Peter M. Black, MD, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-7795
Fax: (617) 730-0903


Peter.Black@childrens.harvard.edu

Peter M. Black, MD, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Franc D. Ingraham Professor of Neurosurgery, Emeritus, Emeritus, Harvard Medical School
  • Neuorsurgeon-in-Chief/Chair, Neurosurgery, Boston Children's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Primary interests are 1) Genetics and Biology of Gliomas: Indentifcation of genetic and biological markers of tumor type to aid in better diagnosis and more accurate prognosis of gliomas, and use of biolgical markers to distinguish between recurrent tumor and reactive gliosis. Current research includes subclassification of gliomas using developmentally regulated antigens GFAP, A2B5, O4, Gal-C, Fibronectin, neurofilament 160 kD, and Vimentin, and use of gene chip technology to better define gene expression in gliomas. 2) Meningiomas: Studies underway include a medical history study of 200 female meningioma patients from BWH, which reveals that women with transitional and fibroblastic meningiomas have a larger number if conditions indicative of high systemic estrogen then patients with other types of meningiomas. A second collaborative questionnaire study of over 350 women in 42 states and 12 foreign countries is in progress. Preliminary analysis suggests that there may be environmental factors associated with meningioma growth. A third study seeks to correlate expression of estrogen and progestrone receptor status in the meningiomas of the 200 paitients included in the medical history study, in order to determine the specific role of these receptors in tumor growht. 3) Translational research in brain tumors: It is our goal to study and characterize the effects of signal transduction molecules that normally control the growth and differentiation of specific types of cells in the CNS, and to bring these agents to clinical trial. Agents being brought to Phase I clinical trials include the gangioside GM3, retinoic acid, adeno-assciated virally delivered angiostatin and endostatin. 4) Imaging technology: Several novel imaging technologies have been developed at BWH, which allow for improved resection of brain tumors. These inlcude the world's first intraoperative MRI, which allows real-time udpated images during the surgical procedure, 3-D reconstruction of anatomical structures from standard imaging studies, which allows for accurate surgical planning and projection of images onto the surgical field for improved resection, and funcational brain mapping to aid in avoiding functional deficits due to surgery.

Lab url: http://blacklab.bwh.harvard.edu/

Publications

Powered by Harvard Catalyst
  • Astrakas L, Blekas KD, Constantinou C, Andronesi OC, Mindrinos MN, Likas AC, Rahme LG, Black PM, Marcus KJ, Tzika AA. Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone. Int J Oncol 2011; 38:1113-27. PubMed
  • Pohl KM, Konukoglu E, Novellas S, Ayache N, Fedorov A, Talos IF, Golby A, Wells WM, Kikinis R, Black PM. A new metric for detecting change in slowly evolving brain tumors: validation in meningioma patients. Neurosurgery 2011; 68:225-33. PubMed
  • Black P, Jolesz FA, Medani K. From Vision to Reality: The Origins of Intraoperative MR Imaging. Acta Neurochir. Suppl. 2010; 109:3-7. PubMed
  • Bassig BA, Inskip PD, Burdette L, Shapiro WR, Selker RG, Fine HA, Loeffler JS, Black PM, Dubrow R, Brenner AV. Selected human leukocyte antigen class II polymorphisms and risk of adult glioma. J Neuroimmunol 2011. PubMed
  • Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ, Black PM, Giovannini M, Carroll RS, Kalamarides M. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res 2010; 16:4155-64. PubMed
