Photo of Ralph Weissleder,  MD, PhD

Ralph Weissleder, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-8226
Fax: (617) 643-6133


rweissleder@mgh.harvard.edu

Ralph Weissleder, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Systems Biology, Harvard Medical School
  • Thrall Family Professor, Radiology, Harvard Medical School
  • Director, Center for Systems Biology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

DF/HCC ASSOCIATIONS

  • Member, Center Scientific Council

Research Abstract

My research interests include the development of novel high resolution molecular imaging systems, tools for early cancer detection, new and more advanced nanomaterials for imaging, and modeling methods for systems analysis. Increasingly, our work has been focused on reconciling the gap that exists between traditional cell biology and human biology. His work on imaging, nanomaterials and miniaturized chips has already led to a number of advanced clinical trials. When these techniques become routinely available, they are anticipated to have a major impact on clinical practice.

Publications

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  • Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med 2015; 212:497-512. PubMed
  • Nair AV, Keliher EJ, Core AB, Brown D, Weissleder R. Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo. ACS Nano 2015. PubMed
  • Lee K, Shao H, Weissleder R, Lee H. Acoustic purification of extracellular microvesicles. ACS Nano 2015; 9:2321-7. PubMed
  • Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science 2015; 347:1260-5. PubMed
  • Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis. Cell 2015; 160:1246-60. PubMed
  • Castro CM, Im H, Le C, Lee H, Weissleder R, Birrer MJ. Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies. Cancer Metastasis Rev 2015; 34:75-82. PubMed
  • Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, Sun Y, Severe N, Dutta P, Scharff J, Scadden DT, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M. Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res 2015; 116:407-17. PubMed
  • Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Deshpande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes C, Engelman JA, Bardeesy N. Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. Clin Cancer Res 2015; 21:396-404. PubMed
  • Langer R, Weissleder R. Nanotechnology. JAMA 2015; 313:135-6. PubMed
  • Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Chronic variable stress activates hematopoietic stem cells. Nat Med 2014; 20:754-8. PubMed
  • Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Silencing of CCR2 in myocarditis. Eur Heart J 2014. PubMed
  • Meimetis LG, Carlson JC, Giedt RJ, Kohler RH, Weissleder R. Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging. Angew Chem Int Ed Engl 2014. PubMed
  • Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med 2014; 211:1243-56. PubMed
  • Sprachman MM, Laughney AM, Kohler RH, Weissleder R. In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor. Bioconjug Chem 2014. PubMed
  • Kim E, Yang KS, Giedt RJ, Weissleder R. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb) 2014; 50:4504-7. PubMed
  • Heidt T, Courties G, Dutta P, Sager H, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, Swirski FK, Weissleder R, Nahrendorf M. Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction. Circ Res 2014. PubMed
  • Im H, Shao H, Park YI, Peterson VM, Castro CM, Weissleder R, Lee H. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol 2014. PubMed
  • Thurber GM, Reiner T, Yang KS, Kohler RH, Weissleder R. Effect of Small-Molecule Modification on Single-Cell Pharmacokinetics of PARP Inhibitors. Mol Cancer Ther 2014; 13:986-95. PubMed
  • Ghazani AA, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R. Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. 2014; 10:661-8. PubMed
  • Keliher EJ, Klubnick JA, Reiner T, Mazitschek R, Weissleder R. Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes. ChemMedChem 2014. PubMed
  • Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R. Platinum Compounds for High-Resolution In Vivo Cancer Imaging. ChemMedChem 2014. PubMed
  • Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari KI, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J. Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res 2014; 74:738-50. PubMed
  • Ullal AV, Peterson V, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R. Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates. Sci Transl Med 2014; 6:219ra9. PubMed
  • Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H. Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab Chip 2013; 14:14-23. PubMed
  • Elman JS, Murray RM, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B. Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells. PLoS ONE 2014; 9:e89882. PubMed
  • Fu W, Farache J, Clardy SM, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha RK, Benoist C, Mathis D. Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and 硫 cells. Elife 2014; 3:e04631. PubMed
  • Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R. Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Sci Rep 2014; 4:4782. PubMed
  • Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R. Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A 2013; 110:E4978-86. PubMed
  • McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R, Harisinghani MG. Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle. Transl Oncol 2014; 6:670-5. PubMed
  • Yoon TJ, Shao H, Weissleder R, Lee H. Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles. Part Part Syst Charact 2013; 30:667-671. PubMed
  • Zeglis BM, Sevak KK, Reiner T, Mohindra P, Carlin SD, Zanzonico P, Weissleder R, Lewis JS. A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry. J Nucl Med 2013; 54:1389-96. PubMed
  • Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R. Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia 2013; 15:684-93. PubMed
  • Chung HJ, Castro CM, Im H, Lee H, Weissleder R. A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nat Nanotechnol 2013; 8:369-75. PubMed
  • Gounaris E, Martin J, Ishihara Y, Khan MW, Lee G, Sinh P, Chen EZ, Angarone M, Weissleder R, Khazaie K, Barrett TA. Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis. Inflamm Bowel Dis 2013. PubMed
  • Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM. Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system. 2013. PubMed
  • Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun 2013; 4:1504. PubMed
  • Giedt RJ, Koch PD, Weissleder R. Single cell analysis of drug distribution by intravital imaging. PLoS ONE 2013; 8:e60988. PubMed
  • Coffey SE, Giedt RJ, Weissleder R. Automated analysis of clonal cancer cells by intravital imaging. Intravital 2013. PubMed
  • Chung J, Issadore D, Ullal A, Lee K, Weissleder R, Lee H. Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip. Biomicrofluidics 2014; 7:54107. PubMed
  • Kim E, Yang KS, Weissleder R. Bioorthogonal small molecule imaging agents allow single-cell imaging of MET. PLoS ONE 2013; 8:e81275. PubMed
  • Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY. Microfluidic on-chip capture-cycloaddition reaction to reversibly immobilize small molecules or multi-component structures for biosensor applications. 2013. PubMed
  • Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151:1185-99. PubMed
  • Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee H. Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med 2012; 18:1835-40. PubMed
  • Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B. Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci U S A 2012. PubMed
  • Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen CC, Carvajal I, Carter BS. CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy. J. Neurooncol. 2012; 110:37-48. PubMed
  • Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ. Establishment and characterization of a novel chordoma cell line: CH22. J Orthop Res 2012; 30:1666-73. PubMed
  • Feruglio PF, Vinegoni C, Fexon L, Thurber G, Sbarbati A, Weissleder R. Noise suppressed, multifocus image fusion for enhanced intraoperative navigation. J Biophotonics 2012. PubMed
  • Keliher EJ, Reiner T, Thurber GM, Upadhyay R, Weissleder R. Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells. ChemistryOpen 2013; 1:177-183. PubMed
  • Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M. Myocardial infarction accelerates atherosclerosis. Nature 2012; 487:325-9. PubMed
  • Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H. Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med 2012; 4:141ra92. PubMed
  • Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R. Bioorthogonal imaging of aurora kinase A in live cells. Angew Chem Int Ed Engl 2012; 51:6598-603. PubMed
  • Earley S, Vinegoni C, Dunham J, Gorbatov R, Feruglio PF, Weissleder R. In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution. Cancer Res 2012; 72:2949-56. PubMed
  • Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ. Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell Rep 2012; 1:317-24. PubMed
  • Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells protect against microbial sepsis. Science 2012; 335:597-601. PubMed
  • Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V. Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Mol Ther Nucleic Acids 2013; 1:e4. PubMed
  • Haun JB, Devaraj NK, Marinelli BS, Lee H, Weissleder R. Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry. ACS Nano 2011. PubMed
  • Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R. High-yielding, two-step 18F labeling strategy for 18F-PARP1 inhibitors. ChemMedChem 2011; 6:424-7. PubMed
  • Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med 2011; 3:71ra16. PubMed
  • Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R. Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method. Angew Chem Int Ed Engl 2011; 50:1922-5. PubMed
  • Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY. Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. J Immunol 2011; 186:1369-76. PubMed
  • Niers JM, Chen JW, Weissleder R, Tannous BA. Enhanced in vivo imaging of metabolically biotinylated cell surface reporters. Anal Chem 2011; 83:994-9. PubMed
  • Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H. Self-assembled magnetic filter for highly efficient immunomagnetic separation. Lab Chip 2010; 11:147-51. PubMed
  • Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R. High-Yielding, Two-Step (18)F Labeling Strategy for (18)F-PARP1 Inhibitors. ChemMedChem 2011. PubMed
