Photo of Niroshana Anandasabapathy,  MD, PhD

Niroshana Anandasabapathy, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-8502


nanandasabapathy@partners.org

Niroshana Anandasabapathy, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Dermatology, Harvard Medical School
  • Associate Physician, Dermatology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

As the primary barrier between the body and the outside world the skin functions as a unique immune organ, at the intersection of adaptive and innate immune responses. The importance of skin-resident immune cells is demonstrated through several lines of evidence. First, successful vaccination strategies to cytolytic viruses rely on delivery of vaccine antigens to the skin including vaccinia and dermally-delivered influenza. Second, innate immune adjuvants that act on the cutaneous immune network (imiquimod, resiquimod) can lead to the regression of lentigo maligna and superficial spreading basal cell cancers. Third, steady state immune surveillance is critical to prevent skin cancers as evidenced by the markedly increased incidence of cutaneous neoplasias observed in renal transplant recipients maintained on immunosuppressive agents. Despite the immune-responsive nature of skin cancers and the potential for skin resident immune cells to mediate vaccine responses, vaccines have not been generated to prevent the formation of skin cancers. Improved understanding of immune surveillance in the cutaneous microenvironment is needed. A major focus of our program is to study Dendritic Cells (DC) in the cutaneous and local lymphoid environment- specialized cells which train T cells to respond to tumor and viral antigens. Our studies include identifying a role of DC in surveying skin and local lymphoid tissue as cancers arise, as well as finding ways to enhance DC function in ways that may be applied to cancer vaccines.

Publications

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  • Breton G, Lee J, Zhou YJ, Schreiber JJ, Keler T, Puhr S, Anandasabapathy N, Schlesinger S, Caskey M, Liu K, Nussenzweig MC. Circulating precursors of human CD1c+ and CD141+ dendritic cells. J Exp Med 2015; 212:401-13. PubMed
  • Mollah SA, Dobrin JS, Feder RE, Tse SW, Matos IG, Cheong C, Steinman RM, Anandasabapathy N. Flt3L Dependence Helps Define an Uncharacterized Subset of Murine Cutaneous Dendritic Cells. J Invest Dermatol 2014; 134:1265-75. PubMed
  • D'Agostino PM, Gottfried-Blackmore A, Anandasabapathy N, Bulloch K. Brain dendritic cells: biology and pathology. Acta Neuropathol 2012; 124:599-614. PubMed
  • Anandasabapathy N, Victora GD, Meredith M, Feder R, Dong B, Kluger C, Yao K, Dustin ML, Nussenzweig MC, Steinman RM, Liu K. Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med 2011; 208:1695-705. PubMed
  • Farley-Loftus R, Anandasabapathy N, Bossenbroek N, Rosenman K, Pomeranz MK. An unusual pruritic eruption of the feet. Churg-Strauss syndrome (CSS)(allergic granulomatosis). Arch Dermatol 2009; 145:715-20. PubMed
  • Anandasabapathy N, Soldano AC. Multiple apocrine hidrocystomas. Dermatol Online J 2008; 14:12. PubMed
  • Tran HT, Anandasabapathy N, Soldano AC. Amalgam tattoo. Dermatol Online J 2008; 14:19. PubMed
  • Rizzo C, Anandasabapathy N, Walters RF, Rosenman K, Kamino H, Prystowsky S, Schaffer JV. Pretibial epidermolysis bullosa. Dermatol Online J 2008; 14:26. PubMed
  • Anandasabapathy N, Pulitzer M, Epstein W, Rosenman K, Latkowski JA. Pseudolymphoma evolving into diffuse large B-cell lymphoma. Dermatol Online J 2008; 14:22. PubMed
  • Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG. Two isoforms of otubain 1 regulate T cell anergy via GRAIL. Nat Immunol 2003; 5:45-54. PubMed
  • Anandasabapathy N, Ford GS, Bloom D, Holness C, Paragas V, Seroogy C, Skrenta H, Hollenhorst M, Fathman CG, Soares L. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity 2003; 18:535-47. PubMed