  • Agar NY, Malcolm JG, Mohan V, Yang HW, Johnson MD, Tannenbaum A, Agar JN, Black PM. Imaging of Meningioma Progression by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. Anal Chem 2010; 82:2621-5. PubMed
  • Black PM, Heros R, Morcos J, Brotchi J, . The XIV World Congress of Neurosurgery: August 30-September 4, 2009, Boston, Massachusetts. World Neurosurg 2010; 73:242-4. PubMed
  • Arai T, Benny O, Joki T, Menon LG, Machluf M, Abe T, Carroll RS, Black PM. Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes. Anticancer Res 2010; 30:1057-64. PubMed
  • Lee JW, Wen PY, Hurwitz S, Black P, Kesari S, Drappatz J, Golby AJ, Wells WM, Warfield SK, Kikinis R, Bromfield EB. Morphological characteristics of brain tumors causing seizures. Arch Neurol 2010; 67:336-42. PubMed
  • Mislow JM, Golby AJ, Black PM. Origins of intraoperative MRI. Magn Reson Imaging Clin N Am 2009; 18:1-10. PubMed
  • Righi V, Andronesi OC, Mintzopoulos D, Black PM, Tzika AA. High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors. Int J Oncol 2009; 36:301-6. PubMed
  • Schmidt NO, Ziu M, Cargioli T, Westphal M, Giese A, Black PM, Carroll RS. Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy. Transl Oncol 2010; 3:43-9. PubMed
  • Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. 2010; 12:37-48. PubMed
  • Yang HW, Menon LG, Black PM, Carroll RS, Johnson MD. SNAI2/Slug promotes growth and invasion in human gliomas. BMC Cancer 2010; 10:301. PubMed
  • Menon LG, Kelly K, Yang HW, Kim SK, Black PM, Carroll RS. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells 2009; 27:2320-30. PubMed
  • Lee DH, Ahn Y, Kim SU, Wang KC, Cho BK, Phi JH, Park IH, Black PM, Carroll RS, Lee J, Kim SK. Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res 2009; 15:4925-34. PubMed
  • Coble JB,Dosemeci M,Stewart PA,Blair A,Bowman J,Fine HA,Shapiro WR,Selker RG,Loeffler JS,Black PM,Linet MS,Inskip PD. Occupational exposure to magnetic fields and the risk of brain tumors. Neuro-oncol 2009; 11:242-9. PubMed
  • Schmidt NO,Koeder D,Messing M,Mueller FJ,Aboody KS,Kim SU,Black PM,Carroll RS,Westphal M,Lamszus K. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Res 2009; 1268:24-37. PubMed
  • Mislow JM, Golby AJ, Black PM. Origins of intraoperative MRI. Neurosurg Clin N Am 2009; 20:137-46. PubMed
  • Benny O,Menon LG,Ariel G,Goren E,Kim SK,Stewman C,Black PM,Carroll RS,Machluf M. Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. Clin Cancer Res 2009; 15:1222-31. PubMed
  • Drappatz J,Wong ET,Schiff D,Kesari S,Batchelor TT,Doherty L,Lafrankie DC,Ramakrishna N,Weiss S,Smith ST,Ciampa A,Zimmerman J,Ostrowsky L,David K,Norden A,Barron L,Sceppa C,Black PM,Wen PY. A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2008; 73:222-7. PubMed
  • Kesari S,Schiff D,Drappatz J,LaFrankie D,Doherty L,Macklin EA,Muzikansky A,Santagata S,Ligon KL,Norden AD,Ciampa A,Bradshaw J,Levy B,Radakovic G,Ramakrishna N,Black PM,Wen PY. Phase II study of protracted daily temozolomide for low-grade gliomas in adults. Clin Cancer Res 2009; 15:330-7. PubMed
  • Andronesi OC,Blekas KD,Mintzopoulos D,Astrakas L,Black PM,Tzika AA. Molecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers. Int J Oncol 2008; 33:1017-25. PubMed
  • Bracht LK,Wen P,Meyerhardt JA,Kulke MH,Hornick JL,Redston M,LaFrankie DC,Black PM,Kesari S,Norden A,Drappatz J. DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor. J Clin Oncol 2008; 26:4843-4. PubMed
  • Rajaraman P,Hutchinson A,Rothman N,Black PM,Fine HA,Loeffler JS,Selker RG,Shapiro WR,Linet MS,Inskip PD. Oxidative response gene polymorphisms and risk of adult brain tumors. Neuro-oncol 2008; 10:709-15. PubMed
  • Shillito J,Black PM. The Harvard Neurosurgical Service at the Children's Hospital Boston and Brigham & Women's Hospital, 1912-2007. Neurosurgery 2008; 63:579-93; discussion 593. PubMed
