Photo of Raina Fichorova,  MD, PhD

Raina Fichorova, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital


rfichorova@partners.org

Raina Fichorova, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Director, Research Division, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am a researcher in basic and translational biology of the female genital tract and reproductive health. Specifically, my research provides insights into mechanisms of microbe-epithelial interactions, inflammation and innate immunity, which hold the key to solving major problems in reproductive outcomes, resistance to infection and cancer.

My early work concentrated on the basic aspects of the vaginal biome, e.g., epithelial cell differentiation and innate immunity phenotypes, sperm immunogenicity, toll-like receptor signaling, and sensitization to Gram-negative bacteria in the reproductive tract. More recently my research brakes ground in discovering the role of protozoan endosymbiont viruses in human disease. I have generated epithelial cell lines immortalized by expression of HPV16/E6E7 and to date, these are the only non-cancer cell lines available through the ATCC, representing the human endocervical, ectocervical and vaginal epithelia, which are widely used for studies on infection, immunity and cancer pathogenesis.

I am the Principal Investigator of several NIH-funded studies of Trichomonas vaginalis, a protozoan genitourinary parasite, which is an established risk factor for cervical and prostate cancer. I plan on investigating the role of the Trichomonas vaginal endosymbiont viruses in cancer pathogenesis.

I have been a co-investigator on several clinical research projects focused on mechanisms and biomarkers of ovarian cancer, cervical cancer and prostate cancer. In the past 10 years my laboratory has been continuously accredited by the College of American Pathologists for detection of systemic and mucosal biomarkers of immunity in a variety of clinical samples.

