Photo of Mizuki Nishino,  MD

Mizuki Nishino, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute

Mizuki Nishino, MD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Staff Radiologist, Radiology, Dana-Farber Cancer Institute
  • Staff Radiologist, Radiology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am an Associate Professor of Radiology at Harvard Medical School and staff radiologist at the Department of Radiology at Brigham and Women’s Hospital and Dana-Farber Cancer Institute. I have been engaged in lung cancer imaging research, focusing on radiographic response assessment of lung cancer treated with molecular targeting therapy. My research is currently supported by K23 award from NIH. I am committed to continuing these efforts and making further contributions to fill the gap between radiology and oncology, and to move the field of cancer imaging forward.

Publications

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  • Nishino M, Tirumani SH, Ramaiya NH, Hodi FS. Cancer immunotherapy and immune-related response assessment: The role of radiologists in the new arena of cancer treatment. Eur J Radiol 2015; 84:1259-1268. PubMed
  • Tirumani SH, Ramaiya NH, Keraliya A, Bailey N, Ott PA, Hodi FS, Nishino M. Radiographic Profiling of Immune-related Adverse Events in Advanced Melanoma Patients Treated With Ipilimumab. Cancer Immunol Res 2015. PubMed
  • Shinagare AB, O'Neill AC, Cheng S, Somarouthu B, Tirumani SH, Nishino M, Van den Abbeele AD, Ramaiya NH. Advanced High-Grade Serous Ovarian Cancer: Frequency and Timing of Thoracic Metastases and the Implications for Chest Imaging Follow-up. Radiology 2015. PubMed
  • Fairchild A, Tirumani SH, Rosenthal MH, Howard SA, Krajewski KM, Nishino M, Shinagare AB, Jagannathan JP, Ramaiya NH. Hormonal therapy in oncology: a primer for the radiologist. AJR Am J Roentgenol 2015; 204:W620-30. PubMed
  • Sholl LM, Nishino M, Pokharel S, Mino-Kenudson M, French CA, Janne PA, Lathan C. Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. J Thorac Oncol 2015; 10:951-9. PubMed
  • Tirumani SH, Shinagare AB, O'Neill AC, Nishino M, Rosenthal MH, Ramaiya NH. Accuracy and feasibility of estimated tumour volumetry in primary gastric gastrointestinal stromal tumours: validation using semiautomated technique in 127 patients. Eur Radiol 2015. PubMed
  • Luke JJ, Donahue H, Nishino M, Giobbie-Hurder A, Davis M, Bailey N, Ott PA, Hodi FS. Single Institution Experience of Ipilimumab 3 mg/kg with Sargramostim (GM-CSF) in Metastatic Melanoma. Cancer Immunol Res 2015. PubMed
  • Lo PC, Dahlberg SE, Nishino M, Johnson BE, Sequist LV, Jackman DM, Jänne PA, Oxnard GR. Delay of treatment change after objective progression on first-line erlotinib in epidermal growth factor receptor-mutant lung cancer. Cancer 2015. PubMed
  • Krajewski KM, Nishino M, Ramaiya NH, Choueiri TK. RECIST 1.1 Compared With RECIST 1.0 in Patients With Advanced Renal Cell Carcinoma Receiving Vascular Endothelial Growth Factor-Targeted Therapy. AJR Am J Roentgenol 2015; 204:W282-8. PubMed
  • Nishino M, Cardarella S, Dahlberg SE, Araki T, Lydon C, Jackman DM, Rabin MS, Hatabu H, Johnson BE. Interstitial lung abnormalities in treatment-na誰ve advanced non-small-cell lung cancer patients are associated with shorter survival. Eur J Radiol 2015. PubMed
  • Chong CR, Wirth LJ, Nishino M, Chen AB, Sholl LM, Kulke MH, McNamee CJ, Jänne PA, Johnson BE. Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors. Lung Cancer 2014. PubMed
  • Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M. Thymic measurements in pathologically proven normal thymus and thymic hyperplasia: intraobserver and interobserver variabilities. Acad Radiol 2014; 21:733-42. PubMed
  • Krajewski KM, Franchetti Y, Nishino M, Fay AP, Ramaiya N, Van den Abbeele AD, Choueiri TK. 10% Tumor Diameter Shrinkage on the First Follow-Up Computed Tomography Predicts Clinical Outcome in Patients With Advanced Renal Cell Carcinoma Treated With Angiogenesis Inhibitors: A Follow-Up Validation Study. Oncologist 2014. PubMed
  • Nishino M, Hatabu H, Johnson BE, McLoud TC. State of the art: response assessment in lung cancer in the era of genomic medicine. Radiology 2014; 271:6-27. PubMed
  • Krajewski KM, Nishino M, Franchetti Y, Ramaiya NH, Van den Abbeele AD, Choueiri TK. Intraobserver and interobserver variability in computed tomography size and attenuation measurements in patients with renal cell carcinoma receiving antiangiogenic therapy: implications for alternative response criteria. Cancer 2014; 120:711-21. PubMed
  • Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M. Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. AJR Am J Roentgenol 2014; 202:471-8. PubMed
  • Nishino M, Gargano M, Suda M, Ramaiya NH, Hodi FS. Optimizing immune-related tumor response assessment: does reducing the number of lesions impact response assessment in melanoma patients treated with ipilimumab? J Immunother Cancer 2014; 2:17. PubMed
  • Nishino M, Giobbie-Hurder A, Ramaiya NH, Hodi FS. Response assessment in metastatic melanoma treated with ipilimumab and bevacizumab: CT tumor size and density as markers for response and outcome. J Immunother Cancer 2014; 2:40. PubMed
  • Cooley C, Nishino M, Jagannathan J, Ramaiya N, Di Salvo D, Krajewski KM. Clinical problem solving: utility of sonography in oncologic patients. J Ultrasound Med 2013; 33:9-22. PubMed
  • Nishino M, Dahlberg SE, Cardarella S, Jackman DM, Rabin MS, Ramaiya NH, Hatabu H, Jänne PA, Johnson BE. Volumetric tumor growth in advanced non-small cell lung cancer patients with EGFR mutations during EGFR-tyrosine kinase inhibitor therapy: developing criteria to continue therapy beyond RECIST progression. Cancer 2013; 119:3761-8. PubMed
  • Cardarella S, Ogino A, Nishino M, Butaney M, Shen J, Lydon C, Yeap BY, Sholl LM, Johnson BE, Jänne PA. Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. Clin Cancer Res 2013; 19:4532-40. PubMed
  • Nishino M, Dahlberg SE, Cardarella S, Jackman DM, Rabin MS, Hatabu H, Jänne PA, Johnson BE. Tumor volume decrease at 8 weeks is associated with longer survival in EGFR-mutant advanced non-small-cell lung cancer patients treated with EGFR TKI. J Thorac Oncol 2013; 8:1059-68. PubMed
  • Nishino M, Giobbie-Hurder A, Gargano M, Suda M, Ramaiya NH, Hodi FS. Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements. Clin Cancer Res 2013; 19:3936-43. PubMed
  • Nishino M, Cardarella S, Jackman DM, Ramaiya NH, Rabin MS, Hatabu H, Jänne PA, Johnson BE. RECIST 1.1 in NSCLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors: comparison with RECIST 1.0. AJR Am J Roentgenol 2013; 201:W64-71. PubMed
  • Nishino M, Cardarella S, Dahlberg SE, Jackman DM, Ramaiya NH, Hatabu H, Rabin MS, Jänne PA, Johnson BE. Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors. Lung Cancer 2013; 79:283-8. PubMed
  • Nishino M, Itoh H, Hatabu H. A practical approach to high-resolution CT of diffuse lung disease. Eur J Radiol 2013. PubMed
