Photo of Robert L. Barbieri,  MD

Robert L. Barbieri, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-4265
Fax: (617) 277-1440


rbarbieri@partners.org

Robert L. Barbieri, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Kate Macy Ladd Professor of Obstetrics, Gynecology and Reproductive Biology, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Chairman, Obstetrics and Gynecology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our projects focus on the role of sex steroids, including estrogen, progesterone and androgens in disease of the reproductive tract. A major focus of the laboratory is the role of estrogen in the development of breast cancer, endometriosis and uterine leiomyomata.

Publications

Powered by Harvard Catalyst
  • Fortner RT, Eliassen AH, Spiegelman D, Willett WC, Barbieri RL, Hankinson SE. Premenopausal endogenous steroid hormones and breast cancer risk: results from the Nurses' Health Study II. Breast Cancer Res 2013; 15:R19. PubMed
  • Danforth KN, Eliassen AH, Tworoger SS, Missmer SA, Barbieri RL, Rosner BA, Colditz GA, Hankinson SE. The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women. Int J Cancer 2009; 126:199-207. PubMed
  • Galli L, Fontana A, Galli C, Landi L, Fontana E, Antonuzzo A, Andreuccetti M, Aitini E, Barbieri R, Di Marsico R, Falcone A. Phase II study of sequential chemotherapy with docetaxel-estramustine followed by mitoxantrone-prednisone in patients with advanced hormone-refractory prostate cancer. Br J Cancer 2007; 97:1613-7. PubMed
  • Barbieri RL. Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: the winner is .... J Clin Endocrinol Metab 2007; 92:3399-401. PubMed
  • Tworoger SS, Missmer SA, Eliassen AH, Barbieri RL, Dowsett M, Hankinson SE. Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Cancer Causes Control 2007; 18:743-52. PubMed
  • Fung TT, Hu FB, Barbieri RL, Willett WC, Hankinson SE. Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women. Int J Cancer 2007; 121:803-9. PubMed
  • Derenzini M, Montanaro L, Vici M, Barbieri S, Ceccarelli C, Santini D, Taffurelli M, Martinelli GN, Trer. Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome. Histol Histopathol 2007; 22:505-13. PubMed
  • Barbieri F, Bajetto A, Porcile C, Pattarozzi A, Schettini G, Florio T. Role of stromal cell-derived factor 1 (SDF1/CXCL12) in regulating anterior pituitary function. J Mol Endocrinol 2007; 38:383-9. PubMed
  • Rossi G, Marchioni A, Romagnani E, Bertolini F, Longo L, Cavazza A, Barbieri F. Primary lung cancer presenting with gastrointestinal tract involvement: clinicopathologic and immunohistochemical features in a series of 18 consecutive cases. J Thorac Oncol 2007; 2:115-20. PubMed
  • Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M, Hankinson SE. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. Journal of the National Cancer Institute 2006; 98:1406-15. PubMed
  • Tworoger SS, Missmer SA, Eliassen AH, Spiegelman D, Folkerd E, Dowsett M, Barbieri RL, Hankinson SE. The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women. Cancer Epidemiol Biomarkers Prev 2006; 15:967-71. PubMed
  • Missmer SA, Spiegelman D, Bertone-Johnson ER, Barbieri RL, Pollak MN, Hankinson SE. Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth factor levels among premenopausal women over a 2- to 3-year period. Cancer Epidemiol Biomarkers Prev 2006; 15:972-8. PubMed
  • Missmer SA, Spiegelman D, Hankinson SE, Malspeis S, Barbieri RL, Hunter DJ. Natural hair color and the incidence of endometriosis. Fertil Steril 2006; 85:866-70. PubMed
