Photo of Peter M. Mauch,  MD

Peter M. Mauch, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 632-4116
Fax: (617) 632-4115


pmauch@partners.org

Peter M. Mauch, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Radiation Oncology, Harvard Medical School
  • Associate Chair, Radiation Oncology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

CLINICAL MEDICINE

1. Optimizing radiation therapy and chemotherapy in Hodgkin's disease

2. Optimizing radiation therapy for early stage Non-Hodgkin's lymphoma

3. Improving tumor control and engraftment and reducing complications after TBI/TLI for bone marrow transplantation

LABORATORY

1. In vitro and in vivo bone marrow stem cell research

2. Toxicity and efficacy of host preparation for bone marrow transplantation

3. Effect of cytotoxic agents and cytokines on hematopoietic stem cells

4. Blood primitive and progenitor cells in hematopoietic stem cell transplantation

5. Factors important for long term hematopoiesis in clinical bone marrow transplantation

Publications

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  • Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Bello CM, Benitez CM, Bierman PJ, Blum KA, Chen R, Dabaja B, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Huang J, Johnston PB, Khan N, Maloney DG, Mauch PM, Metzger M, Moore JO, Morgan D, Moskowitz CH, Mulroney C, Poppe M, Rabinovitch R, Seropian S, Tsien C, Winter JN, Yahalom J, Burns JL, Sundar H. Hodgkin lymphoma, version 2.2015. J Natl Compr Canc Netw 2015; 13:554-86. PubMed
  • Wattson DA, Hunink MG, DiPiro PJ, Das P, Hodgson DC, Mauch PM, Ng AK. Low-dose chest computed tomography for lung cancer screening among hodgkin lymphoma survivors: a cost-effectiveness analysis. Int J Radiat Oncol Biol Phys 2014; 90:344-53. PubMed
  • Russo AL, Chen YH, Martin NE, Vinjamoori A, Luthy SK, Freedman A, Michaelson EM, Silver B, Mauch PM, Ng AK. Low-dose involved-field radiation in the treatment of non-hodgkin lymphoma: predictors of response and treatment failure. Int J Radiat Oncol Biol Phys 2013; 86:121-7. PubMed
  • Ng AK, Garber JE, Diller LR, Birdwell RL, Feng Y, Neuberg DS, Silver B, Fisher DC, Marcus KJ, Mauch PM. Prospective Study of the Efficacy of Breast Magnetic Resonance Imaging and Mammographic Screening in Survivors of Hodgkin Lymphoma. J Clin Oncol 2013. PubMed
  • Pashtan I, Mauch PM, Chen YH, Dorfman DM, Silver B, Ng AK. Radiotherapy in the management of localized primary cutaneous B-cell lymphoma. Leuk Lymphoma 2012. PubMed
  • Giardino AA, Shinagare AB, Shinagare SA, Dewar R, Weckstein D, Mauch P, Ramaiya NH, Freedman AS. Primary bone lymphoma involving bilateral tibia. Am J Hematol 2012; 87:924-5. PubMed
  • Halasz LM, Jacene HA, Catalano PJ, Van den Abbeele AD, Lacasce A, Mauch PM, Ng AK. Combined modality treatment for PET-positive non-Hodgkin lymphoma: favorable outcomes of combined modality treatment for patients with non-Hodgkin lymphoma and positive interim or postchemotherapy FDG-PET. Int J Radiat Oncol Biol Phys 2012; 83:e647-54. PubMed
  • Jiang S, Alberich-Jorda M, Zagozdzon R, Parmar K, Fu Y, Mauch P, Banu N, Makriyannis A, Tenen DG, Avraham S, Groopman JE, Avraham HK. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood 2011; 117:827-38. PubMed
