Photo of Rinaa S. Punglia,  MD, MPH

Rinaa S. Punglia, MD, MPH

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute

Rinaa S. Punglia, MD, MPH

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Associate Professor, Radiation Oncology, Harvard Medical School
  • Active Medical Staff, Radiation Oncology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

On staff in the Department of Radiation Oncology at the Dana-Farber Cancer Institute and the Brigham and Women痴 Hospital, I study decision-making about radiation therapy in breast cancer. My primary goal is to pursue health services research studying radiation therapy for breast cancer, as well as continue to model discrete decisions confronted by individual patients.

With time, I hope to use the results from the decision analyses and health services research to improve the quality of decision-making by individual breast cancer patients and their oncologists. The ability to present outcomes targeted to an individual patient will advance the field of breast oncology, where many therapeutic decisions are made based on the results of large aggregates of patients enrolled in clinical trials, whose results may not be specifically tailored to an individual patient痴 set of clinical circumstances and values.

Publications

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  • Braunstein LZ, Niemierko A, Shenouda MN, Truong L, Sadek BT, Abi Raad R, Wong JS, Punglia RS, Taghian AG, Bellon JR. Outcome following local-regional recurrence in women with early-stage breast cancer: impact of biologic subtype. Breast J 2015; 21:161-7. PubMed
  • Greenberg CC, Habel LA, Hughes ME, Nekhlyudov L, Achacoso N, Acton L, Schrag D, Jiang W, Edge S, Weeks JC, Punglia RS. Characterization and Treatment of Local Recurrence Following Breast Conservation for Ductal Carcinoma In Situ. Ann Surg Oncol 2014. PubMed
  • Sher DJ, Punglia RS. Decision analysis and cost-effectiveness analysis for comparative effectiveness research--a primer. Semin Radiat Oncol 2013; 24:14-24. PubMed
  • Punglia RS, Schnitt SJ, Weeks JC. Treatment of ductal carcinoma in situ after excision: would a prophylactic paradigm be more appropriate? Journal of the National Cancer Institute 2013; 105:1527-33. PubMed
  • Ruddy KJ, Desantis SD, Gelman RS, Wu AH, Punglia RS, Mayer EL, Tolaney SM, Winer EP, Partridge AH, Burstein HJ. Personalized medicine in breast cancer: tamoxifen, endoxifen, and CYP2D6 in clinical practice. Breast Cancer Res Treat 2013; 141:421-7. PubMed
  • Russo AL, Arvold ND, Niemierko A, Wong N, Wong JS, Bellon JR, Punglia RS, Golshan M, Troyan SL, Brock JE, Harris JR. Margin status and the risk of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy. Breast Cancer Res Treat 2013; 140:353-61. PubMed
  • Soeteman DI, Stout NK, Ozanne EM, Greenberg C, Hassett MJ, Schrag D, Punglia RS. Modeling the effectiveness of initial management strategies for ductal carcinoma in situ. Journal of the National Cancer Institute 2013; 105:774-81. PubMed
  • Krishnan MS, Recht A, Bellon JR, Punglia RS. Trade-offs associated with axillary lymph node dissection with breast irradiation versus breast irradiation alone in patients with a positive sentinel node in relation to the risk of non-sentinel node involvement: implications of ACOSOG Z0011. Breast Cancer Res Treat 2013; 138:205-13. PubMed
  • Sher DJ, Parikh R, Mays-Jackson S, Punglia RS. Cost-effectiveness Analysis of SBRT Versus IMRT for Low-risk Prostate Cancer. Am J Clin Oncol 2012. PubMed
  • Halasz LM, Weeks JC, Neville BA, Taback N, Punglia RS. Use of Stereotactic Radiosurgery for Brain Metastases From Non-Small Cell Lung Cancer in the United States. Int J Radiat Oncol Biol Phys 2012. PubMed
  • Childs SK, Chen YH, Duggan MM, Golshan M, Pochebit S, Punglia RS, Wong JS, Bellon JR. Impact of Margin Status on Local Recurrence After Mastectomy for Ductal Carcinoma In Situ. Int J Radiat Oncol Biol Phys 2012. PubMed
  • Arvold ND, Punglia RS, Hughes ME, Jiang W, Edge SB, Javid SH, Laronga C, Niland JC, Theriault RL, Weeks JC, Wong YN, Lee SJ, Hassett MJ. Pathologic characteristics of second breast cancers after breast conservation for ductal carcinoma in situ. Cancer 2012. PubMed
