Photo of Richard A. Hodin,  MD

Richard A. Hodin, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-2570
Fax: (617) 724-2574


rhodin@partners.org

Richard A. Hodin, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Surgery, Harvard Medical School
  • Professor, Surgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The long-term objectives of this ongoing project is to elucidate the mechanisms underlying gut mucosal defense. We are particularly interested in understanding the mechanisms that which go awry in a number of gut disease states, including inflammatory conditions, prolonged starvation, systemic trauma and sepsis. as well as cancer.

Publications

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  • Chen Y, Hodin RA, Pandolfi C, Ruan DT, McKenzie TJ. Hypoglycemia after resection of pheochromocytoma. Surgery 2014; 156:1404-8; discussion 1408-9. PubMed
  • Chen Y, Masiakos PT, Gaz RD, Hodin RA, Parangi S, Randolph GW, Sadow PM, Stephen AE. Pediatric thyroidectomy in a high volume thyroid surgery center: Risk factors for postoperative hypocalcemia. J Pediatr Surg 2015. PubMed
  • Shin J, Carr A, Corner GA, Tögel L, Dávaos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM. The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner. J Biol Chem 2014; 289:25306-16. PubMed
  • Morrison SA, Suh H, Hodin RA. The surgical management of thyroid cancer. Rambam Maimonides Med J 2014; 5:e0008. PubMed
  • Prescott JD, Sadow PM, Hodin RA, Le LP, Gaz RD, Randolph GW, Stephen AE, Parangi S, Daniels GH, Lubitz CC. BRAF V600E status adds incremental value to current risk classification systems in predicting papillary thyroid carcinoma recurrence. Surgery 2012; 152:984-90. PubMed
  • Nagarkatti SS, Faquin WC, Lubitz CC, Garcia DM, Barbesino G, Ross DS, Hodin RA, Daniels GH, Parangi S. Management of Thyroid Nodules with Atypical Cytology on Fine-needle Aspiration Biopsy. Ann Surg Oncol 2012. PubMed
  • Lubitz CC, Stephen AE, Hodin RA, Pandharipande P. Preoperative Localization Strategies for Primary Hyperparathyroidism: An Economic Analysis. Ann Surg Oncol 2012. PubMed
  • Lubitz CC, Nagarkatti SS, Faquin WC, Samir AE, Hassan MC, Barbesino G, Ross DS, Randolph GW, Gaz RD, Stephen AE, Hodin RA, Daniels GH, Parangi S. Diagnostic yield of nondiagnostic thyroid nodules is not altered by timing of repeat biopsy. Thyroid 2012; 22:590-4. PubMed
  • Moaven O, Hodin RA. Chilaiditi syndrome: a rare entity with important differential diagnoses. Gastroenterol Hepatol (N Y) 2012; 8:276-8. PubMed
  • Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S. Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer. Oncologist 2011; 16:296-309. PubMed
  • Nehs MA, Nagarkatti S, Nucera C, Hodin RA, Parangi S. Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer. Surgery 2010; 148:1154-62; discussion 1162. PubMed
  • Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? 2011; 1:751-6. PubMed
  • Klos CL, Shellito PC, Rattner DW, Hodin RA, Cusack JC, Bordeianou L, Sylla P, Hong TS, Blaszkowsky L, Ryan DP, Lauwers GY, Chang Y, Berger DL. The effect of neoadjuvant chemoradiation therapy on the prognostic value of lymph nodes after rectal cancer surgery. Am J Surg 2010; 200:440-5. PubMed
  • Mekel M, Nucera C, Hodin RA, Parangi S. Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules. Am J Surg 2010; 200:136-43. PubMed
  • Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A 2010; 107:10649-54. PubMed
  • Mekel M, Stephen AE, Gaz RD, Randolph GW, Richer S, Perry ZH, Lubitz CC, Nehs MA, Parangi S, Hodin RA. Surgical drains can be safely avoided in lateral neck dissections for papillary thyroid cancer. Am J Surg 2010; 199:485-90. PubMed
  • Lubitz CC, Faquin WC, Yang J, Mekel M, Gaz RD, Parangi S, Randolph GW, Hodin RA, Stephen AE. Clinical and cytological features predictive of malignancy in thyroid follicular neoplasms. Thyroid 2010; 20:25-31. PubMed
  • Mekel M, Stephen AE, Gaz RD, Perry ZH, Hodin RA, Parangi S. Thyroid surgery in octogenarians is associated with higher complication rates. Surgery 2009; 146:913-21. PubMed
  • Henneman D,Chang Y,Hodin RA,Berger DL. Effect of laparoscopy on the indications for adrenalectomy. Arch Surg 2009; 144:255-9; discussion 259. PubMed
  • Kaplan GG, McCarthy EP, Ayanian JZ, Korzenik J, Hodin R, Sands BE. Impact of Hospital Volume on Postoperative Morbidity and Mortality Following a Colectomy for Ulcerative Colitis. Gastroenterology 2008; 134:680-7. PubMed
  • Hodin RA. Gnothi se auton: SUS Presidential Address. Surgery 2007; 142:127-35. PubMed
  • Bordeianou L, Hodin R. Controversies in the surgical management of sigmoid diverticulitis. J Gastrointest Surg 2007; 11:542-8. PubMed
  • Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA. Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas. Arch Surg 2007; 142:381-6. PubMed
  • Malo MS, Biswas S, Abedrapo MA, Yeh L, Chen A, Hodin RA. The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression. DNA Cell Biol 2007; 25:684-95. PubMed
  • Stephen AE, Hodin RA. Neuroendocrine tumors of the pancreas, excluding gastrinoma. Surg Oncol Clin N Am 2006; 15:497-510. PubMed
