Photo of Ramnik J. Xavier,  MD, FAAN

Ramnik J. Xavier, MD, FAAN

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 643-3331
Fax: (617) 643-3328


xavier@frodo.mgh.harvard.edu

Ramnik J. Xavier, MD, FAAN

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology, Medicine, Harvard Medical School
  • Assistant, Molecular Biology, Massachusetts General Hospital
  • Assistant Professor of Medicine, Center for Computational and Integrative Biology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Publications

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  • Wlodarska M, Kostic AD, Xavier RJ. An integrative view of microbiome-host interactions in inflammatory bowel diseases. Cell Host Microbe 2015; 17:577-91. PubMed
  • Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ. Discovery of a Small-Molecule Probe for V-ATPase Function. J Am Chem Soc 2015; 137:5563-8. PubMed
  • Sarmento OF, Svingen PA, Xiong Y, Xavier RJ, McGovern D, Smyrk TC, Papadakis KA, Urrutia RA, Faubion WA. A novel role for KLF14 in T regulatory cell differentiation. Cell Mol Gastroenterol Hepatol 2015; 1:188-202.e4. PubMed
  • Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA. Pyruvate kinase M2 regulates Hif-1留 activity and IL-1硫 induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab 2015; 21:65-80. PubMed
  • Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, Sharpe AH, Shaw SY, Xavier RJ. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells. Elife 2015. PubMed
  • Paulus GL, Xavier RJ. Autophagy and checkpoints for intracellular pathogen defense. Curr Opin Gastroenterol 2014; 31:14-23. PubMed
  • Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling. Cell 2014; 159:440-55. PubMed
  • Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF. Small-molecule control of cytokine function: new opportunities for treating immune disorders. Curr Opin Chem Biol 2014; 23C:23-30. PubMed
  • Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE. Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat Biotechnol 2014. PubMed
  • Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dančík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A 2014; 111:12468-73. PubMed
  • Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN. Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. PLoS Pathog. 2014; 10:e1003981. PubMed
  • Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM. SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-虜B Activity and Associates with Intestinal Perforation. PLoS ONE 2014; 9:e100515. PubMed
  • Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W. Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL. Cancer Immunol Res 2014; 1:426-37. PubMed
  • He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell 2013; 154:1085-99. PubMed
  • Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 2013; 14:480-8. PubMed
  • Graham DB, Xavier RJ. From genetics of inflammatory bowel disease towards mechanistic insights. Trends Immunol 2013. PubMed
  • Giallourakis CC, Benita Y, Molinie B, Cao Z, Despo O, Pratt HE, Zukerberg LR, Daly MJ, Rioux JD, Xavier RJ. Genome-wide Analysis of Immune System Genes by Expressed Sequence Tag Profiling. J Immunol 2013. PubMed
  • Coffee EM, Faber AC, Roper J, Sinnamon M, Goel G, Keung L, Wang WV, Vecchione L, Devriendt V, Weinstein BJ, Bronson RT, Tejpar S, Xavier RJ, Engelman JA, Martin ES, Hung KE. Concomitant BRAF and PI3K/mTOR Blockade is Required for Effective Treatment of BRAFV600E Colorectal Cancer. Clin Cancer Res 2013. PubMed
  • Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ. ATG5 regulates plasma cell differentiation. Autophagy 2013; 9:528-37. PubMed
  • Gmyrek GB, Graham DB, Sandoval GJ, Blaufuss GS, Akilesh HM, Fujikawa K, Xavier RJ, Swat W. Polarity gene discs large homolog 1 regulates the generation of memory T cells. Eur J Immunol 2013; 43:1185-94. PubMed