  • Recklitis CJ, Sanchez Varela V, Ng A, Mauch P, Bober S. Sexual functioning in long-term survivors of Hodgkin's lymphoma. 2010; 19:1229-33. PubMed
  • McCullough L, Ng A, Najita J, Janov A, Henderson T, Mauch P, Diller L. Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy. Cancer 2010; 116:4866-71. PubMed
  • Galper SL, Yu JB, Mauch PM, Strasser JF, Silver B, Lacasce A, Marcus KJ, Stevenson MA, Chen MH, Ng AK. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood 2010. PubMed
  • Chen RC, Chin MS, Ng AK, Feng Y, Neuberg D, Silver B, Pinkus GS, Stevenson MA, Mauch PM. Early-stage, lymphocyte-predominant Hodgkin's lymphoma: patient outcomes from a large, single-institution series with long follow-up. J Clin Oncol 2009; 28:136-41. PubMed
  • Rodrigues NA,Killion L,Hickey G,Silver B,Martin C,Stevenson MA,Mauch PM,Ng AK. A Prospective Study of Salivary Gland Function in Lymphoma Patients Receiving Head and Neck Irradiation. Int J Radiat Oncol Biol Phys 2009; 75:1079-83. PubMed
  • Chen AB, Punglia RS, Kuntz KM, Mauch PM, Ng AK. Cost effectiveness and screening interval of lipid screening in Hodgkin's lymphoma survivors. J Clin Oncol 2009; 27:5383-9. PubMed
  • Sher DJ, Mauch PM, Van Den Abbeele A, Lacasce AS, Czerminski J, Ng AK. Prognostic significance of mid- and post-ABVD PET imaging in Hodgkin's lymphoma: the importance of involved-field radiotherapy. Ann Oncol 2009; 20:1848-53. PubMed
  • Ng AK,Mauch PM. Late effects of Hodgkin's disease and its treatment. Cancer J 2009; 15:164-8. PubMed
  • Luthy SK,Ng AK,Silver B,Degnan KO,Fisher DC,Freedman AS,Mauch PM. Response to low-dose involved-field radiotherapy in patients with non-Hodgkin's lymphoma. Ann Oncol 2008; 19:2043-7. PubMed
  • Ng AK, Li S, Neuberg D, Chi R, Fisher DC, Silver B, Mauch PM. A prospective study of pulmonary function in Hodgkin's lymphoma patients. Ann Oncol 2008; 19:1754-8. PubMed
  • Hoppe RT,Advani RH,Ambinder RF,Bierman PJ,Bloomfield CD,Blum K,Dabaja B,Djulbegovic B,Forero A,Gordon LI,Hernandez-Ilizaliturri FJ,Hudson MM,Kaminski MS,Love G,Maloney DG,Mansur D,Mauch PM,Moore JO,Schilder RJ,Weiss LM,Winter JN,Yahalom J,Zelenetz AD. Hodgkin disease/lymphoma. J Natl Compr Canc Netw 2008; 6:594-622. PubMed
  • Ng AK, Li S, Recklitis C, Diller LR, Neuberg D, Silver B, Mauch PM. Health Practice in Long-Term Survivors of Hodgkin Lymphoma. Int J Radiat Oncol Biol Phys 2008; 71:468-76. PubMed
  • Hellman S, Botnick L, Mauch P. Stem-cell biology and cancer therapy: the more things change... J Clin Oncol 2008; 26:821-2. PubMed
  • Brown JR, Feng Y, Gribben JG, Neuberg D, Fisher DC, Mauch P, Nadler LM, Freedman AS. Long-term survival after autologous bone marrow transplantation for follicular lymphoma in first remission. Biol Blood Marrow Transplant 2007; 13:1057-65. PubMed
  • Tsai HK, Mauch PM. Nodular lymphocyte-predominant hodgkin lymphoma. Semin Radiat Oncol 2007; 17:184-9. PubMed
  • Rohatiner AZ, Nadler L, Davies AJ, Apostolidis J, Neuberg D, Matthews J, Gribben JG, Mauch PM, Lister TA, Freedman AS. Myeloablative Therapy With Autologous Bone Marrow Transplantation for Follicular Lymphoma at the Time of Second or Subsequent Remission: Long-Term Follow-Up. J Clin Oncol 2007; 25:2554-9. PubMed
