Photo of Peter M. Black,  MD, PhD

Peter M. Black, MD, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-7795
Fax: (617) 730-0903

Peter M. Black, MD, PhD

Boston Children's Hospital


  • Franc D. Ingraham Professor of Neurosurgery, Emeritus, Emeritus, Harvard Medical School
  • Neuorsurgeon-in-Chief/Chair, Neurosurgery, Boston Children's Hospital


Research Abstract

Primary interests are 1) Genetics and Biology of Gliomas: Indentifcation of genetic and biological markers of tumor type to aid in better diagnosis and more accurate prognosis of gliomas, and use of biolgical markers to distinguish between recurrent tumor and reactive gliosis. Current research includes subclassification of gliomas using developmentally regulated antigens GFAP, A2B5, O4, Gal-C, Fibronectin, neurofilament 160 kD, and Vimentin, and use of gene chip technology to better define gene expression in gliomas. 2) Meningiomas: Studies underway include a medical history study of 200 female meningioma patients from BWH, which reveals that women with transitional and fibroblastic meningiomas have a larger number if conditions indicative of high systemic estrogen then patients with other types of meningiomas. A second collaborative questionnaire study of over 350 women in 42 states and 12 foreign countries is in progress. Preliminary analysis suggests that there may be environmental factors associated with meningioma growth. A third study seeks to correlate expression of estrogen and progestrone receptor status in the meningiomas of the 200 paitients included in the medical history study, in order to determine the specific role of these receptors in tumor growht. 3) Translational research in brain tumors: It is our goal to study and characterize the effects of signal transduction molecules that normally control the growth and differentiation of specific types of cells in the CNS, and to bring these agents to clinical trial. Agents being brought to Phase I clinical trials include the gangioside GM3, retinoic acid, adeno-assciated virally delivered angiostatin and endostatin. 4) Imaging technology: Several novel imaging technologies have been developed at BWH, which allow for improved resection of brain tumors. These inlcude the world's first intraoperative MRI, which allows real-time udpated images during the surgical procedure, 3-D reconstruction of anatomical structures from standard imaging studies, which allows for accurate surgical planning and projection of images onto the surgical field for improved resection, and funcational brain mapping to aid in avoiding functional deficits due to surgery.