  • Oxnard GR, Lo PC, Nishino M, Dahlberg SE, Lindeman NI, Butaney M, Jackman DM, Johnson BE, Jänne PA. Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol 2013; 8:179-84. PubMed
  • Kamran SC, Shinagare AB, Howard SA, Nishino M, Hornick JL, Krajewski KM, Ramaiya NH. Intrathoracic malignant peripheral nerve sheath tumors: imaging features and implications for management. Radiol Oncol 2013; 47:230-8. PubMed
  • Shinagare AB, Okajima Y, Oxnard GR, Dipiro PJ, Johnson BE, Hatabu H, Nishino M. Unsuspected pulmonary embolism in lung cancer patients: Comparison of clinical characteristics and outcome with suspected pulmonary embolism. Lung Cancer 2012; 78:161-6. PubMed
  • Nishino M, Cryer SK, Okajima Y, Sholl LM, Hatabu H, Rabin MS, Jackman DM, Johnson BE. Tumoral cavitation in patients with non-small-cell lung cancer treated with antiangiogenic therapy using bevacizumab. Cancer Imaging 2012; 12:225-35. PubMed
  • Nishino M, Jackman DM, Hatabu H, Jänne PA, Johnson BE, Van den Abbeele AD. Imaging of lung cancer in the era of molecular medicine. Acad Radiol 2011; 18:424-36. PubMed
  • Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, . Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 2011; 364:897-906. PubMed
  • Shinagare AB, Guo M, Hatabu H, Krajewski KM, Andriole K, Van den Abbeele AD, Dipiro PJ, Nishino M. Incidence of pulmonary embolism in oncologic outpatients at a tertiary cancer center. Cancer 2011. PubMed
  • Nishino M, Guo M, Jackman DM, DiPiro PJ, Yap JT, Ho TK, Hatabu H, Jänne PA, Van den Abbeele AD, Johnson BE. CT tumor volume measurement in advanced non-small-cell lung cancer: Performance characteristics of an emerging clinical tool. Acad Radiol 2010; 18:54-62. PubMed
  • O'Regan KN, Nishino M, Armand P, Kelly PJ, Hwang DG, Di Salvo D. Sonographic features of pectoralis muscle necrosis secondary to gemcitabine-induced radiation recall: case report and review of current literature. J Ultrasound Med 2010; 29:1499-502. PubMed
  • Nishino M, Jackman DM, Hatabu H, Yeap BY, Cioffredi LA, Yap JT, Jänne PA, Johnson BE, Van den Abbeele AD. New Response Evaluation Criteria in Solid Tumors (RECIST) guidelines for advanced non-small cell lung cancer: comparison with original RECIST and impact on assessment of tumor response to targeted therapy. AJR Am J Roentgenol 2010; 195:W221-8. PubMed
  • Nishino M, Jagannathan JP, Ramaiya NH, Van den Abbeele AD. Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know. AJR Am J Roentgenol 2010; 195:281-9. PubMed
  • Nishino M, Patrick JL, Connors JM. Case 155: Lane-Hamilton syndrome. Radiology 2010; 254:985-8. PubMed
  • Nishino M, Washko GR, Hatabu H. Volumetric expiratory HRCT of the lung: clinical applications. Thorac Surg Clin 2010; 20:121-7, viii-ix. PubMed
  • Nishino M, Lee KS, Itoh H, Hatabu H. The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis. Eur J Radiol 2010; 73:66-73. PubMed
  • Nishino M, Washko GR, Hatabu H. Volumetric expiratory HRCT of the lung: clinical applications. Radiol Clin North Am 2009; 48:177-83. PubMed
  • Kido A, Togashi K, Nishino M, Miyake K, Koyama T, Fujimoto R, Iwasaku K, Fujii S, Hayakawa K. Cine MR imaging of uterine peristalsis in patients with endometriosis. Eur Radiol 2007; 17:1813-9. PubMed
  • Nishino M, Kubo T, Kataoka ML, Raptopoulos V, Hatabu H. Coronal reformations of the chest on 64-row multi-detector row CT: evaluation of image quality in comparison with 16-, 8- and 4-row multi-detector row CT. Eur J Radiol 2006; 59:231-7. PubMed