  • Tsai HK, Li S, Ng AK, Silver B, Stevenson MA, Mauch PM. Role of radiation therapy in the treatment of stage I/II mucosa-associated lymphoid tissue lymphoma. Ann Oncol 2007; 18:672-8. PubMed
  • Ng AK, Mauch PM. Role of radiation therapy in localized aggressive lymphoma. J Clin Oncol 2007; 25:757-9. PubMed
  • Ng AK, Mauch PM. The impact of treatment on the risk of second malignancy after Hodgkin's disease. Ann Oncol 2006; 17:1727-9. PubMed
  • Ng AK, Li S, Neuberg D, Fisher DC, McMillan C, Silver B, Marcus KC, Stevenson MA, Mauch PM. Long-term results of a prospective trial of mantle irradiation alone for early-stage Hodgkin's disease. Ann Oncol 2006; 17:1693-7. PubMed
  • Mauch P. Advances in the treatment of Hodgkin lymphoma. Clin Adv Hematol Oncol 2006; 4:652-4, 675. PubMed
  • Guadagnolo BA, Punglia RS, Kuntz KM, Mauch PM, Ng AK. Cost-effectiveness analysis of computerized tomography in the routine follow-up of patients after primary treatment for Hodgkin's disease. J Clin Oncol 2006; 24:4116-22. PubMed
  • Das P, Ng AK, Earle CC, Mauch PM, Kuntz KM. Computed tomography screening for lung cancer in Hodgkin's lymphoma survivors: decision analysis and cost-effectiveness analysis. Ann Oncol 2006; 17:785-93. PubMed
  • Hoppe RT, Advani RH, Bierman PJ, Bloomfield CD, Buadi F, Djulgegovic B, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Kaminski MS, Love G, Maloney DG, Mauch PM, Moore JO, Schilder RJ, Weiss L, Winter JN, Yahalom J, Zelenetz AD,. Hodgkin disease/lymphoma. Clinical practice guidelines in oncology. J Natl Compr Canc Netw 2006; 4:210-30. PubMed
  • Gribben JG, Zahrieh D, Stephans K, Bartlett-Pandite L, Alyea EP, Fisher DC, Freedman AS, Mauch P, Schlossman R, Sequist LV, Soiffer RJ, Marshall B, Neuberg D, Ritz J, Nadler LM. Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia. Blood 2005; 106:4389-96. PubMed
  • Zhou P, Ng AK, Silver B, Li S, Hua L, Mauch PM. Radiation therapy for orbital lymphoma. Int J Radiat Oncol Biol Phys 2005; 63:866-71. PubMed
  • Das P, Ng AK, Stevenson MA, Mauch PM. Clinical course of thoracic cancers in Hodgkin's disease survivors. Ann Oncol 2005; 16:793-7. PubMed
  • Ng AK, Bernardo MV, Silver B, Van Den Abbeele A, Stevenson MA, Fisher DC, Mauch PM. Mid- and post-ABVD gallium scanning predicts for recurrence in early-stage Hodgkin's disease. Int J Radiat Oncol Biol Phys 2005; 61:175-84. PubMed
  • Ng AK, Hickey G, Li S, Neuberg D, Mauch PM. A randomized phase II trial of amifostine for head and neck irradiation in lymphoma. Semin Oncol 2005; 31:20-4. PubMed
  • Adams MJ, Lipsitz SR, Colan SD, Tarbell NJ, Treves ST, Diller L, Greenbaum N, Mauch P, Lipshultz SE. Cardiovascular Status in Long-Term Survivors of Hodgkin's Disease Treated With Chest Radiotherapy. J Clin Oncol 2004; 22:3139-48. PubMed
  • Brown JR, Gaudet G, Friedberg JW, Neuberg D, Mauch P, Kutok JL, Takvorian T, Fisher DC, Gribben JG, Kim H, Nadler LM, Freedman AS. Autologous bone marrow transplantation for marginal zone non-Hodgkin's lymphoma. Leuk Lymphoma 2004; 45:315-20. PubMed
