Photo of Raina Fichorova,  MD, PhD

Raina Fichorova, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital


rfichorova@partners.org

Raina Fichorova, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Director, Research Division, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am a researcher in basic and translational biology of the female genital tract and reproductive health. Specifically, my research provides insights into mechanisms of microbe-epithelial interactions, inflammation and innate immunity, which hold the key to solving major problems in reproductive outcomes, resistance to infection and cancer.

My early work concentrated on the basic aspects of the vaginal biome, e.g., epithelial cell differentiation and innate immunity phenotypes, sperm immunogenicity, toll-like receptor signaling, and sensitization to Gram-negative bacteria in the reproductive tract. More recently my research brakes ground in discovering the role of protozoan endosymbiont viruses in human disease. I have generated epithelial cell lines immortalized by expression of HPV16/E6E7 and to date, these are the only non-cancer cell lines available through the ATCC, representing the human endocervical, ectocervical and vaginal epithelia, which are widely used for studies on infection, immunity and cancer pathogenesis.

I am the Principal Investigator of several NIH-funded studies of Trichomonas vaginalis, a protozoan genitourinary parasite, which is an established risk factor for cervical and prostate cancer. I plan on investigating the role of the Trichomonas vaginal endosymbiont viruses in cancer pathogenesis.

I have been a co-investigator on several clinical research projects focused on mechanisms and biomarkers of ovarian cancer, cervical cancer and prostate cancer. In the past 10 years my laboratory has been continuously accredited by the College of American Pathologists for detection of systemic and mucosal biomarkers of immunity in a variety of clinical samples.

Publications

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  • Fichorova RN, Mendonca K, Yamamoto HS, Murray R, Chandra N, Doncel GF. A Quantitative Multiplex Nuclease Protection Assay Reveals Immunotoxicity Gene Expression Profiles in the Rabbit Model for Vaginal Drug Safety Evaluation. Toxicol Appl Pharmacol 2015. PubMed
  • Sharma J, Gray KP, Harshman LC, Evan C, Nakabayashi M, Fichorova R, Rider J, Mucci L, Kantoff PW, Sweeney CJ. Elevated IL-8, TNF-留, and MCP-1 in men with metastatic prostate cancer starting androgen-deprivation therapy (ADT) are associated with shorter time to castration-resistance and overall survival. Prostate 2014; 74:820-8. PubMed
  • Cramer DW, Williams K, Vitonis AF, Yamamoto HS, Stuebe A, Welch WR, Titus L, Fichorova RN. Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk. Cancer Causes Control 2013; 24:1911-23. PubMed
  • Sharma J, Gray KP, Evan C, Nakabayashi M, Fichorova R, Rider J, Mucci L, Kantoff PW, Sweeney CJ. Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival. Prostate 2013. PubMed
  • Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A 2013; 110:E2209-18. PubMed
  • Huppert JS, Huang B, Chen C, Dawood HY, Fichorova RN. Clinical evidence for the role of Trichomonas vaginalis in regulation of secretory leukocyte protease inhibitor in the female genital tract. J Infect Dis 2013; 207:1462-70. PubMed
  • Fichorova RN, Lee Y, Yamamoto HS, Takagi Y, Hayes GR, Goodman RP, Chepa-Lotrea X, Buck OR, Murray R, Kula T, Beach DH, Singh BN, Nibert ML. Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy. PLoS ONE 2012; 7:e48418. PubMed
  • Leviton A, Allred EN, Yamamoto H, Fichorova RN, . Relationships among the concentrations of 25 inflammation-associated proteins during the first postnatal weeks in the blood of infants born before the 28th week of gestation. Cytokine 2011; 57:182-90. PubMed
  • Goodman RP, Ghabrial SA, Fichorova RN, Nibert ML. Trichomonasvirus: a new genus of protozoan viruses in the family Totiviridae. Arch Virol 2011; 156:171-9. PubMed
  • Fichorova RN, Onderdonk AB, Yamamoto H, Delaney ML, DuBois AM, Allred E, Leviton A, . Maternal microbe-specific modulation of inflammatory response in extremely low-gestational-age newborns. MBio 2011; 2:e00280-10. PubMed
  • Cramer DW, Vitonis AF, Pinheiro SP, McKolanis JR, Fichorova RN, Brown KE, Hatchette TF, Finn OJ. Mumps and ovarian cancer: modern interpretation of an historic association. Cancer Causes Control 2010; 21:1193-201. PubMed
  • Fichorova RN. Impact of T. vaginalis infection on innate immune responses and reproductive outcome. J. Reprod. Immunol. 2009; 83:185-9. PubMed
  • Singh BN, Hayes GR, Lucas JJ, Sommer U, Viseux N, Mirgorodskaya E, Trifonova RT, Sassi RR, Costello CE, Fichorova RN. Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Glycoconj. J. 2009; 26:3-17. PubMed
  • Fichorova RN, Richardson-Harman N, Alfano M, Belec L, Carbonneil C, Chen S, Cosentino L, Curtis K, Dezzutti CS, Donoval B, Doncel GF, Donaghay M, Grivel JC, Guzman E, Hayes M, Herold B, Hillier S, Lackman-Smith C, Landay A, Margolis L, Mayer KH, Pasicznyk JM, Pallansch-Cokonis M, Poli G, Reichelderfer P, Roberts P, Rodriguez I, Saidi H, Sassi RR, Shattock R, Cummins JE. Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Anal Chem 2008; 80:4741-51. PubMed
  • Fichorova RN, Trifonova RT, Gilbert RO, Costello CE, Hayes GR, Lucas JJ, Singh BN. Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells. Infect Immun 2006; 74:5773-9. PubMed
  • Kleine-Lowinski K, Rheinwald JG, Fichorova RN, Anderson DJ, Basile J, M. Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells. Int J Cancer 2003; 107:407-15. PubMed
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