Publications

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  • Terry KL, Schock H, Fortner RT, Hüsing A, Fichorova RN, Yamamoto HS, Vitonis AF, Johnson T, Overvad K, Tjønneland A, Boutron-Ruault MC, Mesrine S, Severi G, Dossus L, Rinaldi S, Boeing H, Benetou V, Lagiou P, Trichopoulou A, Krogh V, Kuhn E, Panico S, Bueno-de-Mesquita HB, Onland-Moret NC, Peeters PH, Gram IT, Weiderpass E, Duell EJ, Sanchez MJ, Ardanaz E, Etxezarreta N, Navarro C, Idahl A, Lundin E, Jirström K, Manjer J, Wareham NJ, Khaw KT, Smith Byrne K, Travis RC, Gunter MJ, Merritt MA, Riboli E, Cramer D, Kaaks R. A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort. Clin Cancer Res 2016. PubMed
  • Onderdonk AB, Delaney ML, Fichorova RN. The Human Microbiome during Bacterial Vaginosis. Clin. Microbiol. Rev. 2016; 29:223-38. PubMed
  • Leviton A, Allred EN, Fichorova RN, Kuban KC, Michael O'Shea T, Dammann O, . Systemic inflammation on postnatal days 21 and 28 and indicators of brain dysfunction 2years later among children born before the 28th week of gestation. Early Hum. Dev. 2016; 93:25-32. PubMed
  • Fichorova RN, Yamamoto HS, Fashemi T, Foley E, Ryan S, Beatty N, Dawood H, Hayes GR, St-Pierre G, Sato S, Singh BN. Trichomonas vaginalis Lipophosphoglycan Exploits Binding to Galectin-1 and -3 to Modulate Epithelial Immunity. J Biol Chem 2015. PubMed
  • Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U. Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A 2015; 112:E4354-63. PubMed
  • Fichorova RN, Mendonca K, Yamamoto HS, Murray R, Chandra N, Doncel GF. A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation. Toxicol Appl Pharmacol 2015. PubMed
  • Anahtar MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M, Padavattan N, Ismail N, Moodley A, Sabatini ME, Ghebremichael MS, Nusbaum C, Huttenhower C, Virgin HW, Ndung'u T, Dong KL, Walker BD, Fichorova RN, Kwon DS. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity 2015; 42:965-76. PubMed
  • Buvé A, Fichorova RN. Reply to 'Sexual networks, HIV, race and bacterial vaginosis'. AIDS 2015; 29:642-3. PubMed
  • Kyongo JK, Crucitti T, Menten J, Hardy L, Cools P, Michiels J, Delany-Moretlwe S, Mwaura M, Ndayisaba G, Joseph S, Fichorova R, van de Wijgert J, Vanham G, Ariën KK, Jespers V. A cross-sectional analysis of selected genital tract immunological markers and molecular vaginal microbiota in Sub-Saharan African women with relevance to HIV risk and prevention. Clin Vaccine Immunol 2015. PubMed
  • Fichorova RN, Chen PL, Morrison CS, Doncel GF, Mendonca K, Kwok C, Chipato T, Salata R, Mauck C. The Contribution of Cervicovaginal Infections to the Immunomodulatory Effects of Hormonal Contraception. MBio 2015. PubMed
  • Kuban KC, O'Shea TM, Allred EN, Fichorova RN, Heeren T, Paneth N, Hirtz D, Dammann O, Leviton A, . The breadth and type of systemic inflammation and the risk of adverse neurological outcomes in extremely low gestation newborns. Pediatr Neurol 2014; 52:42-8. PubMed
  • Guseh SH, Feinberg BB, Dawood HY, Yamamoto HS, Fichorova RN, Burwick RM. Urinary Excretion of C5b-9 is Associated With the Anti-Angiogenic State in Severe Preeclampsia. Am J Reprod Immunol 2014. PubMed
  • Buve A, Jespers V, Crucitti T, Fichorova RN. The vaginal microbiota and susceptibility to HIV. AIDS 2014; 28:2333-44. PubMed
  • Burwick RM, Easter SR, Dawood HY, Yamamoto HS, Fichorova RN, Feinberg BB. Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia. Hypertension 2014; 64:833-8. PubMed
  • Fichorova RN, Beatty N, Sassi RR, Yamamoto HS, Allred EN, Leviton A. Systemic Inflammation in the Extremely Low Gestational Age Newborn Following Maternal Genitourinary Infections. Am J Reprod Immunol 2014. PubMed
  • Sharma J, Gray KP, Harshman LC, Evan C, Nakabayashi M, Fichorova R, Rider J, Mucci L, Kantoff PW, Sweeney CJ. Elevated IL-8, TNF-α, and MCP-1 in men with metastatic prostate cancer starting androgen-deprivation therapy (ADT) are associated with shorter time to castration-resistance and overall survival. Prostate 2014; 74:820-8. PubMed
  • Gregory KE, Winston AB, Yamamoto HS, Dawood HY, Fashemi T, Fichorova RN, Van Marter LJ. Urinary Intestinal Fatty Acid Binding Protein Predicts Necrotizing Enterocolitis. J Pediatr 2014. PubMed
  • Sharma J, Gray KP, Evan C, Nakabayashi M, Fichorova R, Rider J, Mucci L, Kantoff PW, Sweeney CJ. Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival. Prostate 2014. PubMed
  • Cramer DW, Williams K, Vitonis AF, Yamamoto HS, Stuebe A, Welch WR, Titus L, Fichorova RN. Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk. Cancer Causes Control 2013; 24:1911-23. PubMed
  • Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A 2013; 110:E2209-18. PubMed
  • Huppert JS, Huang B, Chen C, Dawood HY, Fichorova RN. Clinical evidence for the role of Trichomonas vaginalis in regulation of secretory leukocyte protease inhibitor in the female genital tract. J Infect Dis 2013; 207:1462-70. PubMed
  • Fichorova RN, Lee Y, Yamamoto HS, Takagi Y, Hayes GR, Goodman RP, Chepa-Lotrea X, Buck OR, Murray R, Kula T, Beach DH, Singh BN, Nibert ML. Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy. PLoS ONE 2012; 7:e48418. PubMed
  • Leviton A, Allred EN, Yamamoto H, Fichorova RN, . Relationships among the concentrations of 25 inflammation-associated proteins during the first postnatal weeks in the blood of infants born before the 28th week of gestation. Cytokine 2011; 57:182-90. PubMed
  • Goodman RP, Ghabrial SA, Fichorova RN, Nibert ML. Trichomonasvirus: a new genus of protozoan viruses in the family Totiviridae. Arch Virol 2011; 156:171-9. PubMed
  • Fichorova RN, Onderdonk AB, Yamamoto H, Delaney ML, DuBois AM, Allred E, Leviton A, . Maternal microbe-specific modulation of inflammatory response in extremely low-gestational-age newborns. MBio 2011; 2:e00280-10. PubMed
  • Cramer DW, Vitonis AF, Pinheiro SP, McKolanis JR, Fichorova RN, Brown KE, Hatchette TF, Finn OJ. Mumps and ovarian cancer: modern interpretation of an historic association. Cancer Causes Control 2010; 21:1193-201. PubMed
  • Fichorova RN. Impact of T. vaginalis infection on innate immune responses and reproductive outcome. J. Reprod. Immunol. 2009; 83:185-9. PubMed
  • Singh BN, Hayes GR, Lucas JJ, Sommer U, Viseux N, Mirgorodskaya E, Trifonova RT, Sassi RR, Costello CE, Fichorova RN. Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Glycoconj. J. 2009; 26:3-17. PubMed
  • Fichorova RN, Richardson-Harman N, Alfano M, Belec L, Carbonneil C, Chen S, Cosentino L, Curtis K, Dezzutti CS, Donoval B, Doncel GF, Donaghay M, Grivel JC, Guzman E, Hayes M, Herold B, Hillier S, Lackman-Smith C, Landay A, Margolis L, Mayer KH, Pasicznyk JM, Pallansch-Cokonis M, Poli G, Reichelderfer P, Roberts P, Rodriguez I, Saidi H, Sassi RR, Shattock R, Cummins JE. Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Anal Chem 2008; 80:4741-51. PubMed
  • Fichorova RN, Trifonova RT, Gilbert RO, Costello CE, Hayes GR, Lucas JJ, Singh BN. Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells. Infect Immun 2006; 74:5773-9. PubMed
  • Kleine-Lowinski K, Rheinwald JG, Fichorova RN, Anderson DJ, Basile J, M. Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells. Int J Cancer 2003; 107:407-15. PubMed
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