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  • Astrakas L, Blekas KD, Constantinou C, Andronesi OC, Mindrinos MN, Likas AC, Rahme LG, Black PM, Marcus KJ, Tzika AA. Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone. Int J Oncol 2011; 38:1113-27. PubMed
  • Pohl KM, Konukoglu E, Novellas S, Ayache N, Fedorov A, Talos IF, Golby A, Wells WM, Kikinis R, Black PM. A new metric for detecting change in slowly evolving brain tumors: validation in meningioma patients. Neurosurgery 2011; 68:225-33. PubMed
  • Black P, Jolesz FA, Medani K. From Vision to Reality: The Origins of Intraoperative MR Imaging. Acta Neurochir. Suppl. 2010; 109:3-7. PubMed
  • Bassig BA, Inskip PD, Burdette L, Shapiro WR, Selker RG, Fine HA, Loeffler JS, Black PM, Dubrow R, Brenner AV. Selected human leukocyte antigen class II polymorphisms and risk of adult glioma. J Neuroimmunol 2011. PubMed
  • Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ, Black PM, Giovannini M, Carroll RS, Kalamarides M. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res 2010; 16:4155-64. PubMed
  • Black PM, Heros R, Morcos J, Brotchi J, . The XIV World Congress of Neurosurgery: August 30-September 4, 2009, Boston, Massachusetts. World Neurosurg 2010; 73:242-4. PubMed
  • Agar NY, Malcolm JG, Mohan V, Yang HW, Johnson MD, Tannenbaum A, Agar JN, Black PM. Imaging of Meningioma Progression by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. Anal Chem 2010; 82:2621-5. PubMed
  • Arai T, Benny O, Joki T, Menon LG, Machluf M, Abe T, Carroll RS, Black PM. Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes. Anticancer Res 2010; 30:1057-64. PubMed
  • Lee JW, Wen PY, Hurwitz S, Black P, Kesari S, Drappatz J, Golby AJ, Wells WM, Warfield SK, Kikinis R, Bromfield EB. Morphological characteristics of brain tumors causing seizures. Arch Neurol 2010; 67:336-42. PubMed
  • Schmidt NO, Ziu M, Cargioli T, Westphal M, Giese A, Black PM, Carroll RS. Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy. Transl Oncol 2010; 3:43-9. PubMed
  • Righi V, Andronesi OC, Mintzopoulos D, Black PM, Tzika AA. High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors. Int J Oncol 2009; 36:301-6. PubMed
  • Mislow JM, Golby AJ, Black PM. Origins of intraoperative MRI. Magn Reson Imaging Clin N Am 2009; 18:1-10. PubMed
  • Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. 2010; 12:37-48. PubMed
  • Yang HW, Menon LG, Black PM, Carroll RS, Johnson MD. SNAI2/Slug promotes growth and invasion in human gliomas. BMC Cancer 2010; 10:301. PubMed
  • Menon LG, Kelly K, Yang HW, Kim SK, Black PM, Carroll RS. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells 2009; 27:2320-30. PubMed
  • Lee DH, Ahn Y, Kim SU, Wang KC, Cho BK, Phi JH, Park IH, Black PM, Carroll RS, Lee J, Kim SK. Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res 2009; 15:4925-34. PubMed
  • Coble JB,Dosemeci M,Stewart PA,Blair A,Bowman J,Fine HA,Shapiro WR,Selker RG,Loeffler JS,Black PM,Linet MS,Inskip PD. Occupational exposure to magnetic fields and the risk of brain tumors. Neuro-oncol 2009; 11:242-9. PubMed
  • Schmidt NO,Koeder D,Messing M,Mueller FJ,Aboody KS,Kim SU,Black PM,Carroll RS,Westphal M,Lamszus K. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Res 2009; 1268:24-37. PubMed
  • Mislow JM, Golby AJ, Black PM. Origins of intraoperative MRI. Neurosurg Clin N Am 2009; 20:137-46. PubMed
  • Benny O,Menon LG,Ariel G,Goren E,Kim SK,Stewman C,Black PM,Carroll RS,Machluf M. Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. Clin Cancer Res 2009; 15:1222-31. PubMed
  • Kesari S,Schiff D,Drappatz J,LaFrankie D,Doherty L,Macklin EA,Muzikansky A,Santagata S,Ligon KL,Norden AD,Ciampa A,Bradshaw J,Levy B,Radakovic G,Ramakrishna N,Black PM,Wen PY. Phase II study of protracted daily temozolomide for low-grade gliomas in adults. Clin Cancer Res 2009; 15:330-7. PubMed
  • Drappatz J,Wong ET,Schiff D,Kesari S,Batchelor TT,Doherty L,Lafrankie DC,Ramakrishna N,Weiss S,Smith ST,Ciampa A,Zimmerman J,Ostrowsky L,David K,Norden A,Barron L,Sceppa C,Black PM,Wen PY. A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2008; 73:222-7. PubMed
  • Andronesi OC,Blekas KD,Mintzopoulos D,Astrakas L,Black PM,Tzika AA. Molecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers. Int J Oncol 2008; 33:1017-25. PubMed