  • Ng AK, Li S, Neuberg D, Silver B, Stevenson MA, Fisher DC, Mauch PM. Comparison of MOPP versus ABVD as salvage therapy in patients who relapse after radiation therapy alone for Hodgkin's disease. Ann Oncol 2004; 15:270-5. PubMed
  • Ng AK, Li S, Neuberg D, Silver B, Weeks J, Mauch P. Factors influencing treatment recommendations in early-stage Hodgkin's disease: a survey of physicians. Ann Oncol 2004; 15:261-9. PubMed
  • Friedberg JW, Fischman A, Neuberg D, Kim H, Takvorian T, Ng AK, Mauch PM, Canellos GP, van den Abbeele AD. FDG-PET is superior to gallium scintigraphy in staging and more sensitive in the follow-up of patients with de novo Hodgkin lymphoma: a blinded comparison. Leuk Lymphoma 2004; 45:85-92. PubMed
  • Ng AK, Mauch PM. Late complications of therapy of Hodgkin's disease: prevention and management. Curr Hematol Rep 2003; 3:27-33. PubMed
  • Alyea E, Weller E, Schlossman R, Canning C, Mauch P, Ng A, Fisher D, Gribben J, Freeman A, Parikh B, Richardson P, Soiffer R, Ritz J, Anderson KC. Outcome after autologous and allogeneic stem cell transplantation for patients with multiple myeloma: impact of graft-versus-myeloma effect. Bone Marrow Transplant 2003; 32:1145-51. PubMed
  • Ng AK, Li S, Neuberg D, Silver B, Weeks JC, Mauch PM. Factors influencing treatment decision in early-stage Hodgkin disease: a physician survey. Int J Radiat Oncol Biol Phys 2003; 57:S213-4. PubMed
  • Kim HK, Silver B, Li S, Neuberg D, Mauch P. Hodgkin's disease in elderly patients (> or =60): clinical outcome and treatment strategies. Int J Radiat Oncol Biol Phys 2003; 56:556-60. PubMed
  • Molrine DC, Antin JH, Guinan EC, Soiffer RJ, MacDonald K, Malley R, Malinoski F, Trocciola S, Wilson M, Ambrosino DM. Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation. Blood 2002; 101:831-6. PubMed
  • Canellos GP, Gollub J, Neuberg D, Mauch P, Shulman LN. Primary systemic treatment of advanced Hodgkin's disease with EVA (etoposide, vinblastine, doxorubicin): 10-year follow-up. Ann Oncol 2003; 14:268-72. PubMed
  • Ng AK, Bernardo MV, Weller E, Backstrand K, Silver B, Marcus KC, Tarbell NJ, Stevenson MA, Friedberg JW, Mauch PM. Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 2002; 100:1989-96. PubMed
  • Ng AK, Bernardo MP, Weller E, Backstrand KH, Silver B, Marcus KC, Tarbell NJ, Friedberg J, Canellos GP, Mauch PM. Long-term survival and competing causes of death in patients with early-stage Hodgkin's disease treated at age 50 or younger. J Clin Oncol 2002; 20:2101-8. PubMed
  • Diller L, Medeiros Nancarrow C, Shaffer K, Matulonis U, Mauch P, Neuberg D, Tarbell NJ, Litman H, Garber J. Breast cancer screening in women previously treated for Hodgkin's disease: a prospective cohort study. J Clin Oncol 2002; 20:2085-91. PubMed
  • Alyea E, Neuberg D, Mauch P, Marcus K, Freedman A, Webb I, Anderson K, Schlossman R, Fisher D, Gribben J, Ritz J, Soiffer R. Effect of total body irradiation dose escalation on outcome following T-cell-depleted allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 2002; 8:139-44. PubMed