  • Sher DJ, Wee JO, Punglia RS. Cost-Effectiveness Analysis of Stereotactic Body Radiotherapy and Radiofrequency Ablation for Medically Inoperable, Early-Stage Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Punglia RS, Hassett MJ. Using lifetime risk estimates to recommend magnetic resonance imaging screening for breast cancer survivors. J Clin Oncol 2010; 28:4108-10. PubMed
  • Punglia RS, Saito AM, Neville BA, Earle CC, Weeks JC. Impact of interval from breast conserving surgery to radiotherapy on local recurrence in older women with breast cancer: retrospective cohort analysis. BMJ 2010; 340:c845. PubMed
  • Chen AB, Punglia RS, Kuntz KM, Mauch PM, Ng AK. Cost effectiveness and screening interval of lipid screening in Hodgkin's lymphoma survivors. J Clin Oncol 2009; 27:5383-9. PubMed
  • Sher DJ,Wittenberg E,Suh WW,Taghian AG,Punglia RS. Partial-breast irradiation versus whole-breast irradiation for early-stage breast cancer: a cost-effectiveness analysis. Int J Radiat Oncol Biol Phys 2008; 74:440-6. PubMed
  • Punglia RS, Hughes ME, Edge SB, Theriault RL, Bookman MA, Wilson JL, Ottesen RA, Niland JC, Weeks JC. Factors Associated with Guideline-Concordant Use of Radiotherapy After Mastectomy in the National Comprehensive Cancer Network. Int J Radiat Oncol Biol Phys 2008; 72:1434-40. PubMed
  • Hoffman KE,Chen MH,Punglia RS,Beard CJ,D'Amico AV. Influence of year of diagnosis, patient age, and sociodemographic status on recommending adjuvant radiation treatment for stage I testicular seminoma. J Clin Oncol 2008; 26:3937-42. PubMed
  • Punglia RS, Burstein HJ, Winer EP, Weeks JC. Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: a modeling analysis. Journal of the National Cancer Institute 2008; 100:642-8. PubMed
  • Sher DJ, Wittenberg E, Taghian AG, Bellon JR, Punglia RS. Partial breast irradiation versus whole breast radiotherapy for early-stage breast cancer: a decision analysis. Int J Radiat Oncol Biol Phys 2007; 70:469-76. PubMed
  • Punglia RS, Cullen J, McLeod DG, Chen Y, D'Amico AV. Prostate-specific antigen velocity and the detection of gleason score 7 to 10 prostate cancer. Cancer 2007; 110:1973-8. PubMed
  • Punglia RS, Morrow M, Winer EP, Harris JR. Local therapy and survival in breast cancer. N Engl J Med 2007; 356:2399-405. PubMed
  • Landis DM, Luo W, Song J, Bellon JR, Punglia RS, Wong JS, Killoran JH, Gelman R, Harris JR. Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity. Int J Radiat Oncol Biol Phys 2007; 67:1299-308. PubMed
  • Punglia RS, Weeks JC, Neville BA, Earle CC. Effect of distance to radiation treatment facility on use of radiation therapy after mastectomy in elderly women. Int J Radiat Oncol Biol Phys 2006; 66:56-63. PubMed
  • Guadagnolo BA, Punglia RS, Kuntz KM, Mauch PM, Ng AK. Cost-effectiveness analysis of computerized tomography in the routine follow-up of patients after primary treatment for Hodgkin's disease. J Clin Oncol 2006; 24:4116-22. PubMed
  • Punglia RS, Weeks JC, Neville BA, Earle CC. Radiation therapy after mastectomy between 1991 and 1999 in elderly women: response to clinical trial information. J Clin Oncol 2006; 24:3474-82. PubMed
  • Punglia RS, Kuntz KM, Winer EP, Weeks JC, Burstein HJ. The impact of tumor progesterone receptor status on optimal adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer: a decision analysis. Cancer 2006; 106:2576-82. PubMed
  • Punglia RS, D'Amico AV, Catalona WJ, Roehl KA, Kuntz KM. Impact of age, benign prostatic hyperplasia, and cancer on prostate-specific antigen level. Cancer 2006; 106:1507-13. PubMed
  • Punglia RS, Kuntz KM, Catalona WJ, D'Amico A. Operating characteristics of prostate-specific antigen and verification bias. JAMA 2005; 294:2698; author reply 2698-9. PubMed
  • Punglia RS, Kuntz KM, Winer EP, Weeks JC, Burstein HJ. Optimizing adjuvant endocrine therapy in postmenopausal women with early-stage breast cancer: a decision analysis. J Clin Oncol 2005; 23:5178-87. PubMed
  • Punglia RS, D'Amico AV, Catalona WJ, Roehl KA, Kuntz KM. Effect of verification bias on screening for prostate cancer by measurement of prostate-specific antigen. N Engl J Med 2003; 349:335-42. PubMed
  • Punglia RS, Kuntz KM, Lee JH, Recht A. Radiation therapy plus tamoxifen versus tamoxifen alone after breast-conserving surgery in postmenopausal women with stage I breast cancer: a decision analysis. J Clin Oncol 2003; 21:2260-7. PubMed
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