  • Morokoff AP,Zauberman J,Black PM. Surgery for convexity meningiomas. Neurosurgery 2008; 63:427-33; discussion 433-4. PubMed
  • Tailor JK,Kim AH,Folkerth RD,Black PM. The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report. Neurosurgery 2008; 63:E609-10; discussion E610. PubMed
  • Andronesi OC,Mintzopoulos D,Struppe J,Black PM,Tzika AA. Solid-state NMR adiabatic TOBSY sequences provide enhanced sensitivity for multidimensional high-resolution magic-angle-spinning 1H MR spectroscopy. J Magn Reson 2008; 193:251-8. PubMed
  • Lonn S,Rothman N,Shapiro WR,Fine HA,Selker RG,Black PM,Loeffler JS,Hutchinson AA,Inskip PD. Genetic variation in insulin-like growth factors and brain tumor risk. Neuro-oncol 2008; 10:553-9. PubMed
  • Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro-oncol 2008; 10:300-8. PubMed
  • Black PM,Morokoff AP,Zauberman J. Surgery for extra-axial tumors of the cerebral convexity and midline. Neurosurgery 2008; 62:1115-21; discussion 1121-3. PubMed
  • Konya D, Liao WL, Choi H, Yu D, Woodard MC, Newton KM, King AM, Pamir NM, Black PM, Frontera WR, Sabharwal S, Teng YD. Functional recovery in T13-L1 hemisected rats resulting from peripheral nerve rerouting: role of central neuroplasticity. Regen Med 2008; 3:309-27. PubMed
  • Akar S, Drappatz J, Hsu L, Blinder RA, Black PM, Kesari S. Hypertrophic olivary degeneration after resection of a cerebellar tumor. J Neurooncol 2008; 87:341-345. PubMed
  • Talos DM, Kwiatkowski DJ, Cordero K, Black PM, Jensen FE. Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers. Ann Neurol 2008; 63:454-65. PubMed
  • Black PC, Brown GA, Inamoto T, Shrader M, Arora A, Siefker-Radtke AO, Adam L, Theodorescu D, Wu X, Munsell MF, Bar-Eli M, McConkey DJ, Dinney CP. Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells. Clin Cancer Res 2008; 14:1478-86. PubMed
  • Archip N, Clatz O, Whalen S, Dimaio SP, Black PM, Jolesz FA, Golby A, Warfield SK. Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery. Neurosurgery 2008; 62:209-15; discussion 215-6. PubMed
  • Black P. Ensuring a holistic catchphrase of reform. Br J Nurs 2008; 17:217. PubMed
  • Agarwal PK, Black PC, Kamat AM. Considerations on the use of diagnostic markers in management of patients with bladder cancer. World J Urol 2007; 26:39-44. PubMed
  • Kassouf W, Black PC, Tuziak T, Bondaruk J, Lee S, Brown GA, Adam L, Wei C, Baggerly K, Bar-Eli M, McConkey D, Czerniak B, Dinney CP. Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer. J Urol 2007; 179:353-8. PubMed
  • Kalamarides M, Stemmer-Rachamimov AO, Takahashi M, Han ZY, Chareyre F, Niwa-Kawakita M, Black PM, Carroll RS, Giovannini M. Natural history of meningioma development in mice reveals: a synergy of Nf2 and p16(Ink4a) mutations. Brain Pathol 2007; 18:62-70. PubMed
  • Claus EB, Park PJ, Carroll R, Chan J, Black PM. Specific genes expressed in association with progesterone receptors in meningioma. Cancer Res 2008; 68:314-22. PubMed
  • Black PC, Dinney CP. Growth factors and receptors as prognostic markers in urothelial carcinoma. Current Urology Reports 2008; 9:55-61. PubMed
  • Kirsch M, Allende R, Black P, Schackert G. Endogenous growth inhibition of angiogenesis in brain tumors. Cancer Metastasis Rev 2007; 26:469-79. PubMed
  • Wright JL, Black PC, Brown GA, Porter MP, Kamat AM, Dinney CP, Lin DW. Differences in survival among patients with sarcomatoid carcinoma, carcinosarcoma and urothelial carcinoma of the bladder. J Urol 2007; 178:2302-6; discussion 2307. PubMed
  • Bailey A, Black P. Which do you want first: the good news or the bad? Br J Nurs 2007; 16:1175. PubMed
  • Kesari S, Schiff D, Doherty L, Gigas DC, Batchelor TT, Muzikansky A, O'neill A, Drappatz J, Chen-Plotkin AS, Ramakrishna N, Weiss SE, Levy B, Bradshaw J, Kracher J, Laforme A, Black PM, Folkman J, Kieran M, Wen PY. Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults. Neuro-oncol 2007; 9:354-63. PubMed