  • Pinheiro SP, Holmes MD, Pollak MN, Barbieri RL, Hankinson SE. Racial differences in premenopausal endogenous hormones. Cancer Epidemiol Biomarkers Prev 2005; 14:2147-53. PubMed
  • Viswanathan AN, Feskanich D, De Vivo I, Hunter DJ, Barbieri RL, Rosner B, Colditz GA, Hankinson SE. Smoking and the risk of endometrial cancer: results from the Nurses' Health Study. Int J Cancer 2005; 114:996-1001. PubMed
  • Tworoger SS, Missmer SA, Barbieri RL, Willett WC, Colditz GA, Hankinson SE. Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones. J Natl Cancer Inst 2005; 97:595-602. PubMed
  • Barbieri RL, Sluss PM, Powers RD, McShane PM, Vitonis A, Ginsburg E, Cramer DC. Association of body mass index, age, and cigarette smoking with serum testosterone levels in cycling women undergoing in vitro fertilization. Fertil Steril 2005; 83:302-8. PubMed
  • Page JH, Colditz GA, Rifai N, Barbieri RL, Willett WC, Hankinson SE. Plasma adrenal androgens and risk of breast cancer in premenopausal women. Cancer Epidemiol Biomarkers Prev 2004; 13:1032-6. PubMed
  • Barbieri RL. Geographic distribution of obstetrics and gynecology resident training positions. Obstet Gynecol 2004; 103:1317-20. PubMed
  • Barbieri RL, Gargiulo AR. Metformin for the treatment of the polycystic ovary syndrome. Minerva Ginecol 2004; 56:63-79. PubMed
  • Cramer DW, Sluss PM, Powers RD, McShane P, Ginsburgs ES, Hornstein MD, Vitonis AF, Barbieri RL. Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function? J Assist Reprod Genet 2003; 20:210-5. PubMed
  • Barbieri RL. Metformin for the treatment of polycystic ovary syndrome. Obstet Gynecol 2003; 101:785-93. PubMed
  • Harlow BL, Missmer SA, Cramer DW, Barbieri RL. Does tubal sterilization influence the subsequent risk of menorrhagia or dysmenorrhea? Fertil Steril 2002; 77:754-60. PubMed
  • Barbieri RL, Missmer S. Endometriosis and infertility: a cause-effect relationship? Ann N Y Acad Sci 2002; 955:23-33; discussion 34-6, 3. PubMed
  • Cramer DW, Barbieri RL, Fraer AR, Harlow BL. Determinants of early follicular phase gonadotrophin and estradiol concentrations in women of late reproductive age. Hum Reprod 2002; 17:221-7. PubMed
  • Lucero J, Harlow BL, Barbieri RL, Sluss P, Cramer DW. Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertil Steril 2001; 76:723-9. PubMed
  • Holmes MD, Spiegelman D, Willett WC, Manson JE, Hunter DJ, Barbieri RL, Colditz GA, Hankinson SE. Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women. J Clin Oncol 2000; 18:3668-76. PubMed
  • Cramer DW, Petterson KS, Barbieri RL, Huhtaniemi IT. Reproductive hormones, cancers, and conditions in relation to a common genetic variant of luteinizing hormone. Hum Reprod 2000; 15:2103-7. PubMed
  • Hankinson SE, Willett WC, Manson JE, Colditz GA, Hunter DJ, Spiegelman D, Barbieri RL, Speizer FE. Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 1998; 90:1292-9. PubMed
  • Ginsburg ES, Gao X, Shea BF, Barbieri RL. Half-life of estradiol in postmenopausal women. Gynecol Obstet Invest 1998; 45:45-8. PubMed
  • Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, Willett WC, Hunter DJ. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstet Gynecol 1997; 90:967-73. PubMed
  • Barbieri RL, Gao X. Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. Fertil Steril 1997; 68:534-7. PubMed
  • Barbieri RL. Reduction in the size of a uterine leiomyoma following discontinuation of an estrogen-progestin contraceptive. Gynecol Obstet Invest 1997; 43:276-7. PubMed
