My research focuses on how small noncoding RNAs called microRNAs modulate innate and adaptive immunity in chronic inflammatory disorders and cancer. As part of these studies, we have identified specific miRNA pathways involved inflammatory Th1 and Th17 cell differentiation and function. One of the major project in the lab focuses on how miRNAs controls tumor-promoting inflammation in colon cancer. We recently identified an important role for a microRNA and its target genes in colon cancer prevention. We are currently studying how this microRNA functions at the molecular level in multiple cell types involved in the disease pathogenesis. Our research may provide important insights for the development of new therapeutic targets for prevention and treatment of colon cancer.