  • Sandoval GJ, Graham DB, Bhattacharya D, Sleckman BP, Xavier RJ, Swat W. Cutting Edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells. J Immunol 2013; 190:2485-9. PubMed
  • Kirby A, Gnirke A, Jaffe DB, Barešová V, Pochet N, Blumenstiel B, Ye C, Aird D, Stevens C, Robinson JT, Cabili MN, Gat-Viks I, Kelliher E, Daza R, DeFelice M, Hůlková H, Sovová J, Vylet'al P, Antignac C, Guttman M, Handsaker RE, Perrin D, Steelman S, Sigurdsson S, Scheinman SJ, Sougnez C, Cibulskis K, Parkin M, Green T, Rossin E, Zody MC, Xavier RJ, Pollak MR, Alper SL, Lindblad-Toh K, Gabriel S, Hart PS, Regev A, Nusbaum C, Kmoch S, Bleyer AJ, Lander ES, Daly MJ. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nat Genet 2013; 45:299-303. PubMed
  • Martin ES, Belmont PJ, Sinnamon MJ, Georgeon Richard L, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji C, Xie J, Xie T, Lamb J, Weinrich S, Vanarsdale TL, Bronson RT, Xavier RJ, Vander Heiden M, Kan JL, Mahmood U, Hung KE. Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation. Clin Cancer Res 2013. PubMed
  • Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ. The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium. Cell Host Microbe 2012; 12:778-90. PubMed
  • Xavier RJ, Gala MK, Bronzo BK, Kelly PJ. Case records of the Massachusetts General Hospital. Case 23-2012. A 59-year-old man with abdominal pain and weight loss. N Engl J Med 2012; 367:363-73. PubMed
  • Rossin EJ, Lage K, Raychaudhuri S, Xavier RJ, Tatar D, Benita Y, , Cotsapas C, Daly MJ. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet. 2011; 7:e1001273. PubMed
  • Bekpen C, Xavier RJ, Eichler EE. Human IRGM gene "to be or not to be" Semin Immunopathol 2010; 32:437-44. PubMed
  • Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK. LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol 2010; 185:5577-85. PubMed
  • Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 2010; 191:537-52. PubMed
  • Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev 2010; 24:1507-18. PubMed
  • Benita Y, Cao Z, Giallourakis C, Li C, Gardet A, Xavier RJ. Gene enrichment profiles reveal T cell development, differentiation and lineage specific transcription factors including ZBTB25 as a novel NF-AT repressor. Blood 2010; 115:5376-84. PubMed
  • Huett A, Goel G, Xavier RJ. A systems biology viewpoint on autophagy in health and disease. Curr Opin Gastroenterol 2010; 26:302-9. PubMed
  • Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ. Microbes and Health Sackler Colloquium: Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proc Natl Acad Sci U S A 2010. PubMed
  • Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell 2010; 18:1041-52. PubMed
  • Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ. Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res 2010; 28:746-52. PubMed
  • Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z. Characterization and analysis of human chordoma cell lines. Spine 2010; 35:1257-64. PubMed
  • Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM. Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions. PLoS ONE 2011; 5:e15215. PubMed
  • Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2010; 139:1243-54. PubMed
  • Heath RJ, Xavier RJ. Autophagy, immunity and human disease. Curr Opin Gastroenterol 2009; 25:512-20. PubMed
  • Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ. A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A 2009; 106:16410-5. PubMed
  • Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res 2009; 37:4587-602. PubMed
  • Huett A,Leong JM,Podolsky DK,Xavier RJ. The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Exp Cell Res 2009; 315:2001-11. PubMed
  • Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, , Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 2009; 5:e1000534. PubMed
  • Huett A,Ng A,Cao Z,Kuballa P,Komatsu M,Daly MJ,Podolsky DK,Xavier RJ. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. J Immunol 2009; 182:4917-30. PubMed
  • Tai AW,Benita Y,Peng LF,Kim SS,Sakamoto N,Xavier RJ,Chung RT. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 2009; 5:298-307. PubMed
  • Medoff BD,Landry AL,Wittbold KA,Sandall BP,Derby MC,Cao Z,Adams JC,Xavier RJ. CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 2008; 40:286-94. PubMed
  • Imamura T,Kikuchi H,Herraiz MT,Park DY,Mizukami Y,Mino-Kenduson M,Lynch MP,Rueda BR,Benita Y,Xavier RJ,Chung DC. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer 2008; 124:763-71. PubMed
  • Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ. Differential requirement for CARMA1 in agonist-selected T-cell development. Eur J Immunol 2009; 39:78-84. PubMed
  • Hitomi J,Christofferson DE,Ng A,Yao J,Degterev A,Xavier RJ,Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008; 135:1311-23. PubMed
  • Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells. Proc Natl Acad Sci U S A 2008; 105:20321-6. PubMed
  • Cadwell K,Liu JY,Brown SL,Miyoshi H,Loh J,Lennerz JK,Kishi C,Kc W,Carrero JA,Hunt S,Stone CD,Brunt EM,Xavier RJ,Sleckman BP,Li E,Mizushima N,Stappenbeck TS,Virgin HW 4th. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-63. PubMed
  • Irazoqui JE,Ng A,Xavier RJ,Ausubel FM. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc Natl Acad Sci U S A 2008; 105:17469-74. PubMed
  • Krishnan MN,Ng A,Sukumaran B,Gilfoy FD,Uchil PD,Sultana H,Brass AL,Adametz R,Tsui M,Qian F,Montgomery RR,Lev S,Mason PW,Koski RA,Elledge SJ,Xavier RJ,Agaisse H,Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature 2008; 455:242-5. PubMed
  • Fujiki K,Duerr EM,Kikuchi H,Ng A,Xavier RJ,Mizukami Y,Imamura T,Kulke MH,Chung DC. Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology 2008; 135:907-16, 916.e1-2. PubMed
  • McCarroll SA,Huett A,Kuballa P,Chilewski SD,Landry A,Goyette P,Zody MC,Hall JL,Brant SR,Cho JH,Duerr RH,Silverberg MS,Taylor KD,Rioux JD,Altshuler D,Daly MJ,Xavier RJ. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 2009; 40:1107-12. PubMed
  • McCarroll SA,Huett A,Kuballa P,Chilewski SD,Landry A,Goyette P,Zody MC,Hall JL,Brant SR,Cho JH,Duerr RH,Silverberg MS,Taylor KD,Rioux JD,Altshuler D,Daly MJ,Xavier RJ. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 2008. PubMed
  • Xavier RJ,Rioux JD. Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol 2008; 8:631-43. PubMed
  • Barrett JC,Hansoul S,Nicolae DL,Cho JH,Duerr RH,Rioux JD,Brant SR,Silverberg MS,Taylor KD,Barmada MM,Bitton A,Dassopoulos T,Datta LW,Green T,Griffiths AM,Kistner EO,Murtha MT,Regueiro MD,Rotter JI,Schumm LP,Steinhart AH,Targan SR,Xavier RJ,Libioulle C,Sandor C,Lathrop M,Belaiche J,Dewit O,Gut I,Heath S,Laukens D,Mni M,Rutgeerts P,Van Gossum A,Zelenika D,Franchimont D,Hugot JP,de Vos M,Vermeire S,Louis E,Cardon LR,Anderson CA,Drummond H,Nimmo E,Ahmad T,Prescott NJ,Onnie CM,Fisher SA,Marchini J,Ghori J,Bumpstead S,Gwilliam R,Tremelling M,Deloukas P,Mansfield J,Jewell D,Satsangi J,Mathew CG,Parkes M,Georges M,Daly MJ. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-62. PubMed
  • Tamehiro N,Zhou S,Okuhira K,Benita Y,Brown CE,Zhuang DZ,Latz E,Hornemann T,von Eckardstein A,Xavier RJ,Freeman MW,Fitzgerald ML. SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry 2008; 47:6138-47. PubMed
  • Huett A,Xavier RJ. Neither hide nor hair: the difficulty of identifying useful disease biomarkers. Gastroenterology 2008; 134:2164-8. PubMed
  • Seed B, Xavier R. Spinophilin and the immune synapse. J Cell Biol 2008; 181:181-3. PubMed
  • Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer 2008; 15:243-56. PubMed
  • Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008; 319:921-6. PubMed
  • Huett A, Xavier R. SNPping away at the pathogenesis of Crohn's disease. Inflamm Bowel Dis 2007; 14:136-7. PubMed
  • Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ. DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. Cell Signal 2007; 20:73-82. PubMed
  • Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W. DLGH1 is a negative regulator of T-lymphocyte proliferation. Mol Cell Biol 2007; 27:7574-81. PubMed
  • Barnich N, Aguirre JE, Reinecker HC, Xavier R, Podolsky DK. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 2005; 170:21-6. PubMed
  • Xavier R, Seed B. PDZ domains and the politics of polarity in lymphocytes. Immunity 2005; 22:655-6. PubMed
  • Ting A, Lichtenthaler S, Xavier R, Na SY, Rabizadeh S, Holmes T, Seed B. Large-scale screens for cDNAs with in vivo activity. Novartis Found Symp 2005; 267:219-29; discussion 229-30. PubMed
  • Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B. Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol 2004; 166:173-8. PubMed
  • Ishiguro K, Xavier R. Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. Blood 2003; 103:2248-56. PubMed
  • Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW. Essential role for Vav1 in activation, but not development, of gammadelta T cells. Int Immunol 2003; 15:215-21. PubMed
  • Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK. Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 2003; 162:597-608. PubMed
  • Schiffmann R, Mankin H, Dambrosia JM, Xavier RJ, Kreps C, Hill SC, Barton NW, Rosenthal DI. Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy. Blood Cells Mol Dis 2002; 28:288-96. PubMed
  • Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol 2002; 12:253-65. PubMed
  • Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology 2002; 122:134-44. PubMed
  • Colucci R, Fleming JV, Xavier R, Wang TC. L-histidine decarboxylase decreases its own transcription through downregulation of ERK activity. Am J Physiol Gastrointest Liver Physiol 2001; 281:G1081-91. PubMed
  • Chung RT, He W, Saquib A, Contreras AM, Xavier RJ, Chawla A, Wang TC, Schmidt EV. Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system. Proc Natl Acad Sci U S A 2001; 98:9847-52. PubMed
  • Itoh H, Beck PL, Inoue N, Xavier R, Podolsky DK. A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells. J Clin Invest 1999; 104:1539-47. PubMed
  • Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B. Tumor induction of VEGF promoter activity in stromal cells. Cell 1998; 94:715-25. PubMed
  • H. Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells. J Biol Chem 1998; 273:23046-54. PubMed
  • Xavier R, Brennan T, Li Q, McCormack C, Seed B. Membrane compartmentation is required for efficient T cell activation. Immunity 1998; 8:723-32. PubMed
  • Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity 1998; 8:625-34. PubMed
  • Liang TJ, Reid AE, Xavier R, Cardiff RD, Wang TC. Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. J Clin Invest 1996; 97:2872-7. PubMed
  • Pins MR, Mankin HJ, Xavier RJ, Rosenthal DI, Dickersin GR, Rosenberg AE. Malignant epithelioid hemangioendothelioma of the tibia associated with a bone infarct in a patient who had Gaucher disease. A case report. J Bone Joint Surg Am 1995; 77:777-81. PubMed
  • Rachmilewitz D, Stamler JS, Karmeli F, Mullins ME, Singel DJ, Loscalzo J, Xavier RJ, Podolsky DK. Peroxynitrite-induced rat colitis--a new model of colonic inflammation. Gastroenterology 1993; 105:1681-8. PubMed
  • Xavier RJ, Stein CM, Kiire CF, Arrow J, Kitai I. Value of the history and stool occult blood test in selection of patients for upper endoscopy in Zimbabwe. East Afr Med J 1992; 69:268-71. PubMed
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