Photo of Nan M. Laird,  PhD

Nan M. Laird, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-1056
Fax: (617) 739-1781


laird@hsph.harvard.edu

Nan M. Laird, PhD

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Harvey V. Fineberg Professor of Public Health, and Professor of Biostatistics, Biostatistics, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on statistical methods for the analysis of medical/public health data. Specific interests include the analysis of longitudinal data, handling missing data, multivariate methods and genetic data analysis.

Publications

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  • Yip WK, Fier H, DeMeo DL, Aryee M, Laird N, Lange C. A Novel Method for Detecting Association Between DNA Methylation and Diseases Using Spatial Information. Genet Epidemiol 2014. PubMed
  • Javaras KN, Goldsmith HH, Laird NM. Estimating the effect of a predictor measured by two informants on a continuous outcome: a comparison of methods. Epidemiology 2011; 22:390-9. PubMed
  • Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, Demeo DL, Laird NM. Combining Disease Models to Test for Gene-Environment Interaction in Nuclear Families. Biometrics 2011. PubMed
  • Ionita-Laza I, Buxbaum JD, Laird NM, Lange C. A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet. 2011; 7:e1001289. PubMed
  • Sato Y, Yamamoto N, Kunitoh H, Ohe Y, Minami H, Laird NM, Katori N, Saito Y, Ohnami S, Sakamoto H, Sawada J, Saijo N, Yoshida T, Tamura T. Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. J Thorac Oncol 2010; 6:132-8. PubMed
  • Vanderweele TJ, Laird NM. Tests for Compositional Epistasis under Single Interaction-Parameter Models. Ann Hum Genet 2010; 75:146-56. PubMed
  • Sinha SK, Laird NM, Fitzmaurice GM. Multivariate logistic regression with incomplete covariate and auxiliary information. Journal of Multivariate Analysis 2010; 101:2389-2397. PubMed
  • Moreno-Macias H, Romieu I, London SJ, Laird NM. Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. Hum. Genomics 2010; 4:302-26. PubMed
  • Ionita-Laza I, Laird NM. On the optimal design of genetic variant discovery studies. Stat Appl Genet Mol Biol 2010; 9:Article33. PubMed
  • Sato Y, Laird NM, Yoshida T. Biostatistic Tools in Pharmacogenomics - Advances, Challenges, Potential. Curr Pharm Des 2010; 16:2232-40. PubMed
  • Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM. Parsing the effects of individual SNPs in candidate genes with family data. Human Heredity 2010; 69:91-103. PubMed
  • Hoffmann TJ,Lange C,Vansteelandt S,Laird NM. Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol 2009; 33:691-9. PubMed
  • Sangrajrang S,Sato Y,Sakamoto H,Ohnami S,Laird NM,Khuhaprema T,Brennan P,Boffetta P,Yoshida T. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer 2009; 125:837-43. PubMed
  • Ding X,Weiss S,Raby B,Lange C,Laird NM. Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol 2009; 8:Article 17. PubMed
  • Ionita-Laza I,Laird NM,Raby BA,Weiss ST,Lange C. On the frequency of copy number variants. Bioinformatics 2008; 24:2350-5. PubMed
  • Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, Illig T, Fox CS, Levy D, Laird N, Ding X, McQueen MB, Butler J, Ardlie K, Papoutsakis C, Dedoussis G, O'Donnell CJ, Wichmann HE, Celedon JC, Schadt E, Hirschhorn J, Weiss ST, Stefansson K, Lange C. On the replication of genetic associations: timing can be everything! Am J Hum Genet 2008; 82:849-58. PubMed
  • Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST, Lange C. On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol 2008; 32:273-84. PubMed
  • Laird NM, Lange C. Family-based methods for linkage and association analysis. Adv Genet 2008; 60:219-52. PubMed
  • Rakovski CS, Weiss ST, Laird NM, Lange C. FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Human Heredity 2008; 66:122-6. PubMed
  • Ionita-Laza I, McQueen MB, Laird NM, Lange C. Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet 2007; 81:607-14. PubMed
  • Schneiter K, Degnan JH, Corcoran C, Xu X, Laird N. EFBAT: exact family-based association tests. BMC Genet 2007; 8:86. PubMed
  • Horvath S, Xu X, Laird NM. The family based association test method: strategies for studying general genotype--phenotype associations. Eur J Hum Genet 2001; 9:301-6. PubMed
  • Horton NJ, Laird NM. Maximum likelihood analysis of logistic regression models with incomplete covariate data and auxiliary information. Biometrics 2001; 57:34-42. PubMed
  • Lake SL, Blacker D, Laird NM. Family-based tests of association in the presence of linkage. Am J Hum Genet 2000; 67:1515-25. PubMed
  • Fitzmaurice GM, Laird NM. Generalized linear mixture models for handling nonignorable dropouts in longitudinal studies. Biostatistics 2000; 1:141-156.
  • Horvath S, Laird NM, Knapp M. The transmission/disequilibrium test and parental-genotype reconstruction for X-chromosomal markers. Am J Hum Genet 2000; 66:1161-7. PubMed
  • Lunetta KL, Faraone SV, Biederman J, Laird NM. Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions. Am J Hum Genet 2000; 66:605-14. PubMed
  • Laird NM, Horvath S, Xu X. Implementing a unified approach to family-based tests of association. Genet Epidemiol 2000; 19 Suppl 1:S36-42. PubMed
  • Gortmaker SL, Peterson K, Wiecha J, Sobol AM, Dixit S, Fox MK, Laird N. Reducing obesity via a school-based interdisciplinary intervention among youth: Planet Health. Arch Pediatr Adolesc Med 1999; 153:409-18. PubMed
  • Horton NJ, Laird NM. Maximum likelihood analysis of generalized linear models with missing covariates. Stat Methods Med Res 1999; 8:37-50. PubMed
  • Hogan JW, Laird NM. Increasing efficiency from censored survival data by using random effects to model longitudinal covariates. Stat Methods Med Res 1998; 7:28-48. PubMed
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