  • Haun JB, Yoon TJ, Lee H, Weissleder R. Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance. Methods Mol Biol 2011; 726:33-49. PubMed
  • Thurber GM, Figueiredo JL, Weissleder R. Detection limits of intraoperative near infrared imaging for tumor resection. J Surg Oncol 2010; 102:758-64. PubMed
  • Condeelis J, Weissleder R. In Vivo Imaging in Cancer. Cold Spring Harb Perspect Biol 2010; 2:a003848. PubMed
  • McCarthy JR, Bhaumik J, Karver MR, Sibel Erdem S, Weissleder R. Targeted nanoagents for the detection of cancers. Mol Oncol 2010; 4:511-28. PubMed
  • Reiner T, Earley S, Turetsky A, Weissleder R. Bioorthogonal Small-Molecule Ligands for PARP1 Imaging in Living Cells. Chembiochem 2010; 11:2374-7. PubMed
  • Parekkadan B, Upadhyay R, Dunham J, Iwamoto Y, Mizoguchi E, Mizoguchi A, Weissleder R, Yarmush ML. Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b+ Splenocytes. Gastroenterology 2011. PubMed
  • Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R. Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol 2010; 5:660-5. PubMed
  • Thurber GM, Weissleder R. Quantitating Antibody Uptake In Vivo: Conditional Dependence on Antigen Expression Levels. Mol Imaging Biol 2010. PubMed
  • Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer J, Aikawa E. Intravital Molecular Imaging of Small-Diameter Tissue-Engineered Vascular Grafts: A Feasibility Study. 2010; 16:597-607. PubMed
  • Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling. Cancer Res 2010; 70:5305-15. PubMed
  • Guimaraes AR, Ross R, Figuereido JL, Waterman P, Weissleder R. MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition. Mol Imaging Biol 2010. PubMed
  • Han HS, Devaraj NK, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG. Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. J Am Chem Soc 2010; 132:7838-9. PubMed
  • van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K. Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors. Oncogene 2010; 29:3185-95. PubMed
  • Haun JB, Yoon TJ, Lee H, Weissleder R. Magnetic nanoparticle biosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2010; 2:291-304. PubMed
  • Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R. Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci U S A 2010; 107:7910-5. PubMed
  • Martinez-Boubeta C, Balcells L, Cristòfol R, Sanfeliu C, Rodríguez E, Weissleder R, Lope-Piedrafita S, Simeonidis K, Angelakeris M, Sandiumenge F, Calleja A, Casas L, Monty C, Martínez B. Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia. 2010; 6:362-70. PubMed
  • Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R. Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography. Opt Lett 2010; 35:1088-90. PubMed
  • Hingtgen SD, Kasmieh R, van de Water J, Weissleder R, Shah K. Determining Multiple Aspects of Stem Cell-Based Therapies Using Novel Diagnostic and Therapeutic Multifunctional Molecules. Stem Cells 2010; 28:832-41. PubMed
  • Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R. Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells. Angew Chem Int Ed Engl 2010; 49:2869-2872. PubMed
  • Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N. Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A 2010; 107:5124-9. PubMed
  • Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T. Imaging primary lung cancers in mice to study radiation biology. Int J Radiat Oncol Biol Phys 2010; 76:973-7. PubMed
  • Hilderbrand SA, Weissleder R. Near-infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol 2010; 14:71-9. PubMed
  • Figueiredo JL, Siegel C, Nahrendorf M, Weissleder R. Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury. World J Surg 2010; 34:336-43. PubMed
  • Hardcastle J, Kurozumi K, Dmitrieva N, Sayers MP, Ahmad S, Waterman P, Weissleder R, Chiocca EA, Kaur B. Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Mol Ther 2010; 18:285-94. PubMed
  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010; 140:280-93. PubMed
  • Rodríguez E, Nilges M, Weissleder R, Chen JW. Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. J Am Chem Soc 2010; 132:168-77. PubMed
  • Tassa C, Duffner JL, Lewis TA, Weissleder R, Schreiber SL, Koehler AN, Shaw SY. Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles. Bioconjug Chem 2010; 21:14-9. PubMed
  • Hamilton AM, Rogers KA, Belisle AJ, Ronald JA, Rutt BK, Weissleder R, Boughner DR. Early identification of aortic valve sclerosis using iron oxide enhanced MRI. J Magn Reson Imaging 2009; 31:110-6. PubMed
  • Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG. Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS ONE 2010; 5:e10032. PubMed
  • Vinegoni C, Fexon L, Feruglio PF, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R. High throughput transmission optical projection tomography using low cost graphics processing unit. Opt Express 2010; 17:22320-32. PubMed
  • Tsai CC, Vinegoni C, Weissleder R. Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide. Opt Express 2009; 17:21723-31. PubMed
  • Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA. Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation. J Am Chem Soc 2009; 131:15739-44. PubMed
  • Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging 2009; 2:468-75. PubMed
  • Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging 2009; 2:460-7. PubMed
  • Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L. A wortmannin-cetuximab as a double drug. Bioconjug Chem 2009; 20:2185-9. PubMed
  • Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC Cardiovasc Imaging 2009; 2:1213-22. PubMed
  • Swirski FK,Weissleder R,Pittet MJ. Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29:1424-32. PubMed
  • Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R. Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arterioscler Thromb Vasc Biol 2009; 29:1444-51. PubMed
  • McCarthy JR, Bhaumik J, Merbouh N, Weissleder R. High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins. Org Biomol Chem 2009; 7:3430-6. PubMed
  • Bullain SS,Sahin A,Szentirmai O,Sanchez C,Lin N,Baratta E,Waterman P,Weissleder R,Mulligan RC,Carter BS. Genetically engineered T cells to target EGFRvIII expressing glioblastoma. J Neurooncol 2009; 94:373-82. PubMed
  • Vinegoni C, Razansky D, Hilderbrand SA, Shao F, Ntziachristos V, Weissleder R. Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles. Opt Lett 2009; 34:2566-8. PubMed
  • Bhaumik J, Weissleder R, McCarthy JR. Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers. J Org Chem 2010; 74:5894-901. PubMed
  • Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK. Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques. Circulation 2009; 120:592-9. PubMed
  • Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L. A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun (Camb) 2009. PubMed
  • Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett 2009; 19:4223-7. PubMed
  • Rajendran R, Ronald JA, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F. Nuclear microscopy: a novel technique for quantitative imaging of gadolinium distribution within tissue sections. Microsc. Microanal. 2009; 15:338-44. PubMed
  • Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum 2009; 60:2314-24. PubMed
  • Vonken EJ, Korosoglou G, Yu J, Schär M, Weissleder R, Stuber M. On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA). Magn Reson Med 2009; 62:314-24. PubMed
  • Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 2009; 325:612-6. PubMed
  • Lee H, Yoon TJ, Figueiredo JL, Swirski FK, Weissleder R. Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A 2009; 106:12459-64. PubMed
  • Hilderbrand SA, Shao F, Salthouse C, Mahmood U, Weissleder R. Upconverting luminescent nanomaterials: application to in vivo bioimaging. Chem Commun (Camb) 2009. PubMed
  • Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG. Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. Int J Radiat Oncol Biol Phys 2009; 74:1207-16. PubMed
  • Daniel KD,Kim GY,Vassiliou CC,Galindo M,Guimaraes AR,Weissleder R,Charest A,Langer R,Cima MJ. Implantable diagnostic device for cancer monitoring. Biosens Bioelectron 2009; 24:3252-7. PubMed
  • Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther 2009; 8:1666-75. PubMed
  • Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ. Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia 2009; 11:459-68, 2 p following 468. PubMed
  • Tannous BA,Christensen AP,Pike L,Wurdinger T,Perry KF,Saydam O,Jacobs AH,Garcia-Anoveros J,Weissleder R,Sena-Esteves M,Corey DP,Breakefield XO. Mutant sodium channel for tumor therapy. Mol Ther 2009; 17:810-9. PubMed
  • Koh I,Hong R,Weissleder R,Josephson L. Nanoparticle-target interactions parallel antibody-protein interactions. Anal Chem 2009; 81:3618-22. PubMed
  • Christen T,Nahrendorf M,Wildgruber M,Swirski FK,Aikawa E,Waterman P,Shimizu K,Weissleder R,Libby P. Molecular imaging of innate immune cell function in transplant rejection. Circulation 2009; 119:1925-32. PubMed
  • McCann CM,Waterman P,Figueiredo JL,Aikawa E,Weissleder R,Chen JW. Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage 2009; 45:360-9. PubMed
  • Sasportas LS,Kasmieh R,Wakimoto H,Hingtgen S,van de Water JA,Mohapatra G,Figueiredo JL,Martuza RL,Weissleder R,Shah K. Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A 2009; 106:4822-7. PubMed
  • Sheth RA,Upadhyay R,Stangenberg L,Sheth R,Weissleder R,Mahmood U. Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model. Gynecol Oncol 2009; 112:616-22. PubMed
  • Zhu H,Acquaviva J,Ramachandran P,Boskovitz A,Woolfenden S,Pfannl R,Bronson RT,Chen JW,Weissleder R,Housman DE,Charest A. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A 2009; 106:2712-6. PubMed
  • Vinegoni C,Razansky D,Figueiredo JL,Nahrendorf M,Ntziachristos V,Weissleder R. Normalized Born ratio for fluorescence optical projection tomography. Opt Lett 2009; 34:319-21. PubMed
  • Kozloff KM,Quinti L,Patntirapong S,Hauschka PV,Tung CH,Weissleder R,Mahmood U. Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo. Bone 2008; 44:190-8. PubMed
  • Devaraj NK,Keliher EJ,Thurber GM,Nahrendorf M,Weissleder R. 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem 2009; 20:397-401. PubMed
  • Garanger E,Weissleder R,Josephson L. A multifunctional single-attachment-point reagent for controlled protein biotinylation. Bioconjug Chem 2008; 20:170-3. PubMed
  • Lee H, Yoon TJ, Weissleder R. Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system. Angew Chem Int Ed Engl 2009; 48:5657-60. PubMed
