My clinical and research focus is personalizing treatment for men with prostate cancer and optimizing their outcomes. The major areas of focus include:
1) Optimizing the use of androgen deprivation therapy (ADT) with radiation: This work includes understanding which patients are most likely vs. least likely to benefit from ADT, understanding the mechanisms by which ADT may be causing harm, and developing ways to minimize those harms.
2) Translational/Genetic Research: Using archived prostate tissue at the DFCI/BWH and colleagues at the Harvard School of Public Health, we are identifying biomarkers for prostate cancer recurrence and molecular pathways that can potentially be targeted to minimize the risk of recurrence.
3) Technical Innovations in the Delivery of Radiation: Working with collaborators in physics, radiology, and outside collaborators in engineering, we seek to reduce the side-effects of prostate brachytherapy by using additional imaging and novel devices to decrease the dose delivered to the urethra and rectum.