  • Ugur HC, Ramakrishna N, Bello L, Menon LG, Kim SK, Black PM, Carroll RS. Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model. J Neurooncol 2007; 83:267-75. PubMed
  • Smith ER, Manfredi M, Scott RM, Black PM, Moses MA. A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Neurosurgery 2007; 60:E1148-9; discussion E1149. PubMed
  • Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. Journal of the National Cancer Institute 2007; 99:639-52. PubMed
  • Cargioli TG, Ugur HC, Ramakrishna N, Chan J, Black PM, Carroll RS. Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. Neurosurgery 2007; 60:750-9; discussion 759-60. PubMed
  • Archip N, Clatz O, Whalen S, Kacher D, Fedorov A, Kot A, Chrisochoides N, Jolesz F, Golby A, Black PM, Warfield SK. Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery. Neuroimage 2007; 35:609-24. PubMed
  • Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Int J Oncol 2007; 30:651-7. PubMed
  • Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Inskip PD. Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol 2006; 165:63-71. PubMed
  • Yu Y, Jiang X, Schoch BS, Carroll RS, Black PM, Johnson MD. Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. Cancer Res 2007; 67:130-8. PubMed
  • Santagata S, Kesari S, Black PM, Chan JA. Anaplastic variant of medulloblastoma mimicking a vestibular schwannoma. J Neurooncol 2006; 81:49-51. PubMed
  • Rajaraman P, Stewart PA, Samet JM, Schwartz BS, Linet MS, Zahm SH, Rothman N, Yeager M, Fine HA, Black PM, Loeffler J, Shapiro WR, Selker RG, Inskip PD. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev 2006; 15:2514-20. PubMed
  • Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res 2006; 66:11502-13. PubMed
  • Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res 2006; 66:10815-23. PubMed
  • Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC, Cho BK, Kim M, Menon LG, Black PM, Carroll RS. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin Cancer Res 2006; 12:5550-6. PubMed
  • Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, Kikinis R. Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag 2006; 25:67-73. PubMed
  • Ziu M, Schmidt NO, Cargioli TG, Aboody KS, Black PM, Carroll RS. Glioma-produced extracellular matrix influences brain tumor tropism of human neural stem cells. J Neurooncol 2006; 79:125-33. PubMed
  • Chakravarti A, Erkkinen MG, Nestler U, Stupp R, Mehta M, Aldape K, Gilbert MR, Black PM, Loeffler JS. Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. Clin Cancer Res 2006; 12:4738-46. PubMed
  • Talos IF, Zou KH, Ohno-Machado L, Bhagwat JG, Kikinis R, Black PM, Jolesz FA. Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics. Radiology 2006; 239:506-13. PubMed
  • Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hamalainen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA, Dale AM, Rosen BR, Stufflebeam SM. The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. Epilepsy Res 2006; 69:80-6. PubMed
  • Aboody KS, Najbauer J, Schmidt NO, Yang W, Wu JK, Zhuge Y, Przylecki W, Carroll R, Black PM, Perides G. Targeting of melanoma brain metastases using engineered neural stem/progenitor cells. Neuro-oncol 2006; 8:119-26. PubMed
  • De Roos AJ, Rothman N, Brown M, Bell DA, Pittman GS, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD. Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro-oncol 2006; 8:145-55. PubMed
  • Claus EB, Black PM. Survival rates and patterns of care for patients diagnosed with supratentorial low-grade gliomas: data from the SEER program, 1973-2001. Cancer 2006; 106:1358-63. PubMed
  • Black PM. Challenges in contemporary academic neurosurgery. Neurosurgery 2006; 58:419-25; discussion 419-25. PubMed
  • Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. Epidemiology of intracranial meningioma. Neurosurgery 2005; 57:1088-95; discussion 1088-. PubMed
  • Brenner AV, Linet MS, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD. Season of birth and risk of brain tumors in adults. Neurology 2004; 63:276-81. PubMed
  • Chakravarti A, Zhai G, Suzuki Y, Sarkesh S, Black PM, Muzikansky A, Loeffler JS. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 2004; 22:1926-33. PubMed
  • Tzika AA, Astrakas LG, Zarifi MK, Zurakowski D, Poussaint TY, Goumnerova L, Tarbell NJ, Black PM. Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors. Cancer 2004; 100:1246-56. PubMed
  • Schmidt NO, Ziu M, Carrabba G, Giussani C, Bello L, Sun Y, Schmidt K, Albert M, Black PM, Carroll RS. Antiangiogenic therapy by local intracerebral microinfusion improves treatment efficiency and survival in an orthotopic human glioblastoma model. Clin Cancer Res 2004; 10:1255-62. PubMed
  • Hill DA, Inskip PD, Shapiro WR, Selker RG, Fine HA, Black PM, Linet MS. Cancer in first-degree relatives and risk of glioma in adults. Cancer Epidemiol Biomarkers Prev 2003; 12:1443-8. PubMed
  • Nutt CL, Mani DR, Betensky RA, Tamayo P, Cairncross JG, Ladd C, Pohl U, Hartmann C, McLaughlin ME, Batchelor TT, Black PM, von Deimling A, Pomeroy SL, Golub TR, Louis DN. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res 2003; 63:1602-7. PubMed
  • Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Linet MS. Sociodemographic indicators and risk of brain tumours. Int J Epidemiol 2003; 32:225-33. PubMed
  • Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Selker RG, Fine HA, Black PM, Loeffler JS, Shapiro WR, Linet MS. Laterality of brain tumors. Neuroepidemiology 2003; 22:130-8. PubMed
  • De Roos AJ, Stewart PA, Linet MS, Heineman EF, Dosemeci M, Wilcosky T, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD. Occupation and the risk of adult glioma in the United States. Cancer Causes Control 2003; 14:139-50. PubMed
  • Inskip PD, Tarone RE, Brenner AV, Fine HA, Black PM, Shapiro WR, Selker RG, Linet MS. Handedness and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev 2003; 12:223-5. PubMed
  • Brenner AV, Linet MS, Selker RG, Shapiro WR, Black PM, Fine HA, Inskip PD. Polio vaccination and risk of brain tumors in adults: no apparent association. Cancer Epidemiol Biomarkers Prev 2003; 12:177-8. PubMed
  • Bello L, Lucini V, Giussani C, Carrabba G, Pluderi M, Scaglione F, Tomei G, Villani R, Black PM, Bikfalvi A, Carroll RS. IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo. Neurosurgery 2002; 52:177-85; discussion 185-6. PubMed
  • Tzika AA, Astrakas LG, Zarifi MK, Petridou N, Young-Poussaint T, Goumnerova L, Zurakowski D, Anthony DC, Black PM. Multiparametric MR assessment of pediatric brain tumors. Neuroradiology 2003; 45:1-10. PubMed
  • De Roos AJ, Rothman N, Inskip PD, Linet MS, Shapiro WR, Selker RG, Fine HA, Black PM, Pittman GS, Bell DA. Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev 2003; 12:14-22. PubMed
  • Nabavi A, Gering DT, Kacher DF, Talos IF, Wells WM, Kikinis R, Black PM, Jolesz FA. Surgical navigation in the open MRI. Acta Neurochir Suppl 2003; 85:121-5. PubMed
  • Ferrant M, Nabavi A, Macq B, Black PM, Jolesz FA, Kikinis R, Warfield SK. Serial registration of intraoperative MR images of the brain. Med Image Anal 2002; 6:337-59. PubMed
  • Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg 2002; 96:1023-31. PubMed
  • Brenner AV, Linet MS, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD. History of allergies and autoimmune diseases and risk of brain tumors in adults. Int J Cancer 2002; 99:252-9. PubMed
  • Chakravarti A, Noll E, Black PM, Finkelstein DF, Finkelstein DM, Dyson NJ, Loeffler JS. Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol 2002; 20:1063-8. PubMed
  • Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM. Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. AJNR Am J Neuroradiol 2002; 23:322-33. PubMed
  • Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Rifkin R, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub TR. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002; 415:436-42. PubMed
  • Black P, Jaaskelainen J, Chabrerie A, Golby A, Gugino L. Minimalist approach: functional mapping. Clin Neurosurg 2003; 49:90-102. PubMed
  • Bello L, Lucini V, Carrabba G, Giussani C, Machluf M, Pluderi M, Nikas D, Zhang J, Tomei G, Villani RM, Carroll RS, Bikfalvi A, Black PM. Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2. Cancer Res 2001; 61:8730-6. PubMed
  • Tan TC, Black PM. The contributions of Otfrid Foerster (1873-1941) to neurology and neurosurgery. Neurosurgery 2002; 49:1231-5; discussion 1235-6. PubMed
  • Bello L, Carrabba G, Giussani C, Lucini V, Cerutti F, Scaglione F, Landr. Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo. Cancer Res 2001; 61:7501-6. PubMed
  • Kirsch M, Santarius T, Black PM, Schackert G. Therapeutic anti-angiogenesis for malignant brain tumors. Onkologie 2001; 24:423-30. PubMed
  • Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc Natl Acad Sci U S A 2001; 98:10851-6. PubMed
  • Bello L, Francolini M, Marthyn P, Zhang J, Carroll RS, Nikas DC, Strasser JF, Villani R, Cheresh DA, Black PM. Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery. Neurosurgery 2001; 49:380-9; discussion 390. PubMed
  • Chakravarti A, Delaney MA, Noll E, Black PM, Loeffler JS, Muzikansky A, Dyson NJ. Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas. Clin Cancer Res 2001; 7:2387-95. PubMed
  • Noll EN, Lin J, Nakatsuji Y, Miller RH, Black PM. GM3 as a novel growth regulator for human gliomas. Exp Neurol 2001; 168:300-9. PubMed
  • Nabavi A, Black PM, Gering DT, Westin CF, Mehta V, Pergolizzi RS, Ferrant M, Warfield SK, Hata N, Schwartz RB, Wells WM, Kikinis R, Jolesz FA. Serial intraoperative magnetic resonance imaging of brain shift. Neurosurgery 2001; 48:787-97; discussion 797-8. PubMed
  • Tzika AA, Zurakowski D, Poussaint TY, Goumnerova L, Astrakas LG, Barnes PD, Anthony DC, Billett AL, Tarbell NJ, Scott RM, Black PM. Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment. Neuroradiology 2001; 43:169-77. PubMed
  • Kaus MR, Warfield SK, Nabavi A, Black PM, Jolesz FA, Kikinis R. Automated segmentation of MR images of brain tumors. Radiology 2001; 218:586-91. PubMed
  • Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Shapiro WR, Selker RG, Fine HA, Black PM, Loeffler JS, Linet MS. Cellular-telephone use and brain tumors. N Engl J Med 2001; 344:79-86. PubMed
  • Joki T, Machluf M, Atala A, Zhu J, Seyfried NT, Dunn IF, Abe T, Carroll RS, Black PM. Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nat Biotechnol 2001; 19:35-9. PubMed
  • Joki T, Carroll RS, Dunn IF, Zhang J, Abe T, Black PM. Assessment of alterations in gene expression in recurrent malignant glioma after radiotherapy using complementary deoxyribonucleic acid microarrays. Neurosurgery 2001; 48:195-201; discussion 201-2. PubMed
  • Black PM, Black CT. History of neurosurgery for intracranial mass lesions. Neurosurg Clin N Am 2001; 12:1-9, vii. PubMed
  • Dunn IF, Heese O, Black PM. Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs. J Neurooncol 2001; 50:121-37. PubMed
  • Chan AW, Tarbell NJ, Black PM, Louis DN, Frosch MP, Ancukiewicz M, Chapman P, Loeffler JS. Adult medulloblastoma: prognostic factors and patterns of relapse. Neurosurgery 2000; 47:623-31; discussion 631-2. PubMed
  • Cheng LL, Anthony DC, Comite AR, Black PM, Tzika AA, Gonzalez RG. Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy. Neuro-oncol 2001; 2:87-95. PubMed