  • Duchrow T, Shtatland T, Guettler D, Pivovarov M, Kramer S, Weissleder R. Enhancing navigation in biomedical databases by community voting and database-driven text classification. BMC Bioinformatics 2009; 10:317. PubMed
  • Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R. Born normalization for fluorescence optical projection tomography for whole heart imaging. 2009. PubMed
  • Vinegoni C, Razansky D, Pitsouli C, Perrimon N, Ntziachristos V, Weissleder R. Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila. 2009. PubMed
  • Thurber GM, Figueiredo JL, Weissleder R. Multicolor fluorescent intravital live microscopy (FILM) for surgical tumor resection in a mouse xenograft model. PLoS ONE 2009; 4:e8053. PubMed
  • Salthouse C,Hildebrand S,Weissleder R,Mahmood U. Design and demonstration of a small-animal up-conversion imager. Opt Express 2008; 16:21731-7. PubMed
  • Niedre MJ,de Kleine RH,Aikawa E,Kirsch DG,Weissleder R,Ntziachristos V. Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proc Natl Acad Sci U S A 2008; 105:19126-31. PubMed
  • Cortez-Retamozo V,Swirski FK,Waterman P,Yuan H,Figueiredo JL,Newton AP,Upadhyay R,Vinegoni C,Kohler R,Blois J,Smith A,Nahrendorf M,Josephson L,Weissleder R,Pittet MJ. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest 2008; 118:4058-66. PubMed
  • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, Garc. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008; 14:1351-6. PubMed
  • Shao F,Weissleder R,Hilderbrand SA. Monofunctional carbocyanine dyes for bio- and bioorthogonal conjugation. Bioconjug Chem 2008; 19:2487-91. PubMed
  • Devaraj NK,Weissleder R,Hilderbrand SA. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem 2008; 19:2297-9. PubMed
  • Cortez-Retamozo V,Swirski FK,Waterman P,Yuan H,Figueiredo JL,Newton AP,Upadhyay R,Vinegoni C,Kohler R,Blois J,Smith A,Nahrendorf M,Josephson L,Weissleder R,Pittet MJ. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest 2008. PubMed
  • Wurdinger T,Tannous BA,Saydam O,Skog J,Grau S,Soutschek J,Weissleder R,Breakefield XO,Krichevsky AM. miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 2008; 14:382-93. PubMed
  • Guimaraes AR,Rakhlin E,Weissleder R,Thayer SP. Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas 2008; 37:440-4. PubMed
  • Korosoglou G,Shah S,Vonken EJ,Gilson WD,Schar M,Tang L,Kraitchman DL,Boston RC,Sosnovik DE,Weiss RG,Weissleder R,Stuber M. Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies. Radiology 2008; 249:501-9. PubMed
  • Hingtgen S,Ren X,Terwilliger E,Classon M,Weissleder R,Shah K. Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide. Mol Cancer Ther 2008; 7:3575-85. PubMed
  • Girnun GD,Chen L,Silvaggi J,Drapkin R,Chirieac LR,Padera RF,Upadhyay R,Vafai SB,Weissleder R,Mahmood U,Naseri E,Buckley S,Li D,Force J,McNamara K,Demetri G,Spiegelman BM,Wong KK. Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. Clin Cancer Res 2008; 14:6478-86. PubMed
  • Perez JM,Grimm J,Josephson L,Weissleder R. Integrated nanosensors to determine levels and functional activity of human telomerase. Neoplasia 2008; 10:1066-72. PubMed
  • Gee MS,Upadhyay R,Bergquist H,Alencar H,Reynolds F,Maricevich M,Weissleder R,Josephson L,Mahmood U. Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy. Radiology 2008; 248:925-35. PubMed
  • Hilderbrand SA,Kelly KA,Niedre M,Weissleder R. Near infrared fluorescence-based bacteriophage particles for ratiometric pH imaging. Bioconjug Chem 2008; 19:1635-9. PubMed
  • Lee H, Sun E, Ham D, Weissleder R. Chip-NMR biosensor for detection and molecular analysis of cells. Nat Med 2008; 14:869-74. PubMed
  • Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R. Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. J Neurosci 2008; 28:4406-13. PubMed
  • Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med 2008; 5:e85. PubMed
  • Weissleder R, Pittet MJ. Imaging in the era of molecular oncology. Nature 2008; 452:580-9. PubMed
  • Kelly KA, Setlur SR, Ross R, Anbazhagan R, Waterman P, Rubin MA, Weissleder R. Detection of early prostate cancer using a hepsin-targeted imaging agent. Cancer Res 2008; 68:2286-91. PubMed
  • Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG. Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer. Urology 2008; 71:708-12. PubMed
  • Jeong JH,Wang Z,Guimaraes AS,Ouyang X,Figueiredo JL,Ding Z,Jiang S,Guney I,Kang GH,Shin E,Hahn WC,Loda MF,Abate-Shen C,Weissleder R,Chin L. BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. PLoS ONE 2008; 3:e3949. PubMed
  • Gounaris E,Tung CH,Restaino C,Maehr R,Kohler R,Joyce JA,Ploegh HL,Barrett TA,Weissleder R,Khazaie K. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS ONE 2008; 3:e2916. PubMed
  • Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A 2007; 104:19977-82. PubMed
  • Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg FH, Weissleder R, Carson W, Chiocca EA, Kaur B. Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. Journal of the National Cancer Institute 2007; 99:1768-81. PubMed
  • Harisinghani M, Ross RW, Guimaraes AR, Weissleder R. Utility of a new bolus-injectable nanoparticle for clinical cancer staging. Neoplasia 2007; 9:1160-5. PubMed
  • Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Stemmer-Rachamimov AO, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA. Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res 2007; 67:9398-406. PubMed
  • Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res 2007; 67:8994-9000. PubMed
  • Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K. Visualizing the Dynamics of EGFR Activity and Antiglioma Therapies In vivo. Cancer Res 2007; 67:7335-42. PubMed
  • Pittet MJ, Grimm J, Berger CR, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski FK, Weissleder R. In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A 2007; 104:12457-61. PubMed
  • Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U. Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection--Study in Mice. Radiology 2007; 244:232-8. PubMed
  • Kock N, Kasmieh R, Weissleder R, Shah K. Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL. Neoplasia 2007; 9:435-42. PubMed
  • Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R. Tomographic fluorescence imaging of tumor vascular volume in mice. Radiology 2007; 242:751-8. PubMed
  • Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature 2007; 445:661-5. PubMed
  • Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS ONE 2007; 2:e1075. PubMed
  • Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA. Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther 2006; 14:779-88. PubMed
  • Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D. Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging. Radiology 2006; 241:822-30. PubMed
  • Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD. Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity. J Immunol 2006; 177:6991-8. PubMed
  • Funovics MA, Alencar H, Montet X, Weissleder R, Mahmood U. Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization. Gastrointest Endosc 2006; 64:589-97. PubMed
  • Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL. In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice. Neoplasia 2006; 8:772-80. PubMed
  • Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N. Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg 2006; 105:445-54. PubMed
  • Fulci G, Breymann L, Gianni D, Kurozomi K, Rhee SS, Yu J, Kaur B, Louis DN, Weissleder R, Caligiuri MA, Chiocca EA. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A 2006; 103:12873-8. PubMed
  • Chen JW, Querol Sans M, Bogdanov A, Weissleder R. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology 2006; 240:473-81. PubMed
  • Galande AK, Hilderbrand SA, Weissleder R, Tung CH. Enzyme-targeted fluorescent imaging probes on a multiple antigenic Peptide core. J Med Chem 2006; 49:4715-20. PubMed
  • Choi Y, Weissleder R, Tung CH. Selective antitumor effect of novel protease-mediated photodynamic agent. Cancer Res 2006; 66:7225-9. PubMed
  • Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A 2006; 103:10340-5. PubMed
  • Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 2006; 25:129-41. PubMed
  • Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a Peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem 2006; 17:905-11. PubMed
  • Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, J. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 2006; 9:485-95. PubMed
  • Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK. N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. Mol Cell Biol 2006; 26:4185-200. PubMed
  • Weissleder R. Molecular imaging in cancer. Science 2006; 312:1168-71. PubMed
  • Hsiao JK, Law B, Weissleder R, Tung CH. In-vivo imaging of tumor associated urokinase-type plasminogen activator activity. J Biomed Opt 2006; 11:34013. PubMed
  • Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO. Metabolic biotinylation of cell surface receptors for in vivo imaging. Nat Methods 2006; 3:391-6. PubMed
  • Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 2006; 12:797-806. PubMed
  • Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 2006; 103:5947-52. PubMed
  • Tr. Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia 2006; 8:302-11. PubMed
  • Kamal SM, Turner B, He Q, Rasenack J, Bianchi L, Al Tawil A, Nooman A, Massoud M, Koziel MJ, Afdhal NH. Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. Hepatology 2006; 43:771-9. PubMed
  • Law B, Weissleder R, Tung CH. Peptide-based biomaterials for protease-enhanced drug delivery. Biomacromolecules 2006; 7:1261-5. PubMed
  • Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 2006; 7:284-92. PubMed
  • Quinti L, Weissleder R, Tung CH. A fluorescent nanosensor for apoptotic cells. Nano Lett 2006; 6:488-90. PubMed
  • Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Pal. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol 2006; 176:2902-14. PubMed
  • Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle imaging of integrins on tumor cells. Neoplasia 2006; 8:214-22. PubMed
  • Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater 2006; 5:118-22. PubMed
  • Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO. Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Hum Gene Ther 2006; 17:20-30. PubMed
  • Kelly KA, Clemons PA, Yu AM, Weissleder R. High-throughput identification of phage-derived imaging agents. Mol Imaging 2006; 5:24-30. PubMed
  • Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V. Volumetric tomography of fluorescent proteins through small animals in vivo. Proc Natl Acad Sci U S A 2005; 102:18252-7. PubMed