  • Bracht LK,Wen P,Meyerhardt JA,Kulke MH,Hornick JL,Redston M,LaFrankie DC,Black PM,Kesari S,Norden A,Drappatz J. DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor. J Clin Oncol 2008; 26:4843-4. PubMed
  • Rajaraman P,Hutchinson A,Rothman N,Black PM,Fine HA,Loeffler JS,Selker RG,Shapiro WR,Linet MS,Inskip PD. Oxidative response gene polymorphisms and risk of adult brain tumors. Neuro-oncol 2008; 10:709-15. PubMed
  • Morokoff AP,Zauberman J,Black PM. Surgery for convexity meningiomas. Neurosurgery 2008; 63:427-33; discussion 433-4. PubMed
  • Shillito J,Black PM. The Harvard Neurosurgical Service at the Children's Hospital Boston and Brigham & Women's Hospital, 1912-2007. Neurosurgery 2008; 63:579-93; discussion 593. PubMed
  • Tailor JK,Kim AH,Folkerth RD,Black PM. The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report. Neurosurgery 2008; 63:E609-10; discussion E610. PubMed
  • Andronesi OC,Mintzopoulos D,Struppe J,Black PM,Tzika AA. Solid-state NMR adiabatic TOBSY sequences provide enhanced sensitivity for multidimensional high-resolution magic-angle-spinning 1H MR spectroscopy. J Magn Reson 2008; 193:251-8. PubMed
  • Lonn S,Rothman N,Shapiro WR,Fine HA,Selker RG,Black PM,Loeffler JS,Hutchinson AA,Inskip PD. Genetic variation in insulin-like growth factors and brain tumor risk. Neuro-oncol 2008; 10:553-9. PubMed
  • Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro-oncol 2008; 10:300-8. PubMed
  • Black PM,Morokoff AP,Zauberman J. Surgery for extra-axial tumors of the cerebral convexity and midline. Neurosurgery 2008; 62:1115-21; discussion 1121-3. PubMed
  • Akar S, Drappatz J, Hsu L, Blinder RA, Black PM, Kesari S. Hypertrophic olivary degeneration after resection of a cerebellar tumor. J Neurooncol 2008; 87:341-345. PubMed
  • Konya D, Liao WL, Choi H, Yu D, Woodard MC, Newton KM, King AM, Pamir NM, Black PM, Frontera WR, Sabharwal S, Teng YD. Functional recovery in T13-L1 hemisected rats resulting from peripheral nerve rerouting: role of central neuroplasticity. Regen Med 2008; 3:309-27. PubMed
  • Talos DM, Kwiatkowski DJ, Cordero K, Black PM, Jensen FE. Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers. Ann Neurol 2008; 63:454-65. PubMed
  • Black PC, Brown GA, Inamoto T, Shrader M, Arora A, Siefker-Radtke AO, Adam L, Theodorescu D, Wu X, Munsell MF, Bar-Eli M, McConkey DJ, Dinney CP. Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells. Clin Cancer Res 2008; 14:1478-86. PubMed
  • Archip N, Clatz O, Whalen S, Dimaio SP, Black PM, Jolesz FA, Golby A, Warfield SK. Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery. Neurosurgery 2008; 62:209-15; discussion 215-6. PubMed
  • Agarwal PK, Black PC, Kamat AM. Considerations on the use of diagnostic markers in management of patients with bladder cancer. World J Urol 2007; 26:39-44. PubMed
  • Black P. Ensuring a holistic catchphrase of reform. Br J Nurs 2008; 17:217. PubMed
  • Kassouf W, Black PC, Tuziak T, Bondaruk J, Lee S, Brown GA, Adam L, Wei C, Baggerly K, Bar-Eli M, McConkey D, Czerniak B, Dinney CP. Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer. J Urol 2007; 179:353-8. PubMed
  • Black PC, Dinney CP. Growth factors and receptors as prognostic markers in urothelial carcinoma. Current Urology Reports 2008; 9:55-61. PubMed
  • Claus EB, Park PJ, Carroll R, Chan J, Black PM. Specific genes expressed in association with progesterone receptors in meningioma. Cancer Res 2008; 68:314-22. PubMed
  • Kalamarides M, Stemmer-Rachamimov AO, Takahashi M, Han ZY, Chareyre F, Niwa-Kawakita M, Black PM, Carroll RS, Giovannini M. Natural history of meningioma development in mice reveals: a synergy of Nf2 and p16(Ink4a) mutations. Brain Pathol 2007; 18:62-70. PubMed
  • Wright JL, Black PC, Brown GA, Porter MP, Kamat AM, Dinney CP, Lin DW. Differences in survival among patients with sarcomatoid carcinoma, carcinosarcoma and urothelial carcinoma of the bladder. J Urol 2007; 178:2302-6; discussion 2307. PubMed
  • Kirsch M, Allende R, Black P, Schackert G. Endogenous growth inhibition of angiogenesis in brain tumors. Cancer Metastasis Rev 2007; 26:469-79. PubMed
