Robert V. Mulkern, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-3737
Fax: (617) 730-0460


mulkern@bwh.harvard.edu

Robert V. Mulkern, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Associate Physician, Medicine, Brigham And Women's Hospital
  • Associate Physicist, Radiology, Boston Children's Hospital

Research Abstract

Interest in rapid imaging and spectroscopy MR methods for cancer research

Publications

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  • Mulkern RV, Ricci KI, Vajapeyam S, Chenevert TL, Malyarenko DI, Kocak M, Poussaint TY. Pediatric brain tumor consortium multisite assessment of apparent diffusion coefficient z-axis variation assessed with an ice-water phantom. Acad Radiol 2015; 22:363-9. PubMed
  • Yamauchi FI, Penzkofer T, Fedorov A, Fennessy FM, Chu R, Maier SE, Tempany CM, Mulkern RV, Panych LP. Prostate cancer discrimination in the peripheral zone with a reduced field-of-view T2-mapping MRI sequence. Magn Reson Imaging 2015. PubMed
  • Fedorov A, Penzkofer T, Hirsch MS, Flood TA, Vangel MG, Masry P, Tempany CM, Mulkern RV, Fennessy FM. The Role of Pathology Correlation Approach in Prostate Cancer Index Lesion Detection and Quantitative Analysis with Multiparametric MRI. Acad Radiol 2015. PubMed
  • Fennessy FM, Fedorov A, Penzkofer T, Kim KW, Hirsch MS, Vangel MG, Masry P, Flood TA, Chang MC, Tempany CM, Mulkern RV, Gupta SN. Quantitative pharmacokinetic analysis of prostate cancer DCE-MRI at 3T: Comparison of two arterial input functions on cancer detection with digitized whole mount histopathological validation. Magn Reson Imaging 2015. PubMed
  • Ramon-Krauel M, Salsberg SL, Ebbeling CB, Voss SD, Mulkern RV, Apura MM, Cooke EA, Sarao K, Jonas MM, Ludwig DS. A low-glycemic-load versus low-fat diet in the treatment of fatty liver in obese children. Child Obes 2013; 9:252-60. PubMed
  • Hegde JV, Mulkern RV, Panych LP, Fennessy FM, Fedorov A, Maier SE, Tempany CM. Multiparametric MRI of prostate cancer: An update on state-of-the-art techniques and their performance in detecting and localizing prostate cancer. J Magn Reson Imaging 2013; 37:1035-54. PubMed
  • Fennessy FM, Fedorov A, Gupta SN, Schmidt EJ, Tempany CM, Mulkern RV. Practical considerations in T1 mapping of prostate for dynamic contrast enhancement pharmacokinetic analyses. Magn Reson Imaging 2012; 30:1224-33. PubMed
  • Hegde JV, Chen MH, Mulkern RV, Fennessy FM, D'Amico AV, Tempany CM. Preoperative 3-Tesla Multiparametric Endorectal Magnetic Resonance Imaging Findings and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men With Clinically Localized Prostate Cancer. Int J Radiat Oncol Biol Phys 2012. PubMed
  • Shinmoto H, Tamura C, Soga S, Shiomi E, Yoshihara N, Kaji T, Mulkern RV. An intravoxel incoherent motion diffusion-weighted imaging study of prostate cancer. AJR Am J Roentgenol 2012; 199:W496-500. PubMed
  • Mitsouras D, Vemula PK, Yu P, Tao M, Nguyen BT, Campagna CM, Karp JM, Mulkern RV, Ozaki CK, Rybicki FJ. Immobilized contrast-enhanced MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall. Magn Reson Med 2010; 65:176-83. PubMed
  • Nguyen BT, Vemula PK, Mitsouras D, Yu P, Tao M, Campagna C, Mulkern RV, Rybicki FJ, Karp JM, Ozaki CK. Immobilization of iron oxide magnetic nanoparticles for enhancement of vessel wall magnetic resonance imaging--an ex vivo feasibility study. Bioconjug Chem 2010; 21:1408-12. PubMed
  • Maier SE, Sun Y, Mulkern RV. Diffusion imaging of brain tumors. NMR Biomed 2010; 23:849-64. PubMed