  • Malo MS, Mozumder M, Zhang XB, Biswas S, Chen A, Bai LC, Merchant JL, Hodin RA. Intestinal alkaline phosphatase gene expression is activated by ZBP-89. Am J Physiol Gastrointest Liver Physiol 2005; 290:G737-46. PubMed
  • Malo MS, Mozumder M, Chen A, Mostafa G, Zhang XB, Hodin RA. pFRL7: an ideal vector for eukaryotic promoter analysis. Anal Biochem 2006; 350:307-9. PubMed
  • Archer SY, Johnson J, Kim HJ, Ma Q, Mou H, Daesety V, Meng S, Hodin RA. The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol 2005; 289:G696-703. PubMed
  • Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. Am J Physiol Gastrointest Liver Physiol 2005; 289:G285-90. PubMed
  • Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nose V, Li C, Stiles CD. A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet 2005; 1:72-80. PubMed
  • Hall JF, Hodin R. Restorative proctocolectomy: fertile ground for technical improvements? Inflamm Bowel Dis 2005; 11:207-8. PubMed
  • Grikscheit TC, Siddique A, Ochoa ER, Srinivasan A, Alsberg E, Hodin RA, Vacanti JP. Tissue-engineered small intestine improves recovery after massive small bowel resection. Ann Surg 2004; 240:748-54. PubMed
  • Malo MS, Zhang W, Alkhoury F, Pushpakaran P, Abedrapo MA, Mozumder M, Fleming E, Siddique A, Henderson JW, Hodin RA. Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element. Mol Endocrinol 2004; 18:1941-62. PubMed
  • Partridge SK, Hodin RA. Small bowel adenocarcinoma at a strictureplasty site in a patient with Crohn's disease: report of a case. Dis Colon Rectum 2004; 47:778-81. PubMed
  • Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, Abedrapo MA, Chen X, Yang VW, Hodin RA. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol 2003; 286:G23-30. PubMed
  • Chavez AM, Morin MJ, Unno N, Fink MP, Hodin RA. Acquired interferon gamma responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression. Gut 1999; 44:659-65. PubMed
  • Archer SY, Hodin RA. Histone acetylation and cancer. Curr Opin Genet Dev 1999; 9:171-4. PubMed
  • Kim JH, Meng S, Shei A, Hodin RA. A novel Sp1-related cis element involved in intestinal alkaline phosphatase gene transcription. Am J Physiol 1999; 276:G800-7. PubMed
  • Morin MJ, Unno N, Hodin RA, Fink MP. Differential expression of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats. Crit Care Med 1998; 26:1258-64. PubMed
  • Archer SY, Meng S, Shei A, Hodin RA. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci U S A 1998; 95:6791-6. PubMed
  • Matthews JB, Hassan I, Meng S, Archer SY, Hrnjez BJ, Hodin RA. Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate. J Clin Invest 1998; 101:2072-9. PubMed
  • Unno N, Wang H, Menconi MJ, Tytgat SH, Larkin V, Smith M, Morin MJ, Chavez A, Hodin RA, Fink MP. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997; 113:1246-57. PubMed
  • Hodin RA, Shei A, Morin M, Meng S. Thyroid hormone and the gut: selective transcriptional activation of a villus-enterocyte marker. Surgery 1996; 120:138-43. PubMed
  • Hodin RA, Meng S, Archer S, Tang R. Cellular growth state differentially regulates enterocyte gene expression in butyrate-treated HT-29 cells. Cell Growth Differ 1996; 7:647-53. PubMed
  • Hodin RA, Saldinger P, Meng S. Small bowel adaptation: counterregulatory effects of epidermal growth factor and somatostatin on the program of early gene expression. Surgery 1995; 118:206-10; discussion 210-1. PubMed
  • Hodin RA, Chamberlain SM, Meng S. Pattern of rat intestinal brush-border enzyme gene expression changes with epithelial growth state. Am J Physiol 1995; 269:C385-91. PubMed
  • Hodin RA, Meng S, Shei A. Differential cloning of novel intestine-specific genes whose expression is altered under conditions of villus atrophy. J Surg Res 1995; 59:115-20. PubMed
  • Hodin RA, Meng S, Chamberlain SM. Thyroid hormone responsiveness is developmentally regulated in the rat small intestine: a possible role for the alpha-2 receptor variant. Endocrinology 1994; 135:564-8. PubMed
  • Hodin RA, Meng S, Shei A. Bombesin maintains enterocyte phenotype in fasted rats. Surgery 1994; 116:426-31. PubMed
  • Hodin RA, Meng S, Nguyen D. Immediate-early gene expression in EGF-stimulated intestinal epithelial cells. J Surg Res 1994; 56:500-4. PubMed
  • Hodin RA, Graham JR, Meng S, Upton MP. Temporal pattern of rat small intestinal gene expression with refeeding. Am J Physiol 1994; 266:G83-9. PubMed
  • Hodin RA, Chamberlain SM, Upton MP. Thyroid hormone differentially regulates rat intestinal brush border enzyme gene expression. Gastroenterology 1992; 103:1529-36. PubMed
  • Hodin RA, Lazar MA, Wintman BI, Darling DS, Koenig RJ, Larsen PR, Moore DD, Chin WW. Identification of a thyroid hormone receptor that is pituitary-specific. Science 1989; 244:76-9. PubMed
  • Lazar MA, Hodin RA, Darling DS, Chin WW. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol 1989; 9:1128-36. PubMed
  • Koenig RJ, Lazar MA, Hodin RA, Brent GA, Larsen PR, Chin WW, Moore DD. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature 1989; 337:659-61. PubMed
  • Lazar MA, Hodin RA, Darling DS, Chin WW. Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. Mol Endocrinol 1988; 2:893-901. PubMed
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