My laboratory investigates therapeutic uses of ultrasound. Ultrasound, which can be focused deep into the body can be used for a wide range of therapies. Most of my work is centered on using it as a noninvasive tool for ablating tumors or for temporarily modifying vascular barriers to enhance the delivery of drugs. We are particularly interested in the brain, and have been working for years on using focused ultrasound and microbubbles to disrupt the blood-brain barrier. In addition to these basic works, I also have a strong interest in developing imaging methods to guide and monitor focused ultrasound therapies and am closely involved with tumor ablation clinical trials at BWH.