  • Ramadan S, Mulkern RV. Comment on ADC reductions in postcontrast breast tumors. J Magn Reson Imaging 2009; 31:262; author reply 263-4. PubMed
  • Lin JM, Tsai SY, Liu HS, Chung HW, Mulkern RV, Cheng CM, Yeh TC, Chen NK. Quantification of non-water-suppressed MR spectra with correction for motion-induced signal reduction. Magn Reson Med 2009; 62:1394-403. PubMed
  • Mulkern RV, Haker SJ, Maier SE. On high b diffusion imaging in the human brain: ruminations and experimental insights. Magn Reson Imaging 2009; 27:1151-62. PubMed
  • Maier SE, Mulkern RV. Biexponential analysis of diffusion-related signal decay in normal human cortical and deep gray matter. Magn Reson Imaging 2008; 26:897-904. PubMed
  • Mulkern RV,Forbes P,Dewey K,Osganian S,Clark M,Wong S,Ramamurthy U,Kun L,Poussaint TY. Establishment and results of a magnetic resonance quality assurance program for the pediatric brain tumor consortium. Acad Radiol 2008; 15:1099-110. PubMed
  • Winalski CS, Shortkroff S, Schneider E, Yoshioka H, Mulkern RV, Rosen GM. Targeted dendrimer-based contrast agents for articular cartilage assessment by MR imaging. Osteoarthritis Cartilage 2008; 16:815-22. PubMed
  • Marzelli M, Fischer K, Kim YB, Mulkern RV, Yoo SS, Park H, Cho ZH. Composite MR Contrast Agents for Conditional Cell-Labeling. 2009; 18:79-84. PubMed
  • Rybicki FJ, Mitsouras D, Owens CD, Whitmore AG, Ersoy H, Mulkern RV, Creager MA, Conte MS. Lower extremity peripheral vein bypass graft wall thickness changes demonstrated at 1 and 6 months after surgery with ultra-high spatial resolution black blood inner volume three-dimensional fast spin echo magnetic resonance imaging. Int J Cardiovasc Imaging 2007; 24:529-533. PubMed
  • Mitsouras D, Mulkern RV, Owens CD, Conte MS, Ersoy H, Luu TM, Whitmore AG, Creager MA, Rybicki FJ. High-resolution peripheral vein bypass graft wall studies using high sampling efficiency inner volume 3D FSE. Magn Reson Med 2008; 59:650-4. PubMed
  • McDannold N, Barnes AS, Rybicki FJ, Oshio K, Chen NK, Hynynen K, Mulkern RV. Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging. Magn Reson Med 2007; 58:1117-23. PubMed
  • Gambarota G, Veltien A, Klomp D, Van Alfen N, Mulkern RV, Heerschap A. Magnetic resonance imaging and T2 relaxometry of human median nerve at 7 Tesla. Muscle Nerve 2007; 36:368-73. PubMed
  • Mulkern RV, Haker SJ, Maier SE. Complimentary aspects of diffusion imaging and fMRI: II. Elucidating contributions to the fMRI signal with diffusion sensitization. Magn Reson Imaging 2007; 25:939-52. PubMed
  • Haker SJ, Mulkern RV, Roebuck JR, Barnes AS, Dimaio S, Hata N, Tempany CM. Magnetic resonance-guided prostate interventions. Top Magn Reson Imaging 2006; 16:355-68. PubMed
  • Maier SE, Mamata H, Mulkern RV. Characterization of normal brain and brain tumor pathology by chisquares parameter maps of diffusion-weighted image data. Eur J Radiol 2003; 45:199-207. PubMed
  • Maier SE, Bogner P, Bajzik G, Mamata H, Mamata Y, Repa I, Jolesz FA, Mulkern RV. Normal brain and brain tumor: multicomponent apparent diffusion coefficient line scan imaging. Radiology 2001; 219:842-9. PubMed
  • McDannold N, Hynynen K, Oshio K, Mulkern RV. Temperature monitoring with line scan echo planar spectroscopic imaging. Med Phys 2001; 28:346-55. PubMed
  • Mulkern RV, Gudbjartsson H, Westin CF, Zengingonul HP, Gartner W, Guttmann CR, Robertson RL, Kyriakos W, Schwartz R, Holtzman D, Jolesz FA, Maier SE. Multi-component apparent diffusion coefficients in human brain. NMR Biomed 1999; 12:51-62. PubMed