  • Nishino M, Kubo T, Kataoka ML, Gautam S, Raptopoulos V, Hatabu H. Evaluation of thoracic abnormalities on 64-row multi-detector row CT: comparison between axial images versus coronal reformations. Eur J Radiol 2006; 59:33-41. PubMed
  • Ward VL, Nishino M, Hatabu H, Estroff JA, Barnewolt CE, Feldman HA, Levine D. Fetal lung volume measurements: determination with MR imaging--effect of various factors. Radiology 2006; 240:187-93. PubMed
  • Kuroki M, Nishino M, Takahashi M, Mori Y, Raptopoulos VD, Boiselle PM, Tamura S, Hatabu H. Incidence of pulmonary embolism in younger versus older patients using CT. J Thorac Imaging 2006; 21:167-71. PubMed
  • Nishino M, Roberts DH, Sitek A, Raptopoulos V, Boiselle PM, Hatabu H. Loss of anteroposterior intralobar attenuation gradient of the lung: Correlation with pulmonary function. Acad Radiol 2006; 13:589-97. PubMed
  • Nishino M, Hatabu H. Volumetric expiratory HRCT imaging with MSCT. J Thorac Imaging 2005; 20:176-85. PubMed
  • Miyake K, Hayakawa K, Nishino M, Morimoto T, Mukaihara S. Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer. Acad Radiol 2005; 12:722-7. PubMed
  • Baroni RH, Feller-Kopman D, Nishino M, Hatabu H, Loring SH, Ernst A, Boiselle PM. Tracheobronchomalacia: comparison between end-expiratory and dynamic expiratory CT for evaluation of central airway collapse. Radiology 2005; 235:635-41. PubMed
  • Nishino M, Kuroki M, Roberts DH, Mori Y, Boiselle PM, Hatabu H. Bronchomalacia in sarcoidosis: evaluation on volumetric expiratory high-resolution CT of the lung. Acad Radiol 2005; 12:596-601. PubMed
  • Boiselle PM, Hasegawa I, Nishino M, Raptopoulos V, Hatabu H. Comparison of artifacts on coronal reformation and axial CT pulmonary angiography images using single-detector and 4- and 8-detector multidetector-row helical CT scanners. Acad Radiol 2005; 12:602-7. PubMed
  • Nishino M, Iwata S, Hayakawa K, Kanao S, Morimoto T, Mukaihara S, Hatabu H. Functional evaluation of the postoperative gastrointestinal tract using kinematic MR imaging: Quantitative assessment of peristaltic activity. Eur J Radiol 2005; 53:263-7. PubMed
  • Yam CS, Levine D, Nishino M, Sitek A, Larson M. A simple method for displaying cine images on web-based teaching files. AJR Am J Roentgenol 2005; 184:691-4. PubMed
  • Nishino M, Togashi K, Nakai A, Hayakawa K, Kanao S, Iwasaku K, Fujii S. Uterine contractions evaluated on cine MR imaging in patients with uterine leiomyomas. Eur J Radiol 2004; 53:142-6. PubMed
  • Nishino M, Hatabu H. Volumetric expiratory high-resolution CT of the lung. Eur J Radiol 2004; 52:180-4. PubMed
  • Nishino M, Kuroki M, Boiselle PM, Raptopoulos V, Hatabu H. Sagittal reformations of volumetric inspiratory and expiratory high-resolution CT of the lung. Acad Radiol 2004; 11:1282-90. PubMed
  • Itoh H, Nishino M, Hatabu H. Architecture of the lung: morphology and function. J Thorac Imaging 2004; 19:221-7. PubMed
  • Nishino M, Busch JM, Wei J, Barbaras L, Yam CS, Hatabu H. Use of personal digital assistants in diagnostic radiology resident education. Acad Radiol 2004; 11:1153-8. PubMed
  • Nishino M, Wolfe D, Yam CS, Larson M, Boiselle PM, Hatabu H. Comprehensive innovative solution for resident education using the Intranet Journal of Chest Radiology. Acad Radiol 2004; 11:1149-52. PubMed
