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Natasha K. Stout

Harvard Medical School

Harvard Medical School
Phone: (617) 509-9914
Fax: (617) 859-8112


natasha_stout@hms.harvard.edu

Natasha K. Stout

Harvard Medical School

EDUCATIONAL TITLES

  • Assistant Professor, Population Medicine, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research experiences and interests center on the development and utilization of population-based computer simulation models of the natural history of cancer to inform decision making in health policy and improve population health. Specifically, I am interested in the development and application of breast and cervical cancer simulation models to cancer prevention and control. My work is motivated by the fundamental concern for improving both methodology and the information available for decision making at both individual and population levels. My current research agenda includes 1) quantifying outcomes of interest such as the risk of a false positive test result or the reduction in cancer mortality under alternative screening strategies to inform individuals about trade-offs in benefits and risks from participation in those strategies; and 2) evaluation of breast cancer screening policies in the U.S. to guide policy decisions and resource allocation.

Publications

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  • Gangnon RE, Sprague BL, Stout NK, Alagoz O, Weedon-Fekj√¶r H, Holford TR, Trentham-Dietz A. The Contribution of Mammography Screening to Breast Cancer Incidence Trends in the United States: An Updated Age-period-cohort Model. Cancer Epidemiol Biomarkers Prev 2015. PubMed
  • Lee CI, Cevik M, Alagoz O, Sprague BL, Tosteson AN, Miglioretti DL, Kerlikowske K, Stout NK, Jarvik JG, Ramsey SD, Lehman CD. Comparative effectiveness of combined digital mammography and tomosynthesis screening for women with dense breasts. Radiology 2015; 274:772-80. PubMed
  • Sprague BL, Stout NK, Schechter C, van Ravesteyn NT, Cevik M, Alagoz O, Lee CI, van den Broek JJ, Miglioretti DL, Mandelblatt JS, de Koning HJ, Kerlikowske K, Lehman CD, Tosteson AN. Benefits, harms, and cost-effectiveness of supplemental ultrasonography screening for women with dense breasts. Ann Intern Med 2015; 162:157-66. PubMed
  • Stout NK, Lee SJ, Schechter CB, Kerlikowske K, Alagoz O, Berry D, Buist DS, Cevik M, Chisholm G, de Koning HJ, Huang H, Hubbard RA, Miglioretti DL, Munsell MF, Trentham-Dietz A, van Ravesteyn NT, Tosteson AN, Mandelblatt JS. Benefits, Harms, and Costs for Breast Cancer Screening After US Implementation of Digital Mammography. Journal of the National Cancer Institute 2014. PubMed
  • Wang AT, Fan J, Van Houten HK, Tilburt JC, Stout NK, Montori VM, Shah ND. Impact of the 2009 US Preventive Services Task Force guidelines on screening mammography rates on women in their 40s. PLoS ONE 2014; 9:e91399. PubMed
  • Stout NK, Nekhlyudov L, Li L, Malin ES, Ross-Degnan D, Buist DS, Rosenberg MA, Alfisher M, Fletcher SW. Rapid increase in breast magnetic resonance imaging use: trends from 2000 to 2011. JAMA Intern Med 2014; 174:114-21. PubMed
  • Soeteman DI, Stout NK, Ozanne EM, Greenberg C, Hassett MJ, Schrag D, Punglia RS. Modeling the effectiveness of initial management strategies for ductal carcinoma in situ. Journal of the National Cancer Institute 2013; 105:774-81. PubMed
  • Chubak J, Rutter CM, Kamineni A, Johnson EA, Stout NK, Weiss NS, Doria-Rose VP, Doubeni CA, Buist DS. Measurement in comparative effectiveness research. Am J Prev Med 2013; 44:513-9. PubMed
  • Batina NG, Trentham-Dietz A, Gangnon RE, Sprague BL, Rosenberg MA, Stout NK, Fryback DG, Alagoz O. Variation in tumor natural history contributes to racial disparities in breast cancer stage at diagnosis. Breast Cancer Res Treat 2013; 138:519-28. PubMed
  • Stout NK, Nekhlyudov L. Early Uptake of Breast Magnetic Resonance Imaging in a Community-Based Medical Practice, 2000-2004. J Womens Health (Larchmt) 2011. PubMed
  • Goldhaber-Fiebert JD, Stout NK, Goldie SJ. Empirically Evaluating Decision-Analytic Models. Value Health 2010; 13:667-74. PubMed
  • Mandelblatt JS, Cronin KA, Bailey S, Berry DA, de Koning HJ, Draisma G, Huang H, Lee SJ, Munsell M, Plevritis SK, Ravdin P, Schechter CB, Sigal B, Stoto MA, Stout NK, van Ravesteyn NT, Venier J, Zelen M, Feuer EJ, . Effects of mammography screening under different screening schedules: model estimates of potential benefits and harms. Ann Intern Med 2009; 151:738-47. PubMed
  • Stout NK,Goldie SJ. Keeping the noise down: common random numbers for disease simulation modeling. Health Care Manag Sci 2008; 11:399-406. PubMed
  • Stout NK,Goldhaber-Fiebert JD,Ortendahl JD,Goldie SJ. Trade-offs in cervical cancer prevention: balancing benefits and risks. Arch Intern Med 2008; 168:1881-9. PubMed
  • Goldhaber-Fiebert JD, Stout NK, Salomon JA, Kuntz KM, Goldie SJ. Cost-effectiveness of cervical cancer screening with human papillomavirus DNA testing and HPV-16,18 vaccination. Journal of the National Cancer Institute 2008; 100:308-20. PubMed
  • Tosteson AN,Stout NK,Fryback DG,Acharyya S,Herman BA,Hannah LG,Pisano ED. Cost-effectiveness of digital mammography breast cancer screening. Ann Intern Med 2008; 148:1-10. PubMed
  • Kim JJ, Kuntz KM, Stout NK, Mahmud S, Villa LL, Franco EL, Goldie SJ. Multiparameter calibration of a natural history model of cervical cancer. Am J Epidemiol 2007; 166:137-50. PubMed
  • Goldhaber-Fiebert JD, Stout NK, Ortendahl J, Kuntz KM, Goldie SJ, Salomon JA. Modeling human papillomavirus and cervical cancer in the United States for analyses of screening and vaccination. Popul Health Metr 2007; 5:11. PubMed
  • Stout NK,Rosenberg MA,Trentham-Dietz A,Smith MA,Robinson SM,Fryback DG. Retrospective cost-effectiveness analysis of screening mammography. Journal of the National Cancer Institute 2006; 98:774-82. PubMed
  • Fryback DG,Stout NK,Rosenberg MA,Trentham-Dietz A,Kuruchittham V,Remington PL. The Wisconsin Breast Cancer Epidemiology Simulation Model. J Natl Cancer Inst Monogr 2006. PubMed
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