A main focus of the Kalaany lab is to investigate the correlation between systemic metabolism and cancers of different tissues, with the goal of identifying metabolic dependencies that could be targeted therapeutically in cancer patients.
Evidence for a robust correlation between systemic metabolism and cancer incidence and progression has been accumulating for over a century. Indeed, the anti-tumorigenic effects of dietary restriction that are known to delay cancer incidence and decrease tumor growth in lab rodents, have been recognized since the early 1900s. Moreover, the last three decades have witnessed a worldwide epidemic surge of obesity and its associated metabolic syndrome. Recent epidemiological studies demonstrate a linear correlation between the observed increase in obesity as well as type 2 diabetes and mortality from cancers of a wide variety of tissues. This correlation has been estimated to account, in the United States, for 14% and 20% of all deaths from cancer in men and women, respectively.
Using different models of lung and pancreatic cancer, our lab aims at identifying metabolic dependencies in tumors growing under distinct systemic metabolic states, with the goal of targeting them therapeutically.