Photo of Ron Kikinis,  MD

Ron Kikinis, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7389

Ron Kikinis, MD

Brigham And Women's Hospital


  • Professor, Radiology, Harvard Medical School
  • Director, Surgical Planning Laboratory, Brigham And Women's Hospital


Research Abstract

Dr. Kikinis is the founding Director of the Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, and a Professor of Radiology at Harvard Medical School. This laboratory was founded in 1990. In 2009 he was the inaugural recipient of the MICCAI Society "Enduring Impact Award". On February 24, 2010 he was appointed the Robert Greenes Distinguished Director of Biomedical Informatics in the Department of Radiology at Brigham and Women's Hospital. On January 1, 2014, he was appointed "Institutsleiter" of Fraunhofer MEVIS and Honorary Professor of Medical Image Computing at the University of Bremen.

For complete information, please go to the following url:



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  • Fedorov A, Wells W, Kikinis R, Tempany C, Vangel M. Application of Tolerance Limits to the Characterization of Image Registration Performance. IEEE Trans Med Imaging 2014. PubMed
  • Huang W, Li X, Chen Y, Li X, Chang MC, Oborski MJ, Malyarenko DI, Muzi M, Jajamovich GH, Fedorov A, Tudorica A, Gupta SN, Laymon CM, Marro KI, Dyvorne HA, Miller JV, Barbodiak DP, Chenevert TL, Yankeelov TE, Mountz JM, Kinahan PE, Kikinis R, Taouli B, Fennessy F, Kalpathy-Cramer J. Variations of dynamic contrast-enhanced magnetic resonance imaging in evaluation of breast cancer therapy response: a multicenter data analysis challenge. Transl Oncol 2014; 7:153-66. PubMed
  • Parmar C, Rios Velazquez E, Leijenaar R, Jermoumi M, Carvalho S, Mak RH, Mitra S, Shankar BU, Kikinis R, Haibe-Kains B, Lambin P, Aerts HJ. Robust Radiomics feature quantification using semiautomatic volumetric segmentation. PLoS ONE 2014; 9:e102107. PubMed
  • Velazquez ER, Parmar C, Jermoumi M, Mak RH, van Baardwijk A, Fennessy FM, Lewis JH, De Ruysscher D, Kikinis R, Lambin P, Aerts HJ. Volumetric CT-based segmentation of NSCLC using 3D-Slicer. Sci Rep 2013; 3:3529. PubMed
  • Fedorov A, Tuncali K, Fennessy FM, Tokuda J, Hata N, Wells WM, Kikinis R, Tempany CM. Image registration for targeted MRI-guided transperineal prostate biopsy. J Magn Reson Imaging 2012; 36:987-92. PubMed
  • Egger J, Kapur T, Nimsky C, Kikinis R. Pituitary adenoma volumetry with 3D Slicer. PLoS ONE 2012; 7:e51788. PubMed
  • Pohl KM, Konukoglu E, Novellas S, Ayache N, Fedorov A, Talos IF, Golby A, Wells WM, Kikinis R, Black PM. A new metric for detecting change in slowly evolving brain tumors: validation in meningioma patients. Neurosurgery 2011; 68:225-33. PubMed
  • Lee JW, Wen PY, Hurwitz S, Black P, Kesari S, Drappatz J, Golby AJ, Wells WM, Warfield SK, Kikinis R, Bromfield EB. Morphological characteristics of brain tumors causing seizures. Arch Neurol 2010; 67:336-42. PubMed
  • Oguro S, Tokuda J, Elhawary H, Haker S, Kikinis R, Tempany CM, Hata N. MRI signal intensity based B-spline nonrigid registration for pre- and intraoperative imaging during prostate brachytherapy. J Magn Reson Imaging 2009; 30:1052-8. PubMed
  • Rubin DL,Talos IF,Halle M,Musen MA,Kikinis R. Computational neuroanatomy: ontology-based representation of neural components and connectivity. BMC Bioinformatics 2009; 10 Suppl 2:S3. PubMed
  • Talos IF, Rubin DL, Halle M, Musen M, Kikinis R. A prototype symbolic model of canonical functional neuroanatomy of the motor system. J Biomed Inform 2008; 41:251-63. PubMed
