Photo of Robert D. Odze,  MD

Robert D. Odze, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7549


rodze@partners.org

Robert D. Odze, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Chief of Gastrointestinal Pathology, Pathology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am the Director of GI Pathology Division at Brigham and Women's Hospital and Professor of Pathology at Harvard Medical School. My main research interests include the pathology, pathogenesis, natural history, and molecular biology of cancer development in chronic inflammatory conditions of the GI tract - most notably Barrett's esophagus and inflammatory bowel disease. This research focuses on the mechanisms of progression from chronic inflammation through various grades of dysplasia to adenocarcinoma. Other research interests include laboratory and animal research on the mechanisms involved in inflammation, and in the development, of Barrett's esophagus in patients with gastroesophageal reflux disease. I collaborate with a number of basic research laboratories, and with clinical services from other widely acclaimed institutes in America and in Europe. I have authored more than 300 peer reviewed research papers, reviews, editorials, and book chapters. I am the senior editor of the largest most comprehensive textbook of GI pathology titled "Surgical Pathology of the GI Tract and the Biliary tract and Pancreas"

Publications

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  • Agoston AT, Srivastava A, Zheng Y, Bueno R, Odze RD, Szallasi Z. Paraneoplastic thrombocytosis is associated with increased mortality and increased rate of lymph node metastasis in oesophageal adenocarcinoma. Pathology 2017. PubMed
  • Vennalaganti P, Kanakadandi V, Goldblum JR, Mathur SC, Patil DT, Offerhaus GJ, Meijer SL, Vieth M, Odze RD, Shreyas S, Parasa S, Gupta N, Repici A, Bansal A, Mohammad T, Sharma P. Discordance Among Pathologists in the United States and Europe in Diagnosis of Low-Grade Dysplasia for Patients With Barrett's Esophagus. Gastroenterology 2016; 152:564-570.e4. PubMed
  • Hamilton MJ, Makrauer FM, Golden K, Wang H, Friedman S, Burakoff RB, Levine JS, Joshi P, Banks PA, Odze RD. Prospective Evaluation of Terminal Ileitis in a Surveillance Population of Patients with Ulcerative Colitis. Inflamm Bowel Dis 2016; 22:2448-55. PubMed
  • Patil DT, Moss AC, Odze RD. Role of Histologic Inflammation in the Natural History of Ulcerative Colitis. Gastrointest. Endosc. Clin. N. Am. 2016; 26:629-40. PubMed
  • Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF. Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD. Gut 2016. PubMed
  • Asanuma K, Huo X, Agoston A, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Wang DH, Iijima K, Shimosegawa T, Odze RD, Spechler SJ, Souza RF. In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression. Gut 2016; 65:1416-26. PubMed
  • Srivastava A1, Golden KL1, Sanchez CA2, Liu K3, Fong PY4, Li X2, Cowan DS2, Rabinovitch PS5, Reid BJ6, Blount PL7, Odze RD1.. High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett's Esophagus. PLoS ONE 2015.