  • Busch JM, Barbaras L, Wei J, Nishino M, Yam CS, Hatabu H. A mobile solution: PDA-based platform for radiology information management. AJR Am J Roentgenol 2004; 183:237-42. PubMed
  • Nishino M, Hayakawa K, Iwasaku K, Togashi K, Ueda H, Sago T, Noguchi M. MR imaging of ovarian hemorrhage. Eur J Radiol 2004; 51:34-40. PubMed
  • Nishino M, Kuroki M, Boiselle PM, Copeland JF, Raptopoulos V, Hatabu H. Coronal reformations of volumetric expiratory high-resolution CT of the lung. AJR Am J Roentgenol 2004; 182:979-82. PubMed
  • Nakayama T, Nishino M, Takasu K, Hayakawa K, Toguchida J, Tanaka C. Endovascular papillary angioendothelioma (Dabska tumor) of bone. Orthopedics 2004; 27:327-8. PubMed
  • Nishino M, Hayakawa K, Nakamura Y, Morimoto T, Mukaihara S. Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy. AJR Am J Roentgenol 2002; 180:129-34. PubMed
  • Kubo T, Nishino M, Kino A, Yoshimura N, Lin PJ, Takahashi M, Raptopoulos V, Hatabu H. 3-dimensional adaptive raw-data filter: evaluation in low dose chest multidetector-row computed tomography. J Comput Assist Tomogr 2006; 30:933-8. PubMed
  • Nishino M, Hayakawa K, Yamamoto A, Nakamura Y, Morimoto T, Mukaihara S, Urata Y. Multiple enhancing lesions detected on dynamic helical computed tomography-mammography. J Comput Assist Tomogr 2003; 27:771-8. PubMed
  • Nishino M, Hayakawa K, Kawamata K, Iwasaku K, Takasu K. MRI of early unruptured ectopic pregnancy: detection of gestational sac. J Comput Assist Tomogr 2002; 26:134-7. PubMed
  • Nishino M, Ashiku SK, Kocher ON, Thurer RL, Boiselle PM, Hatabu H. The thymus: a comprehensive review. Radiographics 2006; 26:335-48. PubMed
  • Nishino M, Hayakawa K, Iwasaku K, Takasu K. Magnetic resonance imaging findings in gynecologic emergencies. J Comput Assist Tomogr 2003; 27:564-70. PubMed
  • Nishino M, Siewert B, Roberts DH, Gautam S, Boiselle PM, Raptopoulos V, Hatabu H. Excessive collapsibility of bronchi in bronchiectasis: evaluation on volumetric expiratory high-resolution CT. J Comput Assist Tomogr 2006; 30:474-8. PubMed
  • Nishino M, Boiselle PM, Copeland JF, Raptopoulos V, Hatabu H. Value of volumetric data acquisition in expiratory high-resolution computed tomography of the lung. J Comput Assist Tomogr 2004; 28:209-14. PubMed
  • Nishino M, Hayakawa K, Minami M, Yamamoto A, Ueda H, Takasu K. Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics 2003; 23:45-57. PubMed
  • Nishino M, Kubo T, Kataoka ML, Gautam S, Raptopoulos V, Hatabu H. Evaluation of pulmonary embolisms using coronal reformations on 64-row multidetector-row computed tomography: Comparison with axial images. J Comput Assist Tomogr 2006; 30:233-7. PubMed
  • Tirumani SH, Kim KW, Nishino M, Howard SA, Krajewski KM, Jagannathan JP, Cleary JM, Ramaiya NH, Shinagare AB. Update on the role of imaging in management of metastatic colorectal cancer. Radiographics 2014; 34:1908-28. PubMed
  • Miyake K, Hayakawa K, Nishino M, Nakamura Y, Morimoto T, Urata Y, Ueda H, Tanikake M, Kanao S, Shiozaki T, Yamamoto A. Benign or malignant?: differentiating breast lesions with computed tomography attenuation values on dynamic computed tomography mammography. J Comput Assist Tomogr 2005; 29:772-9. PubMed
  • Tirumani SH, Fairchild A, Krajewski KM, Nishino M, Howard SA, Baheti AD, Rosenthal MH, Jagannathan JP, Shinagare AB, Ramaiya NH. Anti-VEGF Molecular Targeted Therapies in Common Solid Malignancies: Comprehensive Update for Radiologists. Radiographics 2015; 35:455-74. PubMed
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