  • Pujol S, Kikinis R, Gollub R. Lowering the barriers inherent in translating advances in neuroimage analysis to clinical research applications. Acad Radiol 2007; 15:114-8. PubMed
  • Pohl KM, Bouix S, Nakamura M, Rohlfing T, McCarley RW, Kikinis R, Grimson WE, Shenton ME, Wells WM. A hierarchical algorithm for MR brain image parcellation. IEEE Trans Med Imaging 2007; 26:1201-12. PubMed
  • Larsen S, Kikinis R, Talos IF, Weinstein D, Wells W, Golby A. Quantitative comparison of functional MRI and direct electrocortical stimulation for functional mapping. Int J Med Robot 2007; 3:262-70. PubMed
  • Brem MH, Zamani AA, Riva R, Zou KH, Rumboldt Z, Hennig FF, Kikinis R, Norbash AM, Schoepf UJ. Multidetector CT of the paranasal sinus: potential for radiation dose reduction. Radiology 2007; 243:847-52. PubMed
  • Krissian K, Westin CF, Kikinis R, Vosburgh KG. Oriented speckle reducing anisotropic diffusion. IEEE Trans Image Process 2007; 16:1412-24. PubMed
  • Talos IF, Zou KH, Kikinis R, Jolesz FA. Volumetric assessment of tumor infiltration of adjacent white matter based on anatomic MRI and diffusion tensor tractography. Acad Radiol 2007; 14:431-6. PubMed
  • DiMaio SP, Pieper S, Chinzei K, Hata N, Haker SJ, Kacher DF, Fichtinger G, Tempany CM, Kikinis R. Robot-assisted needle placement in open MRI: system architecture, integration and validation. Comput Aided Surg 2007; 12:15-24. PubMed
  • Von Spiczak J, Samset E, Dimaio S, Reitmayr G, Schmalstieg D, Burghart C, Kikinis R. Device connectivity for image-guided medical applications. Stud Health Technol Inform 2007; 125:482-4. PubMed
  • Wittek A, Miller K, Kikinis R, Warfield SK. Patient-specific model of brain deformation: Application to medical image registration. J Biomech 2007; 40:919-29. PubMed
  • Bricault I, Kikinis R, Morrison PR, Vansonnenberg E, Tuncali K, Silverman SG. Liver metastases: 3D shape-based analysis of CT scans for detection of local recurrence after radiofrequency ablation. Radiology 2006; 241:243-50. PubMed
  • Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, Kikinis R. Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag 2006; 25:67-73. PubMed
  • Das M, Sauer F, Schoepf UJ, Khamene A, Vogt SK, Schaller S, Kikinis R, vanSonnenberg E, Silverman SG. Augmented reality visualization for CT-guided interventions: system description, feasibility, and initial evaluation in an abdominal phantom. Radiology 2006; 240:230-5. PubMed
  • Pohl KM, Fisher J, Grimson WE, Kikinis R, Wells WM. A Bayesian model for joint segmentation and registration. Neuroimage 2006; 31:228-39. PubMed
  • Talos IF, Zou KH, Ohno-Machado L, Bhagwat JG, Kikinis R, Black PM, Jolesz FA. Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics. Radiology 2006; 239:506-13. PubMed
  • DiMaio SP, Kacher DF, Ellis RE, Fichtinger G, Hata N, Zientara GP, Panych LP, Kikinis R, Jolesz FA. Needle artifact localization in 3T MR images. Stud Health Technol Inform 2006; 119:120-5. PubMed
  • DiMaio SP, Pieper S, Chinzei K, Hata N, Balogh E, Fichtinger G, Tempany CM, Kikinis R. Robot-assisted needle placement in open-MRI: system architecture, integration and validation. Stud Health Technol Inform 2006; 119:126-31. PubMed
  • Pohl KM, Fisher J, Shenton M, McCarley RW, Grimson WE, Kikinis R, Wells WM. Logarithm odds maps for shape representation. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2007; 9:955-63. PubMed
  • Zou KH, Greve DN, Wang M, Pieper SD, Warfield SK, White NS, Manandhar S, Brown GG, Vangel MG, Kikinis R, Wells WM,. Reproducibility of functional MR imaging: preliminary results of prospective multi-institutional study performed by Biomedical Informatics Research Network. Radiology 2005; 237:781-9. PubMed