  • McCarthy JR, Perez JM, Br. Polymeric nanoparticle preparation that eradicates tumors. Nano Lett 2005; 5:2552-6. PubMed
  • Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X. Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery. Hum Gene Ther 2006; 16:1367-76. PubMed
  • Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R. Mapping of nodal disease in locally advanced prostate cancer: rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy. Int J Radiat Oncol Biol Phys 2005; 63:1262-9. PubMed
  • Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R. In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging. Cancer Res 2005; 65:8324-30. PubMed
  • Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 2004; 102:419-24. PubMed
  • Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T. Mouse models of human non-small-cell lung cancer: raising the bar. Cold Spring Harb Symp Quant Biol 2006; 70:241-50. PubMed
  • Chen WT, Khazaie K, Zhang G, Weissleder R, Tung CH. Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe. Mol Imaging 2005; 4:67-74. PubMed
  • Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R. In Vivo Imaging of HIV Protease Activity in Amplicon Vector-transduced Gliomas. Cancer Res 2004; 64:273-8. PubMed
  • Shah K, Tang Y, Breakefield X, Weissleder R. Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene 2003; 22:6865-72. PubMed
  • Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U. Miniaturized multichannel near infrared endoscope for mouse imaging. Mol Imaging 2004; 2:350-7. PubMed
  • Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R. In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther 2003; 14:1247-54. PubMed
  • Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 2003; 348:2491-9. PubMed
  • Rudin M, Weissleder R. Molecular imaging in drug discovery and development. Nat Rev Drug Discov 2003; 2:123-31. PubMed
  • Bremer C, Mustafa M, Bogdanov A, Ntziachristos V, Petrovsky A, Weissleder R. Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice. Radiology 2003; 226:214-20. PubMed
  • Kim YR, Savellano MD, Weissleder R, Bogdanov A. Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study. Technol Cancer Res Treat 2003; 1:489-95. PubMed
  • Tung CH, Mueller S, Weissleder R. Novel branching membrane translocational peptide as gene delivery vector. Bioorg Med Chem 2002; 10:3609-14. PubMed
  • Ichikawa T, H. MRI of transgene expression: correlation to therapeutic gene expression. Neoplasia 2002; 4:523-30. PubMed
  • Tung CH, Lin Y, Moon WK, Weissleder R. A receptor-targeted near-infrared fluorescence probe for in vivo tumor imaging. Chembiochem 2002; 3:784-6. PubMed
  • Mahmood U, Tung CH, Tang Y, Weissleder R. Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice. Radiology 2002; 224:446-51. PubMed
  • Perez JM, Josephson L, O'Loughlin T, H. Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol 2002; 20:816-20. PubMed
  • Bremer C, Tung CH, Weissleder R. Molecular imaging of MMP expression and therapeutic MMP inhibition. Acad Radiol 2002; 9 Suppl 2:S314-5. PubMed
  • Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R. MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer. Acad Radiol 2002; 9 Suppl 2:S312-3. PubMed
  • Schellenberger EA, H. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol 2002; 9 Suppl 2:S310-1. PubMed
  • Ntziachristos V, Bremer C, Tung C, Weissleder R. Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT). Acad Radiol 2002; 9 Suppl 2:S323-5. PubMed
  • Zhao M, Kircher MF, Josephson L, Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem 2002; 13:840-4. PubMed
  • Ntziachristos V, Tung CH, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med 2002; 8:757-60. PubMed
  • Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R. In vivo imaging of proteolytic activity in atherosclerosis. Circulation 2002; 105:2766-71. PubMed
  • Mahmood U, Weissleder R. Some tools for molecular imaging. Acad Radiol 2002; 9:629-31. PubMed
  • Lin Y, Weissleder R, Tung CH. Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation. Bioconjug Chem 2002; 13:605-10. PubMed
  • Ntziachristos V, Weissleder R. Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media. Med Phys 2002; 29:803-9. PubMed
  • Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem 2002; 13:554-60. PubMed
  • Bogdanov AA, Lin CP, Simonova M, Matuszewski L, Weissleder R. Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment. Neoplasia 2002; 4:228-36. PubMed
  • Moore A, Sun PZ, Cory D, H. MRI of insulitis in autoimmune diabetes. Magn Reson Med 2002; 47:751-8. PubMed
  • Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002; 1:269-77. PubMed
  • Ntziachristos V, Bremer C, Graves EE, Ripoll J, Weissleder R. In vivo tomographic imaging of near-infrared fluorescent probes. Mol Imaging 2003; 1:82-8. PubMed
  • Schellenberger EA, Bogdanov A, H. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging 2003; 1:102-7. PubMed
  • Bremer C, Tung CH, Bogdanov A, Weissleder R. Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology 2002; 222:814-8. PubMed
  • Wunderbaldinger P, Josephson L, Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem 2002; 13:264-8. PubMed