  • Ginsburg ES, Mello NK, Mendelson JH, Barbieri RL, Teoh SK, Rothman M, Gao X, Sholar JW. Effects of alcohol ingestion on estrogens in postmenopausal women. JAMA 1996; 276:1747-51. PubMed
  • Cramer DW, Hornstein MD, Ng WG, Barbieri RL. Endometriosis associated with the N314D mutation of galactose-1-phosphate uridyl transferase (GALT). Mol Hum Reprod 1996; 2:149-52. PubMed
  • Barbieri RL, Gao X, Xu H, Cramer DW. Effects of previous use of oral contraceptives on early follicular phase follicle-stimulating hormone. Fertil Steril 1995; 64:689-92. PubMed
  • Barbieri RL, Gao X, Frost RA. Phosphorylation of 17 beta-hydroxysteroid dehydrogenase in BeWo choriocarcinoma cells. Am J Obstet Gynecol 1994; 171:223-30. PubMed
  • Barbieri RL, Gao X. 17 beta-Hydroxysteroid dehydrogenase: enzymatic activity and mRNA species in choriocarcinoma cells. Gynecol Obstet Invest 1994; 37:210-4. PubMed
  • Barbieri RL, Dilena M, Chumas J, Rein MS, Friedman AJ. Leuprolide acetate depot decreases the number of nucleolar organizer regions in uterine leiomyomata. Fertil Steril 1993; 60:569-70. PubMed
  • Barbieri RL, Ferracci AL, Droesch JN, Rochelson BL. Ovarian torsion in a premenopausal woman treated with tamoxifen for breast cancer. Fertil Steril 1993; 59:459-60. PubMed
  • Barbieri RL, Callery M, Perez SE. Directionality of menstrual flow: cervical os diameter as a determinant of retrograde menstruation. Fertil Steril 1992; 57:727-30. PubMed
  • Barbieri RL, Friedman AJ, Osathanondh R. Cotinine and nicotine inhibit human fetal adrenal 11 beta-hydroxylase. J Clin Endocrinol Metab 1989; 69:1221-4. PubMed
  • Barbieri RL, Rein MS, Hornstein MD, Ryan KJ. Rat Leydig cell and granulosa cell 17-ketosteroid reductase activity: subcellular localization and substrate specificity. Am J Obstet Gynecol 1988; 159:1564-9. PubMed
  • Barbieri RL, York CM, Cherry ML, Ryan KJ. The effects of nicotine, cotinine and anabasine on rat adrenal 11 beta-hydroxylase and 21-hydroxylase. J Steroid Biochem 1987; 28:25-8. PubMed
  • Barbieri RL, McShane PM, Ryan KJ. Constituents of cigarette smoke inhibit human granulosa cell aromatase. Fertil Steril 1986; 46:232-6. PubMed
  • Barbieri RL, Gochberg J, Ryan KJ. Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. J Clin Invest 1986; 77:1727-33. PubMed
  • Barbieri RL, Niloff JM, Bast RC, Scaetzl E, Kistner RW, Knapp RC. Elevated serum concentrations of CA-125 in patients with advanced endometriosis. Fertil Steril 1986; 45:630-4. PubMed
  • Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 1986; 62:904-10. PubMed
  • Barbieri RL, Saltzman DH, Torday JS, Randall RW, Frigoletto FD, Ryan KJ. Elevated concentrations of the beta-subunit of human chorionic gonadotropin and testosterone in the amniotic fluid of gestations of diabetic mothers. Am J Obstet Gynecol 1986; 154:1039-43. PubMed
  • Barbieri RL, Cooper DS, Daniels GH, Nathan D, Klibanski A, Ridgway EC. Prolactin response to thyrotropin-releasing hormone (TRH) in patients with hypothalamic-pituitary disease. Fertil Steril 1984; 43:66-73. PubMed
  • Barbieri RL, Makris A, Ryan KJ. Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca. Obstet Gynecol 1984; 64:73S-80S. PubMed
  • Barbieri RL, Ryan KJ. Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features. Am J Obstet Gynecol 1983; 147:90-101. PubMed
  • Barbieri RL, Petro Z, Canick JA, Ryan KJ. Aromatization of norethindrone to ethinyl estradiol by human placental microsomes. J Clin Endocrinol Metab 1983; 57:299-303. PubMed
Hide