  • Jaume S, Ferrant M, Macq B, Hoyte L, Fielding JR, Schreyer A, Kikinis R, Warfield SK. Tumor detection in the bladder wall with a measurement of abnormal thickness in CT scans. IEEE Trans Biomed Eng 2003; 50:383-90. PubMed
  • Nabavi A, Gering DT, Kacher DF, Talos IF, Wells WM, Kikinis R, Black PM, Jolesz FA. Surgical navigation in the open MRI. Acta Neurochir Suppl 2003; 85:121-5. PubMed
  • Ferrant M, Nabavi A, Macq B, Black PM, Jolesz FA, Kikinis R, Warfield SK. Serial registration of intraoperative MR images of the brain. Med Image Anal 2002; 6:337-59. PubMed
  • Troulis MJ, Everett P, Seldin EB, Kikinis R, Kaban LB. Development of a three-dimensional treatment planning system based on computed tomographic data. Int J Oral Maxillofac Surg 2002; 31:349-57. PubMed
  • Hirose M, Bharatha A, Hata N, Zou KH, Warfield SK, Cormack RA, D'Amico A, Kikinis R, Jolesz FA, Tempany CM. Quantitative MR imaging assessment of prostate gland deformation before and during MR imaging-guided brachytherapy. Acad Radiol 2002; 9:906-12. PubMed
  • Ruiz-Alzola J, Westin CF, Warfield SK, Alberola C, Maier S, Kikinis R. Nonrigid registration of 3D tensor medical data. Med Image Anal 2002; 6:143-61. PubMed
  • Westin CF, Maier SE, Mamata H, Nabavi A, Jolesz FA, Kikinis R. Processing and visualization for diffusion tensor MRI. Med Image Anal 2002; 6:93-108. PubMed
  • Fielding JR, Hoyte LX, Okon SA, Schreyer A, Lee J, Zou KH, Warfield S, Richie JP, Loughlin KR, O'Leary MP, Doyle CJ, Kikinis R. Tumor detection by virtual cystoscopy with color mapping of bladder wall thickness. J Urol 2002; 167:559-62. PubMed
  • Benson RR, Guttmann CR, Wei X, Warfield SK, Hall C, Schmidt JA, Kikinis R, Wolfson LI. Older people with impaired mobility have specific loci of periventricular abnormality on MRI. Neurology 2002; 58:48-55. PubMed
  • Ferrant M, Nabavi A, Macq B, Jolesz FA, Kikinis R, Warfield SK. Registration of 3-D intraoperative MR images of the brain using a finite-element biomechanical model. IEEE Trans Med Imaging 2002; 20:1384-97. PubMed
  • Bharatha A, Hirose M, Hata N, Warfield SK, Ferrant M, Zou KH, Suarez-Santana E, Ruiz-Alzola J, D'Amico A, Cormack RA, Kikinis R, Jolesz FA, Tempany CM. Evaluation of three-dimensional finite element-based deformable registration of pre- and intraoperative prostate imaging. Med Phys 2002; 28:2551-60. PubMed
  • Hata N, Jinzaki M, Kacher D, Cormak R, Gering D, Nabavi A, Silverman SG, D'Amico AV, Kikinis R, Jolesz FA, Tempany CM. MR imaging-guided prostate biopsy with surgical navigation software: device validation and feasibility. Radiology 2001; 220:263-8. PubMed
  • Gering DT, Nabavi A, Kikinis R, Hata N, O'Donnell LJ, Grimson WE, Jolesz FA, Black PM, Wells WM. An integrated visualization system for surgical planning and guidance using image fusion and an open MR. J Magn Reson Imaging 2001; 13:967-75. PubMed
  • Schierlitz L, Dumanli H, Robinson JN, Burrows PE, Schreyer AG, Kikinis R, Jolesz FA, Tempany CM. Three-dimensional magnetic resonance imaging of fetal brains. Lancet 2001; 357:1177-8. PubMed
  • Nabavi A, Black PM, Gering DT, Westin CF, Mehta V, Pergolizzi RS, Ferrant M, Warfield SK, Hata N, Schwartz RB, Wells WM, Kikinis R, Jolesz FA. Serial intraoperative magnetic resonance imaging of brain shift. Neurosurgery 2001; 48:787-97; discussion 797-8. PubMed
  • Kaus MR, Warfield SK, Nabavi A, Black PM, Jolesz FA, Kikinis R. Automated segmentation of MR images of brain tumors. Radiology 2001; 218:586-91. PubMed
