My research group is focused equally on basic and applied research goals. First, we are basic scientists studying the molecular mechanisms whereby viruses replicate themselves and cause disease. Second, we use our understanding of molecular mechanism to discover and validate novel antiviral targets and approaches that can complement traditional antiviral drug discovery efforts. While my laboratory is grounded primarily in the study of dengue virus and hepatitis B and C viruses (HBV, HCV), we also investigate the applicability of our inhibitors and antiviral strategies to other viral pathogens. As a chemist and virologist, I have prioritized opportunities in which chemical tools can be used to investigate questions that have not been accessible using more conventional virological methods. This has included 1) the use of novel screening and profiling platforms to identify host factors with functions in dengue virus replication; 2) the use of medicinal chemistry to develop small molecules as mechanistic probes of dengue virus entry, translation, genome replication, and assembly and tool compounds for pharmacological validation of antiviral targets in vitro and in vivo; 3) the use of chemoproteomic profiling methods to identify virus-induced changes in host protein function (rather than host gene expression); and 4) the use of analytical and biophysical chemistry approaches to study the relationship between specific lipid structure and function in viral processes, using hepatitis B and C viruses as models.