. PubMed
  • Freedberg KA, Kumarasamy N, Losina E, Cecelia AJ, Scott CA, Divi N, Flanigan TP, Lu Z, Weinstein MC, Wang B, Ganesh AK, Bender MA, Mayer KH, Walensky RP. Clinical impact and cost-effectiveness of antiretroviral therapy in India: starting criteria and second-line therapy. AIDS 2007; 21 Suppl 4:S117-28. PubMed
  • Walensky RP, Weinstein MC, Yazdanpanah Y, Losina E, Mercincavage LM, Tour. HIV drug resistance surveillance for prioritizing treatment in resource-limited settings. AIDS 2007; 21:973-82. PubMed
  • McCormick AW, Walensky RP, Lipsitch M, Losina E, Hsu H, Weinstein MC, Paltiel AD, Freedberg KA, Seage GR. The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with men. Clin Infect Dis 2007; 44:1115-22. PubMed
  • Aball. Cost-effectiveness analysis of oxaliplatin compared with 5-fluorouracil/leucovorin in adjuvant treatment of stage III colon cancer in the US. Cancer 2007; 109:1082-9. PubMed
  • Groot Koerkamp B, Hunink MG, Stijnen T, Hammitt JK, Kuntz KM, Weinstein MC. Limitations of acceptability curves for presenting uncertainty in cost-effectiveness analysis. Med Decis Making 2007; 27:101-11. PubMed
  • Paltiel AD, Walensky RP, Schackman BR, Seage GR, Mercincavage LM, Weinstein MC, Freedberg KA. Expanded HIV screening in the United States: effect on clinical outcomes, HIV transmission, and costs. Ann Intern Med 2006; 145:797-806. PubMed
  • Freedberg KA, Hirschhorn LR, Schackman BR, Wolf LL, Martin LA, Weinstein MC, Goldin S, Paltiel AD, Katz C, Goldie SJ, Losina E. Cost-effectiveness of an intervention to improve adherence to antiretroviral therapy in HIV-infected patients. J Acquir Immune Defic Syndr 2006; 43 Suppl 1:S113-8. PubMed
  • Schackman BR, Gebo KA, Walensky RP, Losina E, Muccio T, Sax PE, Weinstein MC, Seage GR, Moore RD, Freedberg KA. The lifetime cost of current human immunodeficiency virus care in the United States. Med Care 2006; 44:990-7. PubMed
  • Kim JJ, Salomon JA, Weinstein MC, Goldie SJ. Packaging health services when resources are limited: the example of a cervical cancer screening visit. PLoS Med 2006; 3:e434. PubMed
  • Bentley TG, Willett WC, Weinstein MC, Kuntz KM. Population-level changes in folate intake by age, gender, and race/ethnicity after folic acid fortification. Am J Public Health 2006; 96:2040-7. PubMed
  • Goldie SJ, Yazdanpanah Y, Losina E, Weinstein MC, Anglaret X, Walensky RP, Hsu HE, Kimmel A, Holmes C, Kaplan JE, Freedberg KA. Cost-effectiveness of HIV treatment in resource-poor settings--the case of Ce d'Ivoire. N Engl J Med 2006; 355:1141-53. PubMed
  • McMahon PM, Zaslavsky AM, Weinstein MC, Kuntz KM, Weeks JC, Gazelle GS. Estimation of mortality rates for disease simulation models using Bayesian evidence synthesis. Med Decis Making 2006; 26:497-511. PubMed
  • Gaziano TA, Opie LH, Weinstein MC. Cardiovascular disease prevention with a multidrug regimen in the developing world: a cost-effectiveness analysis. Lancet 2006; 368:679-86. PubMed
  • Walensky RP, Paltiel AD, Losina E, Mercincavage LM, Schackman BR, Sax PE, Weinstein MC, Freedberg KA. The survival benefits of AIDS treatment in the United States. J Infect Dis 2006; 194:11-9. PubMed
  • Resch SC, Salomon JA, Murray M, Weinstein MC. Cost-effectiveness of treating multidrug-resistant tuberculosis. PLoS Med 2006; 3:e241. PubMed
  • Kim SY, Billah K, Lieu TA, Weinstein MC. Cost effectiveness of hepatitis B vaccination at HIV counseling and testing sites. Am J Prev Med 2006; 30:498-506. PubMed
  • Losina E, Anglaret X, Yazdanpanah Y, Wang B, Toure S, Seage GR, N'Dri-Yoman T, Walensky RP, Dakoury-Dogbo N, Goldie SJ, Messou E, Weinstein MC, Deuffic-Burban S, Salamon R, Freedberg KA. Impact of opportunistic diseases on chronic mortality in HIV-infected adults in Ce d'Ivoire. S Afr Med J 2006; 96:526-9. PubMed
  • Groot Koerkamp B, Myriam Hunink MG, Stijnen T, Weinstein MC. Identifying key parameters in cost-effectiveness analysis using value of information: a comparison of methods. Health Econ 2006; 15:383-92. PubMed
  • Zupancic JA, Richardson DK, O'Brien BJ, Cronin CG, Schmidt B, Roberts R, Weinstein MC,. Retrospective economic evaluation of a controlled trial of indomethacin prophylaxis for patent ductus arteriosus in premature infants. Early Hum Dev 2006; 82:97-103. PubMed
  • Weinstein MC. Recent developments in decision-analytic modelling for economic evaluation. Pharmacoeconomics 2006; 24:1043-53. PubMed
  • Neumann PJ, Lin PJ, Greenberg D, Berger M, Teutsch S, Mansley E, Weinstein MC, Rosen AB. Do drug formulary policies reflect evidence of value? Am J Manag Care 2006; 12:30-6. PubMed
  • Schackman BR, Freedberg KA, Goldie SJ, Weinstein MC, Swartz K. Budget impact of Medicaid Section 1115 demonstrations for early HIV treatment. Health Care Financ Rev 2007; 26:67-80. PubMed
  • Bentley TG, Weinstein MC, Kuntz KM. Effects of categorizing continuous variables in decision-analytic models. Med Decis Making 2009; 29:549-56. PubMed
  • Groot Koerkamp B, Weinstein MC, Stijnen T, Heijenbrok-Kal MH, Hunink MG. Uncertainty and Patient Heterogeneity in Medical Decision Models. Med Decis Making 2010; 30:194-205. PubMed
  • Ladapo JA, Horwitz JR, Weinstein MC, Gazelle GS, Cutler DM. Adoption and spread of new imaging technology: a case study. Health Aff (Millwood) 2009; 28:w1122-32. PubMed