  • Kacher DF, Maier SE, Mamata H, Mamata Y, Nabavi A, Jolesz FA. Motion robust imaging for continuous intraoperative MRI. J Magn Reson Imaging 2001; 13:158-61. PubMed
  • Pergolizzi RS, Nabavi A, Schwartz RB, Hsu L, Wong TZ, Martin C, Black PM, Jolesz FA. Intra-operative MR guidance during trans-sphenoidal pituitary resection: preliminary results. J Magn Reson Imaging 2001; 13:136-41. PubMed
  • Mamata Y, Mamata H, Nabavi A, Kacher DF, Pergolizzi RS, Schwartz RB, Kikinis R, Jolesz FA, Maier SE. Intraoperative diffusion imaging on a 0.5 Tesla interventional scanner. J Magn Reson Imaging 2001; 13:115-9. PubMed
  • Hata N, Nabavi A, Wells WM, Warfield SK, Kikinis R, Black PM, Jolesz FA. Three-dimensional optical flow method for measurement of volumetric brain deformation from intraoperative MR images. J Comput Assist Tomogr 2000; 24:531-8. PubMed
  • Kikinis R, Guttmann CR, Metcalf D, Wells WM, Ettinger GJ, Weiner HL, Jolesz FA. Quantitative follow-up of patients with multiple sclerosis using MRI: technical aspects. J Magn Reson Imaging 1999; 9:519-30. PubMed
  • Ozlen F, Nakajima S, Chabrerie A, Leventon ME, Grimson E, Kikinis R, Jolesz F, Black PM. Excision of cortical dysplasia in the language area with use of a surgical navigator: a case report. Epilepsia 1998; 39:1361-6. PubMed
  • Zientara GP, Saiviroonporn P, Morrison PR, Fried MP, Hushek SG, Kikinis R, Jolesz FA. MRI monitoring of laser ablation using optical flow. J Magn Reson Imaging 1998; 8:1306-18. PubMed
  • Kettenbach J, Silverman SG, Hata N, Kuroda K, Saiviroonporn P, Zientara GP, Morrison PR, Hushek SG, Black PM, Kikinis R, Jolesz FA. Monitoring and visualization techniques for MR-guided laser ablations in an open MR system. J Magn Reson Imaging 1998; 8:933-43. PubMed
  • Nakajima S, Atsumi H, Bhalerao AH, Jolesz FA, Kikinis R, Yoshimine T, Moriarty TM, Stieg PE. Computer-assisted surgical planning for cerebrovascular neurosurgery. Neurosurgery 1997; 41:403-9; discussion 409-10. PubMed
  • Silverman SG, Jolesz FA, Newman RW, Morrison PR, Kanan AR, Kikinis R, Schwartz RB, Hsu L, Koran SJ, Topulos GP. Design and implementation of an interventional MR imaging suite. AJR Am J Roentgenol 1997; 168:1465-71. PubMed
  • Yoo SS, Guttmann CR, Ives JR, Panych LP, Kikinis R, Schomer DL, Jolesz FA. 3D localization of surface 10-20 EEG electrodes on high resolution anatomical MR images. Electroencephalogr Clin Neurophysiol 1997; 102:335-9. PubMed
  • Kikinis R, Gleason PL, Moriarty TM, Moore MR, Alexander E, Stieg PE, Matsumae M, Lorensen WE, Cline HE, Black PM, Jolesz FA. Computer-assisted interactive three-dimensional planning for neurosurgical procedures. Neurosurgery 1996; 38:640-9; discussion 649-51. PubMed
  • Guttmann CR, Ahn SS, Hsu L, Kikinis R, Jolesz FA. The evolution of multiple sclerosis lesions on serial MR. AJNR Am J Neuroradiol 1995; 16:1481-91. PubMed
  • Schenck JF, Jolesz FA, Roemer PB, Cline HE, Lorensen WE, Kikinis R, Silverman SG, Hardy CJ, Barber WD, Laskaris ET. Superconducting open-configuration MR imaging system for image-guided therapy. Radiology 1995; 195:805-14. PubMed
  • Warfield S, Dengler J, Zaers J, Guttmann CR, Wells WM, Ettinger GJ, Hiller J, Kikinis R. Automatic identification of gray matter structures from MRI to improve the segmentation of white matter lesions. J Image Guid Surg 1995; 1:326-38. PubMed
  • Kikinis R, Shenton ME, Gerig G, Hokama H, Haimson J, O'Donnell BF, Wible CG, McCarley RW, Jolesz FA. Temporal lobe sulco-gyral pattern anomalies in schizophrenia: an in vivo MR three-dimensional surface rendering study. Neurosci Lett 1994; 182:7-12. PubMed