  • Alyea EP, Weller E, Fisher DC, Freedman AS, Gribben JG, Lee S, Schlossman RL, Stone RM, Friedberg J, DeAngelo D, Liney D, Windawi S, Ng A, Mauch P, Antin JH, Soiffer RJ. Comparable outcome with T-cell-depleted unrelated-donor versus related-donor allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 2002; 8:601-7. PubMed
  • Alyea E, Weller E, Schlossman R, Canning C, Webb I, Doss D, Mauch P, Marcus K, Fisher D, Freeman A, Parikh B, Gribben J, Soiffer R, Ritz J, Anderson K. T-cell--depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft-versus-myeloma effect. Blood 2001; 98:934-9. PubMed
  • Ng AK, Kuntz KM, Mauch PM, Weeks JC. Costs and effectiveness of staging and treatment options in early-stage Hodgkin's disease. Int J Radiat Oncol Biol Phys 2001; 50:979-89. PubMed
  • Chang BK, Backstrand KH, Ng AK, Silver B, Hitchcock SL, Mauch PM. Significance of epitrochlear lymph node involvement in Hodgkin disease. Cancer 2001; 91:1213-8. PubMed
  • Soiffer RJ, Weller E, Alyea EP, Mauch P, Webb IL, Fisher DC, Freedman AS, Schlossman RL, Gribben J, Lee S, Anderson KC, Marcus K, Stone RM, Antin JH, Ritz J. CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in patients undergoing allogeneic bone marrow transplant from unrelated donors. J Clin Oncol 2001; 19:1152-9. PubMed
  • Wheeler C, Khurshid A, Ibrahim J, Elias A, Mauch P, Ault K, Antin J. Incidence of post transplant myelodysplasia/acute leukemia in non-Hodgkin's lymphoma patients compared with Hodgkin's disease patients undergoing autologous transplantation following cyclophosphamide, carmustine, and etoposide (CBV). Leuk Lymphoma 2001; 40:499-509. PubMed
  • Backstrand KH, Ng AK, Takvorian RW, Jones EL, Fisher DC, Molnar-Griffin BJ, Silver B, Tarbell NJ, Mauch PM. Results of a prospective trial of mantle irradiation alone for selected patients with early-stage Hodgkin's disease. J Clin Oncol 2001; 19:736-41. PubMed
  • van Os R, Sheridan TM, Robinson S, Drukteinis D, Ferrara JL, Mauch PM. Immunogenicity of Ly5 (CD45)-antigens hampers long-term engraftment following minimal conditioning in a murine bone marrow transplantation model. Stem Cells 2001; 19:80-7. PubMed
  • Janov AJ, Tulecke M, O'Neill A, Lester S, Mauch PM, Harris J, Schnitt SJ, Shapiro CL. Clinical and pathologic features of breast cancers in women treated for Hodgkin's disease: a case-control study. Breast J 2001; 7:46-52. PubMed
  • Robinson SN, Freedman AS, Neuberg DS, Nadler LM, Mauch PM. Loss of marrow reserve from dose-intensified chemotherapy results in impaired hematopoietic reconstitution after autologous transplantation: CD34(+), CD34(+)38(-), and week-6 CAFC assays predict poor engraftment. Exp Hematol 2001; 28:1325-33. PubMed
  • van Os R, Robinson SN, Drukteinis D, Sheridan TM, Mauch PM. Respiratory burst of neutrophils is not required for stem cell mobilization in mice. Br J Haematol 2000; 111:695-9. PubMed
  • van Os R, Robinson S, Sheridan T, Mauch PM. Granulocyte-colony stimulating factor impedes recovery from damage caused by cytotoxic agents through increased differentiation at the expense of self-renewal. Stem Cells 2000; 18:120-7. PubMed
  • Robinson S, van Os R, Sheridan T, Mauch P. Reduction of marrow hematopoietic progenitor and stem cell content is not sufficient for enhanced syngeneic engraftment. Stem Cells 2000; 18:93-101. PubMed
