Photo of Murugaiyan Gopal,  PhD

Murugaiyan Gopal, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-5324


mgopal@rics.bwh.harvard.edu

Murugaiyan Gopal, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Neurology, Harvard Medical School
  • Associate Scientist, Neurology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on how small noncoding RNAs called microRNAs modulate innate and adaptive immunity in chronic inflammatory disorders and cancer. As part of these studies, we have identified specific miRNA pathways involved inflammatory Th1 and Th17 cell differentiation and function. One of the major project in the lab focuses on how miRNAs controls tumor-promoting inflammation in colon cancer. We recently identified an important role for a microRNA and its target genes in colon cancer prevention. We are currently studying how this microRNA functions at the molecular level in multiple cell types involved in the disease pathogenesis. Our research may provide important insights for the development of new therapeutic targets for prevention and treatment of colon cancer.

Publications

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  • Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL. Targeting latency-associated peptide promotes antitumor immunity. Sci Immunol 2017. PubMed
  • Murugaiyan G, da Cunha AP, Ajay AK, Joller N, Garo LP, Kumaradevan S, Yosef N, Vaidya VS, Weiner HL. MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest 2015; 125:1069-80. PubMed