  • Vaina LM, Grzywacz NM, Kikinis R. Segregation of computations underlying perception of motion discontinuity and coherence. Neuroreport 1994; 5:2289-94. PubMed
  • Khoury SJ, Guttmann CR, Orav EJ, Hohol MJ, Ahn SS, Hsu L, Kikinis R, Mackin GA, Jolesz FA, Weiner HL. Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology 1994; 44:2120-4. PubMed
  • Reimold SC, Maier SE, Fleischmann KE, Khatri M, Piwnica-Worms D, Kikinis R, Lee RT. Dynamic nature of the aortic regurgitant orifice area during diastole in patients with chronic aortic regurgitation. Circulation 1994; 89:2085-92. PubMed
  • Chernoff DM, Silverman SG, Kikinis R, Adams DF, Seltzer SE, Richie JP, Loughlin KR. Three-dimensional imaging and display of renal tumors using spiral CT: a potential aid to partial nephrectomy. Urology 1994; 43:125-9. PubMed
  • Nestor PG, Shenton ME, McCarley RW, Haimson J, Smith RS, O'Donnell B, Kimble M, Kikinis R, Jolesz FA. Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia. Am J Psychiatry 1993; 150:1849-55. PubMed
  • Altobelli DE, Kikinis R, Mulliken JB, Cline H, Lorensen W, Jolesz F. Computer-assisted three-dimensional planning in craniofacial surgery. Plast Reconstr Surg 1993; 92:576-85; discussion 586-7. PubMed
  • O'Donnell BF, Shenton ME, McCarley RW, Faux SF, Smith RS, Salisbury DF, Nestor PG, Pollak SD, Kikinis R, Jolesz FA. The auditory N2 component in schizophrenia: relationship to MRI temporal lobe gray matter and to other ERP abnormalities. Biol Psychiatry 1993; 34:26-40. PubMed
  • Shenton ME, O'Donnell BF, Nestor PG, Wible CG, Kikinis R, Faux SF, Pollak SD, Jolesz FA, McCarley RW. Temporal lobe abnormalities in a patient with schizophrenia who has word-finding difficulty: use of high-resolution magnetic resonance imaging and auditory P300 event-related potentials. Harv Rev Psychiatry 1997; 1:110-7. PubMed
  • McCarley RW, Shenton ME, O'Donnell BF, Faux SF, Kikinis R, Nestor PG, Jolesz FA. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch Gen Psychiatry 1993; 50:190-7. PubMed
  • Schwartz RB, Jones KM, Chernoff DM, Mukherji SK, Khorasani R, Tice HM, Kikinis R, Hooton SM, Stieg PE, Polak JF. Common carotid artery bifurcation: evaluation with spiral CT. Work in progress. Radiology 1992; 185:513-9. PubMed
  • Kikinis R, Shenton ME, Gerig G, Martin J, Anderson M, Metcalf D, Guttmann CR, McCarley RW, Lorensen W, Cline H. Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging. J Magn Reson Imaging 1992; 2:619-29. PubMed
  • Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, Hokama H, Martin J, Metcalf D, Coleman M. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med 1992; 327:604-12. PubMed
  • Gerig G, Kikinis R, Kuoni W, von Schulthess GK, K. Semiautomated ROI analysis in dynamic MR studies. Part I: Image analysis tools for automatic correction of organ displacements. J Comput Assist Tomogr 1991; 15:725-32. PubMed
  • Shenton ME, Kikinis R, McCarley RW, Metcalf D, Tieman J, Jolesz FA. Application of automated MRI volumetric measurement techniques to the ventricular system in schizophrenics and normal controls. Schizophr Res 1991; 5:103-13. PubMed
  • Cline HE, Lorensen WE, Souza SP, Jolesz FA, Kikinis R, Gerig G, Kennedy TE. 3D surface rendered MR images of the brain and its vasculature. J Comput Assist Tomogr 1991; 15:344-51. PubMed
  • Kikinis R, Wolfensberger M, Boesch C, Martin E. Larynx: MR imaging at 2.35 T. Radiology 1989; 171:165-9. PubMed
  • Boesch C, Issakainen J, Kewitz G, Kikinis R, Martin E, Boltshauser E. Magnetic resonance imaging of the brain in congenital cytomegalovirus infection. Pediatr Radiol 1988; 19:91-3. PubMed