  • Freedman AS, Neuberg D, Mauch P, Soiffer RJ, Anderson KC, Fisher DC, Schlossman R, Alyea EP, Takvorian T, Jallow H, Kuhlman C, Ritz J, Nadler LM, Gribben JG. Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma. Blood 1999; 94:3325-33. PubMed
  • Friedberg JW, Neuberg D, Stone RM, Alyea E, Jallow H, LaCasce A, Mauch PM, Gribben JG, Ritz J, Nadler LM, Soiffer RJ, Freedman AS. Outcome in patients with myelodysplastic syndrome after autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol 1999; 17:3128-35. PubMed
  • Nichols KE, Levitz S, Shannon KE, Wahrer DC, Bell DW, Chang G, Hegde S, Neuberg D, Shafman T, Tarbell NJ, Mauch P, Ishioka C, Haber DA, Diller L. Heterozygous germline ATM mutations do not contribute to radiation-associated malignancies after Hodgkin's disease. J Clin Oncol 1999; 17:1259. PubMed
  • Friedberg JW, Neuberg D, Gribben JG, Mauch P, Anderson KC, Soiffer RJ, Takvorian T, Fisher DC, Schlossman R, Jallow H, Kuhlman C, Ritz J, Freedman AS. Autologous bone marrow transplantation after histologic transformation of indolent B cell malignancies. Biol Blood Marrow Transplant 1999; 5:262-8. PubMed
  • van Os R, Robinson S, Sheridan T, Mislow JM, Dawes D, Mauch PM. Granulocyte colony-stimulating factor enhances bone marrow stem cell damage caused by repeated administration of cytotoxic agents. Blood 1998; 92:1950-6. PubMed
  • Soiffer RJ, Fairclough D, Robertson M, Alyea E, Anderson K, Freedman A, Bartlett-Pandite L, Fisher D, Schlossman RL, Stone R, Murray C, Freeman A, Marcus K, Mauch P, Nadler L, Ritz J. CD6-depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission. Blood 1997; 89:3039-47. PubMed
  • Mauch PM, Kalish LA, Marcus KC, Coleman CN, Shulman LN, Krill E, Come S, Silver B, Canellos GP, Tarbell NJ. Second malignancies after treatment for laparotomy staged IA-IIIB Hodgkin's disease: long-term analysis of risk factors and outcome. Blood 1996; 87:3625-32. PubMed
  • Chan CY, Molrine DC, George S, Tarbell NJ, Mauch P, Diller L, Shamberger RC, Phillips NR, Goorin A, Ambrosino DM. Pneumococcal conjugate vaccine primes for antibody responses to polysaccharide pneumococcal vaccine after treatment of Hodgkin's disease. J Infect Dis 1996; 173:256-8. PubMed
  • Molrine DC, George S, Tarbell N, Mauch P, Diller L, Neuberg D, Shamberger RC, Anderson EL, Phillips NR, Kinsella K. Antibody responses to polysaccharide and polysaccharide-conjugate vaccines after treatment of Hodgkin disease. Ann Intern Med 1995; 123:828-34. PubMed
  • Mauch PM, Canellos GP, Shulman LN, Silver B, Tarbell NJ, Come S, Rabin MS, Coleman CN. Mantle irradiation alone for selected patients with laparotomy-staged IA to IIA Hodgkin's disease: preliminary results of a prospective trial. J Clin Oncol 1995; 13:947-52. PubMed
  • Stone RM, Neuberg D, Soiffer R, Takvorian T, Whelan M, Rabinowe SN, Aster JC, Leavitt P, Mauch P, Freedman AS. Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol 1994; 12:2535-42. PubMed
  • Tarbell NJ, Thompson L, Mauch P. Thoracic irradiation in Hodgkin's disease: disease control and long-term complications. Int J Radiat Oncol Biol Phys 1990; 18:275-81. PubMed
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