Photo of Nathan McDannold,  PhD

Nathan McDannold, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 278-0605
Fax: (617) 525-7450


njm@bwh.harvard.edu

Nathan McDannold, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Research Associate, Radiology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory investigates therapeutic uses of ultrasound. Ultrasound, which can be focused deep into the body can be used for a wide range of therapies. Most of my work is centered on using it as a noninvasive tool for ablating tumors or for temporarily modifying vascular barriers to enhance the delivery of drugs. We are particularly interested in the brain, and have been working for years on using focused ultrasound and microbubbles to disrupt the blood-brain barrier. In addition to these basic works, I also have a strong interest in developing imaging methods to guide and monitor focused ultrasound therapies and am closely involved with tumor ablation clinical trials at BWH.

Publications

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  • Aryal M, Vykhodtseva N, Zhang YZ, McDannold N. Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: A safety study. J Control Release 2015; 204:60-9. PubMed
  • Aryal M, Park J, Vykhodtseva N, Zhang YZ, McDannold N. Enhancement in blood-tumor barrier permeability and delivery of liposomal doxorubicin using focused ultrasound and microbubbles: evaluation during tumor progression in a rat glioma model. Phys Med Biol 2015; 60:2511-27. PubMed
  • Kopechek JA, Park EJ, Zhang YZ, Vykhodtseva NI, McDannold NJ, Porter TM. Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumors in vivo using phase shift nanoemulsions. Phys Med Biol 2014; 59:3465-81. PubMed
  • Jolesz FA, McDannold NJ. Magnetic resonance-guided focused ultrasound: a new technology for clinical neurosciences. Neurol Clin 2013; 32:253-69. PubMed
  • Aryal M, Arvanitis CD, Alexander PM, McDannold N. Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system. Adv Drug Deliv Rev 2014. PubMed
  • Arvanitis CD, Livingstone MS, McDannold N. Combined ultrasound and MR imaging to guide focused ultrasound therapies in the brain. Phys Med Biol 2013; 58:4749-61. PubMed
  • Aryal M, Vykhodtseva N, Zhang YZ, Park J, McDannold N. Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood-tumor and blood-brain barriers improves outcomes in a rat glioma model. J Control Release 2013. PubMed
  • Kopechek JA, Park E, Mei CS, McDannold NJ, Porter TM. Accumulation of phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo. J Healthc Eng 2013; 4:109-26. PubMed
  • Park EJ, Zhang YZ, Vykhodtseva N, McDannold N. Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model. J Control Release 2012; 163:277-84. PubMed
  • Treat LH, McDannold N, Zhang Y, Vykhodtseva N, Hynynen K. Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol 2012; 38:1716-25. PubMed
  • Park J, Zhang Y, Vykhodtseva N, Jolesz FA, McDannold NJ. The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound. J Control Release 2012; 162:134-42. PubMed
  • McDannold N, Arvanitis CD, Vykhodtseva N, Livingstone MS. Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res 2012; 72:3652-63. PubMed
  • McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery 2010; 66:323-32; discussion 332. PubMed
  • McDannold N, Vykhodtseva N, Hynynen K. Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol 2008; 34:834-40. PubMed
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