Photo of Philip Leder,   M.D.

Philip Leder, M.D.

Harvard Medical School

Harvard Medical School
Phone: (617) 432-7667
Fax: (617) 432-7944


leder@rascal.med.harvard.edu

Philip Leder, M.D.

Harvard Medical School

EDUCATIONAL TITLES

  • John Emory Andrus Professor of Genetics, Emeritus, Emeritus, Harvard Medical School

Publications

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  • Leder P. Retrospective. Marshall Warren Nirenberg (1927-2010). Science 2010; 327:972. PubMed
  • Zhou F,Leder P,Zuniga A,Dettenhofer M. Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet 2009; 18:2472-82. PubMed
  • Ravi D, Wiles AM, Bhavani S, Ruan J, Leder P, Bishop AJ. A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 2009; 5:e1000527. PubMed
  • Babbe H,McMenamin J,Hobeika E,Wang J,Rodig SJ,Reth M,Leder P. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol 2008; 182:347-60. PubMed
  • Leder P. An interview with...Philip Leder. Interview by Errol C. Friedberg. Nat Rev Mol Cell Biol 2008; 9:830. PubMed
  • Li X,Ito M,Zhou F,Youngson N,Zuo X,Leder P,Ferguson-Smith AC. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell 2008; 15:547-57. PubMed
  • Leder A, McMenamin J, Zhou F, Moran JL, Beier DR, Leder P. Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency. Oncogene 2007; 27:2456-65. PubMed
  • Dettenhofer M,Zhou F,Leder P. Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation. PLoS ONE 2008; 3:e2497. PubMed
  • Lu J, Ruhf ML, Perrimon N, Leder P. A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A 2007; 104:9381-6. PubMed
  • Babbe H, Chester N, Leder P, Reizis B. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol 2007; 27:1947-59. PubMed
  • Li X, Leder P. Identifying genes preferentially expressed in undifferentiated embryonic stem cells. BMC Cell Biol 2007; 8:37. PubMed
  • Chester N, Babbe H, Pinkas J, Manning C, Leder P. Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol 2006; 26:6713-26. PubMed
  • Fantin VR, Leder P. Mitochondriotoxic compounds for cancer therapy. Oncogene 2006; 25:4787-97. PubMed
  • Ridgeway AG, McMenamin J, Leder P. P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells. Oncogene 2006; 25:3518-27. PubMed
  • Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006; 9:425-34. PubMed
  • Zhou F, Leder P, Martin SS. Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Exp Cell Res 2006; 312:1119-26. PubMed
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