  • Bailey A, Black P. Which do you want first: the good news or the bad? Br J Nurs 2007; 16:1175. PubMed
  • Kesari S, Schiff D, Doherty L, Gigas DC, Batchelor TT, Muzikansky A, O'neill A, Drappatz J, Chen-Plotkin AS, Ramakrishna N, Weiss SE, Levy B, Bradshaw J, Kracher J, Laforme A, Black PM, Folkman J, Kieran M, Wen PY. Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults. Neuro-oncol 2007; 9:354-63. PubMed
  • Ugur HC, Ramakrishna N, Bello L, Menon LG, Kim SK, Black PM, Carroll RS. Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model. J Neurooncol 2007; 83:267-75. PubMed
  • Smith ER, Manfredi M, Scott RM, Black PM, Moses MA. A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Neurosurgery 2007; 60:E1148-9; discussion E1149. PubMed
  • Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. Journal of the National Cancer Institute 2007; 99:639-52. PubMed
  • Archip N, Clatz O, Whalen S, Kacher D, Fedorov A, Kot A, Chrisochoides N, Jolesz F, Golby A, Black PM, Warfield SK. Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery. Neuroimage 2007; 35:609-24. PubMed
  • Cargioli TG, Ugur HC, Ramakrishna N, Chan J, Black PM, Carroll RS. Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. Neurosurgery 2007; 60:750-9; discussion 759-60. PubMed
  • Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Int J Oncol 2007; 30:651-7. PubMed
  • Santagata S, Kesari S, Black PM, Chan JA. Anaplastic variant of medulloblastoma mimicking a vestibular schwannoma. J Neurooncol 2006; 81:49-51. PubMed
  • Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Inskip PD. Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol 2006; 165:63-71. PubMed
  • Yu Y, Jiang X, Schoch BS, Carroll RS, Black PM, Johnson MD. Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. Cancer Res 2007; 67:130-8. PubMed
  • Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res 2006; 66:11502-13. PubMed
  • Rajaraman P, Stewart PA, Samet JM, Schwartz BS, Linet MS, Zahm SH, Rothman N, Yeager M, Fine HA, Black PM, Loeffler J, Shapiro WR, Selker RG, Inskip PD. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev 2006; 15:2514-20. PubMed
  • Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res 2006; 66:10815-23. PubMed
  • Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC, Cho BK, Kim M, Menon LG, Black PM, Carroll RS. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin Cancer Res 2006; 12:5550-6. PubMed
  • Ziu M, Schmidt NO, Cargioli TG, Aboody KS, Black PM, Carroll RS. Glioma-produced extracellular matrix influences brain tumor tropism of human neural stem cells. J Neurooncol 2006; 79:125-33. PubMed
  • Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, Kikinis R. Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag 2006; 25:67-73. PubMed
  • Chakravarti A, Erkkinen MG, Nestler U, Stupp R, Mehta M, Aldape K, Gilbert MR, Black PM, Loeffler JS. Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. Clin Cancer Res 2006; 12:4738-46. PubMed
  • Talos IF, Zou KH, Ohno-Machado L, Bhagwat JG, Kikinis R, Black PM, Jolesz FA. Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics. Radiology 2006; 239:506-13. PubMed
  • Aboody KS, Najbauer J, Schmidt NO, Yang W, Wu JK, Zhuge Y, Przylecki W, Carroll R, Black PM, Perides G. Targeting of melanoma brain metastases using engineered neural stem/progenitor cells. Neuro-oncol 2006; 8:119-26. PubMed
  • Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hamalainen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA, Dale AM, Rosen BR, Stufflebeam SM. The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. Epilepsy Res 2006; 69:80-6. PubMed
  • De Roos AJ, Rothman N, Brown M, Bell DA, Pittman GS, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD. Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro-oncol 2006; 8:145-55. PubMed
  • Claus EB, Black PM. Survival rates and patterns of care for patients diagnosed with supratentorial low-grade gliomas: data from the SEER program, 1973-2001. Cancer 2006; 106:1358-63. PubMed
  • Black PM. Challenges in contemporary academic neurosurgery. Neurosurgery 2006; 58:419-25; discussion 419-25. PubMed
  • Black PC, Brown GA, Dinney CP. The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol Oncol 2008; 27:3-7. PubMed