  • Tung CH, Gerszten RE, Jaffer FA, Weissleder R. A novel near-infrared fluorescence sensor for detection of thrombin activation in blood. Chembiochem 2002; 3:207-11. PubMed
  • Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology 2002; 122:406-14. PubMed
  • Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D. Arthritis critically dependent on innate immune system players. Immunity 2002; 16:157-68. PubMed
  • Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R. Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med 2002; 47:292-7. PubMed
  • Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK. Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia 2002; 4:3-8. PubMed
  • Weissleder R. Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer 2002; 2:11-8. PubMed
  • Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem 2002; 13:122-7. PubMed
  • Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH. Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model. Radiology 2001; 221:523-9. PubMed
  • Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD. Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles. J Immunol Methods 2001; 256:89-105. PubMed
  • Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R. Human transferrin receptor gene as a marker gene for MR imaging. Radiology 2001; 221:244-50. PubMed
  • Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF. Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations. J Comput Assist Tomogr 2001; 25:770-6. PubMed
  • Harisinghani MG, Jhaveri KS, Weissleder R, Schima W, Saini S, Hahn PF, Mueller PR. MRI contrast agents for evaluating focal hepatic lesions. Clin Radiol 2001; 56:714-25. PubMed
  • Spear MA, Breakefield XO, Beltzer J, Schuback D, Weissleder R, Pardo FS, Ladner R. Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells. Cancer Gene Ther 2001; 8:506-11. PubMed
  • Bremer C, Tung CH, Weissleder R. In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat Med 2001; 7:743-8. PubMed
  • Weissleder R, Mahmood U. Molecular imaging. Radiology 2001; 219:316-33. PubMed
  • Weissleder R, Bogdanov A, Tung CH, Weinmann HJ. Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging. Bioconjug Chem 2001; 12:213-9. PubMed
  • Simonova M, Wall A, Weissleder R, Bogdanov A. Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells. Cancer Res 2000; 60:6656-62. PubMed
  • Tung CH, Mahmood U, Bredow S, Weissleder R. In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res 2000; 60:4953-8. PubMed
  • Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol 2000; 18:410-4. PubMed
  • Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP. In vivo magnetic resonance imaging of transgene expression. Nat Med 2000; 6:351-5. PubMed
  • Moore A, Marecos E, Bogdanov A, Weissleder R. Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model. Radiology 2000; 214:568-74. PubMed
  • Ross RW, Zietman AL, Xie W, Coen JJ, Dahl DM, Shipley WU, Kaufman DS, Islam T, Guimaraes AR, Weissleder R, Harisinghani M. Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. Clin Imaging 2009; 33:301-5. PubMed
  • Weissleder R, Tung CH, Mahmood U, Bogdanov A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999; 17:375-8. PubMed
  • Josephson L, Tung CH, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem 1999; 10:186-91. PubMed
  • Moore A, Basilion JP, Chiocca EA, Weissleder R. Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta 1998; 1402:239-49. PubMed
  • Mandeville JB, Marota JJ, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med 1998; 39:615-24. PubMed
  • Enochs WS, Petherick P, Bogdanova A, Mohr U, Weissleder R. Paramagnetic metal scavenging by melanin: MR imaging. Radiology 1997; 204:417-23. PubMed
  • Weissleder R, Simonova M, Bogdanova A, Bredow S, Enochs WS, Bogdanov A. MR imaging and scintigraphy of gene expression through melanin induction. Radiology 1997; 204:425-9. PubMed
  • Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R. Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface. Exp Neurol 1997; 143:61-9. PubMed
  • Weissleder R, Cheng HC, Bogdanova A, Bogdanov A. Magnetically labeled cells can be detected by MR imaging. J Magn Reson Imaging 1997; 7:258-63. PubMed
  • Bogdanov A, Wright SC, Marecos EM, Bogdanova A, Martin C, Petherick P, Weissleder R. A long-circulating co-polymer in "passive targeting" to solid tumors. J Drug Target 1997; 4:321-30. PubMed
  • Muldoon LL, Nilaver G, Kroll RA, Pagel MA, Breakefield XO, Chiocca EA, Davidson BL, Weissleder R, Neuwelt EA. Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am J Pathol 1995; 147:1840-51. PubMed
  • Zimmer C, Weissleder R, Poss K, Bogdanova A, Wright SC, Enochs WS. MR imaging of phagocytosis in experimental gliomas. Radiology 1995; 197:533-8. PubMed
  • Weissleder R, Poss K, Wilkinson R, Zhou C, Bogdanov A. Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging. Antimicrob Agents Chemother 1995; 39:839-45. PubMed
  • Bogdanov AA, Martin C, Weissleder R, Brady TJ. Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes. Biochim Biophys Acta 1994; 1193:212-8. PubMed
  • Neuwelt EA, Weissleder R, Nilaver G, Kroll RA, Roman-Goldstein S, Szumowski J, Pagel MA, Jones RS, Remsen LG, McCormick CI. Delivery of virus-sized iron oxide particles to rodent CNS neurons. Neurosurgery 1994; 34:777-84. PubMed
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