  • Bouterfa H, Picht T, Kess D, Herbold C, Noll E, Black PM, Roosen K, Tonn JC. Retinoids inhibit human glioma cell proliferation and migration in primary cell cultures but not in established cell lines. Neurosurgery 2000; 46:419-30. PubMed
  • Black PC, Brown GA, Dinney CP. The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol Oncol 2008; 27:3-7. PubMed
  • Carroll RS, Zhang J, Bello L, Melnick MB, Maruyama T, McL Black P. KDR activation in astrocytic neoplasms. Cancer 1999; 86:1335-41. PubMed
  • Black PM, Alexander E, Martin C, Moriarty T, Nabavi A, Wong TZ, Schwartz RB, Jolesz F. Craniotomy for tumor treatment in an intraoperative magnetic resonance imaging unit. Neurosurgery 1999; 45:423-31; discussion 431-3. PubMed
  • Carroll RS, Zhang J, Black PM. Expression of estrogen receptors alpha and beta in human meningiomas. J Neurooncol 1999; 42:109-16. PubMed
  • Ozlen F, Nakajima S, Chabrerie A, Leventon ME, Grimson E, Kikinis R, Jolesz F, Black PM. Excision of cortical dysplasia in the language area with use of a surgical navigator: a case report. Epilepsia 1998; 39:1361-6. PubMed
  • Mitsumori M, Shrieve DC, Alexander E, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys 1998; 42:573-80. PubMed
  • Schwartz RB, Holman BL, Polak JF, Garada BM, Schwartz MS, Folkerth R, Carvalho PA, Loeffler JS, Shrieve DC, Black PM, Alexander E. Dual-isotope single-photon emission computerized tomography scanning in patients with glioblastoma multiforme: association with patient survival and histopathological characteristics of tumor after high-dose radiotherapy. J Neurosurg 1998; 89:60-8. PubMed
  • Kassis AI, Wen PY, Van den Abbeele AD, Baranowska-Kortylewicz J, Makrigiorgos GM, Metz KR, Matalka KZ, Cook CU, Sahu SK, Black PM, Adelstein SJ. 5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats. J Nucl Med 1998; 39:1148-54. PubMed
  • Kettenbach J, Silverman SG, Hata N, Kuroda K, Saiviroonporn P, Zientara GP, Morrison PR, Hushek SG, Black PM, Kikinis R, Jolesz FA. Monitoring and visualization techniques for MR-guided laser ablations in an open MR system. J Magn Reson Imaging 1998; 8:933-43. PubMed
  • Le S, Zhu JJ, Anthony DC, Greider CW, Black PM. Telomerase activity in human gliomas. Neurosurgery 1998; 42:1120-4; discussion 1124-5. PubMed
  • Zhu JJ, Santarius T, Wu X, Tsong J, Guha A, Wu JK, Hudson TJ, Black PM. Screening for loss of heterozygosity and microsatellite instability in oligodendrogliomas. Genes Chromosomes Cancer 1998; 21:207-16. PubMed
  • Di Rocco F, Carroll RS, Zhang J, Black PM. Platelet-derived growth factor and its receptor expression in human oligodendrogliomas. Neurosurgery 1998; 42:341-6. PubMed
  • Black PM, Westphal M. Growth factors, glial cells and neuro-oncology. Perspectives for treatment? J Neurooncol 1998; 35:189-90. PubMed
  • Chabrerie A, Ozlen F, Nakajima S, Leventon ME, Atsumi H, Grimson E, Keeve E, Helmers S, Riviello J, Holmes G, Duffy F, Jolesz F, Kikinis R, Black PM. Three-dimensional reconstruction and surgical navigation in pediatric epilepsy surgery. Pediatr Neurosurg 1998; 27:304-10. PubMed
  • Carroll RS, Black PM, Zhang J, Kirsch M, Percec I, Lau N, Guha A. Expression and activation of epidermal growth factor receptors in meningiomas. J Neurosurg 1997; 87:315-23. PubMed
  • Carroll RS, Zhang J, Chauncey BW, Chantziara K, Frosch MP, Black PM. Apoptosis in astrocytic neoplasms. Acta Neurochir (Wien) 1997; 139:845-50. PubMed
  • Kikinis R, Gleason PL, Moriarty TM, Moore MR, Alexander E, Stieg PE, Matsumae M, Lorensen WE, Cline HE, Black PM, Jolesz FA. Computer-assisted interactive three-dimensional planning for neurosurgical procedures. Neurosurgery 1996; 38:640-9; discussion 649-51. PubMed
  • Leon SP, Folkerth RD, Black PM. Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 1996; 77:362-72. PubMed
  • Wen PY, Fine HA, Black PM, Shrieve DC, Alexander E, Loeffler JS. High-grade astrocytomas. Neurol Clin 1995; 13:875-900. PubMed
Hide