Photo of Oliver Jonas,  PhD

Oliver Jonas, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital


ojonas@bwh.harvard.edu

Oliver Jonas, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiology, Harvard Medical School
  • Laboratory for Bio Micro-Devices, Radiology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I develop microdevices that are implanted directly into tumors and measure how the tumor responds to 30 different chemotherapies. These devices carry microdoses of each therapy which are released into small confined regions of tumor. Each therapy interacts with the tumor in its native microenvironment. The effect of each therapy is then assessed using a variety of readouts, including immunohistochemistry, mass spectrometry and RNAseq. This data can then be used to identify which therapy works optimally for a given patient.

Publications

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  • Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science 2017; 357:1156-1160. PubMed
  • Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat Med 2016; 23:235-241. PubMed
  • Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB. MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. Mol Cancer Ther 2016; 16:143-155. PubMed
  • Jonas O, Landry HM, Fuller JE, Santini JT, Baselga J, Tepper RI, Cima MJ, Langer R. An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors. Sci Transl Med 2015; 7:284ra57. PubMed