  • Fielding JR, Griffiths DJ, Versi E, Mulkern RV, Lee ML, Jolesz FA. MR imaging of pelvic floor continence mechanisms in the supine and sitting positions. AJR Am J Roentgenol 1998; 171:1607-10. PubMed
  • Jaramillo D, Connolly SA, Mulkern RV, Shapiro F. Developing epiphysis: MR imaging characteristics and histologic correlation in the newborn lamb. Radiology 1998; 207:637-45. PubMed
  • Schwartz RB, Mulkern RV, Gudbjartsson H, Jolesz F. Diffusion-weighted MR imaging in hypertensive encephalopathy: clues to pathogenesis. AJNR Am J Neuroradiol 1998; 19:859-62. PubMed
  • Mulkern RV, Panych LP, McDannold NJ, Jolesz FA, Hynynen K. Tissue temperature monitoring with multiple gradient-echo imaging sequences. J Magn Reson Imaging 1998; 8:493-502. PubMed
  • Shimizu K, Mulkern RV, Oshio K, Panych LP, Yoo SS, Kikinis R, Jolesz FA. Rapid tip tracking with MRI by a limited projection reconstruction technique. J Magn Reson Imaging 1998; 8:262-4. PubMed
  • Morrison PR, Jolesz FA, Charous D, Mulkern RV, Hushek SG, Margolis R, Fried MP. MRI of laser-induced interstitial thermal injury in an in vivo animal liver model with histologic correlation. J Magn Reson Imaging 1998; 8:57-63. PubMed
  • Panych LP, Mulkern RV, Saiviroonporn P, Zientara GP, Jolesz FA. Non-Fourier encoding with multiple spin echoes. Magn Reson Med 1997; 38:964-73. PubMed
  • Mulkern RV, Chung AH, Jolesz FA, Hynynen K. Temperature monitoring of ultrasonically heated muscle with RARE chemical shift imaging. Med Phys 1998; 24:1899-906. PubMed
  • Chao H, Bowers JL, Holtzman D, Mulkern RV. RARE imaging of PCr in human forearm muscles. J Magn Reson Imaging 1997; 7:1048-55. PubMed
  • Mulkern RV, Chao H, Bowers JL, Holtzman D. Multiecho approaches to spectroscopic imaging of the brain. Ann N Y Acad Sci 1997; 820:97-122. PubMed
  • Chao H, Bowers JL, Holtzman D, Mulkern RV. Multi-echo 31P spectroscopic imaging of ATP: a scan time reduction strategy. J Magn Reson Imaging 1997; 7:425-33. PubMed
  • Shinmoto H, Mulkern RV, Oshio K, Silverman SG, Colucci VM, Jolesz FA. MR appearance and spectral features of injected ethanol in the liver: implication for fast MR-guided percutaneous ethanol injection therapy. J Comput Assist Tomogr 1997; 21:82-8. PubMed
  • Mulkern RV, Meng J, Bowers JL, Oshio K, Zuo C, Li H, Kraft RA, Williamson DS, Jaramillo D. In vivo bone marrow lipid characterization with line scan Carr-Purcell-Meiboom-Gill proton spectroscopic imaging. Magn Reson Imaging 1997; 15:823-37. PubMed
  • Bridges KR, Barabino GD, Brugnara C, Cho MR, Christoph GW, Dover G, Ewenstein BM, Golan DE, Guttmann CR, Hofrichter J, Mulkern RV, Zhang B, Eaton WA. A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy. Blood 1996; 88:4701-10. PubMed
  • Mulkern RV, Bowers JL, Peled S, Kraft RA, Williamson DS. Citrate signal enhancement with a homonuclear J-refocusing modification to double-echo PRESS sequences. Magn Reson Med 1996; 36:775-80. PubMed
  • Gudbjartsson H, Maier SE, Mulkern RV, M. Line scan diffusion imaging. Magn Reson Med 1996; 36:509-19. PubMed
  • Habboush IH, Mitchell KD, Mulkern RV, Barnes PD, Treves ST. Registration and alignment of three-dimensional images: an interactive visual approach. Radiology 1996; 199:573-8. PubMed
  • Zoarski GH, Mackey JK, Anzai Y, Hanafee WN, Melki PS, Mulkern RV, Jolesz FA, Lufkin RB. Head and neck: initial clinical experience with fast spin-echo MR imaging. Radiology 1993; 188:323-7. PubMed
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