Over the past 20 years, I have spent the majority of my research time dedicated to the field of endocrine diseases, specifically thyroid hormone receptor signaling. My current position, focusing in ENT (ear, nose throat), GU (genitourinary) and endocrine pathology allows for development of my personal interests in molecular defects in thyroid and adrenal neoplasms, in addition to facilitating additional collaborations in other areas of head and neck and genitourinary pathology. My research activities since completing graduate school have focused on translational studies aimed at understanding malignant potential of endocrine neoplasms. Specifically, I have studied malignant transformation in pheochromocytoma and thyroid carcinoma. Additionally, I have collaborated on projects involving quality assurance and quality improvement in surgical pathology, as well as with basic scientists studying angiogenesis as a means for prostate carcinoma development. I am currently collaborating with surgical oncologists and endocrinologists at MGH to investigate molecular mechanisms of thyroid carcinomas utilizing tissues from thyroid cancer patients, as well as mouse models of thyroid carcinomas and material derived from cell lines. Additional collaborations involve the study of squamous cell carcinomas and salivary tumors of the head in neck with MGH oncologists and molecular oncologists.